The effects of insulin-like growth factor-1 and basic fibroblast growth factor on the proliferation of chondrocytes embedded in the collagen gel using an integrated microfluidic device

Tissue Engineering - Part C: Methods

Volumn 16, Issue 6, 2010, Pages 1267-1275

  Li, Yuancheng ^a   Qin, Jianhua ^b   Lin, Bingcheng ^b   Zhang, Weiguo ^a  

^a DALIAN MEDICAL UNIVERSITY   (China)

^b DALIAN INSTITUTE OF CHEMICAL PHYSICS   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BODY FLUIDS; CELL CULTURE; CONCENTRATION (PROCESS); FIBROBLASTS; FLUIDIC DEVICES; INSULIN; MICROFLUIDICS; OPTIMIZATION; TISSUE; TISSUE ENGINEERING;

ARTICULAR CHONDROCYTES; AUTOLOGOUS CHONDROCYTE IMPLANTATIONS; BASIC FIBROBLAST GROWTH FACTOR; CARTILAGE TISSUE ENGINEERING; CELLULAR LEVELS; CHONDROCYTE PROLIFERATION; CHONDROCYTES; COLLAGEN GELS; CONCENTRATION GRADIENTS; CONVENTIONAL METHODS; DOSE-DEPENDENT MANNER; EXPERIMENTAL CONDITIONS; GROWTH FACTOR; INSULIN-LIKE GROWTH FACTOR-1; INTEGRATED MICROFLUIDIC DEVICES; MICRO-FLUIDIC DEVICES; PROLIFERATION RATE; PROLIFERATION TESTS; STATISTICALLY SIGNIFICANT DIFFERENCE; THREE DIMENSIONAL CELL CULTURE;

PEPTIDES;

ORYCTOLAGUS CUNICULUS;

COLLAGEN; FIBROBLAST GROWTH FACTOR 2; SOMATOMEDIN C; TISSUE SCAFFOLD;

ANIMAL; ARTICLE; BIOLOGICAL MODEL; CARTILAGE CELL; CELL CULTURE; CELL PROLIFERATION; CHEMISTRY; CULTURE TECHNIQUE; DRUG EFFECT; DRUG SCREENING; EVALUATION; GEL; INSTRUMENTATION; METHODOLOGY; MICROFLUIDIC ANALYSIS; PHYSIOLOGY; RABBIT; VALIDATION STUDY;

ANIMALS; CELL CULTURE TECHNIQUES; CELL PROLIFERATION; CELLS, CULTURED; CHONDROCYTES; COLLAGEN; DRUG EVALUATION, PRECLINICAL; FIBROBLAST GROWTH FACTOR 2; GELS; INSULIN-LIKE GROWTH FACTOR I; MICROFLUIDIC ANALYTICAL TECHNIQUES; MODELS, BIOLOGICAL; RABBITS; TISSUE SCAFFOLDS;

EID: 78649654901     PISSN: 19373384     EISSN: 19373392     Source Type: Journal    
DOI: 10.1089/ten.tec.2009.0682     Document Type: Article

References (39)

1. Steinert, A.F., Ghivizzani, S.C., Rethwilm, A., Tuan, R.S., Evans, C.H., and Noth, U. Major biological obstacles for persistent cellbased regeneration of articular cartilage. Arthritis Res Ther 9, 213, 2007.
2. Knutsen, G., Engebretsen, L., Ludvigsen, T.C., Drogset, J.O., Grontvedt, T., and Solheim, E. Autologous chondrocyte implantation compared with microfracture in the kneea randomized trial. J Bone Joint Surg Am 86A, 455, 2004.
3. Ochi, M., Adachi, N., Nobuto, H., Yanada, S., Ito, Y., and Agung, M. Articular cartilage repair using tissue engineering techniquenovel approach with minimally invasive procedure. Artif Organs 28, 28, 2004.
4. Peterson, L., Minas, T., Brittberg, M., and Lindahl, A. Treatment of osteochondritis dissecans of the knee with autologous chondrocyte transplantation-Results at two to ten years. J Bone Joint Surg Am 85A, 17, 2003.
5. Roberts, S., McCall, I.W., Darby, A.J., Menage, J., Evans, H., and Harrison, P.E. Autologous chondrocyte implantation for cartilage repair: monitoring its success by magnetic resonance imaging and histology. Arthritis Res Ther 5, R60, 2003.
6. Freed, L.E., Grande, D.A., Lingbin, Z., Emmanual, J., Marquis, J.C., and Langer, R. Joint resurfacing using allograft chondrocytes and synthetic biodegradable polymer scaffolds. J Biomed Mater Res 28, 891, 1994.
7. Barbero, A., Grogan, S., Schafer, D., Heberer, M., Mainil-Varlet, P., and Martin, I. Age related changes in human articular chondrocyte yield, proliferation and postexpansion chondrogenic capacity. Osteoarthritis Cartilage 12, 476, 2004.
8. Saltzman, W.M., and Olbricht, W.L. Building drug delivery into tissue engineering. Nat Rev Drug Discov 1, 177, 2002.
9. Wu, M.H., Huang, S.B., Cui, Z.F., Cui, Z., and Lee, G.B. Development of perfusionbased micro 3-D cell culture platform and its application for high throughput drug testing. Sens Actuators B 129, 231, 2008.
10. Yeon, J.H., and Park, J.K. Microfluidic cell culture systems for cellular analysis. Biochip J 1, 17, 2007.
11. Sittinger, M., Schultz, O., Keyszer, G., Minuth, W.W., and Burmester, G.R. Artificial tissues in perfusion culture. Int J Artif Organs 20, 57, 1997.
12. Wu, M.H., Urban, J.P.G., Cui, Z., and Cui, Z.F. Development of PDMS microbioreactor with welldefined and homogenous culture environment for chondrocyte 3-D culture. Biomed Microdevices 8, 331, 2006.
13. Powers, M.J., Domansky, K., Kaazempur-Mofrad, M.R., Kalezi, A., Capitano, A., and Upadhyaya, A. A microfabricated array bioreactor for perfused 3D liver culture. Biotechnol Bioeng 78, 257, 2002.
14. Andersson, H., and van den Berg, A. Microfluidic devices for cellomics: a review. Sens Actuators B 92, 315, 2003.
15. Jeon, N.L., Dertinger, S.K.W., Chiu, D.T., Choi, I.S., Stroock, A.D., and Whitesides, G.M. Generation of solution and surface gradients using microfluidic systems. Langmuir 16, 8311, 2000.
16. McDonald, J.C., Duffy, D.C., Anderson, J.R., Chiu, D.T., Wu, H.K., and Schueller, O.J.A. Fabrication of microfluidic systems in poly(dimethylsiloxane). Electrophoresis 21, 27, 2000.
17. Xia, Y. Soft lithography and the art of patterning-A tribute to Professor George M. Whitesides. Adv Mater 16, 1245, 2004.
18. Liang, H.J., Tsai, C.L., Chen, P.Q., and Lu, F.J. Oxidative injury induced by synthetic humic acid polymer and monomer in cultured rabbit articular chondrocytes. Life Sci 65, 1163, 1999.
19. Jakob, M., Demarteau, O., Schafer, D., Hintermann, B., Dick, W., and Heberer, M. Specific growth factors during the expansion and redifferentiation of adult human articular chondrocytes enhance chondrogenesis and cartilaginous tissue formation in vitro. J Cell Biochem 81, 368, 2001.
20. Matsusaki, M., Ochi, M., Uchio, Y., Shu, N., Kurioka, H., and Kawasaki, K. Effects of basic fibroblast growth factor on proliferation and phenotype expression of chondrocytes embedded in collagen gel. Gen Pharmacol 31, 759, 1998.
21. Whitesides, G.M. The origins and the future of microfluidics. Nature 442, 368, 2006.
22. Merkel, T.C., Bondar, V.I., Nagai, K., Freeman, B.D., and Pinnau, I. Gas sorption, diffusion, and permeation in poly(dimethylsiloxane). J Polym Sci B 38, 415, 2000.
23. Kane, B.J., Zinner, M.J., Yarmush, M.L., and Toner, M. Liverspecific functional studies in a microfluidic array of primary mammalian hepatocytes. Anal Chem 78, 4291, 2006.
24. Tourovskaia, A., Figueroa-Masot, X., and Folch, A. Differentiationona- chip: a microfluidic platform for longterm cell culture studies. Lab Chip 5, 14, 2005.
25. Vondermark, K., Gauss, V., Vondermark, H., and Muller, P. Relationship between cellshape and type of collagen synthesized as chondrocytes lose their cartilage phenotype in culture. Nature 267, 531, 1977.
26. Martin, J.A., and Buckwalter, J.A. The role of chondrocytematrix interactions in maintaining and repairing articular cartilage. Biorheology 37, 129, 2000.
27. Bohlen, P., Baird, A., Esch, F., Ling, N., and Gospodarowicz, D. Isolation and partial molecular characterization of pituitary fibroblast growthfactor. Proc Natl Acad Sci USA (Biol Sci) 81, 5364, 1984.
28. Cuevas, P., Burgos, J., and Baird, A. Basic fibroblast growthfactor (FGF) promotes cartilage repair in vivo. Biochem Biophys Res Commun 156, 611, 1988.
29. Cucchiarini, M., Madry, H., Ma, C.Y., Thurn, T., Zurakowski, D., and Menger, M.D. Improved tissue repair in articular cartilage defects in vivo by rAAV-mediated overexpression of human fibroblast growth factor 2. Mol Ther 12, 229, 2005.
30. Sah, R.L., Chen, A.C., Grodzinsky, A.J., and Trippel, S.B. Differentialeffects of bFGF and IGF-1 on matrix metabolism in calf and adult bovine cartilage explants. Arch Biochem Biophys 308, 137, 1994.
31. Rechler, M.M., and Nissley, S.P. The nature and regulation of the receptors for insulinlike growthfactors. Annu Rev Physiol 47, 425, 1985.
32. Chiyokura, Y. Effects of IGF-I, IGF-II, and PDGF on the proliferation of rabbit articular chondrocytes in culture. J Orthop Sci 1, 59, 1996.
33. Veilleux, N., and Spector, M. Effects of FGF-2 and IGF-1 on adult canine articular chondrocytes in type II collagenglycosaminoglycan scaffolds in vitro. Osteoarthritis Cartilage 13, 278, 2005.
34. Wroblewski, J., and Edwallarvidsson, C. Inhibitory effects of basic fibroblast growthfactor on chondrocyte differentiation. J Bone Miner Res 10, 735, 1995.
35. Kilkenny, D.M., and Hill, D.J. Fibroblast growth factor receptor-1 species, including a truncated form related to the extracellular domain, are encoded by several mRNA transcripts. J Endocrinol 148 (Suppl), 103, 1996.
36. Aikawa, T., Segre, G.V., and Lee, K. Fibroblast growth factor inhibits chondrocytic growth through induction of p21 and subsequent inactivation of cyclin E-Cdk2. J Biol Chem 276, 29347, 2001.
37. Muddasani, P., Norman, J.C., Ellman, M., van Wijnen, A.J., and Im, H.J. Basic fibroblast growth factor activates the MAPK and NF kappa B pathways that converge on Elk-1 to control production of matrix metalloproteinase-13 by human adult articular chondrocytes. J Biol Chem 282, 31409, 2007.
38. Yamanaka, Y., Tanaka, H., Ueda, K., Yamagami, E., Nishimura, R., and Seino, Y. Sprouty2 induced by constitutively active FGF receptor 3 suppresses the chondrocyte proliferation through inhibition of IGF-1 signaling. Bone 32, S89, 2003.
39. Dunham, B.P., and Koch, R.J. Basic fibroblast growth factor and insulin like growth factor I support the growth of human septal chondrocytes in a serumfree environment. Arch Otolaryngol Head Neck Surg 124, 1325, 1998.