Primary conservative treatment results in mortality comparable to surgery in patients with infected pancreatic necrosis

Clinical Gastroenterology and Hepatology

Volumn 8, Issue 12, 2010, Pages

  Garg, Pramod Kumar ^a   Sharma, Manik ^a   Madan, Kaushal ^a   Sahni, Peush ^a   Banerjee, Debabrata ^a   Goyal, Rohit ^a  

^a ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

Acute Pancreatitis; Infected Pancreatic Necrosis; Medical Therapy; Necrosectomy

Indexed keywords

ANTIBIOTIC AGENT;

ADULT; ARTICLE; CONSERVATIVE TREATMENT; FEMALE; HUMAN; INFECTIOUS PANCREATIC NECROSIS; INTENSIVE CARE UNIT; INTERMETHOD COMPARISON; MAJOR CLINICAL STUDY; MALE; MORTALITY; NECROSECTOMY; NUTRITIONAL SUPPORT; PANCREAS SURGERY; PERCUTANEOUS DRAINAGE; SURVIVAL RATE; TREATMENT FAILURE; TREATMENT OUTCOME;

EID: 78649667449     PISSN: 15423565     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cgh.2010.04.011     Document Type: Article

References (24)

1. Whitcomb D.C. Clinical practice: acute pancreatitis. N Engl J Med 2006, 354:2142-2150.
2. Bradley E.L. A clinically based classification system for acute pancreatitis: summary of the International Symposium on Acute Pancreatitis, Atlanta, GA, September 11 through 13, 1992. Arch Surg 1993, 128:586-590.
3. Isenmann R., Rau B., Beger H.G. Bacterial infection and extent of necrosis are determinants of organ failure in patients with acute necrotizing pancreatitis. Br J Surg 1999, 86:1020-1024.
4. Garg P.K., Madan K., Pande G.K., et al. Association of extent and infection of pancreatic necrosis with organ failure and death in acute necrotizing pancreatitis. Clin Gastroenterol Hepatol 2005, 3:159-166.
5. Werner J., Feuerbach S., Uhl W., et al. Management of acute pancreatitis: from surgery to interventional intensive care. Gut 2005, 54:426-436.
6. Uhl W., Warshaw A., Imrie C., et al. IAP guidelines for the surgical management of acute pancreatitis. Pancreatology 2002, 2:565-573.
7. UK guidelines for the management of acute pancreatitis. Gut 2005, 54(Suppl III):iii1-iii9. UK Working Party on Acute Pancreatitis.
8. Adler D.G., Chari S.T., Dahl T.J., et al. Conservative management of infected necrosis complicating severe acute pancreatitis. Am J Gastroenterol 2003, 98:98-103.
9. Runzi M., Niebel W., Goebell H., et al. Severe acute pancreatitis: nonsurgical treatment of infected necroses. Pancreas 2005, 30:195-198.
10. Lee J.K., Kwak K.K., Park J.K., et al. The efficacy of nonsurgical treatment of infected pancreatic necrosis. Pancreas 2007, 8:468-470.
11. Garg P.K., Khanna S., Bohidar N.P., et al. Incidence, spectrum, and antibiotic sensitivity pattern of bacterial infections among patients with acute pancreatitis. J Gastroenterol Hepatol 2001, 16:1055-1059.
12. Bohidar N.P., Garg P.K., Khanna S., et al. Incidence, etiology and impact of fever in patients with acute pancreatitis. Pancreatology 2003, 3:9-13.
13. Sharma M., Banerjee D., Garg P.K. Characterization of newer subgroups of fulminant and subfulminant pancreatitis associated with a high early mortality. Am J Gastroenterol 2007, 102:2688-2695.
14. Sharma P.K., Madan K., Garg P.K. Hemorrhage in acute pancreatitis: should gastrointestinal bleeding be considered an organ failure?. Pancreas 2008, 36:141-145.
15. Baron T.H., Morgan D.E., Vickers S.M., et al. Organized pancreatic necrosis: endoscopic, radiologic, and pathologic features of a distinct clinical entity. Pancreas 1999, 19:105-108.
16. Rotman N., Methieu D., Anglade M.C., et al. Failure of percutaneous drainage of pancreatic abscesses complicating severe acute pancreatitis. Surg Gynecol Obstet 1992, 174:141-144.
17. Widdison A.L., Karanjia N.D. Pancreatic infection complicating acute pancreatitis. Br J Surg 1993, 80:148-154.
18. Connor S., Alexakis N., Raraty M.G., et al. Early and late complications after pancreatic necrosectomy. Surgery 2005, 137:499-505.
19. Basslink M.G., Verwer T.J., Schoenmaeckers E.J., et al. Timing of surgical intervention in necrotizing pancreatitis. Arch Surg 2007, 142:1194-1201.
20. Connor S., Raraty M.G., Neoptolemos J.P., et al. Does infected pancreatic necrosis require immediate or emergency debridement?. Pancreas 2006, 33:128-134.
21. Baril N.B., Ralls P.W., Wren S.M., et al. Does an infected peripancreatic fluid collection or abscess mandate operation?. Ann Surg 2000, 231:361-367.
22. Mier J., Luque-de-Leon E., Castillo A., et al. Early versus late necrosectomy in severe necrotizing pancreatitis. Am J Surg 1997, 173:71-75.
23. Seifert H., Biermer M., Schmitt W., et al. Transluminal endoscopic necrosectomy after acute pancreatitis: a multicentre study with long-term follow-up (the GEPARD Study). Gut 2009, 58:1260-1266.
24. Ross A., Gluck M., Irani S., et al. Combined endoscopic and percutaneous drainage of organized pancreatic necrosis. Gastrointest Endosc 2010, 71:79-84.