Long-range tertiary interactions in single hammerhead ribozymes bias motional sampling toward catalytically active conformations

RNA

Volumn 16, Issue 12, 2010, Pages 2414-2426

  McDowell, S Elizabeth ^a   Jun, Jesse M ^a   Walter, Nils G ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Conformational change; Fluorescence microscopy; Fluorescence spectroscopy; Molecular dynamics simulation; Single molecule fret

Indexed keywords

HAMMERHEAD RIBOZYME; MAGNESIUM ION;

ARTICLE; ASSAY; CATALYSIS; CONFORMATION; FLUORESCENCE RESONANCE ENERGY TRANSFER; MOLECULAR DYNAMICS; MOTION; PRIORITY JOURNAL; PROTEIN BINDING; RNA STRUCTURE; SIMULATION; TITRIMETRY; WILD TYPE;

BASE SEQUENCE; CATALYSIS; DRUG DESIGN; DRUG INTERACTIONS; FLUORESCENCE RESONANCE ENERGY TRANSFER; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOTION; NUCLEIC ACID CONFORMATION; RESEARCH DESIGN; RNA, CATALYTIC; SPECIMEN HANDLING; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 78649677325     PISSN: 13558382     EISSN: 14699001     Source Type: Journal    
DOI: 10.1261/rna.1829110     Document Type: Article

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