Amiodarone-induced pulmonary toxicity: An under-recognized and severe adverse effect?

Clinical Research in Cardiology

Volumn 99, Issue 11, 2010, Pages 693-700

  Schwaiblmair, Martin ^a   Berghaus, Thomas ^a   Haeckel, Thomas ^a   Wagner, Theodor ^a   Von Scheidt, Wolfgang ^a  

^a NONE

Author keywords

Adverse effect; Amiodarone; Pulmonary toxicity

Indexed keywords

AMIODARONE; ANTIARRHYTHMIC AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CORTICOSTEROID; DRONEDARONE; PLACEBO; PREDNISOLONE; SOTALOL;

COMPUTER ASSISTED TOMOGRAPHY; DIFFERENTIAL DIAGNOSIS; DRUG EXCRETION; DRUG MEGADOSE; DRUG WITHDRAWAL; HUMAN; LOW DRUG DOSE; LUNG BIOPSY; LUNG FUNCTION TEST; LUNG LAVAGE; LUNG TOXICITY; MORBIDITY; NONHUMAN; PATHOGENESIS; PROGNOSIS; REVIEW; RISK FACTOR; SEROLOGY; THORACOSCOPY; THORAX RADIOGRAPHY;

AMIODARONE; ANTI-ARRHYTHMIA AGENTS; ARRHYTHMIAS, CARDIAC; DRUG TOXICITY; HUMANS; LUNG INJURY; PNEUMONIA; PULMONARY FIBROSIS; RISK FACTORS; SEVERITY OF ILLNESS INDEX;

EID: 78649645682     PISSN: 18610684     EISSN: 18610692     Source Type: Journal    
DOI: 10.1007/s00392-010-0181-3     Document Type: Review

References (60)

1. G Adams R Kehoe M Lesch J Glassroth 1988 Amiodarone-induced pneumonitis. Assessment of risk factors and possible risk reduction Chest 93 254 263 1:STN:280:DyaL1c7htVKquw%3D%3D 10.1378/chest.93.2.254 3338292
2. Adverse Drug Reactions Advisory Committee 2005 The multiple toxicities of amiodarone Aust Adv Drug React Bull 24 11
3. S Al-Khatib N LaPointe L Curtis, et al. 2003 Outpatient prescribing of antiarrythmic drugs from 1995 to 2000 Am J Cardiol 91 91 94 10.1016/S0002- 9149(02)03008-4 12505582 (Pubitemid 36050781)
4. Amiodarone Trials Meta-Analysis Investigators 1997 Effect of prophylactic amiodarone on mortality after acute myocardial infarction and in congestive heart failure: meta-analysis of individual data from 6500 patients in randomised trials Lancet 350 1417 1424 10.1016/S0140-6736(97)05281-1 (Pubitemid 28036862)
5. H Ashrafian P Davey 2001 Is amiodarone an underrecognized cause of acute respiratory failure in the ICU? Chest 120 275 282 1:CAS:528:DC%2BD3MXlvVKitbk%3D 10.1378/chest.120.1.275 11451849 (Pubitemid 32744890)
6. I Azzam N Tov N Elias J Naschitz 2006 Amiodarone toxicity presenting as pulmonary mass and peripheral neuropathy Postgrad Med J 82 73 75 1:STN:280:DC%2BD28%2FhtFSktQ%3D%3D 10.1136/pgmj.2005.040105 16397086 (Pubitemid 43111809)
7. R Bargout A Jankov E Dincer, et al. 2000 Amiodarone induces apoptosis of human and rat alveolar epithelial cells in vitro Am J Physiol Lung Cell Mol Physiol 278 L1039 L1044 1:CAS:528:DC%2BD3cXjvFagtbc%3D 10781436
8. M Beasley T Franks J Galvon, et al. 2002 Acute fibrinous and organizing pneumonia. A histologic pattern of lung injury and possible variant of diffuse alveolar damage Arch Pathol Lab Med 126 1064 1070 12204055
9. C Bedrossian C Warren J Ohar R Bhan 1997 Amiodarone pulmonary toxicity: cytopathology, ultrastructure, and immunocytochemistry Ann Diagn Pathol 1 47 56 1:STN:280:DyaK1M%2Fos1Knuw%3D%3D 10.1016/S1092-9134(97)80008-1 9869825
10. J Brien S Jimmo F Brennan, et al. 1987 Distribution of amiodarone and its metabolite, desethylamiodarone, in human tissues Can J Physiol Pharmacol 65 360 364 1:CAS:528:DyaL2sXhs1ynur8%3D 3580958
11. P Camus W Martin E Rosenow 2004 Amiodarone pulmonary toxicity Clin Chest Med 25 65 75 10.1016/S0272-5231(03)00144-8 15062598 (Pubitemid 38296332)
12. S Connolly 1999 Evidence based analysis of amiodarone efficacy and safety Circulation 100 2025 2034 1:CAS:528:DyaK1MXnvVaqsbY%3D 10556230
13. B Coudert F Bailly F André, et al. 1992 Amiodarone pneumonitis: bronchoalveolar lavage findings in 15 patients and review of the literature Chest 102 1005 1012 1:STN:280:DyaK3s%2FgvFyrsg%3D%3D 10.1378/chest.102.4.1005 1395734
14. L Donaldson I Grant M Naysmith J Thomas 1998 Acute amiodarone-induced lung toxicity Intensive Care Med 24 626 630 1:STN:280:DyaK1czksFWisQ%3D%3D 10.1007/s001340050627 9681788 (Pubitemid 28344768)
15. R Dusman M Stanpon W Miles, et al. 1990 Clinical features of amiodarone-induced pulmonary toxicity Circulation 82 51 59 1:STN:280: DyaK3czgsFWitQ%3D%3D 2364524
16. Y Endoh R Hanai K Uto, et al. 2000 KL-6 as a potential new marker for amiodarone-induced pulmonary toxicity Am J Cardiol 86 229 231 1:CAS:528:DC%2BD3cXksFekur0%3D 10.1016/S0002-9149(00)00864-X 10913491 (Pubitemid 30410737)
17. D Ernawati L Stafford J Hughes 2008 Amiodarone-induced pulmonary toxicity Br J Clin Pharmacol 66 82 87 1:CAS:528:DC%2BD1cXptVKisrc%3D 10.1111/j.1365-2125.2008.03177.x 18460037 (Pubitemid 351822167)
18. V Ghezel-Ahmadi V Kürschner A Fisseler-Eckhoff, et al. 2008 Amiodaroninduzierte pneumonitis Anaesthesist 57 982 9877 1:STN:280: DC%2BD1cnns1Smsg%3D%3D 10.1007/s00101-008-1407-x 18597061
19. I Goldstein M Topilsky D Segev, et al. 1997 Very early onset of acute amiodarone pulmonary toxicity presenting with hemoptysis Chest 111 1446 1447 1:STN:280:DyaK2s3ptlOitA%3D%3D 10.1378/chest.111.5.1446 9149610
20. N Haas C Camphausen 2008 Acute hemodynamic effects of intravenous amiodarone treatment in pediatric patients with cardiac surgery Clin Res Cardiol 97 801 810 1:CAS:528:DC%2BD1cXhsVKisr3E 10.1007/s00392-008-0683-4 18536864
21. N Haas C Wegendt R Schäffler, et al. 2008 ECMO for cardiac rescue in a neonate with accidental amiodarone overdose Clin Res Cardiol 97 878 881 10.1007/s00392-008-0700-7 18712427
22. D Handschin Am Lardinois D Schneiter, et al. 2003 Acute amiodarone-induced pulmonary toxicity following lung resection Respiration 70 310 312 10.1159/000072016 (Pubitemid 36980779)
23. S Hohnloser H Crijns M van Eickels, et al. 2009 Effect of dronedarone on cardiovascular events in atrial fibrillation N Engl J Med 360 668 678 1:CAS:528:DC%2BD1MXhvVyisbg%3D 10.1056/NEJMoa0803778 19213680
24. M Hughes A Binning 2000 Intravenous amiodarone in intensive care Intensive Care Med 26 1730 1739 1:STN:280:DC%2BD3M7ntVCnuw%3D%3D 10.1007/s001340000668 11271079 (Pubitemid 32009991)
25. G Jessurun W Boersma H Crijns 1998 Amiodarone-induced pulmonary toxicity: predisposing factors, clinical symptoms and treatment Drug Saf 18 339 344 1:CAS:528:DyaK1cXjtF2isLo%3D 10.2165/00002018-199818050-00003 9589845 (Pubitemid 28206012)
26. S Kaushik A Hussain P Clarke H Lazar 2001 Acute pulmonary toxicity after low-dose amiodarone therapy Ann Thorac Surg 72 1760 1761 1:STN:280: DC%2BD3Mnns1eitQ%3D%3D 10.1016/S0003-4975(01)02585-1 11722091 (Pubitemid 33049811)
27. G Kay A Epstein J Kirklin, et al. 1988 Fatal postoperative amiodarone pulmonary toxicity Am J Cardiol 62 490 492 1:STN:280:DyaL1czisVWgtg%3D%3D 10.1016/0002-9149(88)90991-5 3414530
28. S Kharabsheh C Abendroth M Kozak 2002 Fatal pulmonary toxicity occurring within two weeks of initiation of amiodarone Am J Cardiol 89 896 898 10.1016/S0002-9149(02)02213-0 11909587 (Pubitemid 34241479)
29. L Kober C Torp-Pedersen J McMurray, et al. 2008 Increased mortality after dronedarone therapy for severe heart failure N Engl J Med 358 2678 2687 10.1056/NEJMoa0800456 18565860 (Pubitemid 351860860)
30. L Lehmann W Weichert D Schnapauff R Dietz M Stockburger 2008 Interstitial pneumonitis with accumulation of intraalveolar macrophages, a facet Amiodarone therapy Clin Res Cardiol 97 917 920 10.1007/s00392-008-0706-1 18979057
31. S Magro E Lawrence S Wheeler, et al. 1988 Amiodarone pulmonary toxicity: prospective evaluation of serial pulmonary function tests J Am Coll Cardiol 12 781 788 1:STN:280:DyaL1c3pvFeqtQ%3D%3D 10.1016/0735-1097(88)90321-X 3403839
32. A Malhorta V Muse E Mark 2003 An 82-year-old man with dyspnea and pulmonary abnormalities N Engl J Med 348 1574 1585 10.1056/NEJMcpc030005 (Pubitemid 36437935)
33. W Martin E Rosenow 1988 Amiodarone pulmonary toxicity. Recognition and pathogenesis (Part 1) Chest 93 1067 1075 10.1378/chest.93.5.1067 3282816
34. W Martin E Rosenow 1988 Amiodarone pulmonary toxicity. Recognition and pathogenesis (Part 2) Chest 93 1242 1248 1:CAS:528:DyaL1cXks1Kitbs%3D 10.1378/chest.93.6.1242 3286141
35. J Mason 1987 Amiodarone N Engl J Med 316 455 1:STN:280: DyaL2s7hsFKrug%3D%3D 10.1056/NEJM198702193160807 3543680
36. T Massey R Leeder E Rafeiro J Brien 1995 Mechanisms in the pathogenesis of amiodarone-induced pulmonary toxicity Can J Physiol Pharmacol 73 1675 1685 1:CAS:528:DyaK28XhtFCisbc%3D 8834480
37. W Van Mieghem L Coolen I Malysse, et al. 1994 Amiodarone and the development of ARDS after lung surgery Chest 105 1642 1645 10.1378/chest.105.6. 1642 8205854
38. G Naccarelli D Wolbrette H Patel, et al. 2000 Amiodarone: clinical trials Curr Opin Cardiol 15 64 72 1:STN:280:DC%2BD3c7jtFeitw%3D%3D 10.1097/00001573-200001000-00009 10666663 (Pubitemid 30055222)
39. H Nägele S Behrens A Castel 2008 Ventricular tachycardia and aggravation of Brugada ECG pattern in a patient with coronary artery disease and combined amiodarone and betablocker therapy Clin Res Cardiol 97 56 60 10.1007/s00392-008-0607-3 18075767
40. N Nagata R Suematsu C Yoshii, et al. 1997 Characterization of amiodarone pneumonitis as related to inflammatory cells and surfactant apoprotein Chest 112 1068 1074 1:CAS:528:DyaK2sXntVCrsbY%3D 10.1378/chest.112.4.1068 9377919
41. J Ohar F Jackson R Redd, et al. 1989 Usefulness of serial pulmonary function testing as an indicator of amiodarone toxicity Am J Cardiol 64 1322 1326 1:STN:280:DyaK3c%2FntFyhtg%3D%3D 10.1016/0002-9149(89)90575-4 2589198 (Pubitemid 20000083)
42. B Olshansky M Sami A Rubin, et al. 2005 Use of amiodarone for atrial fibrillation in patients with preexisting pulmonary disease in the AFFIRM study Am J Cardiol 95 404 405 1:CAS:528:DC%2BD2MXmvFyntQ%3D%3D 10.1016/j.amjcard.2004. 09.044 15670555 (Pubitemid 40164550)
43. M Ott A Khoor J Leventhal, et al. 2003 Pulmonary toxicity in patients receiving low-dose amiodarone Chest 123 646 651 10.1378/chest.123.2.646 12576397 (Pubitemid 36269460)
44. N Oyama H Yokoshiki T Kamishima, et al. 2005 Detection of amiodarone-induced pulmonary toxicity in supine and prone positions - high-resolution computed tomography study Circ J 69 466 470 1:CAS:528: DC%2BD2MXjsFyqtbo%3D 10.1253/circj.69.466 15791044
45. M Polkey P Wilson P Rees 1995 Amiodarone pneumonitis: no safe dose Respir Med 89 233 235 1:STN:280:DyaK2M3msFOhtg%3D%3D 10.1016/0954-6111(95)90254-6 7746919
46. R Polverosi E Zanellato C Doroldi 1996 Thoracic radiography and high-resolution computerized tomography in the diagnosis of pulmonary disorders caused by amiodarone Radiol Med 92 58 62 1:STN:280:DyaK2s%2FjtlGqsA%3D%3D 8966274
47. H Ren J Kuhlman R Hruban, et al. 1990 CT-pathology correlation of amiodarone lung J Comput Assist Tomogr 14 760 765 1:STN:280:DyaK3cznsFKqtQ%3D%3D 10.1097/00004728-199009000-00015 2398156
48. D Roden 1999 Mechanisms underlying variability in response to drug therapy: implications for amiodarone use Am J Cardiol 84 29R 36R 1:CAS:528:DyaK1MXnvVeitr8%3D 10.1016/S0002-9149(99)00699-2 10568657 (Pubitemid 29527988)
49. J Rodriguez-Garcia J Garcia-Nieto F Ballesta, et al. 2001 Pulmonary mass and multiple lung nodules mimicking a lung neoplasm as amiodarone-induced pulmonary toxicity Eur J Intern Med 12 372 376 10.1016/S0953-6205(01)00127-3 11395302 (Pubitemid 32611565)
50. S Rossi J Erasmus P McAdams, et al. 2000 Pulmonary drug toxicity: radiologic and pathologic manifestations Radiographics 5 1245 1259
51. R Ruangchira-Urai T Colby J Klein, et al. 2008 Nodular amiodarone lung disease Am J Surg Pathol 32 1654 1660 10.1097/PAS.0b013e31816d1cbc 18753942
52. B Singh S Connolly H Crijns, et al. 2007 Dronedarone for maintenance of sinus rhythm in atrial fibrillation or flutter N Engl J Med 357 987 999 1:CAS:528:DC%2BD2sXhtVensrfM 10.1056/NEJMoa054686 17804843 (Pubitemid 47367078)
53. S Singh R Fletcher S Fisher, et al. 1995 Amiodarone in patients with congestive heart failure and asymptomatic ventricular arrhythmia N Engl J Med 333 77 82 1:STN:280:DyaK2M3psFyjtg%3D%3D 10.1056/NEJM199507133330201 7539890
54. S Singh S Fisher P Deedwania, et al. 1997 Pulmonary effects of amiodarone in patients with heart failure. The Congestive Heart Failure-Survival Trial of Antiarrhythmic Therapy (CHF-STAT) Investigators J Am Coll Cardiol 30 514 517 1:CAS:528:DyaK2sXlsFWrsbY%3D 10.1016/S0735-1097(97)00157-5 9247526 (Pubitemid 27339333)
55. R Siniakowicz D Narula B Suster J Steinberg 2001 Diagnosis of amiodarone pulmonary toxicity with high-resolution computerized tomographic scan J Cardiovasc Electrophysiol 12 431 436 1:STN:280:DC%2BD3MrgsFSqsg%3D%3D 10.1046/j.1540-8167.2001.00431.x 11332563
56. H Stelfox S Ahmed J Fiskio D Bates 2004 Monitoring amiodarone's toxicities: recommendations, evidence, and clinical practice Clin Pharmacol Ther 75 110 122 1:CAS:528:DC%2BD2cXntVKhtA%3D%3D 10.1016/j.clpt.2003.09.010 14749697 (Pubitemid 38130123)
57. P Vassallo R Rohmann 2007 Prescribing amiodarone JAMA 298 1312 1322 1:CAS:528:DC%2BD2sXhtVygsb7I 10.1001/jama.298.11.1312 17878423 (Pubitemid 47449439)
58. H Vernhet C Bousquet G Durand, et al. 2001 Reversible amiodarone-induced lung disease: HRCT findings Eur Radiol 11 1697 1703 1:STN:280: DC%2BD3Mvms1CrsQ%3D%3D 10.1007/s003300000809 11511891 (Pubitemid 34669803)
59. V Vorperian T Havighurst S Miller, et al. 1997 Adverse effects of low dose amiodarone: a meta-analysis J Am Coll Cardiol 30 791 798 1:CAS:528:DyaK2sXmtVGjsbs%3D 10.1016/S0735-1097(97)00220-9 9283542 (Pubitemid 27397663)
60. B Weinberg W Miles L Klein, et al. 1993 Five-year follow-up of 589 patients treated with amiodarone Am Heart J 125 109 120 1:STN:280: DyaK3s7htFagsg%3D%3D 10.1016/0002-8703(93)90063-F 8417505 (Pubitemid 23021632)