Screening RAD51C nucleotide alterations in patients with a family history of breast and ovarian cancer

Breast Cancer Research and Treatment

Volumn 124, Issue 3, 2010, Pages 857-861

  Zheng, Yonglan ^a   Zhang, Jing ^a   Hope, Kisha ^a   Niu, Qun ^a   Huo, Dezheng ^a   Olopade, Olufunmilayo I ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

BRCA1 2 negative; Breast and ovarian cancer; Gene fusion; Germline mutation; RAD51C

Indexed keywords

BRCA1 PROTEIN; BRCA2 PROTEIN; DNA;

ARTICLE; BREAST CANCER; BREAST CARCINOGENESIS; CANCER CELL CULTURE; CHROMOSOME STRUCTURE; CONTROLLED STUDY; DNA SEQUENCE; FAMILY HISTORY; FEMALE; GENE FUSION; GENE MUTATION; GENETIC SCREENING; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; NUCLEOTIDE SEQUENCE; OVARY CANCER; PEDIGREE; PRIORITY JOURNAL; RAD51C GENE; TUMOR GENE;

ADULT; BREAST NEOPLASMS; CELL LINE, TUMOR; CHICAGO; DNA MUTATIONAL ANALYSIS; DNA-BINDING PROTEINS; FEMALE; GENE FUSION; GENETIC PREDISPOSITION TO DISEASE; GENETIC TESTING; HEREDITY; HUMANS; MASS SCREENING; MIDDLE AGED; MUTATION; NERVE TISSUE PROTEINS; OVARIAN NEOPLASMS; PEDIGREE;

EID: 78649319824     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-010-1095-5     Document Type: Article

References (19)

1. JD Fackenthal OI Olopade 2007 Breast cancer risk associated with brca1 and brca2 in diverse populations Nat Rev Cancer 7 12 937 948 10.1038/nrc2054 1:CAS:528:DC%2BD2sXhtlCrsLbK 10.1038/nrc2054 18034184 (Pubitemid 350165853)
2. HM Sowter A Ashworth 2005 Brca1 and brca2 as ovarian cancer susceptibility genes Carcinogenesis 26 10 1651 1656 10.1093/carcin/bgi136 1:CAS:528:DC%2BD2MXhtVWnt7bE 10.1093/carcin/bgi136 15917310 (Pubitemid 41487980)
3. S Reid D Schindler H Hanenberg K Barker S Hanks R Kalb K Neveling P Kelly S Seal M Freund M Wurm SD Batish FP Lach S Yetgin H Neitzel H Ariffin M Tischkowitz CG Mathew AD Auerbach N Rahman 2007 Biallelic mutations in palb2 cause Fanconi anemia subtype fa-n and predispose to childhood cancer Nat Genet 39 2 162 164 10.1038/ng1947 1:CAS:528:DC%2BD2sXpvFersA%3D%3D 10.1038/ng1947 17200671 (Pubitemid 46184345)
4. B Xia JC Dorsman N Ameziane Y de Vries MA Rooimans Q Sheng G Pals A Errami E Gluckman J Llera W Wang DM Livingston H Joenje JP de Winter 2007 Fanconi anemia is associated with a defect in the brca2 partner palb2 Nat Genet 39 2 159 161 10.1038/ng1942 1:CAS:528:DC%2BD2sXpvFekug%3D%3D 10.1038/ng1942 17200672 (Pubitemid 46184344)
5. F Vaz H Hanenberg B Schuster K Barker C Wiek V Erven K Neveling D Endt I Kesterton F Autore F Fraternali M Freund L Hartmann D Grimwade RG Roberts H Schaal S Mohammed N Rahman D Schindler CG Mathew 2010 Mutation of the rad51c gene in a Fanconi anemia-like disorder Nat Genet 42 5 406 409 10.1038/ng.570 1:CAS:528:DC%2BC3cXkvVCjt7k%3D 10.1038/ng.570 20400963
6. A Meindl H Hellebrand C Wiek V Erven B Wappenschmidt D Niederacher M Freund P Lichtner L Hartmann H Schaal J Ramser E Honisch C Kubisch HE Wichmann K Kast H Deissler C Engel B Muller-Myhsok K Neveling M Kiechle CG Mathew D Schindler RK Schmutzler H Hanenberg 2010 Germline mutations in breast and ovarian cancer pedigrees establish rad51c as a human cancer susceptibility gene Nat Genet 42 5 410 414 10.1038/ng.569 1:CAS:528:DC%2BC3cXkvVCjtbo%3D 10.1038/ng.569 20400964
7. OA Hampton P Den Hollander CA Miller DA Delgado J Li C Coarfa RA Harris S Richards SE Scherer DM Muzny RA Gibbs AV Lee A Milosavljevic 2009 A sequence-level map of chromosomal breakpoints in the mcf-7 breast cancer cell line yields insights into the evolution of a cancer genome Genome Res 19 2 167 177 10.1101/gr.080259.108 1:CAS:528:DC%2BD1MXhvVSjurg%3D 10.1101/gr.080259.108 19056696
8. AD D'Andrea 2010 Susceptibility pathways in Fanconi's anemia and breast cancer N Engl J Med 362 20 1909 1919 10.1056/NEJMra0809889 10.1056/NEJMra0809889 20484397
9. H Joenje KJ Patel 2001 The emerging genetic and molecular basis of Fanconi anemia Nat Rev Genet 2 6 446 457 10.1038/3507659035076590 1:CAS:528:DC%2BD3MXktlKqu78%3D 10.1038/35076590 11389461
10. W Wang 2007 Emergence of a DNA-damage response network consisting of Fanconi anemia and brca proteins Nat Rev Genet 8 10 735 748 10.1038/nrg2159 1:CAS:528:DC%2BD2sXhtVCrsb3J 10.1038/nrg2159 17768402 (Pubitemid 47429206)
11. GL Moldovan AD D'Andrea 2009 How the Fanconi anemia pathway guards the genome Annu Rev Genet 43 223 249 10.1146/annurev-genet-102108-134222 1:CAS:528:DC%2BD1MXhsF2qtrnO 10.1146/annurev-genet-102108-134222 19686080
12. M Berwick JM Satagopan L Ben-Porat A Carlson K Mah R Henry R Diotti K Milton K Pujara T Landers S Dev Batish J Morales D Schindler H Hanenberg R Hromas O Levran AD Auerbach 2007 Genetic heterogeneity among Fanconi anemia heterozygotes and risk of cancer Cancer Res 67 19 9591 9596 10.1158/0008-5472. CAN-07-1501 1:CAS:528:DC%2BD2sXhtFSnurjE 10.1158/0008-5472.CAN-07-1501 17909071 (Pubitemid 47535951)
13. M Barlund O Monni J Kononen R Cornelison J Torhorst G Sauter O-P Kallioniemi A Kallioniemi 2000 Multiple genes at 17q23 undergo amplification and overexpression in breast cancer Cancer Res 60 19 5340 5344 1:CAS:528: DC%2BD3cXns1ehsLw%3D 11034067
14. GJ Wu CS Sinclair J Paape JN Ingle PC Roche CD James FJ Couch 2000 17q23 amplifications in breast cancer involve the pat1, rad51c, ps6k, and sigma1b genes Cancer Res 60 19 5371 5375 1:CAS:528:DC%2BD3cXns1ehsLY%3D 11034073
15. CA French JY Masson CS Griffin P O'Regan SC West J Thacker 2002 Role of mammalian rad51l2 (rad51c) in recombination and genetic stability J Biol Chem 277 22 19322 19330 10.1074/jbc.M201402200M201402200 1:CAS:528: DC%2BD38XksVWltLo%3D 10.1074/jbc.M201402200 11912211
16. J Thacker 2005 The rad51 gene family, genetic instability and cancer Cancer Lett 219 2 125 135 10.1016/j.canlet.2004.08.018 1:CAS:528: DC%2BD2MXhsVOgu7w%3D 10.1016/j.canlet.2004.08.018 15723711 (Pubitemid 40269475)
17. SK Sharan SG Kuznetsov 2007 Resolving rad51c function in late stages of homologous recombination Cell Div 2 15 10.1186/1747-1028-2-15 10.1186/1747-1028-2-15 17547768 (Pubitemid 46939548)
18. S Badie C Liao M Thanasoula P Barber MA Hill M Tarsounas 2009 Rad51c facilitates checkpoint signaling by promoting chk2 phosphorylation J Cell Biol 185 4 587 600 10.1083/jcb.200811079 1:CAS:528:DC%2BD1MXmtlGru74%3D 10.1083/jcb.200811079 19451272
19. G Smeenk AJ de Groot RJ Romeijn PP van Buul MZ Zdzienicka LH Mullenders A Pastink BC Godthelp 2010 Rad51c is essential for embryonic development and haploinsufficiency causes increased DNA damage sensitivity and genomic instability Mutat Res 689 1-2 50 58 10.1016/j.mrfmmm.2010.05.001 1:CAS:528:DC%2BC3cXotVSrt7Y%3D 20471405