Multiple myeloma in the elderly: When to treat, when to go to transplant

ONCOLOGY

Volumn 24, Issue 11, 2010, Pages

  Harousseau, Jean Luc ^a  

^a UNIVERSITÉ DE NANTES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BORTEZOMIB; DEXAMETHASONE; DOXORUBICIN; INTERFERON; LENALIDOMIDE; MELPHALAN; PREDNISONE; THALIDOMIDE;

ARTICLE; AUTOLOGOUS STEM CELL TRANSPLANTATION; BONE MARROW TOXICITY; CANCER CHEMOTHERAPY; CANCER COMBINATION CHEMOTHERAPY; CLINICAL TRIAL; DOSE RESPONSE; DRUG WITHDRAWAL; FEASIBILITY STUDY; GERIATRIC CARE; HUMAN; LOW DRUG DOSE; MULTIPLE CYCLE TREATMENT; MULTIPLE MYELOMA; NEUROTOXICITY; PATIENT COMPLIANCE; PERIPHERAL NEUROPATHY; PROGRESSION FREE SURVIVAL; TREATMENT RESPONSE; UNSPECIFIED SIDE EFFECT;

EID: 78649664191     PISSN: 08909091     EISSN: 08909091     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Ludwig H, Bolejack V, Crowley J, et al. Survival and years of life lost in different age cohorts of patients with multiple myeloma. J Clin Oncol. 2008;28:1599-1605
2. Ludwig H, Durie B, Bolejack V, et al. Myeloma in patients under age 50 presents with more favorable features and shows better survival: an analysis of 10549 patients from International Myeloma Working Group. Blood. 2008;11:4039-47.
3. Harousseau J-L, Moreau P Autologous stem-cell transplantation in multiple myeloma. N Engl J Med. 2009;360:2645-54.
4. Brenner H, Gondos A, Pulte D. Recent major improvement in long-term survival of younger patients with multiple myeloma. Blood. 2008;111:2521-6.
5. Kyle R, Rajkumar SV. Multiple myeloma. N Engl J Med. 2004;351:1860-73.
6. Kumar SK, Rajkumar SV, Dispenzieri A, et al. Improved survival in multile myeloma and the impact of novel therapies. Blood. 2008;111:2516-20.
7. Palumbo A, Bringhen S, Caravita T, et al. Oral melphalan and prednisone chemotherapy plus thalidomide compared with melphalan and prednisone alone in elderly patients with multiple myeloma. Randomized controlled trial. Lancet. 2006;367:825-31.
8. Palumbo A, Bringhen S, Liberati A, et al. Oral melphalan, prednisone, and thalidomide in elderly patients with multiple myeloma: updated results of a randomized, controlled trial. Blood. 2008;112:3107-14.
9. Facon T, Mary JY, Hulin C, et al. Intergroupe Francophone du Myélome. Melphalan and prednisone plus thalidomide versus melphalan and prednisone alone or reduced-intensity autologous stem cell transplantation in elderly patients with multiple myeloma (IFM 99-06): a randomised trial. Lancet. 2007;307:1209-1218.
10. Hulin C, Facon T, Rodon P, et al. Efficacy of melphalan and prednisone plus thalidomide in patients older than 75 years with newly diagnosed multiple myeloma; IFM 01/01 trial J Clin Oncol. 2009;27:3664-70.
11. Wijermans P, Schaafsma M, Termorhuizen, et al. Phase III study of the value of thalidomide added to melphalan prednisone in elderly patients with newly diagnosed multiple myeloma: the Hovon 49 study. J Clin Oncol. 2010;28:3160-6.
12. Waage A, Gimsing P, Fayers P, et al. Melphalan and prednisone plsu thalidomide or placebo in elderly patients with multiple myeloma. Blood. Epub 2010 May 6.
13. Mateos MV, Hernadez JM, Hernadez MT, et al. Bortezomib plus melphalan and prednisone in elderly untreated patients with multiple myeloma: results of a multicenter phase 1/2 study. Blood. 2006;108: 2365-72.
14. San Miguel JF, Schlag R, Khuageva NK, et al. Bortezomib plus melphalan and prednisone for initial treatment of multiple myeloma. N Engl J Med. 2008;35:906-17.
15. Mateos MV, Richardson PG, Schlag R, et al. Bortezomib plus melphalan and prednisone compared with melphalan and prednisone in previously untreated multiple myeloma: updated follow-up and impact of subsequent therapy in the Phase III Vista trial. J Clin Oncol. 2010;28:2258-66.
16. Palumbo A, Falco P, Corradini P, et al. Melphalan, prednisone, lenalidomide treatment for newly diagnosed myeloma: a report from the GIMEMA-Italian Multiple Myeloma Network. J Clin Oncol. 2007;25:4459-65.
17. Palumbo A, Dimopoulos M, Delforge MA. Phase 3 study to determine the efficacy and safety of lenalidomide combined with melphalan and prednisone in patients e 65 years with newly diagnosed myeloma (abstract). Hematologica. 2010;95:566.
18. Ludwig H, Hajek R, Tothova E, et al. Thalidomide-dexamethasone compared to melphalan-prednisolone in elderly patients with multiple myeloma. Blood. 2008;113:3435-42.
19. Rajkumar SV, Jacobus S, Callander NS, et al. Lenalidomide plus high-dose dexamethasone versus lenalidomide plus low-dose dexamethasone as initial therapy for newly diagnosed multiple myeloma: an open-label randomised controlled trial. Lancet Oncol. 2010;11:29-37.
20. Jacobus S, Callander N, Siegel D, et al. Outcome of elderly patients 70 years and older with newly diagnosed myeloma in the ECOG randomized trial of lenalidomide/high-dose dexamethasone versus lenalidomide/low-dose dexamethasone (abstract). Haematologica. 2010;95:370.
21. The Myeloma TrialistsCollaborative Group. Interferon as therapy for multiple myeloma: meta-analysis of 24 randomized trials and 4012 patients. Br J Haematol. 2001;113:1020-34.
22. Boccadoro M, Bringhen S, Gaidano G, et al. Bortezomib, melphalan, prednisone and thalidomide (VMPT) followed by maintenance with bortezomib thalidomide (VT) for initial treatment of elderly multiple myeloma patients (abstract 8013). J Clin Oncol. 2010;28:576s.
23. Mateos MV, Oriol A, Martinez J, et al. A prospective, randomized trial of bortezomib/melphalan/prednisone (VMP) versus bortezomib/thalidomide/prednisone (VTP) as induction therapy followed by maintenance treatment with bortezomib/thalidomide (VT) versus bortezomib/prednisone in elderly untreated patients with multiple myeloma (abstract 3). Blood. 2006;114:3-4.
24. The International Myeloma Working Group Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders. Br J Haematol. 2003;121:749-57.
25. Kyle RA, Therneau TM, Rajkumar SV, et al. A long-term study of prognosis in monoclonal gammopathy of unknown significance. N Engl J Med. 2002;346:564-569.
26. Kyle RA, Rernstein ED, Therneau TM, et al. Clinical course and prognosis of smoldering (asymptomatic) myeloma. N Engl J Med. 2007;356:2582-90.
27. Cesana C, Klersy C, Barbarano L, et al. Prognostic factors for malignant transformation in monoclonal gammopathy of undetermined significance and smoldering multiple myeloma. J Clin Oncol. 2002;20:1625-34.
28. Rosinol L, Blade J, Esteve J, et al. Smoldering multiple myeloma: natural history and recognition of an evolving type. Br J Haematol. 2003;123:631-6.
29. Kumar S, Rajkumar SV, Kyle RA, et al. Prognostic value of circulating plasma cells in monoclonal gammopathy of unknown significance. J Clin Oncol. 2005;23:5668-74.
30. Perez-Persona E, Vidriales MB, Mateo G, et al. New criteria to identify risk of progression in monoclonal gammopathy of uncertain significance and smoldering myeloma based on multiparameter flow cytometry analysis of bone marrow plasma cells. Blood. 2007;110:2586-492.
31. Dispenzieri A, Kyle RA, Katzmann JA, et al. Immunoglobulin free light chain ratio is an independent risk factor for progression of smoldering myeloma. Blood. 2008;111:785-9.
32. Moulopoulos LA, Dimopoulos MA, Smith TL. Prognostic significance of magnetic resonance imaging in patients with asymptomatic multiple myeloma. J Clin Oncol. 1995;13:251-6.
33. Mariette X, Zagdanski AM, Guermazi A, et al. Prognostic value of vertebral lesions detected by magnetic resonance imaging in patients with stage I multiple myeloma. Br J Haematol. 1999;104:723-9.
34. Barlogie B, van Rhee F, Shaughnessy JD Jr, et al. Seven-year time to progression with thalidomide for smoldering myeloma: partial response identifies subset requiring earlier salvage therapy for symptomatic disease. Blood. 2008;112:3122-5.
35. Mateos MV, Lopez-Corral L, Hernandez MT, et al. Multicenter, randomized, open-label phase III trial of lenalidomide-dexamethasone vs therapeutic abstention in smoldering myeloma at high risk of progression to symptomatic MM: results of the first interim analysis (abstract 614). Blood. 2009;114:254.
36. Harousseau J-L, Attal M, Avet-Loiseau H. The role of complete remission in multiple myeloma. Blood. 2009;114:3139-46.
37. Harousseau JL, Palumbo A, Richardson PG, et al. Superior outcomes associated with complete response in newly diagnosed multiple myeloma patients treated with non intensive therapy: analysis of the phase 3 VISTA study of bortezomib plus melphalan-prednisone versus melphalan prednisone. Blood. Epub 2010 July 13.
38. Gay F, Larocca A, Petrucci MT. Achievement of complete remission is a strong prognostic factor in 895 elderly myeloma patients treated with melphalan-prednisone based regimens: results of 3 multicenter Italian trials (abstract). Haematologica. 2010;95:570.
39. Avet-Loiseau H, Leleu X, Roussel M, et al. Bortezomib plus dexamethasone induction improves outcome of patients with t(4;14) but not outcome of patients with del(17p). J Clin Oncol. Epub 2010 Jul 19.
40. Facon T, Mary JY, Pegourie B, et al. Dexamethasone-based regimens versus melphalan-prednisone for elderly multiple myeloma patients ineligible for high-dose therapy. Blood. 2006;107:1292-8.
41. Siegel DS, Desikan KR, Mehta J, et al. Age is not a prognostic variable with autotransplants for multiple myeloma. Blood. 1999;93: 51-4.
42. Badros A, Tricot G, Anaissie E, et al. Autologous stem cell transplantation in elderly multiple myeloma patients over the age of 70 years. Br J Haematol. 2001;114:600-07.
43. Palumbo A, Triolo S, Argentino C, et al. Dose-intensive melphalan with stem cell support (Mel 100) is superior to standard treatment in elderly myeloma patients. Blood. 1999;94:1248-53.
44. Palumbo A, Bringhen S, Petrucci MT, et al. Intermediate-dose melphalan (100 mg/m2) improves survival of myeloma patients aged 50-70: results of a randomized controlled trial. Blood. 2004;104:3052-7.
45. Palumbo A, Gay F, Falco P, et al. Bortezomib as induction before autologous transplantation, followed by lenalidomide as consolidation- maintenance in untreated multiple myeloma patients. J Clin Oncol. 2010;28:800-07.