Risk assessment and safety evaluation study for ozonolysis of î-pinene: Raw material of a novel prostaglandin D2 receptor antagonist S-5751

Organic Process Research and Development

Volumn 14, Issue 6, 2010, Pages 1485-1489

  Hida, Takemasa ^a   Kikuchi, Junko ^a   Kakinuma, Makoto ^a   Nogusa, Hideo ^a  

^a SHIONOGI AND CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

HEAT OF REACTION; HIGH CONCENTRATION; LOW TEMPERATURES; OZONOLYSIS; PROCESS TEMPERATURE; RECEPTOR ANTAGONISTS; REDUCTIVE DECOMPOSITION; ROOM TEMPERATURE; SAFETY EVALUATIONS; THERMAL STABILITY;

OZONE;

RISK ASSESSMENT;

EID: 78649660809     PISSN: 10836160     EISSN: 1520586X     Source Type: Journal    
DOI: 10.1021/op100065d     Document Type: Article

References (17)

1. Schönbein, C. F. J. Pract. Chem. 1855, 66, 282
2. Van Ornum, S. G.; Champeau, R. M.; Pariza, R. Chem. Rev. 2006, 106, 2990
3. Yoshioka, M. Pure Appl. Chem. 1987, 59, 1041
4. Bernasconi, E.; Lee, J.; Sogli, L.; Walker, D. Org. Process Res. Dev. 2002, 6, 169
5. Hübner, S.; Bentrup, U.; Budde, U.; Lovis, K.; Dietrich, T.; Freitag, A.; Küpper, L.; Jähnisch, K. Org. Process Res. Dev. 2009, 13, 952
6. Arimura, A.; Yasui, K.; Kishino, J.; Asanuma, F.; Hasegawa, H.; Kakudo, S.; Ohtani, M.; Arita, H. J. Pharmacol. Exp. Ther. 2001, 298, 411
7. Mitsumori, S.; Tsuri, T.; Honma, T.; Hiramatsu, Y.; Okada, T.; Hashizume, H.; Kida, S.; Inagaki, M.; Arimura, A.; Yasui, K.; Asanuma, F.; Kishino, J.; Ohtani, M. J. Med. Chem. 2003, 46, 2446
8. Campos, K. R.; Lee, S.; Journet, M.; Kowal, J. J.; Cai, D.; Larsen, R. D.; Reider, P. J. Tetrahedron Lett. 2002, 43, 6957
9. Campos, K. R.; Journet, M.; Lee, S.; Cai, D.; Kowal, J. J.; Lee, S.; Larsen, R. D.; Reider, P. J. J. Org. Chem. 2003, 68, 2338
10. Jennequin, T.; Labat, S.; Toupet, L.; Caille, J. C.; Mauduit, M. Synlett 2008, 11, 1669
11. Hida, T.; Mitsumori, S.; Honma, T.; Hiramatsu, Y.; Hashizume, H.; Okada, T.; Kakinuma, M.; Kawata, K.; Oda, K.; Hasegawa, A.; Masui, T.; Nogusa, H. Org. Process Res. Dev. 2009, 13, 1413
12. Grimshaw, J.; Grimshaw, J. T.; Junejia, H. R. J. Chem. Soc. Perkin 1 1972, 50
13. Criegee, R.; Scröder, G. Chem. Ber. 1960, 93, 689
14. Murray, R. W. Acc. Chem. Res. 1968, 1, 313
15. CHETAH has been developed by ASTM (American Society for Testing and Materials), which can calculate the released energy of organic compound under ideal gas state.
16. PS: specific heat of sample).
17. 24 (adiabatic decomposition temperature for 24 h) is the temperature at which time to maximum rate (TMR) is 24 h.