AS1387392, a novel immunosuppressive cyclic tetrapeptide compound with inhibitory activity against mammalian histone deacetylase

Journal of Antibiotics

Volumn 63, Issue 11, 2010, Pages 633-636

  Sasamura, Satoshi ^a   Sakamoto, Kazutoshi ^a   Takagaki, Shoji ^a   Yamada, Toshiko ^a   Takase, Shigehiro ^a   Mori, Hiroaki ^a,b   Fujii, Takashi ^a,b   Hino, Motohiro ^a   Hashimoto, Michizane ^a  

^a ASTELLAS PHARMA INC   (Japan)

^b Chemo Sero Therapeutic Research Institute   (Japan)

Author keywords

Acremonium sp.; AS1387392; fermentation; FR235222; histone deacetylase inhibitor; immunosuppressant; isolation

Indexed keywords

AS 1387392; ENZYME INHIBITOR; FR 235222; HISTONE DEACETYLASE; IMMUNOSUPPRESSIVE AGENT; TETRAPEPTIDE; UNCLASSIFIED DRUG;

ACREMONIUM; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG ACTIVITY; DRUG BLOOD LEVEL; DRUG ISOLATION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTROSPRAY MASS SPECTROMETRY; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; FERMENTATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; LYMPHOCYTE PROLIFERATION; MALE; MOUSE; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; T LYMPHOCYTE; TIME OF FLIGHT MASS SPECTROMETRY;

ACREMONIUM; ANIMALS; CELL PROLIFERATION; FEMALE; FERMENTATION; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HUMANS; IMMUNOSUPPRESSIVE AGENTS; MALE; MICE; MICE, INBRED BALB C; PEPTIDES, CYCLIC; RATS; RATS, INBRED LEW; T-LYMPHOCYTES;

ACREMONIUM SP.; MAMMALIA;

EID: 78649648097     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.1038/ja.2010.51     Document Type: Article

References (9)

1. First, M. R. Immunosuppressive agents and their actions. Transplant. Proc. 34, 1369-1371 (2002).
2. Gorantla, V. S. et al. Immunosuppressive agents in transplantation: mechanism of action and current anti-rejection strategies. Microsurgery20, 420-429 (2000).
3. Su, Q. L., Weber, M., Hir, M. L., Zenke, G. & Ryffel, B. Nephrotoxicityofcyclosporin A and FK506: inhibitionofcalcineurinphosphatase. Ren. Physiol. Biochem. 18, 128-139 (1995).
4. Mcdiarmid, S. V., Colonna, J. O., Shaked, M., Ament, M. E. & Busuttil, R. W. A comparison of renal function in cyclosporine-and FK506-treated patients after primary orthotopic liver transplantation. Transplantation 56, 847-853 (1993).
5. Bechstein, W. O. Neurotoxicity of calcineurin inhibitors: impact and clinical manage-ment. Transpl. Int. 13, 313-326 (2000).
6. Mori, H. et al. FR235222, a fungal metabolite, is a novel immunosuppressant that inhibits mammalian histone deacetylase (HDAC). I. Taxonomy, fermentation, isolation and biological activities. J. Antibiot. 56, 72-79 (2003). (Pubitemid 36372787)
7. Mori, H. et al. FR235222, a fungal metabolite, is a novel immunosuppressant that inhibits mammalian histone deacetylase (HDAC). III. Structure determination. J. Anti-biot. 56, 181-185 (2003). (Pubitemid 36372803)
8. Mori, H. et al. FR235222, a fungal metabolite, is a novel immunosuppressant that inhibits mammalian histone deacetylase (HDAC). II. Biological activities in animal models. J. Antibiot. 56, 80-86 (2003). (Pubitemid 36372788)
9. Fujii, K., Ikai, Y., Oka, M., Suzuki, M. & Harada, K. I. A non-empirical method using LC/MS for determination of the absolute configuration of constituent amino acids in a peptide: combination of Marfey's method with mass spectrometry and its practical application. Anal. Chem. 69, 5146-5151 (1997).