A haplotype of glycogen synthase kinase 3β is associated with early onset of unipolar major depression

Genes, Brain and Behavior

Volumn 9, Issue 7, 2010, Pages 799-807

  Saus, E ^a   Soria, V ^b   Escaramis G ^a   Crespo, J M ^b,c   Valero, J ^d   Gutierrez Zotes A ^d   Martorell, L ^d   Vilella, E ^d   Menchon J M ^b,c   Estivill, X ^a,e   Gratacos M ^a   Urretavizcaya, M ^b,c  

^a CENTRE FOR GENOMIC REGULATION CRG   (Spain)

^b HOSPITAL UNIVERSITARI DE BELLVITGE   (Spain)

^c UNIVERSITY OF BARCELONA   (Spain)

^d IISPV   (Spain)

^e UNIVERSITAT POMPEU FABRA   (Spain)

Author keywords

Age at onset; Association; Copy number variation; GSK3 ; Mood disorders; Polymorphism

Indexed keywords

GLYCOGEN SYNTHASE KINASE 3BETA;

ADULT; ARTICLE; COPY NUMBER VARIATION; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; PHENOTYPE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; AGE OF ONSET; BIPOLAR DISORDER; CASE-CONTROL STUDIES; DEPRESSIVE DISORDER, MAJOR; DNA COPY NUMBER VARIATIONS; FEMALE; GENETIC VARIATION; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; GLYCOGEN SYNTHASE KINASE 3; HAPLOTYPES; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 78649623419     PISSN: 16011848     EISSN: 1601183X     Source Type: Journal    
DOI: 10.1111/j.1601-183X.2010.00617.x     Document Type: Article

References (46)

1. Adli, M., Hollinde, D.L., Stamm, T., Wiethoff, K., Tsahuridu, M., Kirchheiner, J., Heinz, A. & Bauer, M. (2007) Response to lithium augmentation in depression is associated with the glycogen synthase kinase 3-beta -50T/C single nucleotide polymorphism. Biol Psychiatry 62, 1295-1302.
2. Akiskal, H.S., Maser, J.D., Zeller, P.J., Endicott, J., Coryell, W., Keller, M., Warshaw, M., Clayton, P. & Goodwin, F. (1995) Switching from 'unipolar' to bipolar II. An 11-year prospective study of clinical and temperamental predictors in 559 patients. Arch Gen Psychiatry 52, 114-123.
3. Altschul, S.F., Gish, W., Miller, W., Myers, E.W. & Lipman, D.J. (1990) Basic local alignment search tool. J Mol Biol 215, 403-410.
4. American Psychiatric Association (1994) Diagnostic and Statistical Manual of Mental Disorders, 4th edn. American Psychiatric Press, Washington, DC.
5. Armengol, L., Rabionet, R. & Estivill, X. (2008) The emerging role of structural variations in common disorders: initial findings and discovery challenges. Cytogenet Genome Res 123, 108-117.
6. Barnett, J.H. & Smoller, J.W. (2009) The genetics of bipolar disorder. Neuroscience 164, 331-343.
7. Baron, M., Risch, N. & Mendlewicz, J. (1982) Age at onset in bipolar-related major affective illness: clinical and genetic implications. J Psychiatr Res 17, 5-18.
8. Benedetti, F., Serretti, A., Colombo, C., Lorenzi, C., Tubazio, V. & Smeraldi, E. (2004) A glycogen synthase kinase 3-beta promoter gene single nucleotide polymorphism is associated with age at onset and response to total sleep deprivation in bipolar depression. Neurosci Lett 368, 123-126.
9. Benedetti, F., Serretti, A., Pontiggia, A., Bernasconi, A., Lorenzi, C., Colombo, C. & Smeraldi, E. (2005) Long-term response to lithium salts in bipolar illness is influenced by the glycogen synthase kinase 3-beta -50 T/C SNP. Neurosci Lett 376, 51-55.
10. Carlson, C.S., Eberle, M.A., Rieder, M.J., Yi, Q., Kruglyak, L. & Nickerson, D.A. (2004) Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium. Am J Hum Genet 74, 106-120.
11. Carter, T.D., Mundo, E., Parikh, S.V. & Kennedy, J.L. (2003) Early age at onset as a risk factor for poor outcome of bipolar disorder. J Psychiatr Res 37, 297-303.
12. Cook, E.H. Jr & Scherer, S.W. (2008) Copy-number variations associated with neuropsychiatric conditions. Nature 455, 919-923.
13. Coryell, W., Endicott, J. & Keller, M.B. (1991) Predictors of relapse into major depressive disorder in a nonclinical population. Am J Psychiatry 148, 1353-1358.
14. Faraone, S.V., Glatt, S.J., Su, J. & Tsuang, M.T. (2004) Three potential susceptibility loci shown by a genome-wide scan for regions influencing the age at onset of mania. Am J Psychiatry 161, 625-630.
15. First, M.B., Spitzer, R.L., Gibbon, M. & Williams, J.B.W. (1997) Structured Clinical Interview for DSM-IV Axis I Disorders (SCID). American Psychiatric Press, Washington, DC.
16. Gauderman, W.J. (2002) Sample size requirements for matched case-control studies of gene-environment interaction. Stat Med 21, 35-50.
17. Gauderman, W.J. & Morrison, J.M. (2006) QUANTO 1.1: a computer program for power and sample size calculations for genetic-epidemiology studies. URL (last access on March 2010).
18. Ghaemi, S.N., Hsu, D.J., Ko, J.Y., Baldassano, C.F., Kontos, N.J. & Goodwin, F.K. (2004) Bipolar spectrum disorder: a pilot study. Psychopathology 37, 222-226.
19. Gonzalez, J.R., Armengol, L., Sole, X., Guino, E., Mercader, J.M., Estivill, X. & Moreno, V. (2007) SNPassoc: an R package to perform whole genome association studies. Bioinformatics 23, 644-645.
20. Grimes, C.A. & Jope, R.S. (2001) The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling. Prog Neurobiol 65, 391-426.
21. Hamilton, M. (1960) A rating scale for depression. J Neurol Neurosurg Psychiatry 23, 56-62.
22. Iafrate, A.J., Feuk, L., Rivera, M.N., Listewnik, M.L., Donahoe, P.K., Qi, Y., Scherer, S.W. & Lee, C. (2004) Detection of large-scale variation in the human genome. Nat Genet 36, 949-951.
23. Inkster, B., Nichols, T.E., Saemann, P.G., Auer, D.P., Holsboer, F., Muglia, P. & Matthews, P.M. (2009) Association of GSK3beta polymorphisms with brain structural changes in major depressive disorder. Arch Gen Psychiatry 66, 721-728.
24. Jope, R.S., Yuskaitis, C.J. & Beurel, E. (2007) Glycogen synthase kinase-3 (GSK3): inflammation, diseases, and therapeutics. Neurochem Res 32, 577-595.
25. Kaidanovich-Beilin, O., Milman, A., Weizman, A., Pick, C.G. & Eldar-Finkelman, H. (2004) Rapid antidepressive-like activity of specific glycogen synthase kinase-3 inhibitor and its effect on beta-catenin in mouse hippocampus. Biol Psychiatry 55, 781-784.
26. Klein, P.S. & Melton, D.A. (1996) A molecular mechanism for the effect of lithium on development. Proc Natl Acad Sci U S A 93, 8455-8459.
27. Kupfer, D.J., Frank, E., Carpenter, L.L. & Neiswanger, K. (1989) Family history in recurrent depression. J Affect Disord 17, 113-119.
28. Kwok, J.B., Hallupp, M., Loy, C.T., Chan, D.K., Woo, J., Mellick, G.D., Buchanan, D.D., Silburn, P.A., Halliday, G.M. & Schofield, P.R. (2005) GSK3B polymorphisms alter transcription and splicing in Parkinson's disease. Ann Neurol 58, 829-839.
29. Lachman, H.M., Pedrosa, E., Petruolo, O.A., Cockerham, M., Papolos, A., Novak, T., Papolos, D.F. & Stopkova, P. (2007) Increase in GSK3beta gene copy number variation in bipolar disorder. Am J Med Genet B Neuropsychiatr Genet 144, 259-265.
30. Lee, K.Y., Ahn, Y.M., Joo, E.J., Jeong, S.H., Chang, J.S., Kim, S.C. & Kim, Y.S. (2006) No association of two common SNPs at position -1727 A/T, -50 C/T of GSK-3 beta polymorphisms with schizophrenia and bipolar disorder of Korean population. Neurosci Lett 395, 175-178.
31. Levinson, D.F. (2006) The genetics of depression: a review. Biol Psychiatry 60, 84-92.
32. Li, X., Zhu, W., Roh, M.S., Friedman, A.B., Rosborough, K. & Jope, R.S. (2004) In vivo regulation of glycogen synthase kinase-3beta (GSK3beta) by serotonergic activity in mouse brain. Neuropsychopharmacology 29, 1426-1431.
33. Lobo, A., Perez-Echeverria, M.J. & Artal, J. (1986) Validity of the scaled version of the General Health Questionnaire (GHQ-28) in a Spanish population. Psychol Med 16, 135-140.
34. Michelon, L., Meira-Lima, I., Cordeiro, Q., Miguita, K., Breen, G., Collier, D. & Vallada, H. (2006) Association study of the INPP1, 5HTT, BDNF, AP-2beta and GSK-3beta GENE variants and retrospectively scored response to lithium prophylaxis in bipolar disorder. Neurosci Lett 403, 288-293.
35. Mills, R.E., Luttig, C.T., Larkins, C.E., Beauchamp, A., Tsui, C., Pittard, W.S. & Devine, S.E. (2006) An initial map of insertion and deletion (INDEL) variation in the human genome. Genome Res 16, 1182-1190.
36. Nestler, E.J., Barrot, M., DiLeone, R.J., Eisch, A.J., Gold, S.J. & Monteggia, L.M. (2002) Neurobiology of depression. Neuron 34, 13-25.
37. Nishiguchi, N., Breen, G., Russ, C., St Clair, D. & Collier, D. (2006) Association analysis of the glycogen synthase kinase-3beta gene in bipolar disorder. Neurosci Lett 394, 243-245.
38. Pritchard, J.K., Stephens, M. & Donnelly, P. (2000) Inference of population structure using multilocus genotype data. Genetics 155, 945-959.
39. Rowe, M.K., Wiest, C. & Chuang, D.M. (2007) GSK-3 is a viable potential target for therapeutic intervention in bipolar disorder. Neurosci Biobehav Rev 31, 920-931.
40. Sanchez, J.J., Phillips, C., Borsting, C., Balogh, K., Bogus, M., Fondevila, M., Harrison, C.D., Musgrave-Brown, E., Salas, A., Syndercombe-Court, D., Schneider, P.M., Carracedo, A. & Morling, N. (2006) A multiplex assay with 52 single nucleotide polymorphisms for human identification. Electrophoresis 27, 1713-1724.
41. Searle, S., Casella, G. & McCulloch, C. (1992) Variance Components. Wiley Press, New York.
42. Soria, V., Martinez-Amoros, E., Escaramis, G., Valero, J., Perez-Egea, R., Garcia, C., Gutierrez-Zotes, A., Puigdemont, D., Bayes, M., Crespo, J.M., Martorell, L., Vilella, E., Labad, A., Vallejo, J., Perez, V., Menchon, J.M., Estivill, X., Gratacos, M. & Urretavizcaya, M. (2010) Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CLOCK and VIP with bipolar disorder. Neuropsychopharmacology 35, 1279-1289.
43. Szczepankiewicz, A., Skibinska, M., Hauser, J., Slopien, A., Leszczynska-Rodziewicz, A., Kapelski, P., Dmitrzak-Weglarz, M., Czerski, P.M. & Rybakowski, J.K. (2006) Association analysis of the GSK-3beta T-50C gene polymorphism with schizophrenia and bipolar disorder. Neuropsychobiology 53, 51-56.
44. Tsai, S.J., Liou, Y.J., Hong, C.J., Yu, Y.W. & Chen, T.J. (2008) Glycogen synthase kinase-3beta gene is associated with antidepressant treatment response in Chinese major depressive disorder. Pharmacogenomics J 8, 384-390.
45. Wang, N., Akey, J.M., Zhang, K., Chakraborty, R. & Jin, L. (2002) Distribution of recombination crossovers and the origin of haplotype blocks: the interplay of population history, recombination, and mutation. Am J Hum Genet 71, 1227-1234.
46. Wheeler, D.A., Srinivasan, M., Egholm, M. et al. (2008) The complete genome of an individual by massively parallel DNA sequencing. Nature 452, 872-876.