Do not adjust the platelet count in light transmittance aggregometry when predicting thrombotic events after percutaneous coronary intervention

Journal of Thrombosis and Haemostasis

Volumn 8, Issue 10, 2010, Pages 2326-2328

  Breet, N J ^a   van Werkum, J W ^a   Bouman, H J ^a   Kelder, J C ^a   Ten Berg, J M ^a   Hackeng, C M ^a  

^a ST ANTONIUS HOSPITAL   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; CLOPIDOGREL;

ANTICOAGULANT THERAPY; ATHEROSCLEROSIS; FOLLOW UP; HUMAN; LETTER; LIGHT TRANSMITTANCE AGGREGOMETRY; PERCUTANEOUS CORONARY INTERVENTION; PRIORITY JOURNAL; THROMBOCYTE AGGREGATION; THROMBOCYTE COUNT; THROMBOCYTE FUNCTION; THROMBOCYTE RICH PLASMA; THROMBOSIS; TREATMENT OUTCOME;

ANGIOPLASTY, BALLOON, CORONARY; ASPIRIN; BLOOD PLATELETS; COHORT STUDIES; HUMANS; ISCHEMIA; ODDS RATIO; PLATELET AGGREGATION INHIBITORS; PLATELET COUNT; PROSPECTIVE STUDIES; ROC CURVE; THROMBOSIS; TICLOPIDINE;

EID: 78649366668     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/j.1538-7836.2010.04003.x     Document Type: Letter

References (15)

1. Steinhubl SR, Berger PB, Mann JT III, Fry ET, DeLago A, Wilmer C, Topol EJ. Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: a randomized controlled trial. JAMA 2002; 288: 2411-20.
2. Mehta SR, Yusuf S, Peters RJ, Bertrand ME, Lewis BS, Natarajan MK, Malmberg K, Rupprecht H, Zhao F, Chrolavicius S, Copland I, Fox KA. Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study. Lancet 2001; 358: 527-33.
3. Matetzky S, Shenkman B, Guetta V, Shechter M, Bienart R, Goldenberg I, Novikov I, Pres H, Savion N, Varon D, Hod H. Clopidogrel resistance is associated with increased risk of recurrent atherothrombotic events in patients with acute myocardial infarction. Circulation 2004; 109: 3171-5.
4. Breet NJ, van Werkum JW, Bouman HJ, Kelder JC, Ruven H, Bal ET, Deneer VHM, Harmsze AM, Heyden JAS, Rensing BJ, Suttorp MJ, Hackeng CM, Ten Berg JM. Comparison of platelet function tests in predicting clinical outcome in patients undergoing coronary stent implantation. JAMA 2010; 303: 754-62.
5. Gurbel PA, Bliden KP, Guyer K, Cho PW, Zaman KA, Kreutz RP, Bassi AK, Tantry US. Platelet reactivity in patients and recurrent events post-stenting: results of the PREPARE POST-STENTING Study. J Am Coll Cardiol 2005; 46: 1820-6.
6. Hochholzer W, Trenk D, Bestehorn HP, Fischer B, Valina CM, Ferenc M, Gick M, Caputo A, Buttner HJ, Neumann FJ. Impact of the degree of peri-interventional platelet inhibition after loading withclopidogrel on early clinical outcome of elective coronary stent placement. J Am Coll Cardiol 2006; 48: 1742-50.
7. Linnemann B, Schwonberg J, Mani H, Prochnow S, Lindhoff-Last E. Standardization of light transmittance aggregometry for monitoring antiplatelet therapy: an adjustment for platelet count is not necessary. J Thromb Haemost 2008; 6: 677-83.
8. Zhou L, Schmaier AH. Platelet aggregation testing in platelet-rich plasma: description of procedures with the aim to develop standards in the field. Am J Clin Pathol 2005; 123: 172-83.
9. Moffat KA, Ledford-Kraemer MR, Nichols WL, Hayward CP. Variability in clinical laboratory practice in testing for disorders of platelet function: results of two surveys of the North American Specialized Coagulation Laboratory Association. Thromb Haemost 2005; 93: 549-53.
10. Breddin HK. Can platelet aggregometry be standardized? Platelets 2005; 16: 151-8.
11. Guidelines on platelet function testing. The British Society for Haematology BCSH Haemostasis and Thrombosis Task Force. J Clin Pathol 1988; 41: 1322-30.
12. The Clinical and Laboratory Standards Institute. http://www.clsi.org..
13. van der Stelt CA, van Werkum JW, Seesing TH, Berg JM, Hackeng CM. To adjust or not to adjust the platelet count in light transmission aggregometry in patients receiving dual aspirin/clopidogrel treatment. Platelets 2007; 18: 550-3.
14. ManiH, Luxembourg B, Klaffling C, ErbeM, Lindhoff-Last E. Use of native or platelet count adjusted platelet rich plasma for platelet aggregation measurements. J Clin Pathol 2005; 58: 747-50.
15. Cattaneo M, Lecchi A, ZighettiML, Lussana F. Platelet aggregation studies: autologous platelet-poor plasma inhibits platelet aggregation when added to platelet-rich plasma to normalize platelet count. Haematologica 2007; 92: 694-7.