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Volumn 14, Issue 11, 2010, Pages 2667-2674

In vivo and in vitro assessment of brain bioenergetics in aging rats

Author keywords

31P NMR; Aging; Antioxidants; Brain; Mitochondria; OXPHOS

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANTIOXIDANT;

EID: 78649694761     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2009.00879.x     Document Type: Article
Times cited : (23)

References (59)
  • 1
    • 0342894814 scopus 로고    scopus 로고
    • Lipid peroxidation and antioxidant enzymes in livers and brains of aged rats
    • Dogru-Abbasoglu S, Tamer-Toptani S, Ugurnal B, et al Lipid peroxidation and antioxidant enzymes in livers and brains of aged rats. Mech Ageing Dev. 1997; 98: 177-80.
    • (1997) Mech Ageing Dev , vol.98 , pp. 177-80
    • Dogru-Abbasoglu, S.1    Tamer-Toptani, S.2    Ugurnal, B.3
  • 2
    • 0027265381 scopus 로고
    • Free radicals in brain metabolism and pathology
    • Evans PH. Free radicals in brain metabolism and pathology. Br Med Bull. 1993; 49: 577-87.
    • (1993) Br Med Bull , vol.49 , pp. 577-87
    • Evans, P.H.1
  • 3
    • 0027175484 scopus 로고
    • Age-dependent impairment of mitochondrial function in primate brain
    • Bowling AC, Mutisya EM, Walker LC, et al Age-dependent impairment of mitochondrial function in primate brain. J Neurochem. 1993; 60: 1964-7.
    • (1993) J Neurochem , vol.60 , pp. 1964-7
    • Bowling, A.C.1    Mutisya, E.M.2    Walker, L.C.3
  • 4
    • 0033510014 scopus 로고    scopus 로고
    • Mitochondria in neurodegeneration: acute ischemia and chronic neurodegenerative diseases
    • Fiskum G, Murphy AN, Beal MF. Mitochondria in neurodegeneration: acute ischemia and chronic neurodegenerative diseases. J Cereb Blood Flow Metab. 1999; 19: 351-69.
    • (1999) J Cereb Blood Flow Metab , vol.19 , pp. 351-69
    • Fiskum, G.1    Murphy, A.N.2    Beal, M.F.3
  • 5
    • 0018776894 scopus 로고
    • Hydroperoxide metabolism in mammalian organs
    • Chance B, Sies H, Boveris A. Hydroperoxide metabolism in mammalian organs. Physiol Rev. 1979; 59: 527-605.
    • (1979) Physiol Rev , vol.59 , pp. 527-605
    • Chance, B.1    Sies, H.2    Boveris, A.3
  • 6
    • 0015319592 scopus 로고
    • The biologic clock: the mitochondria
    • Harman D. The biologic clock: the mitochondria J Am Geriatr Soc. 1972; 20: 145-7.
    • (1972) J Am Geriatr Soc , vol.20 , pp. 145-7
    • Harman, D.1
  • 7
    • 0031853099 scopus 로고    scopus 로고
    • Substrate and site specificity of hydrogen peroxide generation in mouse mitochondria
    • 1
    • Kwong LK, Sohal RS. Substrate and site specificity of hydrogen peroxide generation in mouse mitochondria. Arch Biochem Biophys. 19981; 350: 118-26.
    • (1998) Arch Biochem Biophys , vol.350 , pp. 118-26
    • Kwong, L.K.1    Sohal, R.S.2
  • 9
    • 58849103904 scopus 로고    scopus 로고
    • Targeting oxidative stress for neuroprotection
    • Linseman DA. Targeting oxidative stress for neuroprotection. Antioxidants Redox Signal. 2008; 11: 421-24.
    • (2008) Antioxidants Redox Signal , vol.11 , pp. 421-24
    • Linseman, D.A.1
  • 10
    • 0027686249 scopus 로고
    • Oxidative stress, glutamate, and neurodegenerative disorders
    • Coyle JT, Puttfarcken P. Oxidative stress, glutamate, and neurodegenerative disorders. Science. 1993; 262: 689-95.
    • (1993) Science , vol.262 , pp. 689-95
    • Coyle, J.T.1    Puttfarcken, P.2
  • 11
    • 58149374037 scopus 로고    scopus 로고
    • Antioxidant therapy in Alzheimer's disease: theory and practice
    • Aliev G, Obrenovich ME, Reddy VP, et al Antioxidant therapy in Alzheimer's disease: theory and practice. Mini Rev Med Chem. 2008; 8: 1395-406.
    • (2008) Mini Rev Med Chem , vol.8 , pp. 1395-406
    • Aliev, G.1    Obrenovich, M.E.2    Reddy, V.P.3
  • 12
    • 0032504710 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in neurodegenerative diseases
    • Beal MF. Mitochondrial dysfunction in neurodegenerative diseases. Biochim Biophys Acta. 1998; 1366: 211-23.
    • (1998) Biochim Biophys Acta , vol.1366 , pp. 211-23
    • Beal, M.F.1
  • 13
    • 0031964359 scopus 로고    scopus 로고
    • Neuroprotective effects of creatine and cyclocreatine in animal models of Huntington's disease
    • Matthews RT, Yang L, Jenkins BG, et al Neuroprotective effects of creatine and cyclocreatine in animal models of Huntington's disease. J Neurosci. 1998; 18: 156-63.
    • (1998) J Neurosci , vol.18 , pp. 156-63
    • Matthews, R.T.1    Yang, L.2    Jenkins, B.G.3
  • 14
    • 0027967788 scopus 로고
    • Age-related changes in swine brain creatine kinase-catalyzed 31P exchange measured in vivo using 31P NMR magnetization transfer
    • Corbett RJ, Laptook AR. Age-related changes in swine brain creatine kinase-catalyzed 31P exchange measured in vivo using 31P NMR magnetization transfer. J Cereb Blood Flow Metab. 1994; 14: 1070-7.
    • (1994) J Cereb Blood Flow Metab , vol.14 , pp. 1070-7
    • Corbett, R.J.1    Laptook, A.R.2
  • 15
    • 0027504939 scopus 로고
    • Determination of creatine kinase kinetic parameters in rat brain by NMR magnetization transfer. Correlation with brain function
    • Sauter A, Rudin M. Determination of creatine kinase kinetic parameters in rat brain by NMR magnetization transfer. Correlation with brain function. J Biol Chem. 1993; 268: 13166-71.
    • (1993) J Biol Chem , vol.268 , pp. 13166-71
    • Sauter, A.1    Rudin, M.2
  • 16
    • 0025965030 scopus 로고
    • Multisite saturation transfer using DANTE and continuous wave
    • Clark JF, Harris GI, Dillon PF. Multisite saturation transfer using DANTE and continuous wave. Magn Reson Med. 1991; 17: 274-8.
    • (1991) Magn Reson Med , vol.17 , pp. 274-8
    • Clark, J.F.1    Harris, G.I.2    Dillon, P.F.3
  • 17
    • 33846851242 scopus 로고
    • Study of moderately rapid chemical exchange reactions by means of nuclear magnetic double resonance
    • Forsen F, Hoffman R. Study of moderately rapid chemical exchange reactions by means of nuclear magnetic double resonance. J Chem Phys. 1963; 39: 2892-901.
    • (1963) J Chem Phys , vol.39 , pp. 2892-901
    • Forsen, F.1    Hoffman, R.2
  • 18
    • 0017060767 scopus 로고
    • Biochemical and contractile properties of heart muscle after prolonged alcohol administration
    • Sarma JS, Ikeda S, Fischer R, et al Biochemical and contractile properties of heart muscle after prolonged alcohol administration. J Mol Cell Cardiol. 1976; 8: 951-72.
    • (1976) J Mol Cell Cardiol , vol.8 , pp. 951-72
    • Sarma, J.S.1    Ikeda, S.2    Fischer, R.3
  • 19
    • 71849104860 scopus 로고
    • Protein measurement with the Folin phenol reagent
    • Lowry OH, Rosebrough NJ, Farr AL, et al Protein measurement with the Folin phenol reagent. J Biol Chem. 1951; 193: 265-75.
    • (1951) J Biol Chem , vol.193 , pp. 265-75
    • Lowry, O.H.1    Rosebrough, N.J.2    Farr, A.L.3
  • 20
    • 0021318441 scopus 로고
    • Catalase in vitro
    • Aebi H. Catalase in vitro. Methods Enzymol. 1984; 105: 121-6.
    • (1984) Methods Enzymol , vol.105 , pp. 121-6
    • Aebi, H.1
  • 21
    • 0019740344 scopus 로고
    • Glutathione peroxidase
    • Wendel A. Glutathione peroxidase. Methods Enzymol. 1981; 77: 325-33.
    • (1981) Methods Enzymol , vol.77 , pp. 325-33
    • Wendel, A.1
  • 22
    • 0030586361 scopus 로고    scopus 로고
    • The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay
    • Benzie IF, Strain JJ. The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay. Anal Biochem. 1996; 239: 70-6.
    • (1996) Anal Biochem , vol.239 , pp. 70-6
    • Benzie, I.F.1    Strain, J.J.2
  • 23
    • 0016331976 scopus 로고
    • Measurement of ceruloplasmin from its oxidase activity in serum by use of o-dianisidine dihydrochloride
    • Schosinsky KH, Lehmann HP, Beeler MF. Measurement of ceruloplasmin from its oxidase activity in serum by use of o-dianisidine dihydrochloride. Clin Chem. 1974; 20: 1556-63.
    • (1974) Clin Chem , vol.20 , pp. 1556-63
    • Schosinsky, K.H.1    Lehmann, H.P.2    Beeler, M.F.3
  • 24
    • 47849127831 scopus 로고    scopus 로고
    • Atherosclerotic lesions and mitochondria DNA deletions in brain microvessels: implication in the pathogenesis of Alzheimer's disease
    • Aliev G, Gasimov E, Obrenovich ME, et al Atherosclerotic lesions and mitochondria DNA deletions in brain microvessels: implication in the pathogenesis of Alzheimer's disease. Vasc Health Risk Manag. 2008; 4: 721-30.
    • (2008) Vasc Health Risk Manag , vol.4 , pp. 721-30
    • Aliev, G.1    Gasimov, E.2    Obrenovich, M.E.3
  • 25
    • 68949152521 scopus 로고    scopus 로고
    • Brain mitochondria as a primary target in the development of treatment strategies for Alzheimer disease
    • (in press). doi:.
    • Aliev G, Palacios H, Walrafen B, et al. Brain mitochondria as a primary target in the development of treatment strategies for Alzheimer disease. Int J Biochim Cell Biol. 2009 (in press). doi:.
    • (2009) Int J Biochim Cell Biol
    • Aliev, G.1    Palacios, H.2    Walrafen, B.3
  • 26
    • 0032993404 scopus 로고    scopus 로고
    • Metabolic consequences of the cytochrome c oxidase deficiency in brain of copper-deficient Mo(vbr) mice
    • Kunz WS, Kuznetsov AV, Clark JF, et al Metabolic consequences of the cytochrome c oxidase deficiency in brain of copper-deficient Mo(vbr) mice. J Neurochem. 1999; 72: 1580-5.
    • (1999) J Neurochem , vol.72 , pp. 1580-5
    • Kunz, W.S.1    Kuznetsov, A.V.2    Clark, J.F.3
  • 27
    • 0345734341 scopus 로고    scopus 로고
    • Hypertension and the brain: vulnerability of the prefrontal regions and executive functions
    • Raz N, Rodrigue KM, Acker JD. Hypertension and the brain: vulnerability of the prefrontal regions and executive functions. Behav Neurosci. 2003; 117: 1169-80.
    • (2003) Behav Neurosci , vol.117 , pp. 1169-80
    • Raz, N.1    Rodrigue, K.M.2    Acker, J.D.3
  • 28
    • 0035110424 scopus 로고    scopus 로고
    • Melatonin, mitochondria, and cellular bioenergetics
    • Acuna-Castroviejo D, Martin M, Macias M, et al Melatonin, mitochondria, and cellular bioenergetics. J Pineal Res. 2001; 30: 65-74.
    • (2001) J Pineal Res , vol.30 , pp. 65-74
    • Acuna-Castroviejo, D.1    Martin, M.2    Macias, M.3
  • 29
    • 0035341254 scopus 로고    scopus 로고
    • Mitochondrial abnormalities in Alzheimer's disease
    • Hirai K, Aliev G, Nunomura A, et al Mitochondrial abnormalities in Alzheimer's disease. J Neurosci. 2001; 21: 3017-23.
    • (2001) J Neurosci , vol.21 , pp. 3017-23
    • Hirai, K.1    Aliev, G.2    Nunomura, A.3
  • 30
    • 10644276189 scopus 로고    scopus 로고
    • Mitochondria as a primary target for vascular hypoperfusion and oxidative stress in Alzheimer's disease
    • Aliev G, Smith MA, De La Torre JC, et al Mitochondria as a primary target for vascular hypoperfusion and oxidative stress in Alzheimer's disease. Mitochondrion. 2004; 4: 649-63.
    • (2004) Mitochondrion , vol.4 , pp. 649-63
    • Aliev, G.1    Smith, M.A.2    De La Torre, J.C.3
  • 31
    • 14844311901 scopus 로고    scopus 로고
    • Mitochondria DNA deletions in atherosclerotic hypoperfused brain microvessels as a primary target for the development of Alzheimer's disease
    • 285-92
    • Aliyev A, Chen SG, Seyidova D, et al Mitochondria DNA deletions in atherosclerotic hypoperfused brain microvessels as a primary target for the development of Alzheimer's disease. J Neurol Sci. 2005; 229-230: 285-92.
    • (2005) J Neurol Sci , pp. 229-230
    • Aliyev, A.1    Chen, S.G.2    Seyidova, D.3
  • 32
    • 0030868480 scopus 로고    scopus 로고
    • The role of mitochondrial dysfunction and neuronal nitric oxide in animal models of neurodegenerative diseases
    • Schulz JB, Matthews RT, Klockgether T, et al The role of mitochondrial dysfunction and neuronal nitric oxide in animal models of neurodegenerative diseases. Mol Cell Biochem. 1997; 174: 193-7.
    • (1997) Mol Cell Biochem , vol.174 , pp. 193-7
    • Schulz, J.B.1    Matthews, R.T.2    Klockgether, T.3
  • 33
    • 0036796276 scopus 로고    scopus 로고
    • Role of oxidative stress and antioxidants in neurodegenerative diseases
    • Rao AV, Balachandran B. Role of oxidative stress and antioxidants in neurodegenerative diseases. Nutritional neuroscience. 2002; 5: 291-309.
    • (2002) Nutritional neuroscience , vol.5 , pp. 291-309
    • Rao, A.V.1    Balachandran, B.2
  • 34
    • 0037010312 scopus 로고    scopus 로고
    • Role of mitochondrial dysfunction in Alzheimer's disease
    • Castellani R, Hirai K, Aliev G, et al Role of mitochondrial dysfunction in Alzheimer's disease. J Neurosci Res. 2002; 70: 357-60.
    • (2002) J Neurosci Res , vol.70 , pp. 357-60
    • Castellani, R.1    Hirai, K.2    Aliev, G.3
  • 35
    • 61349084847 scopus 로고    scopus 로고
    • Neuronal mitochondrial amelioration by feeding acetyl-L-carnitine and lipoic acid to aged rats
    • Aliev G, Liu J, Shenk JC, et al Neuronal mitochondrial amelioration by feeding acetyl-L-carnitine and lipoic acid to aged rats. J Cell Mol Med. 2009; 13: 320-33.
    • (2009) J Cell Mol Med , vol.13 , pp. 320-33
    • Aliev, G.1    Liu, J.2    Shenk, J.C.3
  • 37
    • 0034784359 scopus 로고    scopus 로고
    • An energy budget for signaling in the grey matter of the brain
    • Attwell D, Laughlin SB. An energy budget for signaling in the grey matter of the brain. J Cereb Blood Flow Metab. 2001; 21: 1133-45.
    • (2001) J Cereb Blood Flow Metab , vol.21 , pp. 1133-45
    • Attwell, D.1    Laughlin, S.B.2
  • 38
    • 0033667655 scopus 로고    scopus 로고
    • Non-invasive methods for studying brain energy metabolism: what they show and what it means
    • Kemp GJ. Non-invasive methods for studying brain energy metabolism: what they show and what it means. Dev Neurosci. 2000; 22: 418-28.
    • (2000) Dev Neurosci , vol.22 , pp. 418-28
    • Kemp, G.J.1
  • 40
    • 33846088914 scopus 로고    scopus 로고
    • Efficient in vivo 31P magnetization transfer approach for noninvasively determining multiple kinetic parameters and metabolic fluxes of ATP metabolism in the human brain
    • Du F, Zhu XH, Qiao H, et al Efficient in vivo 31P magnetization transfer approach for noninvasively determining multiple kinetic parameters and metabolic fluxes of ATP metabolism in the human brain. Magn Reson Med. 2007; 57: 103-14.
    • (2007) Magn Reson Med , vol.57 , pp. 103-14
    • Du, F.1    Zhu, X.H.2    Qiao, H.3
  • 41
    • 1542708267 scopus 로고    scopus 로고
    • Measurement of unidirectional Pi to ATP flux in human visual cortex at 7 T by using in vivo 31P magnetic resonance spectroscopy
    • Lei H, Ugurbil K, Chen W. Measurement of unidirectional Pi to ATP flux in human visual cortex at 7 T by using in vivo 31P magnetic resonance spectroscopy. Proc Natl Acad Sci USA. 2003; 100: 14409-14.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 14409-14
    • Lei, H.1    Ugurbil, K.2    Chen, W.3
  • 42
    • 0023162434 scopus 로고
    • 31P magnetization transfer studies of creatine kinase kinetics in living rabbit brain
    • Degani H, Alger JR, Shulman RG, et al 31P magnetization transfer studies of creatine kinase kinetics in living rabbit brain. Magn Reson Med. 1987; 5: 1-12.
    • (1987) Magn Reson Med , vol.5 , pp. 1-12
    • Degani, H.1    Alger, J.R.2    Shulman, R.G.3
  • 43
    • 0022152164 scopus 로고
    • Magnetization transfer measurements of creatine kinase and ATPase rates in intact hearts
    • Ugurbil K. Magnetization transfer measurements of creatine kinase and ATPase rates in intact hearts. Circulation. 1985; 72: IV94-6.
    • (1985) Circulation , vol.72
    • Ugurbil, K.1
  • 44
    • 62349088898 scopus 로고    scopus 로고
    • Mitochondrial decay in the brains of old rats: ameliorating effect of alpha-lipoic acid and acetyl-L-carnitine
    • Long J, Gao F, Tong L, et al Mitochondrial decay in the brains of old rats: ameliorating effect of alpha-lipoic acid and acetyl-L-carnitine. Neurochem Res. 2009; 34: 755-63.
    • (2009) Neurochem Res , vol.34 , pp. 755-63
    • Long, J.1    Gao, F.2    Tong, L.3
  • 45
    • 0026754574 scopus 로고
    • Reactive oxygen species and the central nervous system
    • Halliwell B. Reactive oxygen species and the central nervous system. J Neurochem. 1992; 59: 1609-23.
    • (1992) J Neurochem , vol.59 , pp. 1609-23
    • Halliwell, B.1
  • 46
    • 0032823769 scopus 로고    scopus 로고
    • Antioxidant defence mechanisms: from the beginning to the end (of the beginning)
    • Halliwell B. Antioxidant defence mechanisms: from the beginning to the end (of the beginning). Free Radic Res. 1999; 31: 261-72.
    • (1999) Free Radic Res , vol.31 , pp. 261-72
    • Halliwell, B.1
  • 47
    • 0032904412 scopus 로고    scopus 로고
    • An evaluation of the role of mitochondria in neurodegenerative diseases: mitochondrial mutations and oxidative pathology, protective nuclear responses, and cell death in neurodegeneration
    • Cassarino DS, Bennett JP Jr. An evaluation of the role of mitochondria in neurodegenerative diseases: mitochondrial mutations and oxidative pathology, protective nuclear responses, and cell death in neurodegeneration. Brain Res Brain Res Rev. 1999; 29: 1-25.
    • (1999) Brain Res Brain Res Rev , vol.29 , pp. 1-25
    • Cassarino, D.S.1    Bennett Jr, J.P.2
  • 49
    • 0025371191 scopus 로고
    • Immunocytochemical localization of manganese superoxide dismutase (Mn-SOD) in the hippocampus of the rat
    • Akai F, Maeda M, Suzuki K, et al Immunocytochemical localization of manganese superoxide dismutase (Mn-SOD) in the hippocampus of the rat. Neurosci Lett. 1990; 115: 19-23.
    • (1990) Neurosci Lett , vol.115 , pp. 19-23
    • Akai, F.1    Maeda, M.2    Suzuki, K.3
  • 50
    • 0028856231 scopus 로고
    • Redox perturbations in cysteamine-stressed astroglia: implications for inclusion formation and gliosis in the aging brain
    • Manganaro F, Chopra VS, Mydlarski MB, et al Redox perturbations in cysteamine-stressed astroglia: implications for inclusion formation and gliosis in the aging brain. Free Radic Biol Med. 1995; 19: 823-35.
    • (1995) Free Radic Biol Med , vol.19 , pp. 823-35
    • Manganaro, F.1    Chopra, V.S.2    Mydlarski, M.B.3
  • 51
    • 0031916984 scopus 로고    scopus 로고
    • The free radical theory of aging matures
    • Beckman KB, Ames BN. The free radical theory of aging matures. Physiol Rev. 1998; 78: 547-81.
    • (1998) Physiol Rev , vol.78 , pp. 547-81
    • Beckman, K.B.1    Ames, B.N.2
  • 52
    • 0032413244 scopus 로고    scopus 로고
    • Mitochondrial aging: open questions
    • Beckman KB, Ames BN. Mitochondrial aging: open questions. Ann N Y Acad Sci. 1998; 854: 118-27.
    • (1998) Ann N Y Acad Sci , vol.854 , pp. 118-27
    • Beckman, K.B.1    Ames, B.N.2
  • 53
    • 0033535365 scopus 로고    scopus 로고
    • Endogenous oxidative damage of mtDNA
    • Beckman KB, Ames BN. Endogenous oxidative damage of mtDNA. Mutat Res. 1999; 424: 51-8.
    • (1999) Mutat Res , vol.424 , pp. 51-8
    • Beckman, K.B.1    Ames, B.N.2
  • 54
    • 0033525773 scopus 로고    scopus 로고
    • Mitochondrial diseases in man and mouse
    • Wallace DC. Mitochondrial diseases in man and mouse. Science. 1999; 283: 1482-8.
    • (1999) Science , vol.283 , pp. 1482-8
    • Wallace, D.C.1
  • 55
    • 8444227821 scopus 로고    scopus 로고
    • Reactive oxygen species and synaptic plasticity in the aging hippocampus
    • Serrano F, Klann E. Reactive oxygen species and synaptic plasticity in the aging hippocampus. Ageing Res Rev. 2004; 3: 431-43.
    • (2004) Ageing Res Rev , vol.3 , pp. 431-43
    • Serrano, F.1    Klann, E.2
  • 56
    • 0037111169 scopus 로고    scopus 로고
    • Cognitive impairment and chronic cerebral hypoperfusion: what can be learned from experimental models
    • 263-6
    • Sarti C, Pantoni L, Bartolini L, et al Cognitive impairment and chronic cerebral hypoperfusion: what can be learned from experimental models. J Neurol Sci. 2002; 203-204: 263-6.
    • (2002) J Neurol Sci , pp. 203-204
    • Sarti, C.1    Pantoni, L.2    Bartolini, L.3
  • 57
    • 0034603552 scopus 로고    scopus 로고
    • Critically attained threshold of cerebral hypoperfusion: the CATCH hypothesis of Alzheimer's pathogenesis
    • De La Torre JC. Critically attained threshold of cerebral hypoperfusion: the CATCH hypothesis of Alzheimer's pathogenesis. Neurobiol Aging. 2000; 21: 331-42.
    • (2000) Neurobiol Aging , vol.21 , pp. 331-42
    • De La Torre, J.C.1
  • 58
    • 0036218738 scopus 로고    scopus 로고
    • Alzheimer disease as a vascular disorder: nosological evidence
    • De La Torre JC. Alzheimer disease as a vascular disorder: nosological evidence. Stroke. 2002; 33: 1152-62.
    • (2002) Stroke , vol.33 , pp. 1152-62
    • De La Torre, J.C.1
  • 59
    • 33749504441 scopus 로고    scopus 로고
    • Evaluation of treatment effects in Alzheimer's and other neurodegenerative diseases by MRI and MRS
    • Mueller SG, Schuff N, Weiner MW. Evaluation of treatment effects in Alzheimer's and other neurodegenerative diseases by MRI and MRS. NMR Biomed. 2006; 19: 655-68.
    • (2006) NMR Biomed , vol.19 , pp. 655-68
    • Mueller, S.G.1    Schuff, N.2    Weiner, M.W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.