Vagal tone augmentation to the atrioventricular node in humans: Efficacy and safety of burst endocardial stimulation

Heart Rhythm

Volumn 7, Issue 5, 2010, Pages 683-689

  Rossi, Pietro ^a   Bianchi, Stefano ^b   Monari, Giancarlo ^c   Della Scala, Alberto ^d   Porcelli, Daniele ^b   Valsecchi, Sergio ^d   Canonaco, Sergio ^d   Kornet, Lilian ^e   Azzolini, Paolo ^b  

^a BELCOLLE HOSPITAL   (Italy)

^b SAN GIOVANNI CALIBITA FATEBENEFRATELLI HOSPITAL   (Italy)

^c ENEA   (Italy)

^d Medtronic Italy   (Italy)

^e MEDTRONIC BAKKEN RESEARCH CENTER   (Netherlands)

Author keywords

Atrial fibrillation; Atrioventricular node; Burst stimulation; Vagal stimulation

Indexed keywords

AGED; ARTICLE; ATRIOVENTRICULAR BLOCK; ATRIOVENTRICULAR CONDUCTION; ATRIOVENTRICULAR NODAL VAGAL STIMULATION; CLINICAL ARTICLE; FEMALE; HEART ATRIOVENTRICULAR NODE; HEART ATRIUM FIBRILLATION; HUMAN; MALE; PACEMAKER; PATIENT SAFETY; PR INTERVAL; PRIORITY JOURNAL; SICK SINUS SYNDROME; SINUS RHYTHM; VAGUS NERVE STIMULATION; VAGUS TONE; ELECTROCARDIOGRAPHY; ELECTRODE; ENDOCARDIUM; HEART ATRIUM; HEART MUSCLE CONDUCTION SYSTEM; HEART RATE; HEART VENTRICLE; INNERVATION; INSTRUMENTATION; ITALY; METHODOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SAFETY; VAGUS NERVE;

AGED; ATRIAL FIBRILLATION; ATRIOVENTRICULAR NODE; BODY SURFACE POTENTIAL MAPPING; ELECTRODES, IMPLANTED; ENDOCARDIUM; FEMALE; HEART ATRIA; HEART CONDUCTION SYSTEM; HEART RATE; HEART VENTRICLES; HUMANS; ITALY; MALE; SAFETY; SICK SINUS SYNDROME; VAGUS NERVE; VAGUS NERVE STIMULATION;

EID: 78649379486     PISSN: 15475271     EISSN: 15563871     Source Type: Journal    
DOI: 10.1016/j.hrthm.2010.01.029     Document Type: Article

References (28)

1. Zhang Y, Mowrey KA, Zhuang S, Wallick DW, Popović ZB, Mazgalev TN. Optimal ventricular rate slowing during atrial fibrillation by feedback AV nodal-selective vagal stimulation. Am J Physiol Heart Circ Physiol 2002;282: H1102-H1110.
2. Schauerte P, Mischke K, Plisiene J, et al. Catheter stimulation of cardiac parasympathetic nerves in humans: a novel approach to the cardiac autonomic nervous system. Circulation 2001;104:2430-2435.
3. Rossi P, Bianchi S, Barretta A, et al. Post-operative atrial fibrillation management by selective epicardial vagal fat pad stimulation. J Interv Card Electrophysiol 2009;24:37-45.
4. Quan KJ, Lee JH, Van Hare GF, Biblo LA, Mackall JA, Carlson MD. Identification and characterization of atrioventricular parasympathetic innervation in humans. J Cardiovasc Electrophysiol 2002;13:735-739.
5. Bianchi S, Rossi P, Della Scala A, Kornet L. Endocardial transcatheter stimulation of the AV nodal fat pad: stabilization of rapid ventricular rate response during atrial fibrillation in left ventricular failure. J Cardiovasc Electrophysiol 2009;20:103-105.
6. Bianchi S, Rossi P, Della Scala A, et al. Atrioventricular (AV) node vagal stimulation by transvenous permanent lead implantation to modulate AV node function: safety and feasibility in humans. Heart Rhythm 2009;6:1282-1286.
7. Gemein C, Schauerte P, Hatam N, et al. Targeting of cardiac autonomic plexus for modulation of intracardiac neural tone. Europace 2009;11:1090-1096.
8. McComb JM. Rate control during atrial fibrillation achieved by chronic endocardial vagal stimulation: proof of principle. Heart Rhythm 2009;6:1287-1288.
9. Zhang Y, Yamada H, Bibevski S, et al. Chronic atrioventricular nodal vagal stimulation: first evidence for long-term ventricular rate control in canine atrial fibrillation model. Circulation 2005;112:2904-2911.
10. Mischke K, Zarse M, Schmid M, et al. Chronic Augmentation of the Parasympathetic Tone to the Atrioventricular Node: A Nonthoracotomy Neurostimulation Technique for Ventricular Rate Control During Atrial Fibrillation. J Cardiovasc Electrophysiol. 2009 Oct 5. [Epub ahead of print] PubMed PMID: 19804547.
11. Daoud EG, Weiss R, Bahu M, et al. Effect of an irregular ventricular rhythm on cardiac output. Am J Cardiol 1996;78:1433-1436.
12. Wallick DW, Zhang Y, Tabata T, et al. Selective AV nodal vagal stimulation improves hemodynamics during acute atrial fibrillation in dogs. Am J Physiol Heart Circ Physiol 2001;281:H1490-H1497.
13. Brignole M, Menozzi C, Gianfranchi L, et al. Assessment of atrioventricular junction ablation and VVIR pacemaker versus pharmacological treatment in patients with heart failure and chronic atrial fibrillation: a randomized, controlled study. Circulation 1998;98:953-960.
14. Natale A, Zimerman L, Tomassoni G, et al. AV node ablation and pacemaker implantation after withdrawal of effective rate-control medications for chronic atrial fibrillation: effect on quality of life and exercise performance. Pacing Clin Electrophysiol 1999;22:1634-1639.
15. Zhuang S, Zhang Y, Mowrey KA, et al. Ventricular rate control by selective vagal stimulation is superior to rhythm regularization by atrioventricular nodal ablation and pacing during atrial fibrillation. Circulation 2002;106:1853-1858.
16. Zhang Y, Mazgalev TN. Achieving regular slow rhythm during atrial fibrillation without atrioventricular nodal ablation: selective vagal stimulation plus ventricular pacing. Heart Rhythm 2004;4:469-475.
17. Wittkampf FHM, De Jongste MJL, Lie HI, Meijler FL. Effect of right ventricular pacing on ventricular rhythm during atrial fibrillation. J Am Coll Cardiol 1988;11:539-545.
18. Wittkampf FHM, De Jongste MJL. Rate stabilization by right ventricular ondemand pacing in patients with atrial fibrillation. Pacing Clin Electrophysiol 1986;9:1147-1153.
19. Puglisi A, Gasparini M, Lunati M, et al. Persistent atrial fibrillation worsens heart rate variability, activity and heart rate, as shown by a continuous monitoring by implantable biventricular pacemakers in heart failure patients. J Cardiovasc Electrophysiol 2008;19:693-701.
20. Hoppe UC, Casares JM, Eiskjaer H, et al. Effect of cardiac resynchronization on the incidence of atrial fibrillation in patients with severe heart failure. Circulation 2006;114:18-25.
21. Knight BP, Desai A, Coman J, Faddis M, Yong P. Long-term retention of cardiac resynchronization therapy. J Am Coll Cardiol 2004;44:72-77.
22. Bibevski S, Dunlap ME. Ganglionic mechanisms contribute to diminished vagal control in heart failure. Circulation 1999;99:2958-2963.
23. Po SS, Li Y, Tang D, et al. Rapid and stable re-entry within the pulmonary vein as a mechanism initiating paroxysmal atrial fibrillation. J Am Coll Cardiol 2005;45:1871-1877.
24. Po SS, Scherlag BJ, Yamanashi WS, et al. Experimental model for paroxysmal atrial fibrillation arising at the pulmonary vein-atrial junctions. Heart Rhythm 2006;3:201-208.
25. Soos P, Merkely B, Horvat PM, Zima E, Schauerte P. Determinants and effects of electrical stimulation of the inferior interatrial parasympathetic plexus during atrial fibrillation. J Cardiovasc Electrophysiol 2005;16:1362-1367.
26. Jhanjee R, Templeton GA, Sattiraju S, et al. Relationship of paroxysmal atrial tachyarrhythmias to volume overload: assessment by implanted transpulmonary impedance monitoring. Circ Arrhythm Electrophysiol 2009; 2:488-494.
27. Daubert JP, Zareba W, Cannom DS, et al. Inappropriate implantable cardioverter-defibrillator shocks in MADIT II: frequency, mechanisms, predictors, and survival impact. J Am Coll Cardiol 2008;51:1357-1365.
28. Kamphuis HC, De Leeuw JR, Derksen R, Hauer R, Winnubst JA. A 12 month quality of life assessment of cardiac arrest survivors treated with or without an implantable cardioverter defibrillator. Europace 2002;4:417-425.