Resveratrol restores lysophosphatidylcholine-induced loss of endothelium-dependent relaxation in rat aorta tissue coinciding with inhibition of extracellular-signal-regulated protein kinase activation

Phytotherapy Research

Volumn 24, Issue 12, 2010, Pages 1762-1768

  Min, Zhang ^a   Kang, Liu ^a   Lin, Li ^a   Jinghua, Fan ^a   Junna, Song ^a   Baolin, Liu ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

endothelium dependent relaxation; extracellular signal regulated protein kinase; human umbilical vein endothelial cells; lysophosphatidylcholine; resveratrol

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ACETYLCHOLINE; CYCLOOXYGENASE 1; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ENDOTHELIUM DERIVED HYPERPOLARIZING FACTOR; ENDOTHELIUM DERIVED RELAXING FACTOR; LYSOPHOSPHATIDYLCHOLINE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PHENYLEPHRINE; POTASSIUM ION; RESVERATROL;

ANIMAL TISSUE; AORTA; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; ENDOTHELIUM CELL; ENDOTHELIUM DEPENDENT RELAXATION; ENDOTHELIUM INJURY; ENZYME INHIBITION; GENE EXPRESSION; HUMAN; HUMAN CELL; INFLAMMATION; NONHUMAN; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VASODILATATION; WESTERN BLOTTING;

ANIMALS; AORTA, THORACIC; BIOLOGICAL FACTORS; CELLS, CULTURED; CYCLOOXYGENASE 1; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; ENDOTHELIUM-DEPENDENT RELAXING FACTORS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLAVONOIDS; GENE EXPRESSION REGULATION; HUMANS; LYSOPHOSPHATIDYLCHOLINES; MALE; MEMBRANE PROTEINS; NITRIC OXIDE SYNTHASE TYPE III; RATS; RATS, SPRAGUE-DAWLEY; STILBENES;

RATTUS;

EID: 78649661343     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.3136     Document Type: Article

References (17)

1. Bochkov VN, Mechtcheriakova D, Lucerna M, et al,. 2002. Oxidized phospholipids stimulate tissue factor expression in human endothelial cells via activation of ERK/EGR-1 and Ca (++)/NFAT. Blood 99: 199-206.
2. Campbell WB, Gebremedhin D, Pratt PF, Harder DR., 1996. Identification of epoxyeicosatrienoic acids as endothelium- derived hyperpolarizing factors. Circ Res 78: 415-423.
3. Chen CK, Pace-Asciak CR., 1996. Vasorelaxing activity of resveratrol and quercetin in isolated rat aorta. Gen Pharmacol 27: 363-366.
4. Chen L, Liang B, Froese DE, et al,. 1997. Oxidative modification of low density lipoprotein in normal and hyperlipidemic patients: effect of lysophosphatidylcholine composition on vascular relaxation. J Lipid Res 38: 546-553.
5. Csiszar A, Smith K, Labinskyy N, Orosz Z, Rivera A, Ungavari Z., 2006. Resveratrol attenuates TNF-alpha-induced activation of coronary arterial endothelial cells: role of NF-kappaB inhibition. AJP-Heart Circ Physiol 291: 694-699.
6. El-Mowafy AM, White RE., 1999. Resveratrol inhibits MAPK activity and nuclear translocation in coronary artery smooth muscle: reversal of endothelin-1 stimulatory effects. FEBS Lett 451: 63-67.
7. Froese DE, McMaster J, Man RYK, Choy PC, Kroeger EA., 1999. Inhibition of endothelium-dependent vascular relaxation by lysophosphatidylcholine: Impact of lysophosphatidylcholine on mechanisms involving endothelium-derived nitric oxide and endothelium derived hyperpolarizing factor. Mol Cell Biochem 197: 1-6.
8. Kume N, Cybulsky MI, Jr Gimbrone MA., 1992. Lysophosphatidylcholine, a component of atherogenic lipoproteins, induces mononuclear leukocyte adhesion molecules in cultured human and rabbit arterial endothelial cells. J Clin Invest 90: 1138-1144.
9. Matsumoto T, Kobayashi T, Kamata K., 2006. Mechanisms underlying lysophosphatidylcholine-induced potentiation of vascular contractions in the Otsrka Long-Evans Tokushima Fatty (OLETE) rat aorta. Br J Pharmacol 149: 931-941.
10. McIntyre TM, Zimmerman GA, Prescott SM., 1999. Biologic 20alpha-Hydroxysteroid dehydrogenase active oxidized phospholipids. J Biol Chem 274: 25189-25192.
11. Naderali EK, Doyle PJ, Williams G., 2000. Resveratrol induces vasorelaxation of mesenteric and uterine arteries from female guinea-pigs. Clin Sci 98: 537-543.
12. Suenaga H, Kamata K., 2003. Lysophosphatidylcholine activates extracellular-signal- regulated protein kinase and potentiates vascular contractile responses in rat aorta. J Pharmacol 92: 348-358.
13. Wang Z, Huang Y, Zou J, Cao K, Xu Y, Wu JM., 2002. Effects of red wine and wine polyphenol resveratrol on platelet aggregation in vivo and in vitro. Int J Mol Med 9: 77-79.
14. Witztum JL, Steinberg D., 1991. Role of oxidized low density lipoprotein in atherogenesis. J Clin Invest 88: 1785-1792.
15. + channels contributes to ROS-dependent proliferation of cultured human endothelial cells. J Mol Cell Cardiol 36: 675-682.
16. Xu H, Duan J, Wang W, et al,. 2008. Reactive oxygen species mediate oxidized low-density lipoprotein-induced endothelin-1 gene expression via extracellular signal-regulated kinase in vascular endothelial cells. J Hypertens 26: 956-963.
17. Zou J, Huang Y, Chen Q, Wei E, Cao K, Wu JM., 2000. Effects of resveratrol on oxidative modification of human low density lipoprotein. Chin Med J 113: 99-102.