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Volumn 17, Issue 9, 2010, Pages 60-66

Safety of varenicline in patients with mental illness

Author keywords

[No Author keywords available]

Indexed keywords

AMFEBUTAMONE; PLACEBO; VARENICLINE;

EID: 78649658079     PISSN: 10826319     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (9)

References (52)
  • 1
    • 40749151926 scopus 로고    scopus 로고
    • Efficacy and safety of varenicline for smoking cessation
    • Hays JT, Ebbert JO, Sood AS. Efficacy and safety of varenicline for smoking cessation. Am J Med. 2008;121(4 suppl 1):S32-S42.
    • (2008) Am J Med , vol.121 , Issue.4 SUPPL. 1
    • Hays, J.T.1    Ebbert, J.O.2    Sood, A.S.3
  • 4
    • 33745611449 scopus 로고    scopus 로고
    • Efficacy of varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, vs placebo or sustained-release bupropion for smoking cessation: A randomized controlled trial
    • Jorenby DE, Hays JT, Rigotti NA, et al. Efficacy of varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, vs placebo or sustained-release bupropion for smoking cessation: a randomized controlled trial. JAMA. 2006;296(1):56-63.
    • (2006) JAMA , vol.296 , Issue.1 , pp. 56-63
    • Jorenby, D.E.1    Hays, J.T.2    Rigotti, N.A.3
  • 5
    • 33745611449 scopus 로고    scopus 로고
    • Efficacy of varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, vs placebo or sustained-release bupropion for smoking cessation: A randomized controlled trial
    • Erratum in
    • Erratum in: JAMA. 2006;296(11):1355.
    • (2006) JAMA , vol.296 , Issue.11 , pp. 1355
    • Jorenby, D.E.1    Hays, J.T.2    Rigotti, N.A.3
  • 6
    • 33745599140 scopus 로고    scopus 로고
    • Effect of maintenance therapy with varenicline on smoking cessation: A randomized controlled trial
    • Tonstad S, Tonnesen P, Hajek P, et al. Effect of maintenance therapy with varenicline on smoking cessation: a randomized controlled trial. JAMA. 2006;296(1):64-71.
    • (2006) JAMA , vol.296 , Issue.1 , pp. 64-71
    • Tonstad, S.1    Tonnesen, P.2    Hajek, P.3
  • 7
    • 33747199571 scopus 로고    scopus 로고
    • Smoking cessation with varenicline, a selective α4β2 nicotinic receptor partial agonist: Results from a 7-week, randomized, placebo- and bupropion-controlled trial with 1-year follow-up
    • Nides M, Oncken C, Gonzales D, et al. Smoking cessation with varenicline, a selective α4β2 nicotinic receptor partial agonist: results from a 7-week, randomized, placebo- and bupropion-controlled trial with 1-year follow-up. Arch Intern Med. 2006;166(15):1561-1568.
    • (2006) Arch Intern Med , vol.166 , Issue.15 , pp. 1561-1568
    • Nides, M.1    Oncken, C.2    Gonzales, D.3
  • 8
    • 33747154992 scopus 로고    scopus 로고
    • Efficacy and safety of the novel selective nicotinic acetylcholine receptor partial agonist, varenicline, for smoking cessation
    • Oncken C, Gonzales D, Nides M, et al. Efficacy and safety of the novel selective nicotinic acetylcholine receptor partial agonist, varenicline, for smoking cessation. Arch Intern Med. 2006;166(15):1571-1577.
    • (2006) Arch Intern Med , vol.166 , Issue.15 , pp. 1571-1577
    • Oncken, C.1    Gonzales, D.2    Nides, M.3
  • 9
    • 33745614361 scopus 로고    scopus 로고
    • Varenicline, an α4β2 nicotinic acetylcholine receptor partial agonist, vs sustained-release buproprion and placebo for smoking cessation: A randomized controlled trial
    • Gonzales D, Rennard SI, Nides M, et al. Varenicline, an α4β2 nicotinic acetylcholine receptor partial agonist, vs sustained-release buproprion and placebo for smoking cessation: a randomized controlled trial. JAMA. 2006;296(1):47-55.
    • (2006) JAMA , vol.296 , Issue.1 , pp. 47-55
    • Gonzales, D.1    Rennard, S.I.2    Nides, M.3
  • 10
    • 47549112072 scopus 로고    scopus 로고
    • Treating Tobacco Use and Dependence: 2008 Update
    • Rockville, MD: U.S. Department of Health and Human Services. Public Health Service. May
    • Fiore MC, Jaén CR, Baker TB, et al. Treating Tobacco Use and Dependence: 2008 Update. Clinical Practice Guideline. Rockville, MD: U.S. Department of Health and Human Services. Public Health Service. May 2008.
    • (2008) Clinical Practice Guideline
    • Fiore, M.C.1    Jaén, C.R.2    Baker, T.B.3
  • 11
    • 34548142181 scopus 로고    scopus 로고
    • Varenicline: A review of the literature and place in therapy
    • Whitley HP, Moorman KL. Varenicline: a review of the literature and place in therapy. Pharmacy Practice. 2007;5(2):51-58.
    • (2007) Pharmacy Practice , vol.5 , Issue.2 , pp. 51-58
    • Whitley, H.P.1    Moorman, K.L.2
  • 12
    • 43949124868 scopus 로고    scopus 로고
    • Cost-utility analysis of varenicline versus existing smoking cessation strategies using the BENESCO simulation model: Application to a population of US adult smokers
    • Howard P, Knight C, Boler A, Baker C. Cost-utility analysis of varenicline versus existing smoking cessation strategies using the BENESCO simulation model: application to a population of US adult smokers. Pharmacoeconomics. 2008;26(6):497-511.
    • (2008) Pharmacoeconomics , vol.26 , Issue.6 , pp. 497-511
    • Howard, P.1    Knight, C.2    Boler, A.3    Baker, C.4
  • 13
    • 77149151846 scopus 로고    scopus 로고
    • The cost effectiveness of an extended course (12 +12 weeks) of varenicline compared with other available smoking cessation strategies in the United States: An extension and update to the BENESCO model
    • Knight C, Howard P, Baker CL, Marton JP. The cost effectiveness of an extended course (12 +12 weeks) of varenicline compared with other available smoking cessation strategies in the United States: an extension and update to the BENESCO model. Value Health. 2010;13(2):209-214.
    • (2010) Value Health , vol.13 , Issue.2 , pp. 209-214
    • Knight, C.1    Howard, P.2    Baker, C.L.3    Marton, J.P.4
  • 14
    • 76349119987 scopus 로고    scopus 로고
    • New York, NY: Pfizer Labs
    • Chantix [package insert]. New York, NY: Pfizer Labs; 2009.
    • (2009) Chantix [package Insert]
  • 15
    • 33750264137 scopus 로고    scopus 로고
    • Varenicline: A review of its use as an aid to smoking cessation therapy
    • Keating GM, Siddiqui MA. Varenicline: a review of its use as an aid to smoking cessation therapy. CNS Drugs. 2006;20(11):945-960.
    • (2006) CNS Drugs , vol.20 , Issue.11 , pp. 945-960
    • Keating, G.M.1    Siddiqui, M.A.2
  • 17
    • 84869280663 scopus 로고    scopus 로고
    • New York Times. May 22, 2008. Available at, Accessed August 4
    • Saul S. F.A.A. bans antismoking drug, citing side effects. New York Times. May 22, 2008. Available at: www.nytimes.com/2008/05/22/business/22drug.html. Accessed August 4, 2010.
    • (2010) Bans Antismoking Drug, Citing Side Effects
    • Saul, S.F.A.A.1
  • 19
    • 78649675736 scopus 로고    scopus 로고
    • U.S. Food and Drug Administration, Available at, Accessed July 28
    • U.S. Food and Drug Administration. Early communication about an ongoing safety review: varenicline (marketed as chantix). Available at: www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/DrugSafetyInformationforHeathcareProfessionals/ucm070765.htm. Accessed July 28, 2010.
    • (2010) Early Communication About An Ongoing Safety Review: Varenicline (marketed as Chantix)
  • 21
    • 67650504189 scopus 로고    scopus 로고
    • Chantix-induced mental status changes in a young healthy female
    • Kutscher EC, Stanley M, Oehlke K. Chantix-induced mental status changes in a young healthy female. S D Med. 2009;62(5):193,195.
    • (2009) S D Med , vol.62 , Issue.5
    • Kutscher, E.C.1    Stanley, M.2    Oehlke, K.3
  • 22
    • 66149167339 scopus 로고    scopus 로고
    • Hallucinations in the context of varenicline withdrawal
    • Laine P, Marttlia J, Lindeman S. Hallucinations in the context of varenicline withdrawal. Am J Psychiatry. 2009;166(5):619-620.
    • (2009) Am J Psychiatry , vol.166 , Issue.5 , pp. 619-620
    • Laine, P.1    Marttlia, J.2    Lindeman, S.3
  • 23
    • 66249112505 scopus 로고    scopus 로고
    • Safety and drug utilization profile of varenicline as used in general practice in England: Interim results from a prescription-event monitoring study
    • Kasliwal R, Wilton LV, Shakir SA. Safety and drug utilization profile of varenicline as used in general practice in England: interim results from a prescription-event monitoring study. Drug Saf. 2009;32(6):499-507.
    • (2009) Drug Saf , vol.32 , Issue.6 , pp. 499-507
    • Kasliwal, R.1    Wilton, L.V.2    Shakir, S.A.3
  • 24
    • 70449392796 scopus 로고    scopus 로고
    • Varenicline and suicidal behavior: A cohort study based on data from the General Practice Research Database
    • Gunnell D, Irvine D, Wise L, Davies C, Martin RM. Varenicline and suicidal behavior: a cohort study based on data from the General Practice Research Database. BMJ. 2009;339:b3805.
    • (2009) BMJ , vol.339
    • Gunnell, D.1    Irvine, D.2    Wise, L.3    Davies, C.4    Martin, R.M.5
  • 25
    • 46949099038 scopus 로고    scopus 로고
    • Varenicline-induced mixed mood and psychotic episode in a patient with a past history of depression
    • Pumariega AJ, Nelson R, Rotenberg L. Varenicline-induced mixed mood and psychotic episode in a patient with a past history of depression. CNS Spectr. 2008;13(6):511-514.
    • (2008) CNS Spectr , vol.13 , Issue.6 , pp. 511-514
    • Pumariega, A.J.1    Nelson, R.2    Rotenberg, L.3
  • 26
    • 51649123202 scopus 로고    scopus 로고
    • Neuropsychiatric disturbance after initiation of varenicline in a patient with a history of alcohol abuse and major depression
    • Pirmoradi P, Roshan S, Nadeem SS. Neuropsychiatric disturbance after initiation of varenicline in a patient with a history of alcohol abuse and major depression. Am J Health Syst Pharm. 2008;65(17):1624-1626.
    • (2008) Am J Health Syst Pharm , vol.65 , Issue.17 , pp. 1624-1626
    • Pirmoradi, P.1    Roshan, S.2    Nadeem, S.S.3
  • 27
    • 59049103876 scopus 로고    scopus 로고
    • Possible varenicline-induced paranoia and irritability in a patient with major depressive disorder, borderline personality disorder, and methamphetamine abuse in remission
    • Lyon GJ. Possible varenicline-induced paranoia and irritability in a patient with major depressive disorder, borderline personality disorder, and methamphetamine abuse in remission. J Clin Psychopharmacol. 2008;28(6):720-721.
    • (2008) J Clin Psychopharmacol , vol.28 , Issue.6 , pp. 720-721
    • Lyon, G.J.1
  • 28
    • 72449148717 scopus 로고    scopus 로고
    • Visual hallucinations associated with varenicline: A case report
    • Raidoo BM and Kutscher EC. Visual hallucinations associated with varenicline: a case report. J Med Case Reports. 2009;3:7560.
    • (2009) J Med Case Reports , vol.3 , pp. 7560
    • Raidoo, B.M.1    Kutscher, E.C.2
  • 29
    • 39049140884 scopus 로고    scopus 로고
    • Hypomania with agitation associated with varenicline use in bipolar II disorder
    • Morstad AE, Kutscher EC, Kennedy WK, Carnahan RM. Hypomania with agitation associated with varenicline use in bipolar II disorder. Ann Pharmacother. 2008;42(2):288-289.
    • (2008) Ann Pharmacother , vol.42 , Issue.2 , pp. 288-289
    • Morstad, A.E.1    Kutscher, E.C.2    Kennedy, W.K.3    Carnahan, R.M.4
  • 30
    • 34548073110 scopus 로고    scopus 로고
    • Varenicline-induced manic episode in a patient with bipolar disorder
    • Kohen I, Kremen N. Varenicline-induced manic episode in a patient with bipolar disorder. Am J Psychiatry. 2007;164(8):1269-1270.
    • (2007) Am J Psychiatry , vol.164 , Issue.8 , pp. 1269-1270
    • Kohen, I.1    Kremen, N.2
  • 31
    • 67650818286 scopus 로고    scopus 로고
    • Worsening psychosis induced by varenicline in a hospitalized psychiatric patient
    • DiPaula BA, Thomas MD. Worsening psychosis induced by varenicline in a hospitalized psychiatric patient. Pharmacotherapy. 2009;29(7):852-857.
    • (2009) Pharmacotherapy , vol.29 , Issue.7 , pp. 852-857
    • Dipaula, B.A.1    Thomas, M.D.2
  • 32
    • 67749142170 scopus 로고    scopus 로고
    • Varenicline-induced mania in a bipolar patient
    • Alhatem F, Black JE. Varenicline-induced mania in a bipolar patient. Clin Neuropharmacol. 2009;32(2):117-118.
    • (2009) Clin Neuropharmacol , vol.32 , Issue.2 , pp. 117-118
    • Alhatem, F.1    Black, J.E.2
  • 33
    • 70350441886 scopus 로고    scopus 로고
    • Varenicline-induced mixed mood and psychotic episode in a patient with schizoaffective disorder
    • Liu ME, Tsai SJ, Yang ST. Varenicline-induced mixed mood and psychotic episode in a patient with schizoaffective disorder. CNS Spectr. 2009;14(7):346.
    • (2009) CNS Spectr , vol.14 , Issue.7 , pp. 346
    • Liu, M.E.1    Tsai, S.J.2    Yang, S.T.3
  • 34
    • 34548071446 scopus 로고    scopus 로고
    • Exacerbation of schizophrenia by varenicline
    • Freedman R. Exacerbation of schizophrenia by varenicline. Am J Psychiatry. 2007;164(8):1269.
    • (2007) Am J Psychiatry , vol.164 , Issue.8 , pp. 1269
    • Freedman, R.1
  • 35
    • 65749117519 scopus 로고    scopus 로고
    • Safety and effectiveness of varenicline in a veteran population with a high prevalence of mental illness
    • Purvis TL, Mambourg SE, Balvanz TM, Magallon HE, Pham RH. Safety and effectiveness of varenicline in a veteran population with a high prevalence of mental illness. Ann Pharmacother. 2009;43(5):862-867.
    • (2009) Ann Pharmacother , vol.43 , Issue.5 , pp. 862-867
    • Purvis, T.L.1    Mambourg, S.E.2    Balvanz, T.M.3    Magallon, H.E.4    Pham, R.H.5
  • 36
    • 36849027596 scopus 로고    scopus 로고
    • Varenicline in the routine treatment of tobacco dependence: A pre-post comparison with nicotine replacement therapy and an evaluation in those with mental illness
    • Stapleton JA, Watson L, Spirling LI, et al. Varenicline in the routine treatment of tobacco dependence: a pre-post comparison with nicotine replacement therapy and an evaluation in those with mental illness. Addiction. 2008;103(1):146-154.
    • (2008) Addiction , vol.103 , Issue.1 , pp. 146-154
    • Stapleton, J.A.1    Watson, L.2    Spirling, L.I.3
  • 37
    • 46749109721 scopus 로고    scopus 로고
    • Varenicline treatment for smokers with schizophrenia: A case series
    • Evins AE, Goff DC. Varenicline treatment for smokers with schizophrenia: a case series. J Clin Psychiatry. 2008;69(6):1016.
    • (2008) J Clin Psychiatry , vol.69 , Issue.6 , pp. 1016
    • Evins, A.E.1    Goff, D.C.2
  • 38
    • 47249085518 scopus 로고    scopus 로고
    • Varenicline efficacy and safety in a subject with schizophrenia
    • Fatemi SH. Varenicline efficacy and safety in a subject with schizophrenia. Schizophrenia Res. 2008;103(1-3):328-329.
    • (2008) Schizophrenia Res , vol.103 , Issue.1-3 , pp. 328-329
    • Fatemi, S.H.1
  • 39
    • 65349104738 scopus 로고    scopus 로고
    • Varenicline reduced smoking behavior in a mentally ill person
    • Ochoa EL. Varenicline reduced smoking behavior in a mentally ill person. J Psychopharmacol. 2009;23(3):340-341.
    • (2009) J Psychopharmacol , vol.23 , Issue.3 , pp. 340-341
    • Ochoa, E.L.1
  • 40
    • 67349146819 scopus 로고    scopus 로고
    • Mood, side effects and smoking outcomes among persons with and without probable lifetime depression taking varenicline
    • McClure JB, Swan GE, Jack L, et al. Mood, side effects and smoking outcomes among persons with and without probable lifetime depression taking varenicline. J Gen Intern Med. 2009;24(5):563-569.
    • (2009) J Gen Intern Med , vol.24 , Issue.5 , pp. 563-569
    • McClure, J.B.1    Swan, G.E.2    Jack, L.3
  • 42
    • 57849159726 scopus 로고    scopus 로고
    • Varenicline improves mood and cognition during smoking abstinence
    • Patterson F, Jepson C, Strasser AA, et al. Varenicline improves mood and cognition during smoking abstinence. Biol Psychiatry. 2009;65(2):144-149.
    • (2009) Biol Psychiatry , vol.65 , Issue.2 , pp. 144-149
    • Patterson, F.1    Jepson, C.2    Strasser, A.A.3
  • 43
    • 33747598710 scopus 로고    scopus 로고
    • Varenicline is a partial agonist at α4β2 and a full agonist at α7 neuronal nicotinic receptors
    • Mihalak KB, Carroll FI, Luetje CW. Varenicline is a partial agonist at α4β2 and a full agonist at α7 neuronal nicotinic receptors. Mol Pharmacol. 2006;70(3):801-805.
    • (2006) Mol Pharmacol , vol.70 , Issue.3 , pp. 801-805
    • Mihalak, K.B.1    Carroll, F.I.2    Luetje, C.W.3
  • 44
    • 68949180394 scopus 로고    scopus 로고
    • Schizophrenia
    • van Os J, Kapur S. Schizophrenia. Lancet. 2009;374(9690):635-645.
    • (2009) Lancet , vol.374 , Issue.9690 , pp. 635-645
    • van Os, J.1    Kapur, S.2
  • 45
    • 71049173312 scopus 로고    scopus 로고
    • The role of dopamine in bipolar disorder
    • Cousins DA, Butts K, Young AH. The role of dopamine in bipolar disorder. Bipolar Disord. 2009;11(8):787-806.
    • (2009) Bipolar Disord , vol.11 , Issue.8 , pp. 787-806
    • Cousins, D.A.1    Butts, K.2    Young, A.H.3
  • 46
    • 61449197838 scopus 로고    scopus 로고
    • Neurobiological mechanisms in major depressive disorder
    • aan het Rot M, Mathew SJ, Charney DS. Neurobiological mechanisms in major depressive disorder. CMAJ. 2009;180(3):305-313.
    • (2009) CMAJ , vol.180 , Issue.3 , pp. 305-313
    • aan het Rot, M.1    Mathew, S.J.2    Charney, D.S.3
  • 47
    • 60349101359 scopus 로고    scopus 로고
    • Varenicline has antidepressant-like activity in the forced swim test and augments sertraline's effect
    • Rollema H, Guanowsky V, Mineur YS, et al. Varenicline has antidepressant-like activity in the forced swim test and augments sertraline's effect. Eur J Pharmacol. 2009;605(1-3):114-116.
    • (2009) Eur J Pharmacol , vol.605 , Issue.1-3 , pp. 114-116
    • Rollema, H.1    Guanowsky, V.2    Mineur, Y.S.3
  • 49
    • 34948846642 scopus 로고    scopus 로고
    • Interference with smoking cessation effects of varenicline after administration of immediate release amphetamine-dextroamphetamine
    • Whitley HP, Moorman KL. Interference with smoking cessation effects of varenicline after administration of immediate release amphetamine-dextroamphetamine. Pharmacotherapy. 2007;27(10):1440-1445.
    • (2007) Pharmacotherapy , vol.27 , Issue.10 , pp. 1440-1445
    • Whitley, H.P.1    Moorman, K.L.2
  • 50
    • 60249086665 scopus 로고    scopus 로고
    • Deaths: Preliminary data for 2006
    • Available at, Accessed July 28, 2010
    • Heron MP, Hoyert DL, Xu JQ, Scott C, Tejada-Vera B. Deaths: preliminary data for 2006. Natl Vital Stat Rep. 2008;56(16). Available at: www.cdc.gov/nchs/data/nvsr/nvsr56/nvsr56_16.pdf. Accessed July 28, 2010.
    • (2008) Natl Vital Stat Rep , vol.56 , Issue.16
    • Heron, M.P.1    Hoyert, D.L.2    Xu, J.Q.3    Scott, C.4    Tejada-Vera, B.5
  • 51
    • 78649644263 scopus 로고    scopus 로고
    • Suicide
    • Centers for Disease Control and Prevention, Summer 2009. Available at, Accessed August 4
    • Centers for Disease Control and Prevention. Suicide. Facts at a Glance. Summer 2009. Available at: www.cdc.gov/violenceprevention/pdf/Suicide-DataSheet-a.pdf. Accessed August 4, 2010.
    • (2010) Facts at a Glance
  • 52
    • 84877598164 scopus 로고    scopus 로고
    • U.S. Food and Drug Administration, Available at, Accessed July 28
    • U.S. Food and Drug Administration. Information for healthcare professionals: varenicline (marketed as chantix). Available at: www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/ucm124818.htm. Accessed July 28, 2010.
    • (2010) Information for Healthcare Professionals: Varenicline (marketed as Chantix)


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