Role of Met-542 as a guide for the conformational changes of Phe-601 that occur during the reaction of β-galactosidase [Escherichia coli

Biochemistry and Cell Biology

Volumn 88, Issue 5, 2010, Pages 861-869

  Dugdale, Megan L ^a   Dymianiw, Dayna L ^a   Minhas, Bhawanjot K ^a   D'Angelo, Igor ^b,c   Huber, Reuben E ^a  

^a UNIVERSITY OF CALGARY   (Canada)

^b CANADIAN LIGHT SOURCE INC   (Canada)

^c Zymeworks Inc   (Canada)

Author keywords

galactosidase; Active site loop; Conformation change; Methionine; Na+; Phenylalanine

Indexed keywords

ACTIVE SITE; CONFORMATION CHANGE; GALACTOSIDASES; METHIONINE; NA+; PHENYLALANINE;

AMINO ACIDS; BINDING ENERGY; ENZYME ACTIVITY; ENZYMES; ESCHERICHIA COLI; LIGANDS; RESTORATION;

ACTIVATION ENERGY;

ASPARAGINE; BETA GALACTOSIDASE; CARBONYL DERIVATIVE; CATION; LACTONE; LIGAND; METHIONINE; PHENYLALANINE; SODIUM ION;

ARTICLE; CONFORMATION; CONFORMATIONAL TRANSITION; ELECTRON; ENERGY; ENZYME MECHANISM; ESCHERICHIA COLI; NONHUMAN; POSITION; PROTEIN FUNCTION;

AMINO ACID SUBSTITUTION; BETA-GALACTOSIDASE; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI; KINETICS; METHIONINE; NITROPHENYLGALACTOSIDES; PHENYLALANINE; PROTEIN CONFORMATION;

ESCHERICHIA COLI;

EID: 78649261616     PISSN: 08298211     EISSN: 12086002     Source Type: Journal    
DOI: 10.1139/O10-009     Document Type: Article

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