Release of DNA from polyelectrolyte multilayers fabricated using 'charge-shifting' cationic polymers: Tunable temporal control and sequential, multi-agent release

Journal of Controlled Release

Volumn 148, Issue 1, 2010, Pages 91-100

  Sun, Bin ^a   Lynn, David M ^a,b  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b University of Wisconsin Madison   (United States)

Author keywords

DNA delivery; Layer by Layer; Polyelectrolyte; Surface mediated; Thin film

Indexed keywords

1-PROPANOL; 2-DIMETHYLAMINOETHANOL; ALKENYL; AZLACTONES; CATIONIC POLYMERS; COATED SURFACE; DNA DELIVERY; DNA RELEASE; ESTER HYDROLYSIS; FUNCTIONALIZED; FUNCTIONALIZED POLYMERS; FURTHER DEVELOPMENT; GRADUAL CHANGES; HIERARCHICAL STRUCTURES; LAYER-BY-LAYER ASSEMBLIES; LAYER-BY-LAYERS; MULTI-AGENT; MULTI-LAYERED; MULTI-LAYERED FILMS; NET CHARGES; NEW STRUCTURES; PLASMID DNA; POLYELECTROLYTE MULTILAYER; RELEASE PROFILES; RING OPENING REACTION; SIDE CHAIN STRUCTURE; SIDE CHAINS; SURFACE COATINGS; SUSTAINED RELEASE; TEMPORAL CONTROLS; TERTIARY AMINE; TUNABLE CONTROL;

DESIGN; DNA; DRUG THERAPY; ESTERIFICATION; ESTERS; FABRICATION; FILM PREPARATION; FUNCTIONAL POLYMERS; HYDROLYSIS; MULTILAYERS; PLASTIC COATINGS; POLYELECTROLYTES; POLYMER BLENDS; POLYMER FILMS; PROPANOL; VAPOR DEPOSITION;

POLYMERS;

2 DIMETHYLAMINETHANOL; 3 DIMETHYLAMINO 1 PROPANOL; ALCOHOL DERIVATIVE; CATION; DNA; PLASMID DNA; POLY (2 VINYL 4,4 DIMETHYLAZLACTONE; POLYMER; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL STRUCTURE; DNA STRUCTURE; DRUG RELEASE; FILM; HYDROLYSIS; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SUSTAINED DRUG RELEASE;

ANIMALS; CERCOPITHECUS AETHIOPS; COS CELLS; DNA; GENE TRANSFER TECHNIQUES; PLASMIDS; POLYMERS;

EID: 78649529333     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2010.07.112     Document Type: Article

References (54)

1. Shea L.D., Smiley E., Bonadio J., Mooney D.J. DNA delivery from polymer matrices for tissue engineering. Nat. Biotechnol. 1999, 17:551-554.
2. Klugherz B.D., Jones P.L., Cui X.M., Chen W.L., Meneveau N.F., DeFelice S., Connolly J., Wilensky R.L., Levy R.J. Gene delivery from a DNA controlled-release stent in porcine coronary arteries. Nat. Biotechnol. 2000, 18:1181-1184.
3. Ziauddin J., Sabatini D.M. Microarrays of cells expressing defined cDNAs. Nature 2001, 411:107-110.
4. Wu R.Z., Bailey S.N., Sabatini D.M. Cell-biological applications of transfected-cell microarrays. Trends Cell Biol. 2002, 12:485-488.
5. Saltzman W.M., Olbricht W.L. Building drug delivery into tissue engineering. Nat. Rev. Drug Discovery 2002, 1:177-186.
6. Segura T., Shea L.D. Surface-tethered DNA complexes for enhanced gene delivery. Bioconjugate Chem. 2002, 13:621-629.
7. Jang J.H., Houchin T.L., Shea L.D. Gene delivery from polymer scaffolds for tissue engineering. Expert Rev. Med. Devices 2004, 1:127-138.
8. Pannier A.K., Shea L.D. Controlled release systems for DNA delivery. Mol. Ther. 2004, 10:19-26.
9. Shen H., Tan J., Saltzman W.M. Surface-mediated gene transfer from nanocomposites of controlled texture. Nat. Mater. 2004, 3:569-574.
10. Kong H.J., Liu J.D., Riddle K., Matsumoto T., Leach K., Mooney D.J. Non-viral gene delivery regulated by stiffness of cell adhesion substrates. Nat. Mater. 2005, 4:460-464.
11. Fishbein I., Stachelek S.J., Connolly J.M., Wilensky R.L., Alferiev I., Levy R.J. Site specific gene delivery in the cardiovascular system. J. Control. Release 2005, 109:37-48.
12. Fishbein I., Alferiev I.S., Nyanguile O., Gaster R., Vohs J.M., Wong G.S., Felderman H., Chen I.W., Choi H., Wilensky R.L., Levy R.J. Bisphosphonate-mediated gene vector delivery from the metal surfaces of stents. Proc. Natl Acad. Sci. USA 2006, 103:159-164.
13. De Laporte L., Shea L.D. Matrices and scaffolds for DNA delivery in tissue engineering. Adv. Drug Deliv. Rev. 2007, 59:292-307.
14. Takahashi H., Letourneur D., Grainger D.W. Delivery of large biopharmaceuticals from cardiovascular stents: a review. Biomacromolecules 2007, 8:3281-3293.
15. Jewell C.M., Lynn D.M. Multilayered polyelectrolyte assemblies as platforms for the delivery of DNA and other nucleic acid-based therapeutics. Adv. Drug Deliv. Rev. 2008, 60:979-999.
16. Jewell C.M., Lynn D.M. Surface-mediated delivery of DNA: cationic polymers take charge. Curr. Opin. Colloid Interface Sci. 2008, 13:395-402.
17. Decher G. Fuzzy nanoassemblies: toward layered polymeric multicomposites. Science 1997, 277:1232-1237.
18. Bertrand P., Jonas A., Laschewsky A., Legras R. Ultrathin polymer coatings by complexation of polyelectrolytes at interfaces: suitable materials, structure and properties. Macromol. Rapid Commun. 2000, 21:319-348.
19. Peyratout C.S., Dahne L. Tailor-made polyelectrolyte microcapsules: from multilayers to smart containers. Angew. Chem. Int. Ed. 2004, 43:3762-3783.
20. Hammond P.T. Form and function in multilayer assembly: new applications at the nanoscale. Adv. Mater. 2004, 16:1271-1293.
21. Ai H., Jones S.A., Lvov Y.M. Biomedical applications of electrostatic layer-by-layer nano-assembly of polymers, enzymes, and nanoparticles. Cell Biochem. Biophys. 2003, 39:23-43.
22. Tang Z.Y., Wang Y., Podsiadlo P., Kotov N.A. Biomedical applications of layer-by-layer assembly: from biomimetics to tissue engineering. Adv. Mater. 2006, 18:3203-3224.
23. De Geest B.G., Sanders N.N., Sukhorukov G.B., Demeester J., De Smedt S.C. Release mechanisms for polyelectrolyte capsules. Chem. Soc. Rev. 2007, 36:636-649.
24. Sukhishvili S.A. Responsive polymer films and capsules via layer-by-layer assembly. Curr. Opin. Colloid Interface Sci. 2005, 10:37-44.
25. Boudou T., Crouzier T., Ren K.F., Blin G., Picart C. Multiple functionalities of polyelectrolyte multilayer films: new biomedical applications. Adv. Mater. 2010, 22:441-467.
26. Lynn D.M. Peeling back the layers: controlled erosion and triggered disassembly of multilayered polyelectrolyte thin films. Adv. Mater. 2007, 19:4118-4130.
27. Zhang J.T., Chua L.S., Lynn D.M. Multilayered thin films that sustain the release of functional DNA under physiological conditions. Langmuir 2004, 20:8015-8021.
28. Jewell C.M., Zhang J.T., Fredin N.J., Lynn D.M. Multilayered polyelectrolyte films promote the direct and localized delivery of DNA to cells. J. Controlled Release 2005, 106:214-223.
29. Jewell C.M., Zhang J.T., Fredin N.J., Wolff M.R., Hacker T.A., Lynn D.M. Release of plasmid DNA from intravascular stents coated with ultrathin multilayered polyelectrolyte films. Biomacromolecules 2006, 7:2483-2491.
30. Zhang J.T., Montanez S.I., Jewell C.M., Lynn D.M. Multilayered films fabricated from plasmid DNA and a side-chain functionalized poly(beta-amino ester): surface-type erosion and sequential release of multiple plasmid constructs-from surfaces. Langmuir 2007, 23:11139-11146.
31. Ren K.F., Ji J., Shen J.C. Construction and enzymatic degradation of multilayered poly-l-lysine/DNA films. Biomaterials 2006, 27:1152-1159.
32. Jessel N., Oulad-Abdeighani M., Meyer F., Lavalle P., Haikel Y., Schaaf P., Voegel J.C. Multiple and time-scheduled in situ DNA delivery mediated by beta-cyclodextrin embedded in a polyelectrolyte multilayer. Proc. Natl Acad. Sci. USA 2006, 103:8618-8621.
33. Blacklock J., Handa H., Manickam D.S., Mao G.Z., Mukhopadhyay A., Oupicky D. Disassembly of layer-by-layer films of plasmid DNA and reducible TAT polypeptide. Biomaterials 2007, 28:117-124.
34. Chen J., Huang S.W., Lin W.H., Zhuo R.X. Tunable film degradation and sustained release of plasmid DNA from cleavable polycation/plasmid DNA multilayers under reductive conditions. Small 2007, 3:636-643.
35. Dieguez L., Darwish N., Graf N., Voros J., Zambelli T. Electrochemical tuning of the stability of PLL/DNA multilayers. Soft Matter 2009, 5:2415-2421.
36. Wang F., Li D., Li G.P., Liu X.Q., Dong S.J. Electrodissolution of inorganic ions/DNA multilayer film for tunable DNA release. Biomacromolecules 2008, 9:2645-2652.
37. Wang F., Liu X.Q., Li G.P., Li D., Dong S.J. Selective electrodissolution of inorganic ions/DNA multilayer film for tunable DNA release. J. Mater. Chem. 2009, 19:286-291.
38. Zhang J.T., Lynn D.M. Ultrathin multilayered films assembled from "charge-shifting" cationic polymers: extended, long-term release of plasmid DNA from surfaces. Adv. Mater. 2007, 19:4218-4223.
39. Liu X.H., Zhang J.T., Lynn D.M. Ultrathin multilayered films that promote the release of two DNA constructs with separate and distinct release profiles. Adv. Mater. 2008, 20:4148-4153.
40. Liu X.H., Zhang J.T., Lynn D.M. Polyelectrolyte multilayers fabricated from 'charge-shifting' anionic polymers: a new approach to controlled film disruption and the release of cationic agents from surfaces. Soft Matter 2008, 4:1688-1695.
41. Liu X.H., Yang J.W., Miller A.D., Nack E.A., Lynn D.M. Charge-shifting cationic polymers that promote self-assembly and self-disassembly with DNA. Macromolecules 2005, 38:7907-7914.
42. Funhoff A.M., van Nostrum C.F., Janssen A.P.C.A., Fens M.H.A.M., Crommelin D.J.A., Hennink W.E. Polymer side-chain degradation as a tool to control the destabilization of polyplexes. Pharm. Res. 2004, 21:170-176.
43. De Geest B.G., Vandenbroucke R.E., Guenther A.M., Sukhorukov G.B., Hennink W.E., Sanders N.N., Demeester J., De Smedt S.C. Intracellularly degradable polyelectrolyte microcapsules. Adv. Mater. 2006, 18:1005-1009.
44. Luten J., Akeroyd N., Funhoff A., Lok M.C., Talsma H., Hennink W.E. Methacrylamide polymers with hydrolysis-sensitive cationic side groups as degradable gene carriers. Bioconjugate Chem. 2006, 17:1077-1084.
45. Jiang X., Lok M.C., Hennink W.E. Degradable-brushed pHEMA-pDMAEMA synthesized via ATRP and click chemistry for gene delivery. Bioconjugate Chem. 2007, 18:2077-2084.
46. Shim M.S., Kwon Y.J. Controlled delivery of plasmid DNA and siRNA to intracellular targets using ketalized polyethylenimine. Biomacromolecules 2008, 9:444-455.
47. Liu X.H., Yang J.W., Lynn D.M. Addition of "charge-shifting" side chains to linear poly(ethyleneimine) enhances cell transfection efficiency. Biomacromolecules 2008, 9:2063-2071.
48. Sun B., Liu X.H., Buck M.E., Lynn D.M. Azlactone-functionalized polymers as reactive templates for parallel polymer synthesis: synthesis and screening of a small library of cationic polymers in the context of DNA delivery. Chem. Commun. 2010, 46:2016-2018.
49. Debreczeny M., Ball V., Boulmedais F., Szalontai B., Voegel J.C., Schaaf P. Multilayers built from two component polyanions and single component polycation solutions: a way to engineer films with desired secondary structure. J. Phys. Chem. B 2003, 107:12734-12739.
50. Cho J.H., Quinn J.F., Caruso F. Fabrication of polyelectrolyte multilayer films comprising nanoblended layers. J. Am. Chem. Soc. 2004, 126:2270-2271.
51. Quinn J.F., Yeo J.C.C., Caruso F. Layer-by-layer assembly of nanoblended thin films: poly(allylamine hydrochloride) and a binary mixture of a synthetic and natural polyelectrolyte. Macromolecules 2004, 37:6537-6543.
52. Zhang J., Lynn D.M. Multilayered films fabricated from combinations of degradable polyamines: tunable erosion and release of anionic polyelectrolytes. Macromolecules 2006, 39:8928-8935.
53. Kim B.S., Smith R.C., Poon Z., Hammond P.T. MAD (multiagent delivery) nanolayer: delivering multiple therapeutics from hierarchically assembled surface coatings. Langmuir 2009, 25:14086-14092.
54. Wood K.C., Chuang H.F., Batten R.D., Lynn D.M., Hammond P.T. Controlling interlayer diffusion to achieve sustained, multiagent delivery from layer-by-layer thin films. Proc. Natl Acad. Sci. USA 2006, 103:10207-10212.