Prediction of efficacious inhalation lung doses via the use of in silico lung retention quantitative structure-activity relationship models and in vitro potency screens

Drug Metabolism and Disposition

Volumn 38, Issue 12, 2010, Pages 2218-2225

  Cooper, Anne ^a   Potter, Tim ^a   Luker, Tim ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

LIPOPOLYSACCHARIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BINDING AFFINITY; COMPUTER MODEL; CONTROLLED STUDY; DOSE RESPONSE; DRUG HALF LIFE; DRUG POTENCY; DRUG RETENTION; DRUG STRUCTURE; DRUG TISSUE LEVEL; IC 50; INHALATIONAL DRUG ADMINISTRATION; LUNG; MALE; NEUTROPHILIA; NONHUMAN; PLASMA; PLASMA PROTEIN BINDING; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RAT;

ADMINISTRATION, INHALATION; ANIMALS; LUNG; NEUTROPHILS; PHARMACOKINETICS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR;

ANIMALIA; RATTUS;

EID: 78649530347     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.110.034462     Document Type: Article

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