Meconium aspiration delays normal decline of pulmonary vascular resistance shortly after birth through lung parenchymal injury

Neonatology

Volumn 99, Issue 4, 2011, Pages 272-279

  Ban, Ryoichi ^a   Ogihara, Tohru ^b   Mori, Yasuhiko ^b   Oue, Shinya ^b   Ogawa, Satoru ^a   Tamai, Hiroshi ^b  

^a Saiseikai Imperial Gift Foundation Inc Saiseikai Suita Hospital   (Japan)

^b OSAKA MEDICAL COLLEGE   (Japan)

Author keywords

6 Keto prostaglandin F 1 ; Asphyxia; Cyclic guanosine monophosphate; Endothelin 1; KL 6; Meconium aspiration syndrome; Meconium stained amniotic fluid; Persistent pulmonary hypertension of the newborn; Right to left systolic ventricular pressure ratio

Indexed keywords

6 OXOPROSTAGLANDIN F1 ALPHA; CYCLIC GMP; ENDOTHELIN 1; NITRIC OXIDE; PROSTACYCLIN;

AMNION FLUID; BIRTH; CONFERENCE PAPER; CONTROLLED STUDY; ECHOCARDIOGRAPHY; HEART LEFT VENTRICLE PRESSURE; HEART RIGHT VENTRICLE PRESSURE; HUMAN; INFANT; LUNG ARTERY PRESSURE; LUNG INJURY; LUNG PARENCHYMA; LUNG VASCULAR RESISTANCE; MAJOR CLINICAL STUDY; MECONIUM ASPIRATION; PERINATAL ASPHYXIA; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; THORAX RADIOGRAPHY;

ASPHYXIA NEONATORUM; BLOOD PRESSURE; DOWN-REGULATION; FETAL BLOOD; GESTATIONAL AGE; HUMANS; INFANT, NEWBORN; LUNG; LUNG INJURY; MECONIUM ASPIRATION SYNDROME; NATRIURETIC PEPTIDE, BRAIN; PARTURITION; PULMONARY ARTERY; TIME FACTORS; VASCULAR RESISTANCE;

EID: 78649326655     PISSN: 16617800     EISSN: 16617819     Source Type: Journal    
DOI: 10.1159/000318748     Document Type: Conference Paper

References (31)

1. Morin FC 3rd, Stenmark KR: Persistent pulmonary hypertension of the newborn. Am J Respir Crit Care Med 1995; 151: 2010-2032.
2. Dakshinamurti S: Pathophysiologic mechanisms of persistent pulmonary hypertension of the newborn. Pediatr Pulmonol 2005; 39: 492-503. (Pubitemid 40696319)
3. Diaz SH, Van Marter LJ, Werler MM, Louik C, Mitchell AA: Risk factor for persistent pulmonary hypertension of the newborn. Pediatrics 2009; 23:e272-e282. (Pubitemid 47219476)
4. Holopainen R, Soukka H, Halkola L, Kääpä P: Meconium aspiration induces a concentration-dependent pulmonary hypertensive response in newborn piglets. Pediatr Pulmonol 1998; 25: 107-113. (Pubitemid 28110586)
5. Aaltonen M, Soukka H, Halkola L, Jalonen J, Holopainen IE, Kero P, Kaapa PO: Asphyxia aggravates systemic hypotension but not pulmonary hypertension in piglets with meconium aspiration. Pediatr Res 2003; 53: 473-478. (Pubitemid 36237404)
6. Musewe NN, Poppe D, Smallhorn JF, Hellman J, Whyte H, Smith B, Freedom R: Doppler echocardiographic measurement of pulmonary artery pressure from ductal Doppler velocities in the newborn. J Am Coll Cardiol 1990; 15: 446-456. (Pubitemid 20067506)
7. King ME, Braun H, Goldblatt A, Liberthson R, Weyman AE: Interventricular septal configuration as a predictor of right ventricular systolic hypertension in children: a cross-sectional echocardiography study. Circulation 1983; 68: 68-75. (Pubitemid 13058211)
8. Niermeyer S, Shaffer EM, Thilo E, Corbin C, Moore LG: Arterial oxygenation and pulmonary arterial pressure in healthy neonates and infants at high altitude. J Pediatr 1993; 123: 767-772. (Pubitemid 23316432)
9. Spieker LE, Flammer AJ, Lüscher TF: The vascular endothelium in hypertension. Handb Exp Pharmacol 2006; 176: 249-283.
10. Wong J, Fineman JR, Heymann MA: The role of endothelin and endothelin receptor subtypes in regulation of fetal pulmonary vascular tone. Pediatr Res 1994; 35: 664-670. (Pubitemid 24151428)
11. Zeigler JW, Ivy DD, Kinsella JP, Abman SH: The role of nitric oxide, endothelin, and prostaglandins in the transition of the pulmonary circulation. Clin Perinatol 1995; 22: 387-403.
12. Dollberg S, Warner BW, Myatt L: Urinary nitrite and nitrite concentrations in patients with idiopathic persistent pulmonary hypertension of the newborn and effect of extracorporeal membrane oxygenation. Pediatr Res 1995; 37: 31-34.
13. Christou H, Adatia I, Van Marter LJ, Kane JW, Thompson JE, Stark AR, Wessel DL, Kourembanas S: Effect of inhaled nitric oxide on endothelin-1 and cyclic guanosine 5′monophosphate plasma concentration in newborn infants with persistent pulmonary hypertension. J Pediatr 1997; 130: 603-611. (Pubitemid 27492652)
14. Villanueva ME, Zaher FM, Svinarich DM, Konduri GG: Decreased gene expression of endothelial nitric oxide synthase in newborns with persistent pulmonary hypertension. Pediatr Res 1998; 44: 338-343. (Pubitemid 28389988)
15. Soukka H, Vinikka L, Kääpä P: Involvement of thromboxane A2 and prostacyclin in the early pulmonary hypertension after porcine meconium aspiration. Pediatr Res 1998; 44: 838-842. (Pubitemid 28543967)
16. Endo A, Ayusawa M, Minato M, Takada M, Takahashi S, Harada K: Endogenous nitric oxide and endothelin-1 in persistent pulmonary hypertension of the newborn. Eur J Pediatr 2001; 160: 217-222. (Pubitemid 32250001)
17. Ogihara T, Hirano K, Morinobu T, Ogawa S, Hiroi M, Ban R, Ogihara H, Tamai H: KL-6, a mucinous glycoprotein, as an indicator of chronic lung disease of the newborn. J Pediatr 2000; 137: 280-282. (Pubitemid 30659244)
18. Kurotobi S, Maekawa S, Hara T, Hamana K, Inada N, Kawakami N, Honda A, Matsuoka T, Fujita H, Nagai T: Serum KL-6 level in newborns with meconium aspiration syndrome. Pediatr Int 2003; 45: 517-521. (Pubitemid 37430750)
19. Ogihara T, Hirano K, Morinobu T, Kim HS, Ogawa S, Hiroi M, Oue S, Ban R, Hira S, Hasegawa M, Yamaoka S, Yasui M: Plasma KL-6 predicts the development and outcome of bronchopulmonary dysplasia. Pediatr Res 2006; 60: 613-618. (Pubitemid 44627412)
20. Kohno N: Serum marker KL-6/MUC1 for the diagnosis and management of interstitial pneumonitis. J Med Invest 1999; 46: 151-158. (Pubitemid 129622186)
21. Portman MA, Bhat AM, Cohen MH, Jacobstein MD: Left ventricular systolic circular index: an echocardiographic measure of transseptal pressure ratio. Am Heart J 1987; 114: 1178-1182. (Pubitemid 18049048)
22. Kohno N, Akiyama M, Kyoizumi S, Hakoda M, Kobuke K, Yamakido M: Detection of soluble tumor-associated antigens in sera and effusions using novel monoclonal antibodies, KL-3 and KL-6, against lung adenocarcinoma. Jpn J Clin Oncol 1988; 18: 203-216.
23. Steinhorn RH: Nitric oxide and beyond: new insights and therapies for pulmonary hypertension. J Perinatol 2008; 28:S67-S71.
24. Abman SH: Recent advances in the pathogenesis and treatment of persistent pulmonary hypertension of the newborn. Neonatology 2007; 91: 283-290. (Pubitemid 46934213)
25. Hooper WC, Mensah GA, Haworth SG, Black SM, Garcia JG, Langleben D: Vascular endothelium summary statement. V. Pulmonary hypertension and acute lung injury: public health implications. Vascul Pharmacol 2007; 46: 315-317.
26. Black SM, Sanchez LS, Mata-Greenwood E, Bekker JM, Steinhorn RH, Fineman JR: sGC and PDE5 are elevated in lambs with increased pulmonary blood flow and pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol 2001; 281:L1051-L1057.
27. Steinhorn RH, Russell JA, Lakshminrusimha S, Gugino SF, Black SM, Fineman JR: Altered endothelium-dependent relaxations in lambs with high pulmonary blood flow and pulmonary hypertension. Am J Physiol Heart Circ Physiol 2001; 280:H311-H317.
28. Thébaud B, Petit T, De Lagausie P, Dall'Ava-Santucci J, Mercier JC, Dinh-Xuan AT: Altered guanylyl-cyclase activity in vitro of pulmonary arteries from fetal lambs with congenital diaphragmatic hernia. Am J Respir Cell Mol Biol 2002; 27: 42-47. (Pubitemid 34657389)
29. Baber SR, Li H, Simakajornboon N, Kadowitz PJ, Ross-Ascuitto NT, Ascuitto RJ: Analysis of pulmonary vascular response to acute alveolar hypoxic challenge in young rabbits subjected to chronic hypoxia from birth. J Cardiovasc Pharmacol 2005; 45: 431-438. (Pubitemid 40627962)
30. Komai H, Naito Y, Aimi Y, Kimura H: Nitric oxide synthase expression in lungs of pulmonary hypertensive patients with heart disease. Cardiovasc Pathol 2001; 10: 29-32. (Pubitemid 32409987)
31. Yigit S, Tekinalp G, Oran O, Yurdakok M, Aliefendioglu D, Gurgey A: Endothelin 1 concentrations in infants with meconium stained amniotic fluid. Arch Dis Child Fetal Neonatal 2002; 87:F212-F213. (Pubitemid 35252938)