Exercise training and detraining modify the morphological and mechanical properties of single cardiac myocytes obtained from spontaneously hypertensive rats

Brazilian Journal of Medical and Biological Research

Volumn 43, Issue 11, 2010, Pages 1042-1046

  Carneiro Junior M A ^a   Peluzio M C G ^a   Silva, C H O ^a   Amorim, P R S ^a   Silva, K A ^a   Souza, M O ^a   Castro, C A ^a   Roman Campos, D ^b   Primola Gomes T N ^a   Natali, A J ^a  

^a FEDERAL UNIVERSITY OF VIÇOSA   (Brazil)

^b FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

Author keywords

Cardiomyocytes; Hypertension; Inactivity; Physical activity

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL STRUCTURE; CELL VOLUME; EXERCISE; HEART MUSCLE CELL; HYPERTENSION; MALE; NONHUMAN; RAT; SITTING; SPONTANEOUSLY HYPERTENSIVE RAT; TREADMILL EXERCISE;

RATTUS;

EID: 78649457374     PISSN: 0100879X     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/S0100-879X2010007500117     Document Type: Article

References (20)

1. Brooksby P, Levi AJ, Jones JV. Contractile properties of ventricular myocytes isolated from spontaneously hypertensive rat. J Hypertens 1992; 10: 521-527.
2. Hart G. Cellular electrophysiology in cardiac hypertrophy and failure. Cardiovasc Res 1994; 28: 933-946.
3. McCrossan ZA, Billeter R, White E. Transmural changes in size, contractile and electrical properties of SHR left ventricular myocytes during compensated hypertrophy. Cardiovasc Res 2004; 63: 283-292.
4. Evans SJ, Levi AJ, Jones JV. Wall stress induced arrhythmia is enhanced by low potassium and early left ventricular hypertrophy in the working rat heart. Cardiovasc Res 1995; 29: 555-562.
5. Schaible T, Malhotra A, Ciambrone G, Buttrick P, Scheuer J. Combined effects of hypertension and chronic running program on rat heart. J Appl Physiol 1987; 63: 322-327.
6. Nho H, Tanaka K, Kim HS, Watanabe Y, Hiyama T. Exercise training in female patients with a family history of hypertension. Eur J Appl Physiol Occup Physiol 1998; 78: 1-6.
7. Lee IM, Sesso HD, Oguma Y, Paffenbarger RS Jr. Relative intensity of physical activity and risk of coronary heart disease. Circulation 2003; 107: 1110-1116.
8. Bocalini DS, Carvalho EV, de Sousa AF, Levy RF, Tucci PJ. Exercise training-induced enhancement in myocardial mechanics is lost after 2 weeks of detraining in rats. Eur J Appl Physiol 2010; 109: 909-914.
9. Kemi OJ, Haram PM, Wisloff U, Ellingsen O. Aerobic fitness is associated with cardiomyocyte contractile capacity and endothelial function in exercise training and detraining. Circulation 2004; 109: 2897-2904.
10. Pescatello LS, Franklin BA, Fagard R, Farquhar WB, Kelley GA, Ray CA. American College of Sports Medicine position stand. Exercise and hypertension. Med Sci Sports Exerc 2004; 36: 533-553.
11. Veras-Silva AS, Mattos KC, Gava NS, Brum PC, Negrao CE, Krieger EM. Low-intensity exercise training decreases cardiac output and hypertension in spontaneously hypertensive rats. Am J Physiol 1997; 273: H2627-H2631.
12. Lacerda AC, Marubayashi U, Balthazar CH, Leite LH, Coimbra CC. Central nitric oxide inhibition modifies metabolic adjustments induced by exercise in rats. Neurosci Lett 2006; 410: 152-156.
13. Roman-Campos D, Duarte HL, Sales PA Jr, Natali AJ, Ropert C, Gazzinelli RT, et al. Changes in cellular contractility and cytokines profile during Trypanosoma cruzi infection in mice. Basic Res Cardiol 2009; 104: 238-246.
14. Satoh H, Delbridge LM, Blatter LA, Bers DM. Surface:volume relationship in cardiac myocytes studied with confocal microscopy and membrane capacitance measurements: species-dependence and developmental effects. Biophys J 1996; 70: 1494-1504.
15. Moore RL, Musch TI, Yelamarty RV, Scaduto RC Jr, Semanchick AM, Elensky M, et al. Chronic exercise alters contractility and morphology of isolated rat cardiac myocytes. Am J Physiol 1993; 264: C1180-C1189.
16. Sah R, Ramirez RJ, Oudit GY, Gidrewicz D, Trivieri MG, Zobel C, et al. Regulation of cardiac excitation-contraction coupling by action potential repolarization: role of the transient outward potassium current (I(to)). J Physiol 2003; 546: 5-18.
17. Collins HL, Loka AM, Dicarlo SE. Daily exercise-induced cardioprotection is associated with changes in calcium regulatory proteins in hypertensive rats. Am J Physiol Heart Circ Physiol 2005; 288: H532-H540.
18. Garciarena CD, Pinilla OA, Nolly MB, Laguens RP, Escudero EM, Cingolani HE, et al. Endurance training in the spontaneously hypertensive rat: conversion of pathological into physiological cardiac hypertrophy. Hypertension 2009; 53: 708-714.
19. Schaible TF, Malhotra A, Ciambrone GJ, Scheuer J. Chronic swimming reverses cardiac dysfunction and myosin abnormalities in hypertensive rats. J Appl Physiol 1986; 60: 1435-1441.
20. Lajoie C, Calderone A, Beliveau L. Exercise training enhanced the expression of myocardial proteins related to cell protection in spontaneously hypertensive rats. Pflugers Arch 2004; 449: 26-32.