Influence of silibinin on N-nitrosodimethylamine-induced changes in the genomic DNA and protein expression in the liver and lung tissue of rats

Biomedicine

Volumn 30, Issue 3, 2010, Pages 346-352

  Harrison Immanuel, S ^a   Ezhilarasan, D ^b   Vivekanandan, P ^b   Emmannvel Rajan, K ^a   Karthikeyan, S ^b  

^a BHARATHIDASAN UNIVERSITY   (India)

^b UNIVERSITY OF MADRAS   (India)

Author keywords

N nitrosodimethylsamine (DMN); Protein expression; Silibinin (SBN)

Indexed keywords

DIMETHYLNITROSAMINE; GENOMIC DNA; PROTEIN; RNA; SILIBININ;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DNA DETERMINATION; FEMALE; GENE EXPRESSION; LIVER; LIVER PROTECTION; LUNG PARENCHYMA; MALE; NONHUMAN; PROTEIN DETERMINATION; RAT; RNA ANALYSIS;

RATTUS; SILYBUM MARIANUM;

EID: 78649481944     PISSN: 09702067     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Magee P N. The experimental basis for the role of nitroso compounds in human cancer. Cancer Surv 1989; 8: 207-239.
2. International Agency for Research on Cancer. N-nitrosodimethylamine, IARC Monographs on the evaluation of carcinogenic risks of chemicals to humans. IARC scientific publications no. 17, IARC, Lyon, 1978, PP. 125-175.
3. Pignatelli B, Malaveille C and Rogatko A. Mutagens, N-nitroso compounds their precursors in gastric juice from patients with and without precancerous lesions of the stomach. Eur J Cancer 1993; 29A: 2031-2039. (Pubitemid 23324367)
4. Siddique M A, Tricker A R, Kumar R, Fazili Z and Preussmann R. Dietary sources of N-nitrosamines in the high risk area for oesophageal cancer-Kashmir, India. IARC Sci Publ 1991; 105: 210-213.
5. George J and Chandhrakasan G. Biochemical abnormalities during the progression of hepatic fibrosis induced by dimethylnitrosamine. Clin Biochem 2000; 33: 563-570. (Pubitemid 32012440)
6. Phillips J C, Bex C, Lake B G, Cottrell R C, and Gangolli S D. Inhibition of dimethylnitrosamine metabolism by some heterocyclic compounds and by substrates and inhibitors of monoamine oxidase the rat. Cancer Res 1982; 42: 3761-3765. (Pubitemid 12054491)
7. Hsu Y C, Lin Y L, Chiu Y T, Shiao M S and Lee C Y et al. Antifibrotic effects of Salvia miltiorrhiza on dimethylnitrosamine intoxicated rats. J Biomed Sci 2005; 12: 185-195.
8. Kusunose M, Qiu B, Cui T, Hamada A nd Yoshioka S et al. Effect of Sho-saiko-to extract on hepatic inflammation and fibrosis in dimethylnitrosamine induced liver injury in rats. Biol Pharm Bull 2002; 25: 1417-1421.
9. Shin J W, Son J Y, Oh S M, Han S H and Wang J H et al. An herbal formula, CGX, exerts hepatotherapeutic effects on dimethylnitrosamine-induced chronic liver injury model in rats. World J Gasteroenterol 2006; 12: 6142-6148.
10. Schneider W C. Determination of nucleic acids in tissues by pentose analysis. In: Methods in enzymology, Colowick S P and Kaplan N O (eds) Vol-III, Academic Press, New York, 1953; 680-684.
11. Gamer I. Isolation of high molecular weight DNA from animal cells. In: The nucleic acids protocols handbook. Rapley R (ed), Human Press Inc, Totowa, New Jersey, 2000; 3-8.
12. Williams D R and Rapley R. Agarose gel electrophoresis of Nucleic acids. In: The nucleic acids protocols handbook. Rapley R. (ed), Human Press Inc, Totowa, New Jersey, 2000; 67-70.
13. Weber K and Osborn M. The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis. J Biol Chem 1969; 244: 4406-4412.
14. Lowry O H, Rosebrough N J, Farr A L and Randall R J. Protein measurement with the folin phenol reagent. J Biol Chem 1951; 193: 265-275.
15. Haggerty H G and Holsapple M P. Role of metabolism in dimethylnitrosamine- induced immunosupression: a review. Toxicology 1990; 63: 1-23.
16. George J, Rao K R, Stern R and Chandrakasan G. Dimethylnitrosamine- induced liver injury in rats: the early deposition of collagen. Toxicology 2001; 156: 129-138.
17. Lawley P D. Methylation of DNA by carcinogens: some applications of chemical analytical methods. In screening test in chemical carcinogenesis: Proceedings of a workshop organized by IARC and the Commission of the European Communities and held in Brussels, Belgium, 9-12 June 1975. Montesano R, Bartsch H and Tomatis L (eds.). IARC Scient. Publ. no. 12, pp.181. International Agency for Research on Cancer, Lyon.
18. Singer B. The chemical effects of nucleic acid alkylation and their relation to mutagenesis and carcinogenesis. Progr Nucl Acid Res 1975; 15: 219.
19. Brenner D A, Waterboer T, Choi S K, Lindquist J N, Stefanovic B, et al. New aspects of hepatic fibrosis. J Hepatol 2000; 32: 32-38.
20. Ala-Kokko L, Pihlajaniemi T, Myers JC, Kivirikko KI and Savolainen ER. Gene expression of type I, III and IV collagens in hepatic fibrosis induced by dimethylnitrosamine in the rat. Biochem J 1987; 244: 75-79.
21. Zern M A, Saber M A and Shafritz D A. Molecular mechanisms for changes in hepatic protein synthesis induced by schistosomiasis infection in mice. Biochemistry. 1983; 22: 6072-6077.
22. Savolainen E R, Hamalainen L and Kivirikko KI. In pathobiology of hepatic fibrosis: Excerpta Medica international Congress Series. Hirayama C & Kivirikko K I (eds.), Elsevier, Amsterdam. 1985; pp-67-74,
23. Morrison W L, Bouchier I A D, Gibson JNA and Rennie M J. Skeletal muscle and whole body protein turnover in cirrhosis. Clin Sci. 1990; 78: 613-619.
24. Druckrey E, Preussmann R, Ivankovic S and Schmahl D. Organotropic carcinogenic effects of 65 different N-nitrosocompounds on BD rats. Z Krebsforsch. 1967; 69: 103-201.
25. Goth R and Rajewsky MF. Molecular and cellular mechanisms associated with pulse-carcinogenesis in the rat nervous system by ethylnitrosourea: Ethylation of nucleic acids and elimination rates of ethylated bases from the DNA of different tissues. Z Krebsforsch Klin Onkol Cancer Res Clin Oncol 1974; 82: 37-64.
26. 6-methylguanine in rat brain deoxyribonucleic acid during repetitive administration of M-methyl-N- nitrosourea. Biochem J 1975; 148(3): 521-525.
27. Fraschini F, Demartini G and Esposti D. Pharmacology of Silymarin. Clin Drug Invest 2002; 22: 51-65.
28. Saller R, Meier R, Brignoli R. The use of Silymarin in the treatment of liver diseases. Drugs 2001; 61: 2035-2063.
29. Luper N D S. A review of plants used in liver diseases. Part I. Alt Med Rev. 1998; 3: 410-421.
30. Baer-Dubowska W, Szafer H and Krajkakuzniak V. Inhibition of murine hepatic cytochrome P450 activities by natural and synthetic phenolic compounds. Xenobiotics. 1998; 28: 735-743.