Expression and characterization of Mycobacterium tuberculosis CYP144: Common themes and lessons learned in the M. tuberculosis P450 enzyme family

Biochimica et Biophysica Acta - Proteins and Proteomics

Volumn 1814, Issue 1, 2011, Pages 76-87

  Driscoll, Max D ^a   McLean, Kirsty J ^a   Cheesman, Myles R ^b   Jowitt, Thomas A ^a   Howard, Marjorie ^a   Carroll, Paul ^c   Parish, Tanya ^c   Munro, Andrew W ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF EAST ANGLIA   (United Kingdom)

^c QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Azole drug; CYP144; Cytochrome P450; Gene knockout; Ligand binding; Mycobacterium tuberculosis

Indexed keywords

4 PHENYLIMIDAZOLE; BACTERIAL ENZYME; CLOTRIMAZOLE; CYTOCHROME P450; CYTOCHROME P450 121; CYTOCHROME P450 125; CYTOCHROME P450 144; ECONAZOLE; FLUCONAZOLE; IMIDAZOLE; ITRACONAZOLE; KETOCONAZOLE; MICONAZOLE; UNCLASSIFIED DRUG; VORICONAZOLE;

ARTICLE; BACTERIAL GROWTH; BINDING AFFINITY; DRUG BINDING; ENZYME ANALYSIS; ENZYME INHIBITION; GENE INACTIVATION; MYCOBACTERIUM TUBERCULOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; THERMODYNAMICS;

ANTI-INFECTIVE AGENTS, LOCAL; BACTERIAL PROTEINS; BINDING, COMPETITIVE; CELL DIVISION; CLOTRIMAZOLE; CYTOCHROME P-450 ENZYME SYSTEM; ECONAZOLE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ESCHERICHIA COLI; GENE KNOCKOUT TECHNIQUES; KINETICS; MICONAZOLE; MUTATION; MYCOBACTERIUM TUBERCULOSIS; OXIDATION-REDUCTION; POTENTIOMETRY; PROTEIN BINDING; RECOMBINANT PROTEINS; SPECTROPHOTOMETRY; SPECTRUM ANALYSIS, RAMAN; TIME FACTORS;

MYCOBACTERIUM TUBERCULOSIS;

EID: 78649443133     PISSN: 15709639     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbapap.2010.05.015     Document Type: Article

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