Torsades de pointes tachycardia induced by common cold compound medication containing chlorpheniramine

European Journal of Clinical Pharmacology

Volumn 66, Issue 11, 2010, Pages 1173-1175

  Nia, Amir M ^a   Fuhr, Uwe ^a   Gassanov, Natig ^a   Erdmann, Erland ^a   Er, Fikret ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASCORBIC ACID; ASPARTATE AMINOTRANSFERASE; CAFFEINE; CHLORPHENIRAMINE; MAGNESIUM; PARACETAMOL;

ADULT; CASE REPORT; COMMON COLD; ELECTROCARDIOGRAM; FEMALE; HUMAN; LETTER; LONG QT SYNDROME; PRIORITY JOURNAL; QT INTERVAL; RESUSCITATION; SELF MEDICATION; TACHYCARDIA; TORSADE DES POINTES;

ADULT; CARDIOPULMONARY RESUSCITATION; CHLORPHENIRAMINE; ELECTROCARDIOGRAPHY; FEMALE; HEART CONDUCTION SYSTEM; HISTAMINE H1 ANTAGONISTS; HUMANS; NONPRESCRIPTION DRUGS; TORSADES DE POINTES;

EID: 78649315824     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00228-010-0875-5     Document Type: Letter

References (19)

1. MM Rumore 1984 Clinical pharmacokinetics of chlorpheniramine Drug Intell Clin Pharm 18 701 707 1:STN:280:DyaL2M%2FgtlWluw%3D%3D 6383755
2. SU Yasuda P Zannikos AE Young KM Fried IW Wainer RL Woosley 2002 The roles of CYP2D6 and stereoselectivity in the clinical pharmacokinetics of chlorpheniramine Br J Clin Pharmacol 53 519 525 1:CAS:528:DC%2BD38Xks1Omsrw%3D 10.1046/j.1365-2125.2002.01578.x 11994058 (Pubitemid 34526504)
3. DM Paton DR Webster 1985 Clinical pharmacokinetics of H1-receptor antagonists (the antihistamines) Clin Pharmacokinet 10 477 497 1:CAS:528:DyaL2MXmtVGgsLg%3D 10.2165/00003088-198510060-00002 2866055
4. SM Huang NK Athanikar K Sridhar YC Huang WL Chiou 1982 Pharmacokinetics of chlorpheniramine after intravenous and oral administration in normal adults Eur J Clin Pharmacol 22 359 365 1:CAS:528:DyaL38XltVersrk%3D 10.1007/BF00548406 7106172 (Pubitemid 12085325)
5. HK Hong SH Jo 2009 Block of HERG k channel by classic histamine h(1) receptor antagonist chlorpheniramine Korean J Physiol Pharmacol 13 215 220 1:CAS:528:DC%2BD1MXpt1ehs7c%3D 10.4196/kjpp.2009.13.3.215 19885040
6. JJ Salata NK Jurkiewicz AA Wallace RF Stupienski 3rd PJ Guinosso Jr JJ Lynch Jr 1995 Cardiac electrophysiological actions of the histamine H1-receptor antagonists astemizole and terfenadine compared with chlorpheniramine and pyrilamine Circ Res 76 110 119 1:CAS:528:DyaK2MXkt1Sjsbs%3D 8001268
7. M Taglialatela P Castaldo A Pannaccione G Giorgio A Genovese G Marone L Annunziato 1999 Cardiac ion channels and antihistamines: possible mechanisms of cardiotoxicity Clin Exp Allergy 29 Suppl 3 182 189 1:CAS:528:DyaK1MXltVOgu7c%3D 10.1046/j.1365-2222.1999.0290s3182.x 10444235
8. M Taglialatela H Timmerman L Annunziato 2000 Cardiotoxic potential and CNS effects of first-generation antihistamines Trends Pharmacol Sci 21 52 56 1:CAS:528:DC%2BD3cXht1KrsL4%3D 10.1016/S0165-6147(99)01437-6 10664607 (Pubitemid 30100339)
9. WX Wang SN Ebert XK Liu YW Chen MD Drici RL Woosley 1998 "Conventional" antihistamines slow cardiac repolarization in isolated perfused (Langendorff) feline hearts J Cardiovasc Pharmacol 32 123 128 1:CAS:528:DyaK1cXkt12itbw%3D 10.1097/00005344-199807000-00019 9676731 (Pubitemid 28304704)
10. M Khalifa B Drolet P Daleau C Lefez M Gilbert S Plante GE O'Hara O Gleeton BA Hamelin J Turgeon 1999 Block of potassium currents in guinea pig ventricular myocytes and lengthening of cardiac repolarization in man by the histamine H1 receptor antagonist diphenhydramine J Pharmacol Exp Ther 288 858 865 1:CAS:528:DyaK1MXpvFOksA%3D%3D 9918600
11. G Chouinard AM Ghadirian BD Jones 1978 Death attributed to ventricular arrhythmia induced by thioridazine in combination with a single Contac C capsule Can Med Assoc J 119 729 731 1:STN:280:DyaE1M%2FktlCjtA%3D%3D 709472
12. B Drolet F Vincent J Rail M Chahine D Deschenes S Nadeau M Khalifa BA Hamelin J Turgeon 1999 Thioridazine lengthens repolarization of cardiac ventricular myocytes by blocking the delayed rectifier potassium current J Pharmacol Exp Ther 288 1261 1268 1:CAS:528:DyaK1MXhs1Kis7s%3D 10027867 (Pubitemid 29254167)
13. JG Shin N Soukhova DA Flockhart 1999 Effect of antipsychotic drugs on human liver cytochrome P-450 (CYP) isoforms in vitro: preferential inhibition of CYP2D6 Drug Metab Dispos 27 1078 1084 1:CAS:528:DyaK1MXlslCqs74%3D 10460810
14. C von Bahr G Movin C Nordin A Liden M Hammarlund-Udenaes A Hedberg H Ring F Sjoqvist 1991 Plasma levels of thioridazine and metabolites are influenced by the debrisoquin hydroxylation phenotype Clin Pharmacol Ther 49 234 240 10.1038/clpt.1991.22
15. CM Pripp P Blomstrom 1994 Epiglottitis and torsade de pointes tachycardia Br Heart J 72 205 208 1:STN:280:DyaK2M%2FgtFWhsQ%3D%3D 10.1136/hrt.72.2.205 7917701
16. J Silva Marques A Veiga J Nobrega MJ Correia J de Sousa 2010 Electrical storm induced by H1N1 A influenza infection Europace 12 294 295 10.1093/europace/eup430 20045863
17. N Reinsch C Buhr P Krings H Kaelsch K Neuhaus H Wieneke R Erbel T Neumann 2009 Prevalence and risk factors of prolonged QTc interval in HIV-infected patients: results of the HIV-HEART study HIV Clin Trials 10 261 268 10.1310/hct1004-261 19723613
18. TM Craft 1986 Torsade de pointes after astemizole overdose Br Med J (Clin Res Ed) 292 660 1:STN:280:DyaL287jt1GlsQ%3D%3D 10.1136/bmj.292.6521.660
19. BP Monahan CL Ferguson ES Killeavy BK Lloyd J Troy LR Cantilena Jr 1990 Torsades de pointes occurring in association with terfenadine use JAMA 264 2788 2790 1:STN:280:DyaK3M%2FjvFOktg%3D%3D 10.1001/jama.264.21.2788 1977935