Emergence of CTX-M Group 1-ESBL producing Klebsiella pneumonia from a tertiary care centre in Karachi, Pakistan

Journal of Infection in Developing Countries

Volumn 4, Issue 8, 2010, Pages 472-476

  Khan, Erum ^a   Schneiders, Thamarai ^b   Zafar, Afia ^a   Aziz, Erum ^a   Parekh, Asra ^a   Hasan, Rumina ^a  

^a AGA KHAN UNIVERSITY HOSPITAL   (Pakistan)

^b QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

Extended spectrum beta lactamases; Gram negative; Hospital acquired infections; Multidrug resistance; Non clonal isolates

Indexed keywords

AMIKACIN; AMOXICILLIN PLUS CLAVULANIC ACID; AMPICILLIN; AZTREONAM; BETA LACTAMASE CTX M; CIPROFLOXACIN; COTRIMOXAZOLE; EXTENDED SPECTRUM BETA LACTAMASE; GENTAMICIN; IMIPENEM; PIPERACILLIN PLUS TAZOBACTAM; TIGECYCLINE;

ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIUM ISOLATE; BLOOD CULTURE; CLONAL VARIATION; CONTROLLED STUDY; GENOTYPE; HUMAN; KLEBSIELLA PNEUMONIAE; NONHUMAN; PAKISTAN; PHENOTYPE; PULSED FIELD GEL ELECTROPHORESIS; PUS; TERTIARY HEALTH CARE; TISSUE CULTURE; TRACHEAL ASPIRATION PROCEDURE; URINALYSIS;

KLEBSIELLA PNEUMONIAE; NEGIBACTERIA;

EID: 78649305813     PISSN: 20366590     EISSN: 19722680     Source Type: Journal    
DOI: 10.3855/jidc.674     Document Type: Article

References (15)

1. Souli M, Galani I, Giamarellou H (2008) Emergence of extensively drug-resistant and pandrug-resistant Gram-negative bacilli in Europe. Euro Surveil 13: 1-4.
2. Nordmann P, Cuzon G, Naas T (2009) The real threat of Klebsiella pneumoniae carbapenemase-producing bacteria. Lancet Infect Dis 9: 228-236.
3. Jacoby GA and Silvia L (2005) Mechanisms of Disease: The new β lactamases. N Engl J Med 352: 380-391.
4. Patricia A. Bradford (2001) Extended spectrum β lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat. Clin Microbiol Rev 14: 933-951.
5. Shah AA, Hasan F, Ahmed S, Hameed A (2004) Prevalence of extended-spectrum β-lactamases in nosocomial and outpatients (ambulatory). Pak J Med Sci 19: 187-191.
6. Mirza SH, Salman M, Khurshid U, Wiqar AM (2006) CTX-M ESBL enzyme in Escherichia coli from urology patients in Rawalpindi, Pakistan. J Pak Med Assoc 56: 576-578.
7. Washington C Winn (2006) Stephen A, Janda W, Koneman E, Procop G, Schreckenberger P, Woods, editors. In Koneman's Color Atlas and Textbook of Diagnostic Microbiology, Enterobacteriaceae: Numeric Coding Systems, sixth ed. Lippincott Williams & Wilkins, p. 289.
8. Wikler MA, Cockerill FR, Bush K, Dudley MN, Eliopoulos GM, Hardy DJ, Hecht DW, Hindler JF, Patel J.B (2009) Performance standards for Antimicrobial susceptibility testing; Nineteenth informational supplement approved standard M100-S19. Wayne, Clinical and Laboratory Standards Institute 29: 1-181.
9. Woodford N, Fagan EJ, Ellington MJ (2006) Multiplex PCR for rapid detection of genes encoding CTX-M extended-spectrum β-lactamases. J Antimicrob Chemother 57: 154-155.
10. Mena A, Plasencia V, Garcia L, Hidalgo O, Ayestaran JI, Alberti S, Borrell N, Perez L.J, Oliver. A (2006) Characterization of a large outbreak by CTX-M-1-producing Klebsiella pneumoniae and mechanisms leading to in vivo carbapenem resistance development. J Clin Microbiol 44: 2831-2837.
11. Tenover FC, Arbeit RD, Goering RV (1997) How to select and interpret molecular strain typing methods for epidemiological studies of bacterial infections: A review for healthcare epidemiologists. Infection Control and Hospital Epidemiology 18: 426-239.
12. Yu WL, Chuang YC, Walther-Rasmussen J (2006) Extended-spectrum beta-lactamases in Taiwan: epidemiology, detection, treatment and infection control. J Microbiol Immunol Infect 39: 264-277.
13. Padmini SB, Raju BA, Mani KR (2008) Detection of Enterobacteriaceae producing CTX-M extended spectrum β-lactamases from a tertiary care hospital in south India. Indian J Med Microbiol 26: 163-166.
14. Niumsup PR, Tansawai U, Boonkerd N, Polwichai P, Dejsirilert S (2008) Dissemination of extended spectrum β lactamase producing Klebsiella pneumoniae and Escherichia coli in Thai Hospitals. J Infect Chemother 14: 404-408.
15. Bonnet R (2004). Growing group of extended-spectrum β-Lactamases: the CTX-M enzymes. Antimicrob Agents Chemother 48: 1-14.