Stenotrophomonas maltophilia strains from cystic fibrosis patients: Genomic variability and molecular characterization of some virulence determinants

International Journal of Medical Microbiology

Volumn 301, Issue 1, 2011, Pages 34-43

  Nicoletti, Mauro ^a   Iacobino, Angelo ^b   Prosseda, Gianni ^c   Fiscarelli, Ersilia ^d   Zarrilli, Raffaele ^e   De Carolis, Elena ^f   Petrucca, Andrea ^a   Nencioni, Lucia ^c   Colonna, Bianca ^c   Casalino, Mariassunta ^b  

^a UNIVERSITY OF CHIETI   (Italy)

^b ROMA TRE UNIVERSITY   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

^d BAMBINO GESÙ CHILDREN S HOSPITAL   (Italy)

^e UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^f CATHOLIC UNIVERSITY   (Italy)

Author keywords

Animal model; Cystic fibrosis; Esterase; Extracellular proteases; Galleria mellonella; Molecular typing; Stenotrophomonas maltophilia; Virulence factors

Indexed keywords

DNA TOPOISOMERASE (ATP HYDROLYSING) B; ESTERASE; FIMBRIA PROTEIN; PROTEINASE; RNA 16S; VIRULENCE FACTOR;

ARTICLE; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BACTERIUM ISOLATE; CLINICAL ARTICLE; CONTROLLED STUDY; CYSTIC FIBROSIS; ENZYME ACTIVITY; GENE; GENE AMPLIFICATION; GENE EXPRESSION; GENETIC ANALYSIS; GENETIC CODE; GENETIC VARIABILITY; HUMAN; LARVA; MOTH; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; PULSED FIELD GEL ELECTROPHORESIS; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RNA GENE; STENOTROPHOMONAS MALTOPHILIA; STMPR1 GENE; STMPR2 GENE;

CLUSTER ANALYSIS; CYSTIC FIBROSIS; DNA FINGERPRINTING; DNA, BACTERIAL; DNA, RIBOSOMAL; ELECTROPHORESIS, GEL, PULSED-FIELD; GENE EXPRESSION; GRAM-NEGATIVE BACTERIAL INFECTIONS; HUMANS; LOCOMOTION; MOLECULAR SEQUENCE DATA; MOLECULAR TYPING; PHYLOGENY; RNA, RIBOSOMAL, 16S; SEQUENCE ANALYSIS, DNA; STENOTROPHOMONAS MALTOPHILIA; VIRULENCE FACTORS;

EID: 78649633270     PISSN: 14384221     EISSN: 16180607     Source Type: Journal    
DOI: 10.1016/j.ijmm.2010.07.003     Document Type: Article

References (44)

1. Avison M.B., Higgings C.S., von Heldreich C.J., Bennett P.M., Walsh T.R. Plasmid location and molecular heterogeneity of the L1 and L2 β-lactamase genes of Stenotrophomonas maltophilia. Antimicrob. Agents Chemother. 2001, 45:413-419.
2. Ballestero S., Virseda I., Escobar H., Lucrecia L., Baquero F. Stenotrophomonas maltophilia in cystic fibrosis patients. Eur. J. Clin. Microbiol. Infect. Dis. 1995, 14:728-729.
3. Berg G., Roskot N., Smalla K. Genotypic and phenotypic relationships between clinical and environmental isolates of Stenotrophomonas maltophilia. J. Clin. Microbiol. 1999, 37:3594-3600.
4. Calvio C., Celandroni F., Ghelardi E., Amati G., Salvetti S., Ceciliani F., Galizzi A., Senesi S. Swarming differentiation and swimming motility in Bacillus subtilis are controlled by swrA, a newly identified dicistronic operon. J. Bacteriol. 2005, 187:5356-5366.
5. Canton R., Valdezate S., Vindel A., Sanchez Del Saz B., Maiz L., Baquero F. Antimicrobial susceptibility profile of molecular typed cystic fibrosis Stenotrophomonas maltophilia isolates and differences with non cystic fibrosis isolates. Pediatr. Pulmonol. 2003, 35:99-107.
6. Casalino M., Latella M.C., Prosseda G., Colonna B. CadC is the preferential target of a convergent evolution driving enteroinvasive Escherichia coli toward a lysine decarboxylase-defective phenotype. Infect. Immun. 2003, 71:5472-5479.
7. Coenye T., LiPuma J.J. Use of the gyrB gene for the identification of Pandoraea species. FEMS Microbiol. Lett. 2002, 208:15-19.
8. Coenye T., Vanlaere E., LiPuma J.J., Vandamme P. Identification of genomic groups in the genus Stenotrophomonas using gyrB RFLP analysis. FEMS Immunol. Med. Microbiol. 2004, 40:181-185.
9. Crispino M., Boccia M.C., Bagattini M., Villari P., Triassi M., Zarrilli R. Molecular epidemiology of Stenotrophomonas maltophilia in a university hospital. J. Hosp. Infect. 2002, 52:88-92.
10. Crossman L.C., Gould V.C., Dow J.M., Vernikos G.S., Okazaki A., Sebaihia M., Saunders D., Arrowsmith C., Carver T., Peters N., Adlem E., Kerhornou A., Lord A., Murphy L., Seeger K., Squares R., Rutter S., Quail M.A., Rajandream M.A., Harris D., Churcher C., Bentley S.D., Parkhill J., Thomson N.R., Avison M.B. The complete genome, comparative and functional analysis of Stenotrophomonas maltophilia reveals an organism heavily shielded by drug resistance determinants. Genome Biol. 2008, 9:R74.
11. Denton M., Kerr K.G. Microbiological and clinical aspects of infection associated with Stenotrophomonas maltophilia. Clin. Microbiol. Rev. 1998, 11:57-80.
12. Denton M., Todd N.J., Kerr K.G., Hawkey P.M., Littlewood J.M. Molecular epidemiology of Stenotrophomonas maltophilia isolated from clinical specimens from patients with cystic fibrosis and associated environmental samples. J. Clin. Microbiol. 1998, 36:1953-1958.
13. de Oliveira-Garcia D., Dall'Agnol M., Rosales M., Azzuz A.C., Alcantaram N., Martinez M.B., Giron J.A. Fimbriae and adherence of Stenotrophomonas maltophilia to epithelial cells and to abiotic surfaces. Cell. Microbiol. 2003, 5:625-636.
14. de Oliveira-Garcia D., Dall'Agnol M., Rosales M., Azzuz A.C., Martinez M.B., Giron J.A. Characterization of flagella produced by clinical strains of Stenotrophomonas maltophilia. Emerg. Infect. Dis. 2002, 8:918-923.
15. De Vidipò L.A., De Marques E.A., Puchelle E., Plotkowski M.C. Stenotrophomonas maltophilia interaction with human epithelial respiratory cells in vitro. Microbiol. Immunol. 2001, 45:563-569.
16. Di Bonaventura G., Prosseda G., Del Chierico F., Cannavacciuolo S., Cipriani P., Petrucca A., Superti F., Ammendolia M.G., Concato C., Fiscarelli F., Casalino M., Nicoletti M., Colonna B. Molecular characterization of virulence determinants of Stenotrophomonas maltophilia strains isolated from patients affected by cystic fibrosis. Int. J. Immunopathol. Pharmacol. 2007, 20:529-537.
17. Di Bonaventura G., Spedicato I., D'Antonio D., Robuffo I., Piccolomini R. Biofilm formation by Stenotrophomonas maltophilia: modulation by quinolones, trimethoprim-sulfamethoxazole, and ceftazidime. Antimicrob. Agents Chemother. 2004, 48:151-160.
18. Figueiredo P.M., Furumura M.T., Santos A.M., Sousa A.C., Kota D.J., Levy C.E., Yano T. Cytotoxic activity of clinical Stenotrophomonas maltophilia. Lett. Appl. Microbiol. 2006, 43:443-449.
19. Gibson R.L., Burns J.L., Ramsey B.W. Pathophysiology and management of pulmonary infections in cystic fibrosis. Am. J. Respir. Crit. Care Med. 2003, 168:918-951.
20. Goss C.H., Mayer-Hamblett N., Aitken M.L., Rubenfeld G.D., Ramsey B.W. Association between Stenotrophomonas maltophilia and lung function in cystic fibrosis. Thorax 2004, 59:955-959.
21. Gould V.C., Okazaki A., Howe R.A., Avison M.B. Analysis of sequence variation among smeDEF multi drug efflux pump genes and flanking DNA from defined 16S rRNA subgroups of clinical Stenotrophomonas maltophilia isolates. J. Antimicrob. Chemother. 2004, 54:348-453.
22. Gould V.C., Okazaki A., Avison M.B. Beta-lactam resistance and beta-lactamase expression in clinical Stenotrophomonas maltophilia isolates having defined phylogenetic relationships. J. Antimicrob. Chemother. 2006, 57:199-203.
23. Hauben L., Vauterin L., Moore E.R., Hoste B., Swings J. Genomic diversity of the genus Stenotrophomonas. Int. J. Syst. Bacteriol. 1999, 49:1749-1760.
24. Hugh R., Leifson E. A description of the type strain of Pseudomonas maltophilia. Int. Bull. Bacteriol. Nomencl. Taxon. 1963, 13:133-138.
25. Hunter P.R., Gaston M.A. Numerical index of the discriminatory ability of typing systems: an application of Simpson's index of diversity. J. Clin. Microbiol. 1988, 26:2465-2466.
26. Hunter S.B., Vauterin P., Lambert-Fair M.A., Van Duyne M.S., Kubota K., Graves L., Wrigley D., Barrett T., Ribot E. Establishment of a universal size standard strain for use with the PulseNet standardized pulsed-field gel electrophoresis protocols: converting the national databases to the new size standard. J. Clin. Microbiol. 2005, 43:1045-1050.
27. Jander G., Rahme L.G., Ausubel F.M. Positive correlation between virulence of Pseudomonas aeruginosa mutants in mice and insects. J. Bacteriol. 2000, 182:3843-3845.
28. Kavanagh K., Reeves E.P. Exploiting the potential of insects for in vivo pathogenicity testing of microbial pathogens. FEMS Microbiol. Rev. 2004, 28:101-112.
29. Looney W.J., Narita M., Mühlemann K. Stenotrophomonas maltophilia: an emerging opportunist human pathogen. Lancet Infect. Dis. 2009, 9:312-323.
30. Lyczak J.B., Cannon C.L., Pier G.B. Lung infections associated with cystic fibrosis. Clin. Microbiol. Rev. 2002, 15:194-222.
31. Marchac V., Equi A., Le Bihan-Benjamin C., Hodson M., Bush A. Case-control study of Stenotrophomonas maltophilia acquisition in cystic fibrosis patients. Eur. Respir. J. 2004, 23:98-102.
32. Rashid M.H., Kornberg A. Inorganic polyphosphate is needed for swimming, swarming, and twitching motilities of Pseudomonas aeruginosa. Proc. Natl. Acad. Sci. U.S.A. 2000, 97:4885-4890.
33. Rocco F., De Gregorio E., Colonna B., Di Nocera P.P. Stenotrophomonas maltophilia genomes: a start-up comparison. Int. J. Med. Microbiol. 2009, 299:535-546.
34. Roscetto E., Rocco F., Carlomagno M.S., Casalino M., Colonna B., Zarrilli R., Di Nocera P.P. PCR-based rapid genotyping of Stenotrophomonas maltophilia isolates. BMC Microbiol. 2008, 8:202-211.
35. Ryan R.P., Monchy S., Cardinale M., Taghavi S., Crossman L., Avison M.B., Berg G., van der Lelie D., Dow J.M. The versatility and adaptation of bacteria from the genus Stenotrophomonas. Nat. Rev. Microbiol. 2009, 7:514-525.
36. Schaumann R., Laurin F., Rodloff A.C. Molecular typing of clinical isolates of Stenotrophomonas maltophilia by pulsed-field gel electrophoresis and random primer PCR fingerprinting. Int. J. Hyg. Environ. Health 2008, 211:292-298.
37. Seed K.D., Dennis J.J. Development of Galleria mellonella as an alternative infection model for the Burkholderia cepacia complex. Infect. Immun. 2008, 76:1267-1275.
38. Steinkamp G., Wiedemann B., Rietschel E., Krahl A., Gielen J., Barmeier H., Ratjen F. Prospective evaluation of emerging bacteria in cystic fibrosis. J. Cyst. Fibros. 2005, 4:41-48.
39. Talker-Huiber D., Jose J., Glieder A., Pressnig M., Stubenrauch G., Schwab H. Esterase EstE from Xanthomonas vesicatoria (Xv_EstE) is an outer membrane protein capable of hydrolyzing long-chain polar esters. Appl. Microbiol. Biotechnol. 2003, 61:479-487.
40. Valdezate S., Vindel A., Martín-Dávila P., Del Saz B.S., Baquero F., Cantón R. High genetic diversity among Stenotrophomonas maltophilia strains despite their originating at a single hospital. J. Clin. Microbiol. 2004, 42:693-699.
41. Waters V.J., Gómez M.I., Soong G., Amin S., Ernst R., Prince A. Immunostimulatory properties of the emerging pathogen Stenotrophomonas maltophilia. Infect. Immun. 2007, 75:1698-1703.
42. Wilhelm S., Gdynia A., Tielen P., Rosenau F., Jaeger K.E. The autotransporter esterase EstA of Pseudomonas aeruginosa is required for rhamnolipid production, cell motility, and biofilm formation. J. Bacteriol. 2007, 189:6695-6703.
43. Wilhelm S., Tommassen J., Jaeger K.E. A novel lipolytic enzyme located in the outer membrane of Pseudomonas aeruginosa. J. Bacteriol. 1999, 181:6977-6986.
44. Windhorst S., Frank E., Georgieva D.N., Genov N., Buck F., Borowski P., Weber W. The major extracellular protease of the nosocomial pathogen Stenotrophomonas maltophilia: characterization of the protein and molecular cloning of the gene. J. Biol. Chem. 2002, 277:11042-11049.