First-trimester combined screening for trisomy 21 at 7-14 weeks' gestation

Ultrasound in Obstetrics and Gynecology

Volumn 36, Issue 4, 2010, Pages 404-411

  Wright, D ^a   Spencer, K ^b   Kagan, K ^c   Torring N ^d   Petersen, O B ^d   Christou, A ^e   Kallikas, J ^f   Nicolaides, K H ^g  

^a UNIVERSITY OF PLYMOUTH   (United Kingdom)

^b KING GEORGE HOSPITAL   (United Kingdom)

^c UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^d AARHUS UNIVERSITY HOSPITAL   (Denmark)

^e Alpha Medical Diagnosis   (Cyprus)

^f Ultrasound and Fetal Medicine Centre   (Cyprus)

^g KING S COLLEGE HOSPITAL   (United Kingdom)

Author keywords

Combined screening; First trimester; Free hCG; Nuchal translucency; PAPP A; Screening for trisomy 21

Indexed keywords

BIOLOGICAL MARKER; CHORIONIC GONADOTROPIN BETA SUBUNIT; PREGNANCY ASSOCIATED PLASMA PROTEIN A;

ADULT; ALGORITHM; ARTICLE; BLOOD; CLINICAL TRIAL; DOWN SYNDROME; ECHOGRAPHY; FEMALE; FIRST TRIMESTER PREGNANCY; GESTATIONAL AGE; HUMAN; MATERNAL AGE; METHODOLOGY; MULTICENTER STUDY; NUCHAL TRANSLUCENCY MEASUREMENT; PREDICTIVE VALUE; PREGNANCY;

ADULT; ALGORITHMS; BIOLOGICAL MARKERS; CHORIONIC GONADOTROPIN, BETA SUBUNIT, HUMAN; DOWN SYNDROME; FEMALE; GESTATIONAL AGE; HUMANS; MATERNAL AGE; NUCHAL TRANSLUCENCY MEASUREMENT; PREDICTIVE VALUE OF TESTS; PREGNANCY; PREGNANCY TRIMESTER, FIRST; PREGNANCY-ASSOCIATED PLASMA PROTEIN-A;

EID: 78649586753     PISSN: 09607692     EISSN: 14690705     Source Type: Journal    
DOI: 10.1002/uog.7755     Document Type: Article

References (12)

1. Kagan KO, Wright D, Baker A, Sahota D, Nicolaides KH. Screening for trisomy 21 by maternal age, fetal nuchal translucency thickness, free beta-human chorionic gonadotropin and pregnancy-associated plasma protein-A. Ultrasound Obstet Gynecol 2008; 31: 618-624.
2. Spencer K, Crossley JA, Aitken DA, Nix ABJ, Dunstan FDJ, Williams K. Temporal changes in maternal serum biochemical markers of trisomy 21 across the first and second trimester of pregnancy. Ann Clin Biochem 2002; 39: 567-576.
3. Spencer K, Crossley JA, Aitken DA, Nix ABJ, Dunstan FDJ, Williams K. The effect of temporal variation in biochemical markers of trisomy 21 across the first and second trimesters of pregnancy on the estimation of individual patient-specific risks and detection rates for Down's syndrome. Ann Clin Biochem 2003; 40:219-231.
4. Kagan KO, Wright D, Spencer K, Molina FS, Nicolaides KH. First-trimester screening for trisomy 21 by free beta-human chorionic gonadotropin and pregnancy-associated plasma protein-A: impact of maternal and pregnancy characteristics. Ultrasound Obstet Gynecol 2008; 31: 493-502.
5. Kirkegaard I, Petersen OB, Uldbjerg N, Tørring N. Improved performance of first-trimester combined screening for trisomy 21 with the double test taken before a gestational age of 10 weeks. Prenat Diagn 2008; 28: 839-844.
6. Loughna P, Chitty L, Evans T, Chudleigh T. Fetal size and dating: charts recommended for clinical obstetric practice. Ultrasound 2009; 17: 161-167.
7. Draper N, Smith R. Applied Regression Analysis (3rd edn). Wiley: New York, 1998.
8. Wright D, Kagan KO, Molina FS, Gazzoni A, Nicolaides KH. A mixture model of nuchal translucency thickness in screening for chromosomal defects. Ultrasound Obstet Gynecol 2008; 31:376-383.
9. Office for National Statistics. Birth Statistics. Review of the Registrar General on births and patterns of family building in England and Wales. Series FM1, No. 29-31. Stationery Office: London, 2002.
10. Cuckle HS, van LithJMM. Appropriate biochemical parameters in first-trimester screening for Down syndrome. Prenat Diagn 1999; 19: 505-512.
11. Souka AP, Pilalis A, Kavalakis Y, Kosmas Y, Antsaklis P, Antsaklis A. Assessment of fetal anatomy at the 11-13-week ultrasound examination. Ultrasound Obstet Gynecol 2004; 24:730-734.
12. Borrell A, Casals E, Fortuny A, Farre MT, Gonce A, Sanchez A, Soler A, Cararach V, Vanrell JA. First-trimester screening for trisomy 21 combining biochemistry and ultrasound at individually optimal gestational ages. An interventional study. Prenat Diagn 2004; 24: 541-545.