Non-antibiotics reverse resistance of bacteria to antibiotics

In Vivo

Volumn 24, Issue 5, 2010, Pages 751-754

  Kristiansen, J E ^a   Thomsen, V F ^b   Martins, Ana ^c   Viveiros, M ^c   Amaral, Leonard ^c  

^a UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^b International Society of Antimicrobial Activity of Non antibiotics (ISN)   (Denmark)

^c INSTITUTO DE HIGIENE E MEDICINA TROPICAL   (Portugal)

Author keywords

Antibiotics; Bacteria; Non antibiotics; Reversal of resistance

Indexed keywords

AMITRIPTYLINE; AMPICILLIN; CEFUROXIME; CHLORPROMAZINE; CHLORPROTHIXENE; METICILLIN; PENICILLIN G; TOBRAMYCIN;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; CONTROLLED STUDY; CORYNEBACTERIUM; DRUG EFFECT; DRUG MECHANISM; KLEBSIELLA PNEUMONIAE; MINIMUM INHIBITORY CONCENTRATION; MULTIDRUG RESISTANCE; NONHUMAN; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIA;

EID: 78649314198     PISSN: 0258851X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Pagès JM and Amaral L: Mechanisms of drug efflux and strategies to combat themxhallenging the efflux pump of Gram-negative bacteria. Biochim Biophys Acta 1794: 826-833, 2009.
2. Blair JM and Piddock LJ: Structure, function and inhibition of RND efflux pumps in Gram-negative bacteria: an update. Curr Opin Microbiol 12: 512-519, 2009.
3. Li XZ and Nikaido H: Efflux-mediated drug resistance in bacteria: an update. Drugs 69: 1555-1623, 2009.
4. Couto I, Costa SS, Viveiros M, Martins M and Amaral L: Efflux-mediated response of Staphylococcus aureus exposed to ethidium bromide. J Antimicrob Chemother 62: 504-513, 2008.
5. Kristiansen JE: Chlorpromazine: non-antibiotics with antimicrobial activity - new insights in managing resistance? Curr Opin Invest Drugs 2: 587-591, 1993.
6. Kristiansen JE: Antimicrobial activity of psychotherapeutic drugs and stereo-isomeric analogues. Dan Med Bull 37: 165-182, 1990.
7. Kaatz GW, Moudgal V, Seo SM and Kristiansen JE: Phenothiazines and thioxanthenes inhibit multidrug efflux pump activity in Staphylococcus aureus. Antimicrob Agents Chemother 47: 719-726, 2003.
8. Kristiansen JE, Hendricks O, Delvin T, Butterworth TS, Aagaard L, Christensen JB, Flores VC and Keyzer H: Reversal of resistance in microorganisms by help of non-antibiotics. J Antimicrob Chemother 59: 1271-1279, 2007.
9. Van Bambeke F, Pagès JM and Lee VJ: Inhibitors of bacterial efflux pumps as adjuvants in antibiotic treatments and diagnostic tools for detection of resistance by efflux. Recent Pat Antiinfect Drug Discov 1: 157-175, 2006.
10. Martins A, Iversen C, Rodrigues L, Spengler G, Ramos J, Kern WV, Couto I, Viveiros M, Fanning S, Pages JM and Amaral L: An AcrAB-mediated multidrug-resistant phenotype is maintained following restoration of wild-type activities by efflux pump genes and their regulators. Int J Antimicrob Agents 34: 602-604, 2009.
11. Martins M, Dastidar SG, Fanning S, Kristiansen JE, Molnar J, Pagès JM, Schelz Z, Spengler G, Viveiros M and Amaral L: Potential role of non-antibiotics (helper compounds) in the treatment of multidrug-resistant Gram-negative infections: mechanisms for their direct and indirect activities. Int J Antimicrob Agents 31: 198-208, 2008.
12. Martins M, Viveiros M, Couto I and Amaral L: Targeting human macrophages for enhanced killing of intracellular XDR-TB and MDR-TB. Int J Tuberc Lung Dis 13: 569-573, 2009.
13. Ordway D, Viveiros M, Leandro C, Arroz MJ and Amaral L: Intracellular activity of clinical concentrations of phenothiazines including thioridiazine against phagocytosed Staphylococcus aureus. Int J Antimicrob Agents 20: 34-43, 2002.
14. Martins M, Viveiros M, Kristiansen JE, Molnar J and Amaral L: The curative activity of thioridazine on mice infected with Mycobacterium tuberculosis. In Vivo 21: 771-775, 2007.
15. Dasgupta A, Mukherjee S, Chaki S, Dastidar SG, Hendricks O, Christensen JB, Kristiansen JE and Amaral L: Thioridazine protects the mouse from a virulent infection by Salmonella enterica serovar Typhimurium 74. Int J Antimicrob Agents 35: 174-176, 2010.
16. Amaral L, Boeree MJ, Gillespie SH, Udwadia ZF and van Soolingen D: Thioridazine cures extensively drug-resistant tuberculosis (XDR-TB) and the need for global trials is now! Int J Antimicrob Agents 35: 524-526, 2010.
17. Viveiros M, Jesus A, Brito M, Leandro C, Martins M, Ordway D, Molnar AM, Molnar J and Amaral L: Inducement and reversal of tetracycline resistance in Escherichia coli K-12 and expression of proton gradient-dependent multidrug efflux pump genes. Antimicrob Agents Chemother 49: 3578-3582, 2005.
18. Abbate E, Vescoso M, Natiello M, Cufre M, Garcia A, Ambroggi M, Poggi S, Simboli N and Ritacco V: Tuberculosis extensamente resistente (XDR-TB) en Argentina: aspectos destacbles epidemiologicos, bacteriologicos, terapeuticos y evolutivos. Revista Argentina de Medicina Respiratoria 1: 19-25, 2007.