Role of connexin 43 in the maintenance of spontaneous activity in the guinea pig prostate gland

British Journal of Pharmacology

Volumn 161, Issue 8, 2010, Pages 1692-1707

  Dey, Anupa ^a   Kusljic, Snezana ^a,b   Lang, Richard J ^a   Exintaris, Betty ^a  

^a MONASH UNIVERSITY   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Age; BPH; Gap junctions; ICC; Prostate; Slow waves; Smooth muscle

Indexed keywords

CARBENOXOLONE; CONNEXIN 43; GLYCYRRHETINIC ACID; OCTANOL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL MEMBRANE DEPOLARIZATION; CELL MEMBRANE POTENTIAL; CONTROLLED STUDY; ELECTRIC ACTIVITY; GUINEA PIG; IMMUNOHISTOCHEMISTRY; MICROELECTRODE; MUSCLE CONTRACTION; NONHUMAN; PRIORITY JOURNAL; PROSTATE; PROTEIN EXPRESSION; PROTEIN FUNCTION; WESTERN BLOTTING;

AGE FACTORS; ANIMALS; CARBENOXOLONE; CONNEXIN 43; GAP JUNCTIONS; GLYCYRRHETINIC ACID; GUINEA PIGS; MALE; MEMBRANE POTENTIALS; MUSCLE CONTRACTION; MUSCLE, SMOOTH; OCTANOLS; PROSTATE;

EID: 78649416155     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2010.01001.x     Document Type: Article

References (32)

1. Alexander SPH, Mathie A, Peters JA (2009). Guide to receptors and channels (GRAC), 4th edition. Br J Pharmacol 158 (Suppl. 1): S1.
2. Berry SJ, Coffey DS, Walsh PC, Ewing LL (1984). The development of human benign prostatic hyperplasia with age. J Urol 132: 474-479.
3. Christ GJ, Day NS, Day M, Zhao W, Persson K, Pandita RK et al. (2003). Increased connexin43-mediated intercellular communication in a rat model of bladder overactivity in vivo. Am J Physiol Regul Integr Comp Physiol 284: R1241-R1248.
4. Coleman HA, Tare M, Parkington HC (2001). K+ currents underlying the action of endothelium-derived hyperpolarizing factor in guinea-pig, rat and human blood vessels. [see comment]. J Physiol 531 (Pt 2): 359-373.
5. Daniel EE, Wang YF, Cayabyab FS (1998). Role of gap junctions in structural arrangements of interstitial cells of Cajal and canine ileal smooth muscle. Am J Physiol 274 (Pt 1): G1125-G1141.
6. Daniel EE, Yazbi AE, Mannarino M, Galante G, Boddy G, Livergant J et al. (2007). Do gap junctions play a role in nerve transmissions as well as pacing in mouse intestine? Am J Physiol Gastrointest Liver Physiol 292: G734-G745.
7. Dey A, Nguyen DT, Lang RJ, Exintaris B, Dey A, Nguyen D-TT et al. (2009). Spontaneous electrical waveforms in aging guinea pig prostates. J Urol 181: 2797-2805.
8. Exintaris B, Klemm MF, Lang RJ (2002). Spontaneous slow wave and contractile activity of the guinea pig prostate. J Urol 168: 315-322.
9. Exintaris B, Nguyen D-TT, Dey A, Lang RJ (2006). Spontaneous electrical activity in the prostate gland. Auton Neurosci 126-127: 371-379. Up-dating the Autonomic Nervous System: from Gene to Behaviour" - A Special Issue devoted to the 4th Congress of the International Society for Autonomic Neuroscience.
10. Exintaris B, Nguyen DT, Lam M, Lang RJ (2009). Inositol trisphosphate-dependent Ca stores and mitochondria modulate slow wave activity arising from the smooth muscle cells of the guinea pig prostate gland. Br J Pharmacol 156: 1098-1106.
11. Geiger B, Yehuda-Levenberg S, Bershadsky AD (1995). Molecular interactions in the submembrane plaque of cell-cell and cell-matrix adhesions. Acta Anat (Basel) 154: 46-62.
12. Guan X, Wilson S, Schlender KK, Ruch RJ (1996). Gap-junction disassembly and connexin 43 dephosphorylation induced by 18 beta-glycyrrhetinic acid. Mol Carcinog 16: 157-164.
13. Habermann H, Ray V, Habermann W, Prins GS (2001). Alterations in gap junction protein expression in human benign prostatic hyperplasia and prostate cancer. J Urol 166: 2267-2272.
14. Horowitz B, Ward SM, Sanders KM (1999). Cellular and molecular basis for electrical rhythmicity in gastrointestinal muscles. Annu Rev Physiol 61: 19-43.
15. Isaacs JT, Coffey DS (1989). Etiology and disease process of benign prostatic hyperplasia. [Review][65 refs]. Prostate 2 (Supplement): 33-50.
16. Kusljic DA, Nguyen D-TT, Lang RJ, Exintaris B (2007). Prostatic interstitial cells in ageing guinea pig prostates. Curr Urol 3: 141-144.
17. Larson TR (2003). Current treatment options for benign prostatic hyperplasia and their impact on sexual function. [Review][53 refs]. Urology 61: 692-698.
18. Lavoie B, Balemba OB, Nelson MT, Ward SM, Mawe GM (2007). Morphological and physiological evidence for interstitial cell of Cajal-like cells in the guinea pig gallbladder. J Physiol 579 (Pt 2): 487-501.
19. McCloskey KD, Gurney AM (2002). Kit positive cells in the guinea pig bladder. J Urol 168: 832-836.
20. Nemeth L, Maddur S, Puri P (2000). Immunolocalization of the gap junction protein Connexin43 in the interstitial cells of Cajal in the normal and Hirschsprung's disease bowel. J Pediatr Surg 35: 823-828.
21. Nguyen D-TT, Lang RJ, Exintaris B (2009). [alpha]1-adrenoceptor modulation of spontaneous electrical waveforms in the guinea-pig prostate. Eur J Pharmacol 608: 62-70.
22. Perez-Armendariz M, Roy C, Spray DC, Bennett MV (1991). Biophysical properties of gap junctions between freshly dispersed pairs of mouse pancreatic beta cells. Biophys J 59: 76-92.
23. Risek B, Klier FG, Gilula NB (1992). Multiple gap junction genes are utilized during rat skin and hair development. Development 116: 639-651.
24. Risek B, Klier FG, Gilula NB (1994). Developmental regulation and structural organization of connexins in epidermal gap junctions. Dev Biol 164: 183-196.
25. Ruch RJ (1994). The role of gap junctional intercellular communication in neoplasia. Ann Clin Lab Sci 24: 216-231.
26. Sakai N, Tabb T, Garfield RE (1992). Studies of connexin 43 and cell-to-cell coupling in cultured human uterine smooth muscle. Am J Obstet Gynecol 167: 1267-1277.
27. Serio R, Barajas-Lopez C, Daniel EE, Berezin I, Huizinga JD (1991). Slow-wave activity in colon: role of network of submucosal interstitial cells of Cajal. Am J Physiol 260 (Pt 1): G636-G645.
28. Spray DC, Bennett MV (1985). Physiology and pharmacology of gap junctions. Annu Rev Physiol 47: 281-303.
29. Takeda Y, Ward SM, Sanders KM, Koh SD (2005). Effects of the gap junction blocker glycyrrhetinic acid on gastrointestinal smooth muscle cells 1152/ajpgi.00389.2004. Am J Physiol Gastrointest Liver Physiol 288: G832-G841.
30. Tare M, Coleman HA, Parkington HC, Tare M, Parkington HC (2002). Glycyrrhetinic derivatives inhibit hyperpolarization in endothelial cells of guinea pig and rat arteries. Am J Physiol Heart Circ Physiol 282: H335-H341.
31. Van der Aa F, Roskams T, Blyweert W, De Ridder D (2003). Interstitial cells in the human prostate: a new therapeutic target? Prostate 56: 250-255.
32. Yamada S, Ashizawa N, Ushijima H, Nakayama K, Hayahi EZH (1987). Alpha-1 adrenoceptors in human prostate: characterisation alteration in benign prostatic hypertrophy. J Pharmacol Exp Ther 242: 326-330.