Neuronal injury in chronic CNS inflammation

Best Practice and Research: Clinical Anaesthesiology

Volumn 24, Issue 4, 2010, Pages 551-562

  Zindler, Eva ^a   Zipp, Frauke ^a  

^a UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

Author keywords

Chronic inflammatory disease; Inflammatory demyelination; Neurodegeneration; Neurogenesis; Neuroprotection; Neuroregenration; Neurotrophins; Remyelination

Indexed keywords

BEPRIDIL; BETA INTERFERON; EPI GALLO CATECHIN 3 GALLIC ACID; FINGOLIMOD; FLECAINIDE; GALLIC ACID DERIVATIVE; GLATIRAMER; LAMOTRIGINE; NITRENDIPINE; PHENYTOIN; PROTEINASE; SPHINGOSINE 1 PHOSPHATE RECEPTOR; UNCLASSIFIED DRUG;

ALLERGIC ENCEPHALOMYELITIS; APOPTOSIS; AXONAL INJURY; BRAIN INJURY; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL MIGRATION; CLINICAL TRIAL; HUMAN; MACROPHAGE; MICROGLIA; MULTIPLE SCLEROSIS; NERVE DEGENERATION; NERVE FIBER DEGENERATION; NERVOUS SYSTEM DEVELOPMENT; NEUROPROTECTION; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; REVIEW;

ANIMALS; CENTRAL NERVOUS SYSTEM DISEASES; CHRONIC DISEASE; HUMANS; INFLAMMATION; INFLAMMATION MEDIATORS; MICROGLIA; MULTIPLE SCLEROSIS; NEURONS; NEUROPROTECTIVE AGENTS; SEVERITY OF ILLNESS INDEX;

EID: 78649675622     PISSN: 15216896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bpa.2010.11.001     Document Type: Review

References (107)

1. R. Aharoni, D. Teitelbaum, and M. Sela Copolymer 1 induces T cells of the T helper type 2 that cross react with myelin basic protein and suppress experimental autoim- mune encephalomyelitis PNAS 94 20 1997 10821 10826
2. O. Aktas, T. Prozorovski, and A. Smorodchenko Green tea epigallocatechin-3-gallate mediates T cellular NF-κB inhibition and exerts neuroprotection in autoimmune encephalomyelitis Journal of Immunology 173 2004 5794 5800
3. O. Aktas, A. Smorodchenko, and S. Brocke Neuronal damage in autoimmune neuroinflammation mediated by the death ligand TRAIL Neuron 46 3 2005 421 432
4. O. Aktas, S. Waiczies, and F. Zipp Neurodegeneration in autoimmune demyelination: recent mechanistic insights reveal novel therapeutic targets Journal of Neuroimmunology 184 1-2 2007 Mar 17 26 Epub 10.01.07
5. O. Aktas, B. Kieseier, and H.P. Hartung Neuroprotection, regeneration and immunomodulation: broadening the therapeutic repertoire in multiple sclerosis Trends in Neurosciences 33 3 2010 Mar 140 152 Epub 04.01.10
6. J. Altman, and G.D. Das Autoradiographic and histological investigation of changes in the visual system of rats after unilateral enucleation Anatomical Record 148 1964 Apr 535 545
7. D.L. Arnold, G.T. Riess, and P.M. Matthews Use of proton magnetic resonance spectroscopy for monitoring disease progression in multiple sclerosis Annals of Neurology 36 1 1994 Jul 76 82
8. D.L. Arnold, N. de Stefano, and P.M. Matthews N-acetylaspartate: usefulness as an indicator of viable neuronal tissue Annals of Neurology 50 6 2001 823 825
9. R. Arnon, and R. Aharoni Mechanism of action of glatiramer acetate in multiple sclero- sis and its potential for the development of new applications PNAS 101 Suppl. 2 2004 14593 14598
10. A.S. Basso, D. Frenkel, and F.J. Quintana Reversal of axonal loss and disability in a mouse model of progressive multiple sclerosis The Journal of Clinical Investigation 118 4 2008 Apr 1532 1543
11. H. Babbe, A. Roers, and A. Waisman Clonal expansions of CD8(+) T cells dominate the T cell infiltrate in active multiple sclerosis lesions as shown by micromanipulation and single cell polymerase chain reaction Journal of Experimental Medicine 192 3 2000 Aug 7 393 404
12. R.B. Banati, J. Newcombe, and R.N. Gunn The peripheral benzodiazepine binding site in the brain in multiple sclerosis: quantitative in vivo imaging of microglia as a measure of disease activity Brain 123 Pt 11 2000 2321 2337
13. M.H. Barnett, and J.W. Prineas Relapsing and remitting multiple sclerosis: pathology of the newly forming lesion Annals of Neurology 55 2004 458 468
14. D.A. Bechtold, R. Kapoor, and K.J. Smith Axonal protection using flecainide in experimental autoimmune encephalomyelitis Annals of Neurology 55 2004 607 616
15. D.A. Bechtold, S.J. Miller, and A.C. Dawson Axonal protection achieved in a model of multiple sclerosis using lamotrigine Journal of Neurology 253 2006 1542 1551
16. A. Bitsch, J. Schuchardt, and S. Bunkowski Acute axonal injury in multiple sclerosis. Correlation with demyelination and inflammation Brain 123 Pt 6 2000 Jun 1174 1183
17. L. Bø, C.A. Vedeler, and H.I. Nyland Subpial demyelination in the cerebral cortex of multiple sclerosis patients Journal of Neuropathology & Experimental Neurology 62 7 2003 723 732
18. L. Bø, C.A. Vedeler, and H. Nyland Intracortical multiple sclerosis lesions are not associated with increased lymphocyte infiltration Multiple Sclerosis 9 4 2003 323 331
19. E. Brand-Schieber, and P. Werner Calcium channel blockers ameliorate disease in a mouse model of multiple sclerosis Experimental Neurology 189 1 2004 Sep 5 9
20. P.A. Brex, O. Ciccarelli, and J.I. O'Riordan A longitudinal study of abnormalities on MRI and disability from multiple sclerosis The New England Journal of Medicine 346 3 2002 158 164
21. V. Brinkmann Sphingosine 1-phosphate receptors in health and disease: mechanistic insights from gene deletion studies and reverse pharmacology Pharmacology Therapy 115 1 2007 Jul 84 105 Epub 2007 May 22
22. V. Brinkmann FTY720 (fingolimod) in Multiple Sclerosis: therapeutic effects in the immune and the central nervous system British Journal of Pharmacology 158 5 2009 Nov 1173 1182 Epub 08.10.10
23. C.F. Brosnan, and C.S. Raine Mechanisms of immune injury in multiple sclerosis Brain Pathology 6 3 1996 243 257
24. S. Cepok, B. Rosche, and V. Grummel Short-lived plasma blasts are the main B cell effector subset during the course of multiple sclerosis Brain 128 Pt 7 2005 1667 1676 Epub 30.03.05
25. J.M. Charcot Lecons sur les maladies du systeme nerveux faites a la Salpetrire 4th ed. 1880 Bourneville Paris
26. I.F. Charo, and R.M. Ransohoff The many roles of chemokines and chemokine receptors in inflammation The New England Journal of Medicine 354 6 2006 610 621
27. A.J. Coles, M.G. Wing, and P. Molyneux Monoclonal antibody treatment exposes three mechanisms underlying the clinical course of multiple sclerosis Annals of Neurology 46 3 1999 296 304
28. M.J. Craner, T.G. Damarjian, and S. Liu Sodium channels contribute to microglia/macrophage activation and function in EAE and MS Glia 49 2005 220 229
29. J. Dawson The histology of dissemated sclerosis Transactions of the Royal Society of Edinburgh 50 1916 517 740
30. N. De Stefano, P.M. Matthews, and L. Fu Axonal damage correlates with disability in patients with relapsing-remitting multiple sclerosis. Results of a longitudinal magnetic resonance spectroscopy study Brain 121 Pt 8 1998 Aug 1469 1477
31. A. Diestel, O. Aktas, and D. Hackel Activation of microglial poly(ADP-ribose)-polymerase-1 by cholesterol breakdown products during neuroinflammation: a link between demyelination and neuronal damage Journal of Experimental Medicine 198 11 2003 1729 1740
32. R. Dutta, J. McDonough, and X. Yin Mitochondrial dysfunction as a cause of axonal degeneration in multiple sclerosis patients Annals of Neurology 59 2006 478 489
33. B. Engelhardt, and R.M. Ransohoff The ins and outs of T-lymphocyte trafficking to the CNS: anatomical sites and molecular mechanisms Trends in Immunology 26 9 2005 485 495
34. P.A. Felts, T.A. Baker, and K.J. Smith Conduction in segmentally demyelinated mammalian central axons Journal of Neuroscience 17 1997 7267 7277
35. B. Ferguson, M.K. Matyszak, and M.M. Esiri Axonal damage in acute multiple sclerosis lesions Brain 120 Pt 3 1997 393 399
36. R.J. Franklin, and C. Ffrench-Constant Remyelination in the CNS: from biology to therapy Nature Reviews Neuroscience 9 11 2008 Nov 839 855
37. M. Greter, F.L. Heppner, and M.P. Lemos Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis Nature Medicine 11 3 2005 328 334 Epub 27.02.10
38. I. Griffiths, M. Klugmann, and T. Anderson Axonal swellings and degeneration in mice lacking the major proteolipid of myelin Science 280 1998 1610 1613
39. F.L. Heppner, M. Greter, and D. Marino Experimental autoimmune encephalomyelitis repressed by microglial paralysis Nature Medicine 11 2 2005 146 152 Epub 23.01.05
40. J. Herz, F. Zipp, and V. Siffrin Neurodegeneration in autoimmune CNS inflammation Experimental Neurology 225 1 2010 Sep 9 17 Epub 01.12.09
41. M. Hobom, M.K. Storch, and R. Weissert Mechanisms and time course of neuronal degeneration in experimental autoimmune encephalomyelitis Brain Pathology 14 2 2004 148 157
42. R. Hohlfeld, and H. Wekerle Autoimmune concepts of MS as a basis for selective immunotherapy: from the pipe dreams to therapeutic pipelines PNAS 101 Suppl. 2 2004 14599 14606
43. R. Hohlfeld, M. Kerschensteiner, and C. Stadel- mann The neuroprotective effect of inflammation: impli- cations for the therapy of multiple sclerosis Neurological Sciences 27 Suppl. 1 2006 S1 S7
44. D. Hu, K. Ikizawa, and L. Lu Analysis of regulatory CD8 T cells in Qa-1-deficient mice Nature Immunology 5 5 2004 May 516 523 Epub 18.04.10
45. M. Inglese, Y. Ge, and M. Filippi Indirect evidence for early widespread gray matter involvement in relapsing-remitting multiple sclerosis Neuroimage 21 4 2004 1825 1829
46. B.C. Kieseier, and H.P. Hartung Interferon- beta and neuroprotection in multiple sclerosis - facts, hopes and phantasies Experimental Neurology 203 1 2007 1 4
47. K.A. Irvine, and W.F. Blakemore Remyelination protects axons from demyelination-associated axon degeneration Brain 131 Pt 6 2008 Jun 1464 1477 Epub 18.05.18
48. R. Kapoor, M. Davies, and P.A. Blaker Blockers of sodium and calcium entry protect axons from nitric oxide-mediated degeneration Annals of Neurology 53 2003 174 180
49. T. Kamradt, and N.A. Mitchison Tolerance and autoimmunity The New England Journal of Medicine 344 9 2001 Mar 1 655 664
50. A. Kutzelnigg, C.F. Lucchinetti, and C. Stadelmann Cortical demyelination and diffuse white matter injury in multiple sclerosis Brain. 128 Pt 11 2005 2705 2712 Epub 17.10.05
51. B. Kornek, M.K. Storch, and R. Weissert Multiple sclerosis and chronic autoimmune encephalomyelitis: a comparative quantitative study of axonal injury in active, inactive, and remyelinated lesions American Journal Of Pathology 157 1 2000 267 276
52. H. Lassmann, W. Brück, and C.F. Lucchinetti The immunopathology of multiple sclerosis: an overview Brain Pathology 17 2 2007 210 218
53. S. Lindquist, N. Bodammer, and J. Kaufmann Histopathology and serial, multimodal magnetic resonance imaging in a multiple sclerosis variant Multiple Sclerosis 13 2007 471 482
54. A.C. Lo, C.Y. Saab, and J.A. Black Phenytoin protects spinal cord axons and preserves axonal conduction and neurological function in a model of neuroinflammation in vivo Journal of Neurophysiology 90 2003 3566 3571
55. C. Lucchinetti, W. Bruck, and J. Parisi Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination Annals of Neurology 47 2000 707 717
56. D. Mahad, I. Ziabreva, and H. Lassmann Mitochondrial defects in acute multiple sclerosis lesions Brain 131 2008 1722 1735
57. D.J. Mahad, I. Ziabreva, and G. Campbell Mitochondrial changes within axons in multiple sclerosis Brain 132 2009 1161 1174
58. O. Malik, D.A. Compston, and N.J. Scolding Interferon-beta inhibits mitogen induced astrocyte proliferation in vitro Journal of Neuroimmunology 86 2 1998 155 162
59. L.T. Mars, J. Bauer, and D.A. Gross CD8 T cell responses to myelin oligodendrocyte glycoprotein-derived peptides in humanized HLA-A (*)0201-transgenic mice Journal of Immunology 179 8 2007 Oct 15 5090 5098
60. H.K. Mathiesen, A. Jonsson, and T. Tscherning Correlation of global N-acetyl aspartate with cognitive impairment in multiple sclerosis Archives of Neurology 63 4 2006 533 536
61. K. McAllister, L.C. Katz, and C. Lo Neurotrophins and synaptic plasticity Annual Review of Neuroscience 22 1999 295 318
62. F.A. McMorris, and R.D. McKinnon Regulation of oligodendrocyte development and CNS myelination by growth factors: prospects for therapy of demyelinating disease Brain Pathology 6 3 1996 Jul 313 329
63. I. Medana, M.A. Martinic, and H. Wekerle Transection of major histocompatibility complex class I-induced neurites by cytotoxic T lymphocytes American Journal Of Pathology 159 3 2001 Sep 809 815
64. R. Meyer, R. Weissert, and R. Diem Acute neuronal apoptosis in a rat model of multiple sclerosis Journal of Neuroscience 21 16 2001 6214 6220
65. S.G. Meuth, A.M. Herrmann, and O.J. Simon Cytotoxic CD8+ T cell-neuron interactions: perforin-dependent electrical silencing precedes but is not causally linked to neuronal cell death Journal of Neuroscience 29 49 2009 Dec 9 15397 15409
66. S. Mi, B. Hu, and K. Hahm LINGO-1 antagonist promotes spinal cord remyelination and axonal integrity in MOG-induced experimental autoimmune encephalomyelitis Nature Medicine 13 10 2007 Oct 1228 1233 Epub 30.09.07
67. K.A. Nave, and B.D. Trapp Axon-glial signaling and the glial support of axon function Annual Review of Neuroscience 31 2008 535 561
68. M.A. Nikolaeva, B. Mukherjee, and P.K. Stys Na+-dependent sources of intra-axonal Ca2+ release in rat optic nerve during in vitro chemical ischemia Journal of Neuroscience 25 2005 9960 9967
69. A. Nimmerjahn, F. Kirchhoff, and F. Helmchen Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo Science 308 2005 1314 1318 (Pubitemid 40746128)
70. R. Nitsch, I. Bechmann, and R.A. Deisz Human brain-cell death induced by tumour-necrosis-factor-related apoptosis-inducing ligand (TRAIL) Lancet 356 9232 2000 Sep 2 827 828
71. R. Nitsch, E.E. Pohl, and A. Smorodchenko Direct impact of T cells on neurons revealed by two-photon microscopy in living brain tissue Journal of Neuroscience 24 10 2004 2458 2464
72. J.H. Noseworthy, C. Lucchinetti, and M. Rodriguez Multiple sclerosis The New England Journal of Medicine 343 13 2000 938 952
73. P. O'Connor Canadian Multiple Sclerosis Working Group Key issues in the diagnosis and treatment of multiple sclerosis. An overview Neurology 59 6 Suppl. 3 2002 S1 S33
74. P.H. Ozdinler, and J.D. Macklis IGF-I specifically enhances axon outgrowth of corticospinal motor neurons Nature Neuroscience 9 11 2006 Nov 1371 1381 Epub 22.10.06
75. H.A. O'Malley, A.B. Shreiner, and G.H. Chen Loss of Na+ channel beta2 subunits is neuroprotective in a mouse model of multiple sclerosis Molecular and Cellular Neuroscience 40 2009 143 155
76. A. Perez-Diez, N.T. Joncker, and K. Choi CD4 cells can be more efficient at tumor rejection than CD8 cells Blood 109 12 2007 Jun 15 5346 5354 Epub 27.02.07
77. J.W. Peterson, L. Bö, and S. Mörk Transected neurites, apoptotic neurons, and reduced inflammation in cortical multiple sclerosis lesions Annals of Neurology 50 3 2001 Sep 389 400
78. N. Picard-Riera, L. Decker, and C. Delarasse Experimental autoimmune encephalomyelitis mobilizes neural progenitors from the subventricular zone to undergo oligodendrogenesis in adult mice PNAS 99 20 2002 Oct 1 13211 13216 Epub 16.09.02
79. G. Pilz, P. Wipfler, and G. Ladurner Modern multiple sclerosis treatment - what is approved, what is on the horizon Drug Discovery Today 13 23-24 2008 1013 1025
80. M.M. Poo Neurotrophins as synaptic modulators Nature Reviews Neuroscience 2 2001 24 32
81. B. Pöllinger, G. Krishnamoorthy, and K. Berer Spontaneous relapsing-remitting EAE in the SJL/J mouse: MOG-reactive transgenic T cells recruit endogenous MOG-specific B cells Journal of Experimental Medicine 206 2009 1303 1316
82. R.M. Ransohoff, and V.H. Perry Microglial physiology: unique stimuli, specialized responses Annual Review of Immunology 27 2009 119 145
83. L.T. Remington, A.A. Babcock, and S.P. Zehntner Microglial recruitment, activation, and proliferation in response to primary demyelination American Journal Of Pathology 170 5 2007 May 1713 1724
84. M.B. Sättler, I. Demmer, and S.K. Williams Effects of interferon-beta-1a on neuronal sur- vival under autoimmune inflammatory condi- tions Experimental Neurology 201 1 2006 172 181
85. V. Siffrin, H. Radbruch, and R. Glumm In vivo imaging of partially reversible th17 cell-induced neuronal dysfunction in the course of encephalomyelitis Immunity 33 3 2010 Sep 24 424 436
86. V. Siffrin, J. Vogt, and H. Radbruch Multiple sclerosis -candidate mechanisms underlying CNS atrophy Trends in Neurosciences 33 2010 202 210
87. T. Smith, A. Groom, and B. Zhu Autoimmune encephalomyelitis ameliorated by AMPA antagonists Nature Medicine 6 1 2000 Jan 62 66
88. W. Snider Functions of the neurotrophins during nervous system development: what the knockouts are teaching us Cell 77 1994 627 638
89. L. Steinman Optic neuritis, a new variant of experimental encephalomyelitis, a durable model for all seasons, now in its seventieth year Journal of Experimental Medicine 197 9 2003 1065 1071
90. P.K. Stys, S.G. Waxman, and B.R. Ransom Ionic mechanisms of anoxic injury in mammalian CNS white matter: role of Na+ channels and Na(+)-Ca2+ exchanger Journal of Neuroscience 12 1992 430 439
91. P.K. Stys, and Q. Jiang Calpain-dependent neurofilament breakdown in anoxic and ischemic rat central axons Neuroscience Letters. 328 2002 150 154
92. U. Traugott, E.L. Reinherz, and C.S. Raine Multiple sclerosis. Distribution of T cells, T cell subsets and Ia-positive macrophages in lesions of different ages Journal of Neuroimmunology 4 1983 201 221
93. B.D. Trapp, J. Peterson, and R.M. Ransohoff Axonal transection in the lesions of multiple sclerosis The New England Journal of Medicine 338 5 1998 Jan 29 278 285
94. B.D. Trapp, J.R. Wujek, and G.A. Criste Evidence for synaptic stripping by cortical microglia Glia 55 4 2007 Mar 360 368
95. B.D. Trapp, and K.A. Nave Multiple sclerosis: an immune or neurodegenerative disorder? Annual Review of Neuroscience 31 2008 247 269
96. B.D. Trapp, and P.K. Stys Virtual hypoxia and chronic necrosis of demyelinated axons in multiple sclerosis Lancet Neurology 8 3 2009 Mar 280 291
97. F.J.E. Vajda Neuroprotection and neurode- generative disease Journal of Clinical Neuroscience 9 1 2002 4 8
98. J. Vogt, F. Paul, and O. Aktas Lower motor neuron loss in multiple sclerosis and experimental autoimmune encephalomyelitis Annals of Neurology 66 3 2009 Sep 310 322
99. S.G. Waxman Mechanisms of disease: sodium channels and neuroprotection in multiple sclerosis-current status Nature Clinical Practice Neurology 4 2008 159 169
100. B.G. Weinshenker Epidemiology of multiple sclerosis Neurologic Clinics 14 2 1996 May 291 308
101. H. Wekerle Lessons from multiple sclerosis: models, concepts, observations Annals of the Rheumatic Diseases 67 Suppl. 3 2008 Dec iii56 60
102. P. Werner, D. Pitt, and C.S. Raine Glutamate excitotoxicity-a mechanism for axonal damage and oligodendrocyte death in Multiple Sclerosis? Journal of Neural Transmission Supplementum 60 2000 375 385
103. J.R. Wujek, C. Bjartmar, and E. Richer Axon loss in the spinal cord determines permanent neurological disability in an animal model of multiple sclerosis Journal of Neuropathology & Experimental Neurology 61 1 2002 Jan 23 32
104. X.O. Yang, R. Nurieva, and G.J. Martinez Molecular antagonism and plasticity of regulatory and inflammatory T cell programs Immunity 29 2008 44 56
105. V.W. Yong Differential mechanisms of action of interferon-beta and glatiramer acetate in MS Neurology 59 6 2002 802 808
106. T. Ziemssen, T. Kumpfel, and W.E.F. Kinkert Glatiramer acetate-specific T-helper 1- and 2-type cell lines produce BDNF: implications for multiple sclerosis therapy. Brain-derived neurotrophic factor Brain 125 Pt 11 2002 2381 2391
107. F. Zipp, and O. Aktas The brain as a target of inflammation: common pathways link inflammatory and neurodegenerative diseases Trends in Neurosciences 29 9 2006 Sep 518 527 Epub 01.07.06