Evaluation of in vivo antihypertensive and in vitro vasodepressor activities of the leaf extract of syzygium guineense (willd) D.C.

Phytotherapy Research

Volumn 24, Issue 10, 2010, Pages 1457-1462

  Ayele, Yohannes ^a   Urga, Kelbessa ^b   Engidawork, Ephrem ^a  

^a ADDIS ABABA UNIVERSITY   (Ethiopia)

^b ETHIOPIAN PUBLIC HEALTH INSTITUTE   (Ethiopia)

Author keywords

1K1C rat model; antihypertensive; hydroalcohol extract; Syzyguim guineense; vasorelaxation

Indexed keywords

ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; ANTIHYPERTENSIVE AGENT; CYCLIC GMP; HISTAMINE RECEPTOR; MUSCARINIC RECEPTOR; NITRIC OXIDE; PLANT EXTRACT; PROSTAGLANDIN SYNTHASE; SYZYGIUM GUINEENSE EXTRACT; UNCLASSIFIED DRUG; VASODILATOR AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIHYPERTENSIVE ACTIVITY; AORTA; ARTICLE; BLOOD PRESSURE REGULATION; DIASTOLIC BLOOD PRESSURE; DOSE RESPONSE; FEMALE; IN VITRO STUDY; IN VIVO STUDY; MALE; MEAN ARTERIAL PRESSURE; MYRTACEAE; NONHUMAN; PLANT LEAF; RAT; RETICULOENDOTHELIAL SYSTEM; SYSTOLIC BLOOD PRESSURE; SYZYGIUM GUINEENSE; VASODILATATION;

ANGIOSPERMS; ANIMALS; ANTIHYPERTENSIVE AGENTS; AORTA; BLOOD PRESSURE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GUINEA PIGS; MALE; PLANT EXTRACTS; PLANT LEAVES; RATS; RATS, SPRAGUE-DAWLEY; VASODILATION; VASODILATOR AGENTS;

MYRTACEAE; RATTUS; SYZYGIUM GUINEENSE;

EID: 78649399126     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.3141     Document Type: Article

References (20)

1. Abebe D, Debela A, Urga K., 2003. Medicinal Plants of Ethiopia. Camerapex Publishers International: Nairobi, Kenya, 36.
2. Badyal DK, Lata H, Dadhich AP., 2003. Animal models of hypertension and effect of drugs. Indian J Pharmacol 35: 349-362.
3. Bohn H, Schönafinger K., 1989. Oxygen and oxidation promote the release of nitric oxide from sydnonimines. J Cardiovasc Pharmacol 14 (Suppl 11): S6-S12.
4. Chatora R., 2003. An overview of traditional medicine situation in African region. African Health Monitor 4 (1): 4-7.
5. Chen S, Lv G, Zhang X, et al,. 2007. Anti-hypertensive effects of laiju extract in two different rat models. Asia Pac J Clin Nutr 16 (Suppl 1): 309-312.
6. Evans RG, Kett MM, Shweta A, et al,. 2005. New physiological target within the kidney for antihypertensive therapy. Drug Des Rev 2: 167-178.
7. Fujimoto M, Mihara S, Nakajima S, Ueda M, Nakamura M, Sakurai K., 1992. A novel, non-peptide endothelin antagonist, isolated from bayberry, Myrica Cerifera Febs Lett 305: 41-44.
8. Germino FW., 2009. The management and treatment of hypertension. Clin Cornerstone 9 (Suppl 3): S27-S33.
9. Gilani AH, Aftab K, Suria A, et al,. 2006. Pharmacological studies on hypotensive and spasmolytic activities of pure compounds from Moringa oleifera. Phytother Res 8: 87-91.
10. Gilani AH, Jabeen Q, Ghayur MN, Janbaz KH, Akhtar MS., 2005. Studies on antispasmodic, bronchodilator and hepatoprotective activities of the Carum copticum seed extract. J Ethnopharmacol 98: 127-135.
11. Goldblatt H, Lynch J, Hanzal RF, Summerville WW., 1934. Studies on experimental hypertension. I. The production of persistent evaluation of systolic BP by means of renal ischemia. J Exp Med 59: 347-379.
12. Guinand Y, Lemessa D., 2000. Wild-food Plants in Southern Ethiopia: Reflection on the Role of 'Famine-foods' at a Time of Drought. UN-OCHA Report. UNDP-EUE: Addis Ababa, Ethiopia.
13. Lee HB, Blaufox MD., 1992. Renal functional response to captopril during diuretic therapy. J NucI Med 33: 739-743.
14. Lerman LO, Chade AR, Sica V, Napoli C., 2005. Animal models of hypertension: an overview. J Lab Clin Med 146: 160-173.
15. Malele RS, Moshi MJ, Achola KJ, Munenge RW., 1997. Pharmacological properties of extracts from the stem bark of Syzygium guineense on ileum and heart of laboratory animals. Afr J Health Sci 4: 43-45.
16. National Research Council. 1996. Animal Environment, Housing and Management. In, Guide for the care and use of laboratory animals. National Academy Press: Washington DC, 21.
17. Ssegawa P, Kasenene JM., 2007. Plants for malaria treatment in southern Uganda: traditional use, preference and ecological viability. J Ethnobiol 27: 110-131.
18. Tsakala TM, Penge O, John K., 1996. Screening of in vitro antibacterial activity from Syzygium guineense (Willd) hydrosoluble dry extract. Ann Pharm Fr 54: 276-279.
19. Van Zwieten PA., 2001. Drug treatment of isolated systolic hypertension. Nephrol Dial Transplant 16: 1095-1097.
20. Vogel HG, Vogel WH., 2002. Drug Discovery and Evaluation: Pharmacological Assays, 2nd edn. Springer-Verlag: Berlin, 74-75.