An asymptomatic 61-year-old man with BCR-ABL-positive bone marrow following autologous transplantation for multiple myeloma

American Journal of Hematology

Volumn 85, Issue 12, 2010, Pages 944-946

  Roper, Nitin ^a   DeAngelo, Daniel J ^a   Kuo, Frank ^b   Cin, Paola dal ^b   Ghobrial, Irene ^a   Aster, Jon C ^b  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BCR ABL PROTEIN; BORTEZOMIB; DEXAMETHASONE; MELPHALAN; THALIDOMIDE; ZOLEDRONIC ACID;

ADULT; ARTICLE; AUTOLOGOUS BONE MARROW TRANSPLANTATION; BONE DISEASE; BONE MARROW EXAMINATION; CASE REPORT; CHROMOSOME ANALYSIS; CLINICAL ASSESSMENT; COMPRESSION FRACTURE; CYTOGENETICS; FLOW CYTOMETRY; FLUORESCENCE IN SITU HYBRIDIZATION; FOLLOW UP; HEMATOLOGICAL PARAMETERS; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; MULTIPLE MYELOMA; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RADIODIAGNOSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPINE FRACTURE; TREATMENT OUTCOME;

BONE MARROW; BONE MARROW TRANSPLANTATION; FUSION PROTEINS, BCR-ABL; HUMANS; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; MALE; MIDDLE AGED; MULTIPLE MYELOMA; REMISSION INDUCTION; TRANSPLANTATION, AUTOLOGOUS;

EID: 78649504911     PISSN: 03618609     EISSN: 10968652     Source Type: Journal    
DOI: 10.1002/ajh.21809     Document Type: Article

References (17)

1. Boots MA, Pegrum GD. Simultaneous presentation of chronic granulocytic leukaemia and multiple myeloma. J Clin Pathol 1982; 35: 364-365.
2. Derghazarian C, Whittemore NB. Multiple myeloma superimposed on chronic myelocytic leukemia. Can Med Assoc J 1974; 110: 1047-1050.
3. Klenn PJ, Hyun BH, Lee YH, Zheng WY. Multiple myeloma and chronic myelogenous leukemia--a case report with literature review. Yonsei Med J 1993; 34: 293-300.
4. MacSween JM, Langley GR. Light-chain disease (hypogammaglobulinemia and Bence Jones proteinuria) and sideroblastic anemia-Preleukemic chronic granulocytic leukemia. Can Med Assoc J 1972; 106: 995-998.
5. Nitta M, Tsuboi K, Yamashita S, et al. Multiple myeloma preceding the development of chronic myelogenous leukemia. Int J Hematol 1999; 69: 170-173.
6. Raz I, Polliack A. Coexistence of myelomonocytic leukemia and monoclonal gammopathy or myeloma. Simultaneous presentation in three patients. Cancer 1984; 53: 83-85.
7. Sakai A, Kawano M, Oguma N, Kuramoto A. A case of plasma cell leukemia superimposed on Philadelphia (Ph) chromosome-positive chronic myelogenous leukemia. Am J Hematol 1991; 36: 222-223.
8. Tanaka M, Kimura R, Matsutani A, et al. Coexistence of chronic myelogenous leukemia and multiple myeloma. Case report and review of the literature. Acta Haematol 1998; 99: 221-223.
9. Tanaka K, Takechi M, Hong J, et al. 9;22 translocation and bcr rearrangements in chonic myelocytic leukemia patients among atomic bomb survivors. J Radiat Res 1989; 30: 352-358.
10. Deininger MW, Bose S, Gora-Tybor J, et al. Selective induction of leukemia-associated fusion genes by high-dose ionizing radiation. Cancer Res 1998; 58: 421-425.
11. Basecke J, Griesinger F, Trumper L, Brittinger G. Leukemia- and lymphoma-associated genetic aberrations in healthy individuals. Ann Hematol 2002; 81: 64-75.
12. Biernaux C, Loos M, Sels A, et al. Detection of major bcr-abl gene expression at a very low level in blood cells of some healthy individuals. Blood 1995; 86: 3118-3122.
13. Bose S, Deininger M, Gora-Tybor J, et al. The presence of typical and atypical BCR-ABL fusion genes in leukocytes of normal individuals: biologic significance and implications for the assessment of minimal residual disease. Blood 1998; 92: 3362-3367.
14. Melo JV, Barnes DJ. Chronic myeloid leukaemia as a model of disease evolution in human cancer. Nat Rev Cancer 2007; 7: 441-453.
15. Druker BJ. Translation of the Philadelphia chromosome into therapy for CML. Blood 2008; 112: 4808-4817.
16. Sherbenou DW, Druker BJ. Applying the discovery of the Philadelphia chromosome. J Clin Invest 2007; 117: 2067-2074.
17. Bayraktar S, Goodman M. Detection of BCR-ABL-positive cells in an asymptomatic patient: A case report and literature review. Case Rep Med 2010; article ID 939706.