Effect of strontium ranelate on fracture healing in the osteoporotic rats

Journal of Orthopaedic Research

Volumn 29, Issue 1, 2011, Pages 138-142

  Ozturan, Kutay Engin ^a   Demir, Berfu ^b   Yucel, Istemi ^c   Cakici, Husamettin ^a   Yilmaz, Fahri ^a   Haberal, Ali ^d  

^a ABANT IZZET BAYSAL UNIVERSITY   (Turkey)

^b Etlik Zubeyde Hanim Women's Health Teaching and Research Hospital   (Turkey)

^c DUZCE UNIVERSITY   (Turkey)

^d BASKENT UNIVERSITY   (Turkey)

Author keywords

fracture healing; heparin; osteoporosis; ovariectomized rat; strontium ranelate

Indexed keywords

STRONTIUM RANELATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE DENSITY; BONE MATURATION; CALLUS; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; FRACTURE HEALING; INTRAMEDULLARY NAILING; NONHUMAN; OSTEOPOROSIS; OVARIECTOMY; PRIORITY JOURNAL; RAT; RIGIDITY; STRENGTH; TIBIA SHAFT FRACTURE;

ANIMALS; BIOMECHANICS; BONE DENSITY; BONE DENSITY CONSERVATION AGENTS; DISEASE MODELS, ANIMAL; FEMALE; FRACTURE HEALING; ORGANOMETALLIC COMPOUNDS; OSTEOPOROTIC FRACTURES; RATS; RATS, SPRAGUE-DAWLEY; THIOPHENES;

EID: 78649545301     PISSN: 07360266     EISSN: 1554527X     Source Type: Journal    
DOI: 10.1002/jor.21204     Document Type: Article

References (39)

1. Greendale GA, Barrett-Connor E, Ingles S, et al. 1995. Late physical and functional effects of osteoporotic fracture in women: The Rancho Bernardo Study. J Am Geriatr Soc 43: 955-961.
2. Chrischilles EA, Butler CD, Davis CS, et al. 1991. A model of lifetime osteoporosis impact. Arch Intern Med 151 (10) 2026-2032.
3. Finkelstein JS., Osteoporosis. In:, Cecil RL, Bennett JC, Goldman L, editors. Cecil textbook of medicine. Philadelphia, PA: WB Saunders & Co; 2000.
4. Schindeler A, McDonald MM, Bokko P, et al. 2008. Bone remodeling during fracture repair: The cellular picture. Semin Cell Dev Biol 19: 459-466.
5. Beaver R, Brinker MR, Barrack RL., 1997. An analysis of the actual cost of tibial nonunions. J La State Med Soc 149: 200-206.
6. Cummings SR, Melton LJ., 2002. Epidemiology and outcomes of osteoporotic fractures. Lancet 359: 1761-1767.
7. Meunier PJ, Roux C, Seeman E, et al. 2004. The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis. N Engl J Med 350: 459-468. (Pubitemid 38133766)
8. Reginster JY, Seeman E, De Vernejoul MC, et al. 2005. Strontium ranelate reduces the risk of non-vertebral fractures in postmenopausal women with osteoporosis: Treatment of Peripheral Osteoporosis (TROPOS) study. J Clin Endocrinol Metab 90: 2816-2822.
9. Reginster JY, Felsenberg D, Boonen S, et al. 2008. Effects of long-term strontium ranelate treatment on the risk of nonvertebral and vertebral fractures in postmenopausal osteoporosis results of a five-year, randomized, placebo-controlled trial. Arthritis Rheumatism 58 (6): 1687-1695.
10. Buehler J, Chappuis P, Saffar JL, et al. 2001. Strontium ranelate inhibits bone resorption while maintaining bone formation in alveolar bone in monkeys (Macaca fascicularis). Bone 29: 176-179.
11. Marie PJ., 2005. Strontium ranelate: A novel mode of action of optimizing bone formation and resorption. Osteoporos Int 16 (Suppl 1): 7-10.
12. Chattopadhyay N, Quinn SJ, Kifor O, et al. 2007. The calcium-sensing receptor (CaR) is involved in strontium ranelate-induced osteoblast proliferation. Biochem Pharmacol 74: 438-447.
13. Pi M, Quarles LD., 2004. A novel cation-sensing mechanism in osteoblasts is a molecular target for strontium. J Bone Miner Res 19: 862-869.
14. Caverzasio J., 2008. Strontium ranelate promotes osteoblastic cell replication through at least two different mechanisms. Bone 2: 1131-1136.
15. Bärenholdt O, Kolthoff N, Nielsen SP., 2009. Effect of long-term treatment with strontium ranelate on bone strontium content. Bone 45 (2): 200-206.
16. David R, Nissan M, Cohen I, et al. 1996. Effect of low-power He-Ne laser on fracture healing in rats. Lasers Surg Med 19 (4): 458-464.
17. Ekeland A, Engesaeter LB, Langeland N., 1981. Mechanical properties of fractured and intact rat femora evaluated by bending, torsional and tensile tests. Acta Orthop Scand 52: 605-613.
18. Goldberg VM, Powell A, Shaffer JW, et al. 1985. Bone grafting: Role of histocompatibility in transplantation. J Orthop Res 3: 389-404.
19. Huo MH, Troiano NW, Pelker RR, et al. 1991. The influence of ibuprofen on fracture repair: Biomechanical, biochemical, histologic, and histomorphometric parameters in rats. J Orthop Res 9: 383-390.
20. Giannoidus P, Tzioupis C, Almalki T, et al. 2007. Fracture healing in osteoporotic fractures: is it really different?: A basic science perspective. Injury 38: 90-99.
21. Inderjeeth CA, Foo ACH, Lai MMY, et al. 2009. Efficacy and safety of pharmacological agents in managing osteoporosis in the old: Review of the evidence. Bone 44: 744-751.
22. Riggs BL, Warner HW, Seeman E, et al. 1982. Changes in bone mineral density of the proximal femur and spine with ageing: Differences between the postmenopausal and senile osteoporosis syndromes. J Clin Invest 71: 716-723.
23. Gaston MS, Simpson AHRW., 2007. Inhibition of fracture healing. J Bone Joint Surg (Br) 89 (12): 1553-1560.
24. Wronski TJ, Yen CF, Qi H, et al. 1993. Parathyroid hormone is more effective than estrogen or bisphosphonates for restoration of lost bone mass in ovariectomized rats. Endocrinology 132: 823-831.
25. Fujita T, Inoue T, Morii H, et al. 1999. Effect of an intermittent weekly dose of human parathyroid hormone (1-34) on osteoporosis: A randomized double-masked prospective study using three dose levels. Osteoporos Int 9 (4): 296-306.
26. Uusi-Rasi K, Semanick LM, Zanchetta JR, et al. 2005. Effects of teriparatide [rhPTH (1-34)] treatment on structural geometry of the proximal femur in elderly osteoporotic women. Bone 36 (6): 948-958.
27. Komatsubara S, Mori S, Mashiba T, et al. 2005. Human parathyroid hormone(1-34) accelerates the fracture healing process of woven to lamellar bone replacement and new cortical shell formation in rat femora. Bone 36: 679-687.
28. Andreassen TT, Fledelius C, Ejersted C, et al. 2001. Increases in callus formation and mechanical strength of healing fractures in old rats treated with parathyroid hormone. Acta Orthop Scand 72 (3): 304-307.
29. Alkhiary YM, Gerstenfeld LC, Krall E, et al. 2005. Enhancement of experimental fracture-healing by systemic administration of recombinant human parathyroid hormone (PTH 1-34). J Bone Joint Surg A87 (4): 731-741.
30. Manabe T, Mori S, Mashiba T, et al. 2007. Human parathyroid hormone (1-34) accelerates natural fracture healing process in the femoral osteotomy model of cynomolgus monkeys. Bone 40: 1475-1482.
31. Kaback LA, Soung DY, Naik A, et al. 2008. Teriparatide(1-34 Human PTH) regulation of osterix during fracture repair. J Cell Biochem 105: 219-226.
32. Manabe T, Mori S, Mashiba T, et al. 2009. Eel calcitonin (elcatonin) suppressed callus remodeling but did not interfere with fracture healing in the femoral fracture model of cynomolgus monkeys. J Bone Miner Metab 27 (3) 295-302.
33. Smith SY, Jolette J, Turner CH., 2009. Skeletal health: Primate model of postmenopausal osteoporosis. Am J Primatol 71: 752-765.
34. Genant HK, Cann CE, Ettinger B, et al. 1982. Quantitative computed tomography of vertebral spongiosa: A sensitive method for detecting early bone loss after oophorectomy. Ann Intern Med 97 (5) 699-705.
35. Muir JM, Hirsh J, Weitz JI, et al. 1997. A histomorphometric comparison of the effects of heparin and low-molecular-weight heparin on cancellous bone in rats. Blood 89 (9) 3236-3242.
36. Cebesoy O, Tutar E, Kose KC, et al. 2007. Effect of strontium ranelate on fracture healing in rat tibia. Joint Bone Spine 74 (6): 590-593.
37. Li YF, Luo E, Feng G, et al. 2009. Systemic treatment with strontium ranelate promotes tibial fracture healing in ovariectomized rats. Osteoporos Int DOI: 10.1007/s00198-009-1140-6. [Epub ahead of print].
38. Court-Brown C, McQueen MM., 2008. Nonunions of the proximal humerus: The prevalence and functional outcome. J Trauma 64 (6): 1517-1521.
39. Seeman E, Vellas B, Benhamou C, et al. 2006. Strontium ranelate reduces the risk of vertebral and nonvertebral fractures in women eighty years of age and older. J Bone Miner Res 21 (7) 1113-1120.