Recent advances in the modelling and control of cooling and antisolvent crystallization of pharmaceuticals

IFAC Proceedings Volumes (IFAC-PapersOnline)

Volumn 40, Issue 5, 2007, Pages 29-38

  Nagy, Z K ^a   Fujiwara, M ^b   Braatz, R D ^b  

^a LOUGHBOROUGH UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

Attenuated total reflection FTIR spectroscopy; Focused beam reflectance measurement; Lovastatin; Particle vision and measurement; Pharmaceutical crystallization; Process analytical technology

Indexed keywords

COOLING; FOURIER TRANSFORM INFRARED SPECTROSCOPY;

FOCUSED BEAM REFLECTANCE MEASUREMENT; FTIR SPECTROSCOPY; LOVASTATIN; PHARMACEUTICAL CRYSTALLIZATIONS; PROCESS ANALYTICAL TECHNOLOGY;

PROCESS CONTROL;

EID: 78649518076     PISSN: 14746670     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.3182/20070606-3-MX-2915.00054     Document Type: Conference Paper

References (23)

1. Barrett, P., Smith, B., Worlitschek, J., Bracken, V., O'Sullivan, B., O'Grady, D., A review of the use of process analytical technology for the understanding and optimization of production batch crystallization processes. Organic Process Research & Development, 9 (2005) 348-355.
2. Birch, M., Fussell, S.J., Higginson, P.D., McDowall, N., Marziano, I., Towards a PAT-Based strategy for crystallization development. Organic Process Research & Development 9 (2005) 360-364.
3. Braatz, R.D. Advanced control of crystallization processes. Annual Reviews in Control 26 (2002) 87-99.
4. Doki, N., Seki, H., Takano, K., Asatani, H., Yokota, M. and Kubota, N. Process control of seeded batch cooling crystallisation of the metastable alpha-form glycine using an in-situ ATR-FTIR spectrometer and an in-situ FBRM particle counter. Crystal Growth & Design 4 (2004) 949-953.
5. Feng, L.L., Berglund, K.A. ATR-FTIR for determining optimal cooling curves for batch crystallisation of succinic acid. Crystal Growth & Design 2 (2002) 449-452.
6. FDA, U.S. Department of Health and Human Services, Guidance for industry - PAT, http://www.fda.gov/cder/guidance/6419fnl.pdf (2004).
7. Fujiwara, M., Chow, P.S., Ma, D.L. and Braatz, R.D. Paracetamol crystallisation using laser backscattering and ATR-FTIR spectroscopy: Metastability, agglomeration, and control. Crystal Growth & Design 2 (2002) 363-370.
8. Fujiwara, M., Nagy, Z. K., Chew, J. W., Braatz, R. D., First-principles and direct design approaches for the control of pharmaceutical crystallization. J. of Process Control 15 (2005) 493-504.
9. Hukkanen, E.J., Braatz, R.D. Measurement of particle size distribution in suspension polymerization using in situ laser backscattering. Sensors & Actuators B 96 (2003) 451-459.
10. Jones, A.G. Crystallization Process Systems. Butterworth-Heinemann, Oxford, 2002.
11. Jones, A.G., Teodossiev, N.M. Microcomputer programming of dosage rate during batch precipitation. Crystal Research & Technology 23 (1988) 957-966.
12. Liotta, V., Sabesan, V. Monitoring and feedback control of supersaturation using ATR-FTIR to produce an active pharmaceutical ingredient of a desired crystal size. Organic Process Research & Development 8 (2004) 488-494.
13. Mahajan, A.J., Kirwan, D.J. Nucleation and growth kinetics of biochemicals measured at high supersaturations. J. of Crystal Growth 144 (1994) 281-290.
14. Nagy, Z.K., Braatz, R.D. Robust nonlinear model predictive control of batch processes. AIChE J. 49 (2003) 1776-1786.
15. Nagy, Z.K., Braatz, R.D. Open-loop and closed-loop robust optimal control of batch processes using distributional and worst-case analysis. J. of Process Control 14 (2004) 411-422.
16. Nagy, Z.K., Chew, J.W., Fujiwara, M. Braatz, R.D. Advances in the modeling and control of batch crystallizers. in Proc. of the 7th IFAC Symp. on Advanced Control of Chemical Processes, Elsevier Scientific, Oxford, UK (2004) 83-90.
17. Rawlings, J.B., Miller, S.M., Witkowski, W.R. Model identification and control of solution crystallization processes: A review. Ind. Eng. Chem. Res. 32 (1993) 275-1296.
18. Randolph, A. and Larson, M.A. Theory of Particulate Process. 2nd ed. Academic Press, San Diego, 1988.
19. Togkalidou, T., Fujiwara, M., Patel, S., Braatz, R.D. Solute concentration prediction using chemometrics and ATR-FTIR spectroscopy. J. of Crystal Growth 231 (2001) 534-543.
20. Welz, C., Srinivasan, B., Bonvin, D. Combined online and run-to-run optimization of batch processes with terminal constraints. in Proc. of the IFAC Symp. on Advanced Control of Chemical Processes, Elsevier Scientific, Oxford, UK (2004) 55-62.
21. Woo, X.Y., Tan, R.B.H., Chow, P.S., Braatz, R.D. Simulation of mixing effects in antisolvent crystallisation using a coupled CFD-PDF-PBE approach. Crystal Growth & Design 6 (2006) 1291-1303.
22. Yu, L. X., Lionberger, R. A., Raw, A. S., D'Costa, R., Wu, H. Q., Hussain, A. S. Applications of process analytical technology to crystallization processes. Advanced Drug Delivery Reviews 56 (2004) 349-369.
23. Zhou, G.X., Fujiwara, M., Woo, X.Y., Rusli, E., Tung, H.H., Starbuck, C., Davidson, O., Ge, Z.H., Braatz, R.D. Direct design of pharmaceutical antisolvent crystallization through concentration control. Crystal Growth & Design 6 (2006) 892-898.