Occult hepatitis B: Clinical implications and treatment decisions

Digestive Diseases and Sciences

Volumn 55, Issue 12, 2010, Pages 3328-3335

  Schmeltzer, Paul ^a   Sherman, Kenneth E ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

Chronic hepatitis B; HBs antigenemia; HBV DNA; Occult HBV

Indexed keywords

ADEFOVIR; ENTECAVIR; HEPATITIS B SURFACE ANTIGEN; LAMIVUDINE; TENOFOVIR; VIRUS DNA;

BLOOD TRANSFUSION; CANCER CHEMOTHERAPY; DECISION MAKING; DNA DETERMINATION; GENE MUTATION; HEMATOLOGIC MALIGNANCY; HEPATITIS B; HEPATITIS B VIRUS; HEPATITIS C; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; MORBIDITY; OCCULT HEPATITIS B; ORGAN TRANSPLANTATION; PRIORITY JOURNAL; REVIEW; VIRUS GENOME; VIRUS INTERFERENCE; VIRUS LOAD; VIRUS REACTIVATION; VIRUS TRANSMISSION;

CARCINOMA, HEPATOCELLULAR; COMORBIDITY; DECISION MAKING; DNA, VIRAL; GENE EXPRESSION REGULATION, NEOPLASTIC; HEPATITIS B; HEPATITIS B SURFACE ANTIGENS; HEPATITIS B VIRUS; HEPATITIS C, CHRONIC; HUMANS; IMMUNOCOMPROMISED HOST; LIVER NEOPLASMS; VIRAL LOAD; VIRUS REPLICATION;

EID: 78649321215     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10620-010-1413-0     Document Type: Review

References (38)

1. PM Mulrooney-Cousins TI Michalak 2007 Persistent occult hepatitis B virus infection: Experimental findings and clinical implications World J Gastroenterol 13 43 5682 5686 17963292
2. JP Allain 2004 Occult hepatitis B virus infection Transfus Clin Biol 11 18 25 10.1016/j.tracli.2003.11.007 14980545
3. JH Hoofnagle LB Seef ZB Bales HJ Zimmerman 1978 The type B hepatitis after transfusion with blood containing antibody to hepatitis B core antigen N Engl J Med 298 1379 1383 1:STN:280:DyaE1c7nslSquw%3D%3D 10.1056/ NEJM197806222982502 652005
4. V Thiers E Nakajima D Kremsdorf, et al. 1988 Transmission of hepatitis B from hepatitis-B-seronegative subjects Lancet 2 1273 1276 1:STN:280: DyaL1M%2Fls1CrsA%3D%3D 10.1016/S0140-6736(88)92891-7 2904005
5. I Cacciola T Pollicino G Squadrito, et al. 1999 Occult hepatitis B virus infection in patients with chronic hepatitis C liver disease N Engl J Med 341 22 26 1:STN:280:DyaK1M3psVeltA%3D%3D 10.1056/NEJM199907013410104 10387938
6. M Hofer H Joller-Jemelka P Grob, et al. 1998 Frequent chronic hepatitis B virus infection in HIV-infected patients positive for antibody to hepatitis B core antigen only Eur J Clin Microbiol Infect Dis 17 6 13 1:STN:280: DyaK1c7ntFWhtQ%3D%3D 10.1007/BF01584356 9512175
7. N Shire S Rouster SD Stanford, et al. 2007 The prevalence and significance of occult hepatitis B virus in a prospective cohort of HIV-infected patients J Acquir Immune Defic Syndr 44 309 314 10.1097/QAI.0b013e31802e29a9 17159656
8. S Gupta S Singh 2010 Occult hepatitis B virus infection in ART-Naïve HIV-infected patients seen at a tertiary care centre in North India BMC Infect Dis 10 1 7 10.1186/1471-2334-10-53
9. MC Chevrier M St.-Louis J Perreault, et al. 2007 Detection and characterization of hepatitis B virus of anti-hepatitis core antigen-reactive blood donors in Quebec with an in-house nucleic acid testing assay Transfusion 47 1794 1802 1:CAS:528:DC%2BD2sXht1elsrvO 10.1111/j.1537-2995.2007.01394.x 17880603
10. G Raimondo G Navarra S Mondello, et al. 2008 Occult hepatitis B in liver tissue of individuals without hepatic disease J Hepatol 48 743 746 10.1016/j.jhep.2008.01.023 18314221
11. P Vivekanandan R Kannangai SC Ray, et al. 2008 Comprehensive genetic and epigenetic analysis of occult hepatitis B from liver tissue samples Clin Infect Dis 46 1227 1236 10.1086/529437 18444860
12. K Weinberger T Bauer S Bohm, et al. 2000 High genetic variability of the group specific a-determinant of hepatitis B virus surface antigen (HBsAg) and the corresponding fragment of the viral polymerase in chronic virus carriers lacking detectable HBsAg in serum J General Virol 81 1165 1174 1:CAS:528:DC%2BD3cXjtFWlu7g%3D
13. H Yotsuyanagi K Yasuda S Iino, et al. 1998 Persistent Viremia after recovery from self-limited acute hepatitis B Hepatology 27 1377 1382 1:STN:280:DyaK1c3ktVyhtA%3D%3D 10.1002/hep.510270526 9581694
14. CM Shih SJ Lo T Miyamura, et al. 1993 Suppression of hepatitis B virus expression and replication by hepatitis C virus core protein in HuH-7 cells J Virol 67 5823 5832 1:CAS:528:DyaK3sXms1OrtLg%3D 8396658
15. CJ Liu WL Chuang CM Lee, et al. 2009 Peginterferon Alfa-2a plus ribavirin for the treatment of dual chronic infection with hepatitis B and C viruses Gastroenterology 136 496 504 1:CAS:528:DC%2BD1MXislOhtLg%3D 10.1053/j.gastro. 2008.10.049 19084016
16. V Bruss K Vieluf 1995 Functions of the internal pre-S domain of the large surface protein in hepatitis B virus particle morphogenesis J Virol 69 6652 6657 1:CAS:528:DyaK2MXoslWktro%3D 7474074
17. I Chemin F Zoulim P Merle, et al. 2001 High incidence of hepatitis B infections among chronic hepatitis cases of unknown aetiology J Hepatol 34 447 454 1:STN:280:DC%2BD3M3jtVCmtA%3D%3D 10.1016/S0168-8278(00)00100-8 11322208
18. C Berasain M Betes A Panizo, et al. 2000 Pathological and virological findings in patients with persistent hypertransaminasaemia of unknown aetiology Gut 47 429 435 1:STN:280:DC%2BD3cvjs1Ghsw%3D%3D 10.1136/gut.47.3.429 10940283
19. L Kazemi-Shirazi D Petermann C Muller 2000 Hepatitis B virus DNA in sera and liver tissue of HbsAg negative patients with chronic hepatitis C J Hepatol 33 785 790 1:STN:280:DC%2BD3Mzgtlertw%3D%3D 10.1016/S0168-8278(00)80311-6 11097488
20. N De Maria A Colantoni L Friedlander, et al. 2000 The impact of previous HBV infection on the course of chronic hepatitis C Am J Gastroenterol 95 3529 3536 10.1111/j.1572-0241.2000.03371.x 11151889
21. R Fukuda N Ishimura S Hamamoto, et al. 2001 Co-infection by serologically-silent hepatitis B virus may contribute to poor interferon response in patients with chronic hepatitis C by down-regulation of type-I interferon receptor gene expression in the liver J Med Virol 63 220 227 1:CAS:528:DC%2BD3MXht1agtL0%3D 10.1002/1096-9071(200103)63:3<220::AID- JMV1004>3.0.CO;2-3 11170061
22. C Brechot 2004 Pathogenesis of hepatitis B virus-related hepatocellular carcinoma: Old and new paradigms Gastroenterology 127 S56 S61 1:CAS:528:DC%2BD2cXhtVGmtb7E 10.1053/j.gastro.2004.09.016 15508104
23. G Squadrito T Pollicino I Cacciola, et al. 2006 Occult hepatitis B virus infection is associated with the development of hepatocellular carcinoma in chronic hepatitis C patients Cancer 106 1326 1330 10.1002/cncr.21702 16453330
24. A Kusakabe Y Tanaka E Orito, et al. 2007 A weak association between occult HBV infection and non-B non-C hepatocellular carcinoma in Japan J Gasteroenterol 42 298 305 10.1007/s00535-006-1999-3
25. GB Schreiber MP Busch SH Kleinman, et al. 1996 The risk of transfusion-transmitted viral infections N Engl J Med 334 1685 1690 1:STN:280:DyaK283ktVGhug%3D%3D 10.1056/NEJM199606273342601 8637512
26. S Levicnik-Stezinar U Rahne-Potokar D Candotti, et al. 2008 Anti-HBs positive occult hepatitis B virus carrier blood infectious in two transfusion recipients J Hepatol 48 1022 1025 10.1016/j.jhep.2008.02.016 18436328
27. A Mas 2009 Liver transplantation for hepatitis B virus. Pre-emptive and peri-operative prophylaxis Dig Liver Dis 41S S191 S194 10.1016/S1590-8658(09) 60443-6
28. R Perrillo 2009 Hepatitis B virus prevention strategies for antibody to hepatitis B core antigen-positive liver donation: A survey of North American, European, and Asian-Pacific transplant programs Liver Transplantation 15 223 232 10.1002/lt.21675 19177436
29. V Ghisetti A Marzano F Zamboni, et al. 2004 Occult hepatitis B virus infection in HBsAg negative patients undergoing liver transplantation: Clinical significance Liver Transplant 10 356 362 10.1002/lt.20093
30. B Roche D Samuel M Gigou, et al. 1997 De novo and apparent de novo hepatitis B virus infection after liver transplantation J Hepatol 26 517 526 1:STN:280:DyaK2s3jtVSrsg%3D%3D 10.1016/S0168-8278(97)80416-3 9075658
31. RM Galbraith AL Eddleston R Williams, et al. 1975 Fulminant hepatic failure in leukaemia and choriocarcinoma related to withdrawal of cytotoxic drug therapy Lancet 2 528 530 1:STN:280:DyaE28%2FgvFKjtw%3D%3D 10.1016/S0140- 6736(75)90897-1 51345
32. G Lalazar D Rund D Shouval, et al. 2007 Screening, prevention and treatment of viral hepatitis B reactivation in patients with haematological malignancies Br J Hematol 136 699 712 1:CAS:528:DC%2BD2sXjvFWmtb0%3D 10.1111/j.1365-2141.2006.06465.x
33. C Hsu CA Hsiung I Su, et al. 2008 A revisit of prophylactic Lamivudine for chemotherapy-associated hepatitis B reactivation in Non-Hodgkin's lymphoma: A randomized trial Hepatology 47 844 853 1:CAS:528:DC%2BD1cXktVOiu7Y%3D 10.1002/hep.22106 18302293
34. C Hui W Cheung H Zhang, et al. 2006 Kinetics and risk of de novo hepatitis B infection in HBsAg-negative patients undergoing cytotoxic chemotherapy Gastroenterology 131 59 68 1:CAS:528:DC%2BD28XnvF2gsL0%3D 10.1053/j.gastro.2006.04.015 16831590
35. Meeting report. The management of chronic hepatitis B in the immunocompromised patient: Recommendations from a single topic meeting. J Clin Virol. 2008;41:243-254.
36. E Keefe D Dieterich S Han, et al. 2008 A treatment algorithm for the management of chronic hepatitis B virus infection in the United States: 2008 update Clinical Gastroenterology and Hepatology 6 1315 1341 10.1016/j.cgh.2008. 08.021
37. M Lai BJ Hyatt I Nasser, et al. 2007 The clinical significance of persistently normal ALT in chronic hepatitis B infection J Hepatol 47 760 767 1:CAS:528:DC%2BD2sXht12ns7bI 10.1016/j.jhep.2007.07.022 17928090
38. J Fung C-L Lai D But, et al. 2008 Prevalence of fibrosis and cirrhosis in chronic hepatitis B: Implications for treatment and management Am J Gastroenterol 103 1421 1426 10.1111/j.1572-0241.2007.01751.x 18422821