Asialoerythropoietin to protect the failing heart: Is it possible to run with the hare and hunt with the hounds?

Journal of the American College of Cardiology

Volumn 56, Issue 23, 2010, Pages 1959-1960

  Van Der Meer, Peter ^a   Lipsic, Erik ^a   Van Veldhuisen, Dirk J ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

Anemia; Erythropoietin; Heart failure; Kidney

Indexed keywords

ASIALOERYTHROPOIETIN; CARBAMYLATED ERYTHROPOIETIN; ERYTHROPOIETIN; HEMOGLOBIN; NOVEL ERYTHROPOIESIS STIMULATING PROTEIN; UNCLASSIFIED DRUG;

ANEMIA; CLINICAL PRACTICE; CLINICAL TRIAL; HEART FAILURE; HEART FUNCTION; HEART MUSCLE INJURY; HEART PROTECTION; HUMAN; HYPERTENSION; KIDNEY FAILURE; MORTALITY; NONHUMAN; NOTE; PRIORITY JOURNAL; QUALITY OF LIFE; STROKE; SURVIVAL; THROMBOSIS;

EID: 78649379031     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jacc.2010.05.058     Document Type: Editorial

References (18)

1. H.F. Groenveld, J.L. Januzzi, and K. Damman Anemia and mortality in heart failure patients: a systematic review and meta-analysis J Am Coll Cardiol 52 2008 818 827
2. A. Phrommintikul, S.J. Haas, M. Elsik, and H. Krum Mortality and target haemoglobin concentrations in anaemic patients with chronic kidney disease treated with erythropoietin: a meta-analysis Lancet 369 2007 381 388
3. M.A. Pfeffer, E.A. Burdmann, and C.Y. Chen A trial of darbepoetin alfa in type 2 diabetes and chronic kidney disease N Engl J Med 361 2009 2019 2032
4. E. Lipsic, R.G. Schoemaker, P. van der Meer, A.A. Voors, D.J. van Veldhuisen, and W.H. van Gilst Protective effects of erythropoietin in cardiac ischemia: from bench to bedside J Am Coll Cardiol 48 2006 2161 2167
5. R. Depping, K. Kawakami, and H. Ocker Expression of the erythropoietin receptor in human heart J Thorac Cardiovasc Surg 130 2005 877 878
6. P. van der Meer, E. Lipsic, and R.H. Henning Erythropoietin improves left ventricular function and coronary flow in an experimental model of ischemia-reperfusion injury Eur J Heart Fail 6 2004 853 859
7. E. Lipsic, B.D. Westenbrink, and P. van der Meer Low-dose erythropoietin improves cardiac function in experimental heart failure without increasing haematocrit Eur J Heart Fail 10 2008 22 29
8. M.N. Fukuda, H. Sasaki, L. Lopez, and M. Fukuda Survival of recombinant erythropoietin in the circulation: the role of carbohydrates Blood 73 1989 84 89
9. M. Brines, and A. Cerami Discovering erythropoietin's extra-hematopoietic functions: biology and clinical promise Kidney Int 70 2006 246 250
10. S. Erbayraktar, G. Grasso, and A. Sfacteria Asialoerythropoietin is a nonerythropoietic cytokine with broad neuroprotective activity in vivo Proc Natl Acad Sci U S A 100 2003 6741 6746
11. T. Okada, T. Sawada, and K. Kubota Asialoerythropoietin has strong renoprotective effects against ischemia-reperfusion injury in a murine model Transplantation 84 2007 504 510
12. A. Ogino, G. Takemura, and M. Kawasaki Erythropoietin receptor signaling mitigates renal dysfunction-associated heart failure by mechanisms unrelated to relief of anemia J Am Coll Cardiol 56 2010 1949 1958
13. R.A. De Boer, Y.M. Pinto, and D.J. Van Veldhuisen The imbalance between oxygen demand and supply as a potential mechanism in the pathophysiology of heart failure: the role of microvascular growth and abnormalities Mircocirculation 10 2003 113 126
14. P. van der Meer, E. Lipsic, and R.H. Henning Erythropoietin induces neovascularization and improves cardiac function in rats with heart failure after myocardial infarction J Am Coll Cardiol 46 2005 125 133
15. B.D. Westenbrink, E. Lipsic, and P. van der Meer Erythropoietin improves cardiac function through endothelial progenitor cell and vascular endothelial growth factor mediated neovascularization Eur Heart J 28 2007 2018 2027
16. S. Mori, T. Sawada, and K. Kubota Asialoerythropoietin is a strong modulator of angiogenesis by bone-marrow cells J Invest Surg 20 2007 357 362
17. M. Brines, G. Grasso, and F. Fiordaliso Erythropoietin mediates tissue protection through an erythropoietin and common beta-subunit heteroreceptor Proc Natl Acad Sci U S A 101 2004 14907 14912
18. F. Fiordaliso, S. Chimenti, and L. Staszewsky A nonerythropoietic derivative of erythropoietin protects the myocardium from ischemia-reperfusion injury Proc Natl Acad Sci U S A 102 2005 2046 2051