Lymphocytopenia as a marker for pandemic influenza A/H1N1 2009 virus infection in children

Journal of Medical Virology

Volumn 83, Issue 1, 2011, Pages 1-4

  Chiappini, Elena ^a   Galli, Luisa ^a   Azzi, Alberta ^a   Resti, Massimo ^a   Bonsignori, Francesca ^a   De Martino, Maurizio ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Children; Influenza A (H1N1); Lymphocytopenia

Indexed keywords

C REACTIVE PROTEIN; HEMOGLOBIN;

ADOLESCENT; ARTICLE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE DURATION; ERYTHROCYTE COUNT; FEMALE; HOSPITAL ADMISSION; HUMAN; INFANT; INFLUENZA VIRUS A H1N1; LEUKOCYTE COUNT; LYMPHOCYTE COUNT; LYMPHOCYTOPENIA; MALE; NEUTROPHIL COUNT; NONHUMAN; PANDEMIC INFLUENZA; POLYMERASE CHAIN REACTION; PREDICTION; PRESCHOOL CHILD; SCHOOL CHILD; SENSITIVITY AND SPECIFICITY; THROMBOCYTE COUNT;

ADOLESCENT; BIOLOGICAL MARKERS; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; INFANT; INFLUENZA A VIRUS, H1N1 SUBTYPE; INFLUENZA, HUMAN; LEUKOCYTE COUNT; LYMPHOPENIA; MALE; PREDICTIVE VALUE OF TESTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, VIRAL; ROC CURVE; SENSITIVITY AND SPECIFICITY;

EID: 78649609102     PISSN: 01466615     EISSN: 10969071     Source Type: Journal    
DOI: 10.1002/jmv.21930     Document Type: Article

References (13)

1. Aguileria JF, Paget WJ, Mosnier A, Heijnen ML, Uphoff H, van der Velden J, Vega T, Watson JM. 2003. Heterogeneous case definitions used for the surveillance of influenza in Europe. Eur J Epidemiol 18: 751-754.
2. Cao B, Li XW, Mao Y, Wang J, Lu HZ, Chen YS, Liang ZA, Liang L, Zhang SJ, Zhang B, Gu L, Lu LH, Wang DY, Wang C, National Influenza A Pandemic (H1N1). 2009. Clinical investigation group of China. 2009. Clinical features of the initial cases of 2009 pandemic influenza A (H1N1) virus infection in China. N Engl J Med 361: 2507-2517.
3. Coş'kun O, Avci IY, Sener K, Yaman H, Ogur R, Bodur H, Eyigün CP. 2010. Relative lymphopenia and monocytosis may be considered as a surrogate marker of pandemic influenza A (H1N1). J Clin Virol 47: 388-389.
4. Cunha BA, Pherez FM, Schoch P. 2009. Diagnostic importance of relative lymphopenia as a marker of swine influenza (H1N1) in adults. Clin Infect Dis 49: 1454-1456.
5. European Centre for Disease Prevention and Control. ECDC Forward look risk assessment. Likely scenarios for influenza in 2010 and the 2010/2011 influenza reason in Europe and the consequent work priorities. Available at: (accessed on April 7, 2010).
6. Galli L, Azzi A, Chiappini E, Cornioli F, Bianconi T, Mannelli F, de Martino M. 2010. A real time RT- PCR to evaluate natural history of viral shedding in outpatient children and adolescents with pandemic influenza A/2009 (H1N1). Chest 138: 456-457.
7. Liem NT, Tung CV, Hien ND, Hien TT, Chau NQ, Long HT, Hien NT, Mai le Q, Taylor WR, Wertheim H, Farrar J, Khang DD, Horby P. 2009. Clinical features of human influenza A (H5N1) infection in Vietnam: 2004-2006. Clin Infect Dis 48: 1639-1646.
8. Lupovitch A. 2005. White cell differential count and influenza A. Am J Med 118: 1306-1307.
9. Nicholson JF, Pesce MA. 2003. Chapter 710, Reference ranges for laboratory tests and procedures. In: Richard E. Behrman, Robert M. Kleigman, Hal B. Jenson, editors. Nelson textbook of pediatrics, 17th edition. Philadelphia: WB Saunders pp. 2346-2421.
10. Pembrey L, Newell ML, Tovo PA, European Paediatric Hepatitis C Virus Network. 2008. Age- related lymphocyte and neutrophil levels in children of hepatitis C- infected women. Paediatr Infect Dis J 27: 800-807.
11. Perez- Padilla R, de la Rosa- Zamboni D, Ponce de Leon S, Hernandez M, Quiñones- Falconi F, Bautista E, Ramirez- Venegas A, Rojas- Serrano J, Ormsby CE, Corrales A, Higuera A, Mondragon E, Cordova- Villalobos JA, INER Working Group on Influenza. 2009. Pneumonia and respiratory failure from swine- origin influenza A (H1N1) in Mexico. N Engl J Med 361: 680-689.
12. Stegemann S, Dahlberg S, Kröger A, Gereke M, Bruder D, Henriques- Normark B, Gunzer M. 2009. Increased susceptibility for superinfection with Streptococcus pneumoniae during influenza virus infection is not caused by TLR7- mediated lymphopenia. PLoS One 4: e4840.
13. Weerkamp F, de Haas EF, Naber BA, Comans- Bitter WM, Bogers AJ, van Dongen JJ, Staal FJ. 2005. Age- related changes in the cellular composition of the thymus in children. J Allergy Clin Immunol 115: 834-840.