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Volumn 5, Issue 12, 2010, Pages 1163-1174

Models and screening assays for drug discovery in osteoporosis

Author keywords

animal models; bone cells; efficacy studies; osteoporosis; preclinical

Indexed keywords

GLUCOCORTICOID; PREDNISOLONE;

EID: 78649368289     PISSN: 17460441     EISSN: None     Source Type: Journal    
DOI: 10.1517/17460441.2010.532484     Document Type: Review
Times cited : (17)

References (82)
  • 1
    • 2942523836 scopus 로고    scopus 로고
    • General principles of bone biology
    • Favus MJ, editor American Society for Bone and Mineral Research. Washington, DC, USA
    • Baron R. General principles of bone biology. In: Favus MJ, editor, Primer on the metabolic bone diseases and disorders of mineral metabolism. American Society for Bone and Mineral Research. Washington, DC, USA; 2003. p. 1-8
    • (2003) Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism , pp. 1-8
    • Baron, R.1
  • 2
    • 0027222768 scopus 로고
    • Consensus development conference. diagnosis, prophylaxis, and treatment of osteoporosis
    • Consensus development conference. diagnosis, prophylaxis, and treatment of osteoporosis. Am J Med 1993;94:646-50
    • (1993) Am J Med , vol.94 , pp. 646-50
  • 3
    • 4143114883 scopus 로고    scopus 로고
    • Prevention and management of osteoporosis
    • Geneva Switzerland: World Health Organization Available from
    • Prevention and management of osteoporosis. WHO Technical Report Series. Geneva, Switzerland: World Health Organization, 2003. Available from: http://whqlibdoc. who.int/trs/WHO-TRS-921.pdf
    • (2003) WHO Technical Report Series
  • 4
  • 5
  • 6
    • 0033065233 scopus 로고    scopus 로고
    • Bisphosphonates: From the laboratory to the clinic and back again
    • Russell RG, Rogers MJ. Bisphosphonates: from the laboratory to the clinic and back again. Bone 1999;25(1):97-106
    • (1999) Bone , vol.25 , Issue.1 , pp. 97-106
    • Russell, R.G.1    Rogers, M.J.2
  • 7
    • 70449711520 scopus 로고    scopus 로고
    • Treatment of osteoporosis and prevention of new fractures: Role of intravenously administered bisphosphonates
    • Cosman F. Treatment of osteoporosis and prevention of new fractures: role of intravenously administered bisphosphonates. Endocr Pract 2009;15(5):483-93
    • (2009) Endocr Pract , vol.15 , Issue.5 , pp. 483-93
    • Cosman, F.1
  • 8
    • 3142683004 scopus 로고    scopus 로고
    • Hormone replacement therapy in postmenopausal women
    • Staren ED, Omer S. Hormone replacement therapy in postmenopausal women. Am J Surg 2004;188(2):136-49
    • (2004) Am J Surg , vol.188 , Issue.2 , pp. 136-49
    • Staren, E.D.1    Omer, S.2
  • 9
    • 77955961158 scopus 로고    scopus 로고
    • New selective estrogen receptor modulators (SERMs) in development
    • Silverman SL. New selective estrogen receptor modulators (SERMs) in development. Curr Osteoporos Rep 2010;8(3):151-3
    • (2010) Curr Osteoporos Rep , vol.8 , Issue.3 , pp. 151-3
    • Silverman, S.L.1
  • 10
    • 27744529640 scopus 로고    scopus 로고
    • Osteoprotegerin and RANKL regulate bone resorption, density, geometry and strength
    • Kostenuik PJ. Osteoprotegerin and RANKL regulate bone resorption, density, geometry and strength. Curr Opin Pharmacol 2005;5(6):618-25
    • (2005) Curr Opin Pharmacol , vol.5 , Issue.6 , pp. 618-25
    • Kostenuik, P.J.1
  • 11
    • 76949085453 scopus 로고    scopus 로고
    • Denosumab-an emerging treatment for postmenopausal osteoporosis
    • Lewiecki EM. Denosumab-an emerging treatment for postmenopausal osteoporosis. Expert Opin Biol Ther 2010;10(3):467-76
    • (2010) Expert Opin Biol Ther , vol.10 , Issue.3 , pp. 467-76
    • Lewiecki, E.M.1
  • 12
    • 15744399381 scopus 로고    scopus 로고
    • Teriparatide: A bone formation treatment for osteoporosis
    • Eriksen EF, Robins DA. Teriparatide: a bone formation treatment for osteoporosis. Drugs Today (Barc) 2004;40(11):935-48
    • (2004) Drugs Today (Barc) , vol.40 , Issue.11 , pp. 935-48
    • Eriksen, E.F.1    Robins, D.A.2
  • 14
    • 44849121708 scopus 로고    scopus 로고
    • Combination anabolic and antiresorptive therapy for osteoporosis: Opening the anabolic window
    • Bilezikian JP. Combination anabolic and antiresorptive therapy for osteoporosis: opening the anabolic window. Curr Osteoporos Rep 2008;6(1):24-30
    • (2008) Curr Osteoporos Rep , vol.6 , Issue.1 , pp. 24-30
    • Bilezikian, J.P.1
  • 15
    • 0032864471 scopus 로고    scopus 로고
    • Human osteoclasts derive from CD14-positive monocytes
    • Massey HM, Flanagan AM. Human osteoclasts derive from CD14-positive monocytes. Br J Haematol 1999;106(1):167-70
    • (1999) Br J Haematol , vol.106 , Issue.1 , pp. 167-70
    • Massey, H.M.1    Flanagan, A.M.2
  • 16
    • 3042956278 scopus 로고    scopus 로고
    • Generation of multinuclear tartrate-resistant acid phosphatase positive osteoclasts in liquid culture of purified human peripheral blood CD34+ progenitors
    • Pierelli L, Scambia G, d'Onofrio G, et al. Generation of multinuclear tartrate-resistant acid phosphatase positive osteoclasts in liquid culture of purified human peripheral blood CD34+ progenitors. Br J Haematol 1997;96:64-9
    • (1997) Br J Haematol , vol.96 , pp. 64-9
    • Pierelli, L.1    Scambia, G.2    D'Onofrio, G.3
  • 17
    • 33845753007 scopus 로고    scopus 로고
    • Characterization of osteoclasts derived from CD14+ monocytes isolated from peripheral blood
    • Sorensen MG, Henriksen K, Schaller S, et al. Characterization of osteoclasts derived from CD14+ monocytes isolated from peripheral blood. J Bone Miner Metab 2007;25(1):36-45
    • (2007) J Bone Miner Metab , vol.25 , Issue.1 , pp. 36-45
    • Sorensen, M.G.1    Henriksen, K.2    Schaller, S.3
  • 18
    • 58149181444 scopus 로고    scopus 로고
    • Improved methods for testing antiresorptive compounds in human osteoclast cultures
    • Rissanen JP, Ylipahkala H, Fagerlund KM, et al. Improved methods for testing antiresorptive compounds in human osteoclast cultures. J Bone Miner Metab 2009;27(1):105-9
    • (2009) J Bone Miner Metab , vol.27 , Issue.1 , pp. 105-9
    • Rissanen, J.P.1    Ylipahkala, H.2    Fagerlund, K.M.3
  • 19
    • 39249084294 scopus 로고    scopus 로고
    • Comparison of human and bovine bone substrates in human osteoclast cultures
    • abstract SU289
    • Rissanen JP, Suutari S, Ylonen S, Halleen JM. Comparison of human and bovine bone substrates in human osteoclast cultures. J Bone Miner Res 2005;20(Suppl 1):abstract SU289
    • (2005) J Bone Miner Res , vol.20 , Issue.SUPPL. 1
    • Rissanen, J.P.1    Suutari, S.2    Ylonen, S.3    Halleen, J.M.4
  • 20
    • 0021769778 scopus 로고
    • Resorption of dentine by isolated osteoclasts in vitro
    • Boyde A, Ali NN, Jones SJ. Resorption of dentine by isolated osteoclasts in vitro. Br Dent J 1984;156:216-20
    • (1984) Br Dent J , vol.156 , pp. 216-20
    • Boyde, A.1    Ali, N.N.2    Jones, S.J.3
  • 22
    • 0028077307 scopus 로고
    • The effects of bisphosphonates on the resorption cycle of isolated osteoclasts
    • Selander K, Lehenkari P, Vaananen HK. The effects of bisphosphonates on the resorption cycle of isolated osteoclasts. Calcif Tissue Int 1994;55:368-75
    • (1994) Calcif Tissue Int , vol.55 , pp. 368-75
    • Selander, K.1    Lehenkari, P.2    Vaananen, H.K.3
  • 23
    • 39249083557 scopus 로고    scopus 로고
    • CrossLaps for culture: An improved enzyme-linked immunosorbent assay (ELISA) for measuring bone resorption in vitro
    • abstract S370
    • Bagger YZ, Foged NT, Andersen L, et al. CrossLaps for culture: an improved enzyme-linked immunosorbent assay (ELISA) for measuring bone resorption in vitro. J Bone Miner Res 1999;14(Suppl 1):abstract S370
    • (1999) J Bone Miner Res , vol.14 , Issue.SUPPL. 1
    • Bagger, Y.Z.1    Foged, N.T.2    Andersen, L.3
  • 24
    • 33750452295 scopus 로고    scopus 로고
    • Tartrate-resistant acid phosphatase 5b as a marker of bone resorption
    • Halleen JM, Tiitinen SL, Ylipahkala H, et al. Tartrate-resistant acid phosphatase 5b as a marker of bone resorption. Clin Lab 2006;52:499-509
    • (2006) Clin Lab , vol.52 , pp. 499-509
    • Halleen, J.M.1    Tiitinen, S.L.2    Ylipahkala, H.3
  • 25
    • 0033761219 scopus 로고    scopus 로고
    • Rapid screening method for osteoclast differentiation in vitro that measures tartrate-resistant acid phosphatase 5b activity secreted into the culture medium
    • Alatalo SL, Halleen JM, Hentunen TA, et al. Rapid screening method for osteoclast differentiation in vitro that measures tartrate-resistant acid phosphatase 5b activity secreted into the culture medium. Clin Chem 2000;46:1751-4
    • (2000) Clin Chem , vol.46 , pp. 1751-4
    • Alatalo, S.L.1    Halleen, J.M.2    Hentunen, T.A.3
  • 26
    • 0019120902 scopus 로고
    • Characterization of osteoblast-like cells from fetal rat calvaria
    • Kadis B, Goodson JM, Offenbacher S, et al. Characterization of osteoblast-like cells from fetal rat calvaria. J Dent Res 1980;59(11):2006-13
    • (1980) J Dent Res , vol.59 , Issue.11 , pp. 2006-13
    • Kadis, B.1    Goodson, J.M.2    Offenbacher, S.3
  • 27
    • 0032030503 scopus 로고    scopus 로고
    • Estrogen enhances differentiation of osteoblasts in mouse bone marrow culture
    • Qu Q, Perala-Heape M, Kapanen A, et al. Estrogen enhances differentiation of osteoblasts in mouse bone marrow culture. Bone 1998;22(3):201-9
    • (1998) Bone , vol.22 , Issue.3 , pp. 201-9
    • Qu, Q.1    Perala-Heape, M.2    Kapanen, A.3
  • 28
    • 85010251263 scopus 로고
    • Alkaline phosphatase in osteoblasts and fibroblasts cultivated in vitro
    • Henrichsen E. Alkaline phosphatase in osteoblasts and fibroblasts cultivated in vitro. Exp Cell Res 1956;11(1):115-27
    • (1956) Exp Cell Res , vol.11 , Issue.1 , pp. 115-27
    • Henrichsen, E.1
  • 29
    • 0016054668 scopus 로고
    • Complexes of organic acids with calcium phosphate: The von Kossa stain as a clue to the composition of bone mineral
    • Bills CE, Eisenberg H, Pallante SL. Complexes of organic acids with calcium phosphate: the Von Kossa stain as a clue to the composition of bone mineral. Johns Hopkins Med J 1974;128(4):194-207
    • (1974) Johns Hopkins Med J , vol.128 , Issue.4 , pp. 194-207
    • Bills, C.E.1    Eisenberg, H.2    Pallante, S.L.3
  • 30
    • 39249085228 scopus 로고    scopus 로고
    • Short-term changes in serum PINP predict long-term changes in trabecular bone in the rat ovariectomy model
    • Rissanen JP, Suominen MI, Peng Z, et al. Short-term changes in serum PINP predict long-term changes in trabecular bone in the rat ovariectomy model. Calcif Tissue Int 2008;82:155-61
    • (2008) Calcif Tissue Int , vol.82 , pp. 155-61
    • Rissanen, J.P.1    Suominen, M.I.2    Peng, Z.3
  • 31
    • 7344251166 scopus 로고    scopus 로고
    • Analytical and clinical performance characteristics of Tandem-MP Ostase, a new immunoassay for serum bone alkaline phosphatase
    • Broyles DL, Nielsen RG, Bussett EM, et al. Analytical and clinical performance characteristics of Tandem-MP Ostase, a new immunoassay for serum bone alkaline phosphatase. Clin Chem 1998;44(10):2139-47
    • (1998) Clin Chem , vol.44 , Issue.10 , pp. 2139-47
    • Broyles, D.L.1    Nielsen, R.G.2    Bussett, E.M.3
  • 32
    • 0029938817 scopus 로고    scopus 로고
    • Immunoassay for intact amino-terminal propeptide of human type i procollagen
    • Melkko J, Kauppila S, Niemi S, et al. Immunoassay for intact amino-terminal propeptide of human type I procollagen. Clin Chem 1996;42:947-54
    • (1996) Clin Chem , vol.42 , pp. 947-54
    • Melkko, J.1    Kauppila, S.2    Niemi, S.3
  • 33
    • 0033213830 scopus 로고    scopus 로고
    • Development of the osteoblast phenotype in primary human osteoblasts in culture: Comparison with rat calvarial cells in osteoblast differentiation
    • Siggelkow H, Rebenstorff K, Kurre W, et al. Development of the osteoblast phenotype in primary human osteoblasts in culture: comparison with rat calvarial cells in osteoblast differentiation. J Cell Biochem 1999;75(1):22-35
    • (1999) J Cell Biochem , vol.75 , Issue.1 , pp. 22-35
    • Siggelkow, H.1    Rebenstorff, K.2    Kurre, W.3
  • 34
    • 0347130061 scopus 로고    scopus 로고
    • Nodule formation and mineralisation of human primary osteoblasts cultured on a porous bioactive glass scaffold
    • Cough JE, Jones JR, Hench LL. Nodule formation and mineralisation of human primary osteoblasts cultured on a porous bioactive glass scaffold. Biomaterials 2004;25(11):2039-46
    • (2004) Biomaterials , vol.25 , Issue.11 , pp. 2039-46
    • Cough, J.E.1    Jones, J.R.2    Hench, L.L.3
  • 35
    • 0020678843 scopus 로고
    • In vitro differentiation and calcification in a new clonal osteogenic cell line derived from newborn mouse calvaria
    • Sudo H, Kodama HA, Amagai Y, et al. In vitro differentiation and calcification in a new clonal osteogenic cell line derived from newborn mouse calvaria. J Cell Biol 1983;96(1):191-8
    • (1983) J Cell Biol , vol.96 , Issue.1 , pp. 191-8
    • Sudo, H.1    Kodama, H.A.2    Amagai, Y.3
  • 36
    • 0023358690 scopus 로고
    • Characterization of a human osteoblastic osteosarcoma cell line (SAOS-2) with high bone alkaline phosphatase activity
    • Murray E, Provvedini D, Curran D, et al. Characterization of a human osteoblastic osteosarcoma cell line (SAOS-2) with high bone alkaline phosphatase activity. J Bone Miner Res 1987;2(3):231-8
    • (1987) J Bone Miner Res , vol.2 , Issue.3 , pp. 231-8
    • Murray, E.1    Provvedini, D.2    Curran, D.3
  • 37
    • 0029955512 scopus 로고    scopus 로고
    • Subcloning of three osteoblastic cell lines with distinct differentiation phenotypes from the mouse osteoblastic cell line KS-4
    • Yamashita T, Ishii H, Shimoda K, et al. Subcloning of three osteoblastic cell lines with distinct differentiation phenotypes from the mouse osteoblastic cell line KS-4. Bone 1996;19:429-36
    • (1996) Bone , vol.19 , pp. 429-36
    • Yamashita, T.1    Ishii, H.2    Shimoda, K.3
  • 38
    • 0036182265 scopus 로고    scopus 로고
    • Exposure of KS483 cells to estrogen enhances osteogenesis and inhibits adipogenesis
    • Dang ZC, van Bezooijen RL, Karperien M, et al. Exposure of KS483 cells to estrogen enhances osteogenesis and inhibits adipogenesis. J Bone Miner Res 2002;17:394-404
    • (2002) J Bone Miner Res , vol.17 , pp. 394-404
    • Dang, Z.C.1    Van Bezooijen, R.L.2    Karperien, M.3
  • 39
    • 0032528180 scopus 로고    scopus 로고
    • Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids. Potential mechanisms of their deleterious effects on bone
    • Weinstein RS, Jilka RL, Parfitt AM, Manolagas SC. Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids. Potential mechanisms of their deleterious effects on bone. J Clin Invest 1998;102(2):274-82
    • (1998) J Clin Invest , vol.102 , Issue.2 , pp. 274-82
    • Weinstein, R.S.1    Jilka, R.L.2    Parfitt, A.M.3    Manolagas, S.C.4
  • 40
    • 37249057821 scopus 로고    scopus 로고
    • Osteocytes as dynamic multifunctional cells
    • Bonewald LF. Osteocytes as dynamic multifunctional cells. Ann NY Acad Sci 2007;1116:281-90
    • (2007) Ann NY Acad Sci , vol.1116 , pp. 281-90
    • Bonewald, L.F.1
  • 41
    • 21244498229 scopus 로고    scopus 로고
    • Estrogen protects primary osteocytes against glucocorticoid-induced apoptosis
    • Gu G, Hentunen TA, Nars M, et al. Estrogen protects primary osteocytes against glucocorticoid-induced apoptosis. Apoptosis 2005;10(3):583-95
    • (2005) Apoptosis , vol.10 , Issue.3 , pp. 583-95
    • Gu, G.1    Hentunen, T.A.2    Nars, M.3
  • 42
    • 77949603251 scopus 로고    scopus 로고
    • Osteocytes and WNT: The mechanical control of bone formation
    • Galli C, Passeri G, Macaluso GM. Osteocytes and WNT: the mechanical control of bone formation. J Dent Res 2010;89(4):331-43
    • (2010) J Dent Res , vol.89 , Issue.4 , pp. 331-43
    • Galli, C.1    Passeri, G.2    MacAluso, G.M.3
  • 44
    • 0033055990 scopus 로고    scopus 로고
    • Establishment and characterization of an osteocyte-like cell line, MLO-Y4
    • Bonewald LF. Establishment and characterization of an osteocyte-like cell line, MLO-Y4. J Bone Miner Metab 1999;17(1):61-5
    • (1999) J Bone Miner Metab , vol.17 , Issue.1 , pp. 61-5
    • Bonewald, L.F.1
  • 45
    • 73949150499 scopus 로고    scopus 로고
    • Human primary osteocyte differentiation in a 3D culture system
    • Boukhechba F, Balaguer T, Michiels JF, et al. Human primary osteocyte differentiation in a 3D culture system. J Bone Miner Res 2009;24(11):1927-35
    • (2009) J Bone Miner Res , vol.24 , Issue.11 , pp. 1927-35
    • Boukhechba, F.1    Balaguer, T.2    Michiels, J.F.3
  • 46
    • 34249751708 scopus 로고    scopus 로고
    • Are nonresorbing osteoclasts sources of bone anabolic activity?
    • Karsdal MA, Martin TJ, Bollerslev J, et al. Are nonresorbing osteoclasts sources of bone anabolic activity? J Bone Miner Res 2007;22(4):487-94
    • (2007) J Bone Miner Res , vol.22 , Issue.4 , pp. 487-94
    • Karsdal, M.A.1    Martin, T.J.2    Bollerslev, J.3
  • 47
  • 48
    • 0025522325 scopus 로고
    • Osteoclast bone resorption is enhanced in the presence of osteoblasts
    • Grano M, Colucci S, Cantatore FP, et al. Osteoclast bone resorption is enhanced in the presence of osteoblasts. Boll Soc Ital Biol Sper 1990;66(11):1051-7
    • (1990) Boll Soc Ital Biol Sper , vol.66 , Issue.11 , pp. 1051-7
    • Grano, M.1    Colucci, S.2    Cantatore, F.P.3
  • 49
    • 0022628956 scopus 로고
    • Bone changes after castration in rats. A model for osteoporosis
    • Gurkan L, Ekeland A, Gautvik KM, et al. Bone changes after castration in rats. A model for osteoporosis. Acta Orthop Scand 1986;57:67-70
    • (1986) Acta Orthop Scand , vol.57 , pp. 67-70
    • Gurkan, L.1    Ekeland, A.2    Gautvik, K.M.3
  • 50
    • 0026068145 scopus 로고
    • The ovariectomized rat model of postmenopausal bone loss
    • Kalu DN. The ovariectomized rat model of postmenopausal bone loss. Bone Miner 1991;15:175-91
    • (1991) Bone Miner , vol.15 , pp. 175-91
    • Kalu, D.N.1
  • 51
    • 0026535080 scopus 로고
    • 17 beta estradiol stimulation of endosteal bone formation in the ovariectomized mouse: An animal model for the evaluation of bone-targeted estrogens
    • Edwards MW, Bain SD, Bailey MC, et al. 17 beta estradiol stimulation of endosteal bone formation in the ovariectomized mouse: an animal model for the evaluation of bone-targeted estrogens. Bone 1992;13(1):29-34
    • (1992) Bone , vol.13 , Issue.1 , pp. 29-34
    • Edwards, M.W.1    Bain, S.D.2    Bailey, M.C.3
  • 52
    • 0028818112 scopus 로고
    • Development of osteopenia in ovariectomized cynomolgus monkeys (Macaca fascicularis)
    • Jerome CP, Lees CJ, Weaver DS. Development of osteopenia in ovariectomized cynomolgus monkeys (Macaca fascicularis). Bone 1995;17(4 Suppl):403S-408S
    • (1995) Bone , vol.17 , Issue.4 SUPPL.
    • Jerome, C.P.1    Lees, C.J.2    Weaver, D.S.3
  • 53
    • 69349085848 scopus 로고    scopus 로고
    • Skeletal health: Primate model of postmenopausal osteoporosis
    • Smith SY, Jolette J, Turner CH. Skeletal health: primate model of postmenopausal osteoporosis. Am J Primatol 2009;71(9):752-65
    • (2009) Am J Primatol , vol.71 , Issue.9 , pp. 752-65
    • Smith, S.Y.1    Jolette, J.2    Turner, C.H.3
  • 54
    • 0032880585 scopus 로고    scopus 로고
    • Markers of bone turnover predict postmenopausal forearm bone loss over 4 years: The OFELY study
    • Garnero P, Sornay-Rendu E, Duboeuf F, Delmas PD. Markers of bone turnover predict postmenopausal forearm bone loss over 4 years: the OFELY study. J Bone Miner Res 1999;14:1614-21
    • (1999) J Bone Miner Res , vol.14 , pp. 1614-21
    • Garnero, P.1    Sornay-Rendu, E.2    Duboeuf, F.3    Delmas, P.D.4
  • 55
    • 2942730031 scopus 로고    scopus 로고
    • Biochemical markers of bone metabolism and prediction of fracture in elderly women
    • Gerdhem P, Ivaska KK, Alatalo SL, et al. Biochemical markers of bone metabolism and prediction of fracture in elderly women. J Bone Miner Res 2004;19:386-93
    • (2004) J Bone Miner Res , vol.19 , pp. 386-93
    • Gerdhem, P.1    Ivaska, K.K.2    Alatalo, S.L.3
  • 56
    • 33847762912 scopus 로고    scopus 로고
    • Biochemical markers of bone turnover in the clinical development of drugs for osteoporosis and metastatic bone disease: Potential uses and pitfalls
    • Cremers S, Garnero P. Biochemical markers of bone turnover in the clinical development of drugs for osteoporosis and metastatic bone disease: potential uses and pitfalls. Drugs 2006;66:2031-58
    • (2006) Drugs , vol.66 , pp. 2031-58
    • Cremers, S.1    Garnero, P.2
  • 57
    • 77951687483 scopus 로고    scopus 로고
    • Should biochemical markers of bone turnover be considered standard practice for safety pharmacology?
    • Henriksen K, Bohren KM, Bay-Jensen AC, Karsdal MA. Should biochemical markers of bone turnover be considered standard practice for safety pharmacology? Biomarkers 2010;15(3):195-204
    • (2010) Biomarkers , vol.15 , Issue.3 , pp. 195-204
    • Henriksen, K.1    Bohren, K.M.2    Bay-Jensen, A.C.3    Karsdal, M.A.4
  • 59
    • 39249083918 scopus 로고    scopus 로고
    • Secreted tartrate-resistant acid phosphatase 5b is a Marker of osteoclast number in human osteoclast cultures and the rat ovariectomy model
    • Rissanen JP, Suominen MI, Peng Z, Halleen JM. Secreted tartrate-resistant acid phosphatase 5b is a Marker of osteoclast number in human osteoclast cultures and the rat ovariectomy model. Calcif Tissue Int 2008;82:108-15
    • (2008) Calcif Tissue Int , vol.82 , pp. 108-15
    • Rissanen, J.P.1    Suominen, M.I.2    Peng, Z.3    Halleen, J.M.4
  • 60
    • 0034841528 scopus 로고    scopus 로고
    • Repeated in vivo determinations of bone mineral density during parathyroid hormone treatment in ovariectomized mice
    • Andersson N, Lindberg MK, Ohlsson C, et al. Repeated in vivo determinations of bone mineral density during parathyroid hormone treatment in ovariectomized mice. J Endocrinol 2001;170(3):529-37
    • (2001) J Endocrinol , vol.170 , Issue.3 , pp. 529-37
    • Andersson, N.1    Lindberg, M.K.2    Ohlsson, C.3
  • 61
    • 0035676050 scopus 로고    scopus 로고
    • Effects of long-term administration of clodronate on growing rat bone
    • Koivukangas A, Tuukkanen J, Hannuniemi R, et al. Effects of long-term administration of clodronate on growing rat bone. Calcif Tissue Int 2001;69(6):350-5
    • (2001) Calcif Tissue Int , vol.69 , Issue.6 , pp. 350-5
    • Koivukangas, A.1    Tuukkanen, J.2    Hannuniemi, R.3
  • 62
    • 0023488581 scopus 로고
    • Bone histomorphometry: Standardization of nomenclature, symbols, and units
    • Parfitt AM, Drezner MK, Glorieux FH, et al. Bone histomorphometry: standardization of nomenclature, symbols, and units. J Bone Miner Res 1987;2:595-610
    • (1987) J Bone Miner Res , vol.2 , pp. 595-610
    • Parfitt, A.M.1    Drezner, M.K.2    Glorieux, F.H.3
  • 63
    • 33750563391 scopus 로고    scopus 로고
    • Daily treatment of aged ovariectomized rats with human parathyroid hormone (1-84) for 12 months reverses bone loss and enhances trabecular and cortical bone strength
    • Fox J, Miller MA, Newman MK, et al. Daily treatment of aged ovariectomized rats with human parathyroid hormone (1-84) for 12 months reverses bone loss and enhances trabecular and cortical bone strength. Calcif Tissue Int 2006;79(4):262-72
    • (2006) Calcif Tissue Int , vol.79 , Issue.4 , pp. 262-72
    • Fox, J.1    Miller, M.A.2    Newman, M.K.3
  • 64
    • 67650476919 scopus 로고    scopus 로고
    • Strontium ranelate improves bone strength in ovariectomized rat by positively influencing bone resistance determinants
    • Bain SD, Jerome C, Shen V, et al. Strontium ranelate improves bone strength in ovariectomized rat by positively influencing bone resistance determinants. Osteoporos Int 2009;20(8):1417-28
    • (2009) Osteoporos Int , vol.20 , Issue.8 , pp. 1417-28
    • Bain, S.D.1    Jerome, C.2    Shen, V.3
  • 65
    • 0033305401 scopus 로고    scopus 로고
    • Daily treatment with human recombinant parathyroid hormone-(1-34), LY333334, for 1 year increases bone mass in ovariectomized monkeys
    • Brommage R, Hotchkiss CE, Lees CJ, et al. Daily treatment with human recombinant parathyroid hormone-(1-34), LY333334, for 1 year increases bone mass in ovariectomized monkeys. J Clin Endocrinol Metab 1999;84(10):3757-63
    • (1999) J Clin Endocrinol Metab , vol.84 , Issue.10 , pp. 3757-63
    • Brommage, R.1    Hotchkiss, C.E.2    Lees, C.J.3
  • 66
    • 0037265864 scopus 로고    scopus 로고
    • Intermittent intravenous administration of the bisphosphonate ibandronate prevents bone loss and maintains bone strength and quality in ovariectomized cynomolgus monkeys
    • Smith SY, Recker RR, Hannan M, et al. Intermittent intravenous administration of the bisphosphonate ibandronate prevents bone loss and maintains bone strength and quality in ovariectomized cynomolgus monkeys. Bone 2003;32(1):45-55
    • (2003) Bone , vol.32 , Issue.1 , pp. 45-55
    • Smith, S.Y.1    Recker, R.R.2    Hannan, M.3
  • 67
    • 0026750195 scopus 로고
    • Bone and mineral metabolism in aged male rats: Short and long term effects of androgen deficiency
    • Vanderscueren D, Van Herck E, Suiker AM, et al. Bone and mineral metabolism in aged male rats: short and long term effects of androgen deficiency. Endocrinology 1992;130:2906-16
    • (1992) Endocrinology , vol.130 , pp. 2906-16
    • Vanderscueren, D.1    Van Herck, E.2    Suiker, A.M.3
  • 68
    • 0034088513 scopus 로고    scopus 로고
    • Androgen deficiency induces high turnover osteopenia in aged male rats: A sequential histomorphometric study
    • Erben RG, Eberle J, Stahr K, Goldberg M. Androgen deficiency induces high turnover osteopenia in aged male rats: a sequential histomorphometric study. J Bone Miner Res 2000;15:1085-98
    • (2000) J Bone Miner Res , vol.15 , pp. 1085-98
    • Erben, R.G.1    Eberle, J.2    Stahr, K.3    Goldberg, M.4
  • 69
    • 26844496083 scopus 로고    scopus 로고
    • Selective androgen receptor modulator treatment improves muscle strength and body composition and prevents bone loss in orchidectomized rats
    • Gao W, Reiser PJ, Coss CC, et al. Selective androgen receptor modulator treatment improves muscle strength and body composition and prevents bone loss in orchidectomized rats. Endocrinology 2005;146(11):4887-97
    • (2005) Endocrinology , vol.146 , Issue.11 , pp. 4887-97
    • Gao, W.1    Reiser, P.J.2    Coss, C.C.3
  • 70
    • 77950662581 scopus 로고    scopus 로고
    • Glucocorticoid-induced bone fragility
    • Lane NE, Yao W. Glucocorticoid-induced bone fragility. Ann NY Acad Sci 2010;1192(1):81-3
    • (2010) Ann NY Acad Sci , vol.1192 , Issue.1 , pp. 81-3
    • Lane, N.E.1    Yao, W.2
  • 71
    • 55849147355 scopus 로고    scopus 로고
    • Glucocorticoid-induced bone loss in mice can be reversed by the actions of parathyroid hormone and risedronate on different pathways for bone formation and mineralization
    • Yao W, Cheng Z, Pham A, et al. Glucocorticoid-induced bone loss in mice can be reversed by the actions of parathyroid hormone and risedronate on different pathways for bone formation and mineralization. Arthritis Rheum 2008;58(11):3485-97
    • (2008) Arthritis Rheum , vol.58 , Issue.11 , pp. 3485-97
    • Yao, W.1    Cheng, Z.2    Pham, A.3
  • 72
    • 0014672714 scopus 로고
    • Prevention by a diphosphonate of immobilization "osteoporosis" in rats
    • Fleisch H, Russell RG, Simpson B, Muhlbauer RC. Prevention by a diphosphonate of immobilization "osteoporosis" in rats. Nature 1969;223(5202):211-12
    • (1969) Nature , vol.223 , Issue.5202 , pp. 211-12
    • Fleisch, H.1    Russell, R.G.2    Simpson, B.3    Muhlbauer, R.C.4
  • 73
    • 0019772818 scopus 로고
    • Immobilization osteoporosis and active vitamin D: Effect of active vitamin D analogs on the development of immobilization osteoporosis in rats
    • Izawa Y, Makita T, Hino S, et al. Immobilization osteoporosis and active vitamin D: effect of active vitamin D analogs on the development of immobilization osteoporosis in rats. Calcif Tissue Int 1981;33(6):623-30
    • (1981) Calcif Tissue Int , vol.33 , Issue.6 , pp. 623-30
    • Izawa, Y.1    Makita, T.2    Hino, S.3
  • 74
    • 0028146984 scopus 로고
    • The mechanical strength of bone in different rat models of experimental osteoporosis
    • Peng Z, Tuukkanen J, Zhang H, et al. The mechanical strength of bone in different rat models of experimental osteoporosis. Bone 1994;15(5):523-32
    • (1994) Bone , vol.15 , Issue.5 , pp. 523-32
    • Peng, Z.1    Tuukkanen, J.2    Zhang, H.3
  • 75
    • 0028950225 scopus 로고
    • Rat tail suspension reduces messenger RNA level for growth factors and osteopontin and decreases the osteoblastic differentiation of bone marrow stromal cells
    • Zhang R, Supowit SC, Klein GL, et al. Rat tail suspension reduces messenger RNA level for growth factors and osteopontin and decreases the osteoblastic differentiation of bone marrow stromal cells. J Bone Miner Res 1995;10(3):415-23
    • (1995) J Bone Miner Res , vol.10 , Issue.3 , pp. 415-23
    • Zhang, R.1    Supowit, S.C.2    Klein, G.L.3
  • 76
    • 37249002283 scopus 로고    scopus 로고
    • Bone loss after temporarily induced muscle paralysis by Botox is not fully recovered after 12 weeks
    • Grimston SK, Silva MJ, Civitelli R. Bone loss after temporarily induced muscle paralysis by Botox is not fully recovered after 12 weeks. Ann NY Acad Sci 2007;1116:444-60
    • (2007) Ann NY Acad Sci , vol.1116 , pp. 444-60
    • Grimston, S.K.1    Silva, M.J.2    Civitelli, R.3
  • 77
    • 58949085856 scopus 로고    scopus 로고
    • Osteonecrosis of the jaw and the role of bisphosphonates: A critical review
    • Silverman SL, Landesberg R. Osteonecrosis of the jaw and the role of bisphosphonates: a critical review. Am J Med 2009;122(2 Suppl):S33-45
    • (2009) Am J Med , vol.122 , Issue.2 SUPPL.
    • Silverman, S.L.1    Landesberg, R.2
  • 78
    • 77957657154 scopus 로고    scopus 로고
    • Atypical fractures as a potential complication of long-term bisphosphonate therapy
    • Sellmeyer DE. Atypical fractures as a potential complication of long-term bisphosphonate therapy. JAMA 2010;304(13):1480-4
    • (2010) JAMA , vol.304 , Issue.13 , pp. 1480-4
    • Sellmeyer, D.E.1
  • 79
    • 78149409580 scopus 로고    scopus 로고
    • Increased risk of serious infections in women with osteopenia or osteoporosis treated with denosumab
    • Toulis KA, Anastasilakis AD. Increased risk of serious infections in women with osteopenia or osteoporosis treated with denosumab. Osteoporos Int 2010;21(11):1963-4
    • (2010) Osteoporos Int , vol.21 , Issue.11 , pp. 1963-4
    • Toulis, K.A.1    Anastasilakis, A.D.2
  • 80
    • 38849178302 scopus 로고    scopus 로고
    • Building bone to reverse osteoporosis and repair fractures
    • Khosla S, Westendorf JJ, Oursler MJ. Building bone to reverse osteoporosis and repair fractures. J Clin Invest 2008;118(2):421-8
    • (2008) J Clin Invest , vol.118 , Issue.2 , pp. 421-8
    • Khosla, S.1    Westendorf, J.J.2    Oursler, M.J.3
  • 81
    • 77951075374 scopus 로고    scopus 로고
    • Treatment of osteoporosis: Recognizing and managing cutaneous adverse reactions and drug-induced hypersensitivity
    • Musette P, Brandi ML, Cacoub P, et al. Treatment of osteoporosis: recognizing and managing cutaneous adverse reactions and drug-induced hypersensitivity. Osteoporos Int 2010;21(5):723-32
    • (2010) Osteoporos Int , vol.21 , Issue.5 , pp. 723-32
    • Musette, P.1    Brandi, M.L.2    Cacoub, P.3
  • 82
    • 65249167488 scopus 로고    scopus 로고
    • Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice
    • Kansara M, Tsang M, Kodjabachian L, et al. Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice. J Clin Invest 2009;119(4):837-51
    • (2009) J Clin Invest , vol.119 , Issue.4 , pp. 837-51
    • Kansara, M.1    Tsang, M.2    Kodjabachian, L.3


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