Animal models of neurological disease: Are there any babies in the bathwater?

Practical Neurology

Volumn 10, Issue 6, 2010, Pages 312-314

  Macleod, Malcolm ^a   van der Worp, H Bart ^b  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL; ARTICLE; CONSENSUS; DISEASE MODEL; HUMAN; MEDICAL RESEARCH; NEUROLOGIC DISEASE;

ANIMALS; BIOMEDICAL RESEARCH; CONSENSUS; DISEASE MODELS, ANIMAL; HUMANS; NERVOUS SYSTEM DISEASES;

EID: 78649530340     PISSN: 14747758     EISSN: 14747766     Source Type: Journal    
DOI: 10.1136/jnnp.2010.230524     Document Type: Article

References (6)

1. van der Worp HB, Howells DW, Sena ES, et al. Can animal models of disease reliably inform human studies? PLoS Med 2010;7:e1000245.
2. Macleod MR, van der Worp HB, Sena ES, et al. Evidence for the efficacy of NXY-059 in experimental focal cerebral ischaemia is confounded by study quality. Stroke 2008;39:2824-9.
3. Vesterinen HM, Sena ES, Ffrench-Constant C, et al. Improving the translational hit of experimental treatments in multiple sclerosis. Mult Scler 2010;16:1044-55.
4. Sena ES, van der Worp HB, Bath PM, et al. Publication bias in reports of animal stroke studies leads to major overstatement of efficacy. PLoS Biol 2010;8:e1000344.
5. Macleod MR, Fisher M, O'Collins V, et al. Good laboratory practice: preventing introduction of bias at the bench. Stroke 2009;40:e50-2.
6. Kilkenny C, Browne WJ, Cuthill IC, et al. Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research. PLoS Biol 2010;8:e1000412.