CCK-4: Psychophysiological conditioning elicits features of spontaneous panic attacks

Journal of Psychiatric Research

Volumn 44, Issue 16, 2010, Pages 1148-1153

  Hinkelmann, Kim ^a   Yassouridis, Alexander ^b   Mass, Reinhard ^c   Tenge, Henrike ^a   Kellner, Michael ^a   Jahn, Holger ^a   Wiedemann, Klaus ^a   Wolf, Karsten ^c  

^a UNIVERSITY OF HAMBURG   (Germany)

^b MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

^c Center of Mental Health Marienheide   (Germany)

Author keywords

Activation density; CCK 4; Conditioning; Emotional facial expression; Facial EMG; HPA axis; Panic anxiety

Indexed keywords

PLACEBO; STRESS HORMONE; TETRAGASTRIN;

ADULT; ARTICLE; CLINICAL TRIAL; CONDITIONING; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG DOSE COMPARISON; DRUG EFFECT; ELECTROMYOGRAPHY; EMOTIONALITY; EVOKED MUSCLE RESPONSE; FACE MUSCLE; FACIAL EXPRESSION; FEAR; HUMAN; HUMAN EXPERIMENT; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; MALE; NORMAL HUMAN; PANIC; PRIORITY JOURNAL; PSYCHOPHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL;

ADRENOCORTICOTROPIC HORMONE; ADULT; AREA UNDER CURVE; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; ELECTROMYOGRAPHY; FACIAL MUSCLES; HUMANS; MALE; PAIN MEASUREMENT; PANIC DISORDER; RADIOIMMUNOASSAY; TETRAGASTRIN; TIME FACTORS; YOUNG ADULT;

EID: 78649695297     PISSN: 00223956     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpsychires.2010.04.004     Document Type: Article

References (25)

1. Abelson J.L., Khan S., Liberzon I., Young E.A. HPA axis activity in patients with panic disorder: review and synthesis of four studies. Depression and Anxiety 2007, 241:66-76.
2. Bradwejn J., Koszycki D., Meterissian G. Cholecystokinin-tetrapeptide induces panic attacks in patients with panic disorder. Canadian Journal of Psychiatry 1990, 351:83-85.
3. Bradwejn J., Koszycki D., Paradis M., Reece P., Hinton J., Sedman A. Effect of CI-988 on cholecystokinin tetrapeptide-induced panic symptoms in healthy volunteers. Biological Psychiatry 1995, 3811:742-746.
4. Bradwejn J., Koszycki D., Payeur R., Bourin M., Borthwick H. Replication of action of cholecystokinin tetrapeptide in panic disorder: clinical and behavioral findings. American Journal of Psychiatry 1992, 1497:962-964.
5. Darwin C. The expression of emotions in man and animals 1872, Philosophical Library, New York.
6. Dimberg U., Thunberg M., Elmehed K. Unconscious facial reactions to emotional facial expressions. Psychology Science 2000, 111:86-89.
7. Ekman P., Friesen W.V. The Facial Action Coding System 2002, Salt Lake City: Research Nexus eBook, Weidenfeld & Nicolson, London. 2nd ed.
8. Ekman P., Friesen W.V. Unmasking the face: a guide to recognizing emotions from facial expressions 2003, Malor Books, Cambridge, Ma.
9. Eser D., Leicht G., Baghai T., Pogarell O., Schule C., Karch S., et al. Impact of loudness dependency of auditory evoked potentials on the panic response to CCK-4. Journal of Psychiatric Research 2009, 434:393-400.
10. Eser D., Leicht G., Lutz J., Wenninger S., Kirsch V., Schule C., et al. Functional neuroanatomy of CCK-4-induced panic attacks in healthy volunteers. Human Brain Mapping 2009, 302:511-522.
11. Eser D., Schule C., Baghai T., Floesser A., Krebs-Brown A., Enunwa M., et al. Evaluation of the CCK-4 model as a challenge paradigm in a population of healthy volunteers within a proof-of-concept study. Psychopharmacology (Berl) 2007, 1924:479-487.
12. Fridlund A.J., Cacioppo J.T. Guidelines for human electromyographic research. Psychophysiology 1986, 235:567-589.
13. Graeff F.G., Garcia-Leal C., Del-Ben C.M., Guimaraes F.S. Does the panic attack activate the hypothalamic-pituitary-adrenal axis?. Anais da Academia Brasileira Ciencias 2005, 773:477-491.
14. Gunnarsson T., Mahoney C., Shlik J., Bradwejn J., Knott V. Acute effects of cholecystokinin tetrapeptide on brain stem auditory evoked potentials in healthy volunteers. Pharmacopsychiatry 2003, 365:181-186.
15. Harrigan J.A., O'Connel D.M. How do you look when feeling anxious? Facial displays of anxiety. Person Individual Difference 1996, 21(2):205-212.
16. Kellner M., Muhtz C., Demiralay C., Husemann J., Koelsch W., Yassouridis A., et al. The selective serotonin re-uptake inhibitor escitalopram modulates the panic response to cholecystokinin tetrapeptide in healthy men depending on 5-HTTLPR genotype. Journal of Psychiatric Research 2009, 436:642-648.
17. Kellner M., Wiedemann K. Nonresponse of adrenocorticotropic hormone in first-ever lactate-induced panic attacks in healthy volunteers. Archives of General Psychiatry 1998, 551:85-86.
18. Kellner M., Yassouridis A., Hua Y., Wendrich M., Jahn H., Wiedemann K. Intravenous C-type natriuretic peptide augments behavioral and endocrine effects of cholecystokinin tetrapeptide in healthy men. Journal of Psychiatric Research 2002, 361:1-6.
19. Nakamura M. Shinrigaku Kenkyu 2002, 732:140-147.
20. Preter M., Klein D.F. Panic, suffocation false alarms, separation anxiety and endogenous opioids. Progress in Neuropsychopharmacology and Biological Psychiatry 2008, 323:603-612.
21. Schunck T., Erb G., Mathis A., Gilles C., Namer I.J., Hode Y., et al. Functional magnetic resonance imaging characterization of CCK-4-induced panic attack and subsequent anticipatory anxiety. Neuroimage 2006, 313:1197-1208.
22. Ströhle A., Kellner M., Holsboer F., Wiedemann K. Anxiolytic activity of atrial natriuretic peptide in patients with panic disorder. American Journal of Psychiatry 2001, 1589:1514-1516.
23. Susskind J.M., Lee D.H., Cusi A., Feiman R., Grabski W., Anderson A. Expressing fear enhances sensory acquisition. Nature Neuroscience 2008, 11(7):843-850.
24. Wiedemann K., Jahn H., Yassouridis A., Kellner M. Anxiolyticlike effects of atrial natriuretic peptide on cholecystokinin tetrapeptide-induced panic attacks: preliminary findings. Archives of General Psychiatry 2001, 584:371-377.
25. Wolf K., Mass R., Ingenbleek T., Kiefer F., Naber D., Wiedemann K. The facial pattern of disgust, appetence, excited joy and relaxed joy: an improved facial EMG study. Scandinavian Journal of Psychology 2005, 465:403-409.