Pathological complete response after preoperative systemic therapy and outcome: Relevance of clinical and biologic baseline features

Breast Cancer Research and Treatment

Volumn 124, Issue 3, 2010, Pages 689-699

  Montagna, Emilia ^a   Bagnardi, Vincenzo ^a,b,c   Rotmensz, Nicole ^a   Viale, Giuseppe ^a,d   Pruneri, Giancarlo ^a,d   Veronesi, Paolo ^a,d   Cancello, Giuseppe ^a   Balduzzi, Alessandra ^a   Dellapasqua, Silvia ^a   Cardillo, Anna ^a   Luini, Alberto ^a   Zurrida, Stefano ^a   Gentilini, Oreste ^a   Mastropasqua, Mauro Giuseppe ^a   Bottiglieri, Luca ^a   Iorfida, Monica ^a   Goldhirsch, Aron ^a   Colleoni, Marco ^a  

^a EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

^b UNIVERSITY OF MILANO BICOCCA   (Italy)

^c Southern Europe   (Switzerland)

^d UNIVERSITY OF MILAN   (Italy)

Author keywords

Breast cancer; Predictive factors; Primary therapy

Indexed keywords

ANTHRACYCLINE DERIVATIVE; AROMATASE INHIBITOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN RECEPTOR; GONADORELIN DERIVATIVE; KI 67 ANTIGEN; NAVELBINE; PROGESTERONE RECEPTOR; TAMOXIFEN; TAXANE DERIVATIVE; TRASTUZUMAB;

ADULT; ARTICLE; BREAST CANCER; CANCER GRADING; CANCER HORMONE THERAPY; CANCER REGRESSION; CANCER RELAPSE; DISEASE FREE SURVIVAL; FEMALE; HUMAN; HUMAN TISSUE; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MINIMAL RESIDUAL DISEASE; OVERALL SURVIVAL; PREOPERATIVE TREATMENT; PRIORITY JOURNAL; PROGNOSIS; TUMOR VOLUME;

ADULT; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BIOPSY; BREAST NEOPLASMS; CHEMOTHERAPY, ADJUVANT; CHI-SQUARE DISTRIBUTION; DISEASE-FREE SURVIVAL; FEMALE; HUMANS; ITALY; KAPLAN-MEIER ESTIMATE; LYMPHATIC METASTASIS; MASTECTOMY; MIDDLE AGED; NEOADJUVANT THERAPY; NEOPLASM STAGING; NEOPLASM, RESIDUAL; PATIENT SELECTION; PROPORTIONAL HAZARDS MODELS; RADIOTHERAPY, ADJUVANT; RETROSPECTIVE STUDIES; RISK ASSESSMENT; RISK FACTORS; TIME FACTORS; TREATMENT OUTCOME; TUMOR BURDEN;

EID: 78649330819     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-010-1027-4     Document Type: Article

References (19)

1. B Fisher J Bryant N Wolmark, et al. 1998 Effect of preoperative chemotherapy on the outcome of women with operable breast cancer J Clin Oncol 16 2672 2685 1:CAS:528:DyaK1cXlsFCgurg%3D 9704717
2. V Guarneri K Broglio SW Kau, et al. 2006 Prognostic value of pathologic complete response after primary chemotherapy in relation to hormone receptor status and other factors J Clin Oncol 24 1037 1044 10.1200/JCO.2005.02.6914 16505422 (Pubitemid 46638799)
3. BT Hennessy GN Hortobagy RN Rouzier, et al. 2005 Outcome after pathologic complete eradication of cytologically proven breast cancer axillary node metastases following primary chemotherapy J Clin Oncol 23 9304 9311 10.1200/JCO.2005.02.5023 16361629
4. HM Kuerer LA Newman TM Smith, et al. 1999 Clinical course of breast cancer patients with complete pathologic primary tumor and axillary lymph node response to doxorubicin-based neoadjuvant chemotherapy J Clin Oncol 17 460 469 1:CAS:528:DyaK1MXht1Wmur4%3D 10080586
5. M Colleoni G Viale D Zahrieh, et al. 2004 Chemotherapy is more effective in patients with breast cancer not expressing steroid hormone receptors: a study of preoperative treatment Clin Cancer Res 10 6622 6628 1:CAS:528: DC%2BD2cXot1Oiu7o%3D 10.1158/1078-0432.CCR-04-0380 15475452 (Pubitemid 39346559)
6. R Rouzier L Pusztai S Delaloge, et al. 2004 Nomograms to predict pathologic complete response and metastasis-free survival after preoperative chemotherapy for breast cancer J Clin Oncol 22 2294 2302 10.1200/JCO.2004.05.207 (Pubitemid 41115385)
7. C Liedtke C Mazouni KR Hess, et al. 2008 Response to neoadjuvant therapy and long term survival in patients with triple negative breast cancer J Clin Oncol 26 1274 1281
8. HD Bear S Anderson A Brown, et al. 2003 The effect on tumor response of adding sequential preoperative docetaxel to preoperative doxorubicin and cyclophosphamide: preliminary results from National Surgical Adjuvant Breast and Bowel Project Protocol B-27 J Clin Oncol 21 4165 4174 1:CAS:528: DC%2BD2cXpsVajtrg%3D 10.1200/JCO.2003.12.005 14559892 (Pubitemid 46606185)
9. CM Perou T Sorlie MB Eisen, et al. 2000 Molecular portraits of human breast tumors Nature 406 6797 747 752 1:CAS:528:DC%2BD3cXmt1CnsLw%3D 10.1038/35021093 10963602
10. JJ de Ronde J Hannemann H Halfwerk, et al. 2010 Concordance of clinical and molecular breast cancer subtyping in the context of preoperative chemotherapy response Breast Cancer Res Treat 119 1 119 126 10.1007/s10549-009- 0499-6 19669409
11. MC Cheang SK Chia D Voduc, et al. 2009 Ki67 index, HER2 status, and prognosis of patients with luminal B breast cancer J Natl Cancer Inst 101 10 736 750 1:CAS:528:DC%2BD1MXmtlyit74%3D 10.1093/jnci/djp082 19436038
12. J Hugh J Hanson M Chon, et al. 2009 Breast cancer subtypes and response to docetaxel in node positive breast cancer: use of an immunohistochemical definition in the BCIRG 001 trial J Clin Oncol 27 1168 1176 1:CAS:528: DC%2BD1MXktFKhs7Y%3D 10.1200/JCO.2008.18.1024 19204205
13. LM McShane DG Altman W Sauerbrei, et al. 2006 Reporting recommendations for tumor marker prognostic studies (REMARK) Breast Cancer Res Treat 100 229 235 10.1007/s10549-006-9242-8 16932852 (Pubitemid 44631925)
14. M Colleoni E Orvieto F Nolè, et al. 1999 Prediction of response to primary chemotherapy for operable breast cancer Eur J Cancer 35 574 579 1:STN:280:DyaK1Mvit1aqug%3D%3D 10.1016/S0959-8049(99)00005-2 10492630 (Pubitemid 29192965)
15. A Goldhirsch JH Glick RD Gelber, et al. 1998 Meeting highlights: international consensus panel on the treatment of primary breast cancer J Natl Cancer Inst 90 1601 1608 1:STN:280:DyaK1M%2FislCnug%3D%3D 10.1093/jnci/90.21. 1601 9811309
16. N Wolmark J Wang E Mamounas, et al. 2001 Preoperative chemotherapy in patients with operable breast cancer: nine-year results from the National Surgical Adjuvant Breast and Bowel Project B-18 J Natl Cancer Inst Monogr 30 96 102 11773300
17. P Chollet S Amat H Cure, et al. 2002 Prognostic significance of a complete pathological response after induction chemotherapy in operable breast cancer Br J Cancer 86 1041 1046 1:STN:280:DC%2BD383hs1KgsA%3D%3D 10.1038/sj.bjc.6600210 11953845 (Pubitemid 34441058)
18. AM Gonzalez-Angulo SE McGuire TA Buchholz, et al. 2005 Factors predictive of distant metastases in patients with breast cancer who have a pathologic complete response after neoadjuvant chemotherapy J Clin Oncol 23 7098 7104 10.1200/JCO.2005.11.124 16192593
19. S Dawood K Broglio S-W Kau, et al. 2008 Prognostic value of initial clinical disease stage after achieving pathological complete response Oncologist 13 6 15 10.1634/theoncologist.2007-0107 18245008 (Pubitemid 351206692)