An evaluation of evidence regarding application of silicone gel sheeting for the management of hypertrophic scars and keloids

Journal of Clinical and Aesthetic Dermatology

Volumn 3, Issue 11, 2010, Pages

  McCarty, Morgan ^a   Del Rosso, James Q ^a  

^a VALLEY HOSPITAL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; BLEOMYCIN; CONNECTIVE TISSUE GROWTH FACTOR; CORTICOSTEROID; HYDROCORTISONE; IMIQUIMOD; INTERLEUKIN 1; INTERLEUKIN 6; SILICONE GEL; TRANSFORMING GROWTH FACTOR; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2; TRIAMCINOLONE; VERAPAMIL;

ARTICLE; CLINICAL TRIAL; CRYOTHERAPY; CYTOKINE PRODUCTION; DERMATOLOGICAL PROCEDURES; EPITHELIZATION; HUMAN; HYPERTROPHIC SCAR; IMMUNOMODULATION; KELOID; NONHUMAN; PATHOPHYSIOLOGY; POSTOPERATIVE COMPLICATION; SILICONE GEL SHEETING; TREATMENT OUTCOME; WOUND HEALING;

EID: 78649253954     PISSN: 19412789     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Bolognia JL, Jorizzo JL, Rapini RP, et al, eds. Dermatology. 2nd edition. Spain: Mosby Elsevier; 2008.
2. Bayat A, Arscott G, Ollier WE, McGrouther DA, Ferguson MW. Keloid disease: clinical relevance of single versus multiple site scars. The British Association of Plastic Surgeons. 2005;58:28-37.
3. Marghoob A, Orlow S, Kopf A. Syndromes associated with melano-cytic nevi. J Am Acad Dermatol. 1993;29(3):373-388.
4. Siraganian PA, Rubinstein JH, Miller RW. Keloids and neoplasms in the Rubinstein-Taybi syndrome. Med Pediatr Oncol. 1989;17(6):485-491.
5. Burk CJ. Ehlers-Danlos syndrome type IV: keloidal plaques of the lower extremities, amniotic band limb deformity, and a new mutation. J Am Acad Dermatol. 2007;56(2 Suppl): S53-S54.
6. James WD, Berger TG, et al. Andrews' Diseases of the Skin: Clinical Dermatology. Philadelphia: Saunders Elsevier; 2006.
7. Chernoff WG, Cramer H, Su-Huang S. The efficacy of topical silicone gel elastomers in the treatment of hypertrophic scars, keloid scars, and post-laser exfoliation erythema. Aesthet Plast Surg. 2007;31: 495-500.
8. O'Brien L, Pandit A. Silicon gel sheeting for preventing and treating hypertrophic and keloid scars. Cochrane Database of Systematic Reviews. 2006;1.
9. Ackerman AB, Chongchitnant N, Sanchez J, et al, eds. Histologic Diagnosis of Inflammatory Skin Disorders. An Algorithmic Method Based on Pattern Analysis. 2nd ed. Baltimore: Williams & Wilkins; 1997.
10. Butler P, Ly D, Longaker M, et al. Use of organotypic coculture to study keloid biology. Am J Surg. 2008; 195:144.
11. Varga J, Pasche B. Transforming growth factor ' as a therapeutic target in systemic sclerosis. B Nat Rev Rheumatol. 2009;5;200-206.
12. Järveläinen H, Sainio A, Koulu M, Wight TN, Penttinen R. Extracellular matrix molecules: potential targets in pharmacotherapy. Pharmacol Rev. 2009;61:198-223.
13. Cutroneo KR, White SL, Phan SH, Ehrlich HP. Therapies for bleomycin induced lung fibrosis through regulation of TGF-beta1 induced collagen gene expression. J Cell Physiol. 2007;211:585-589.
14. Durani P, Bayat A. Levels of evidence for the treatment of keloid disease. J Plast Reconstr Aesthet Surg. 2008;61(1):4-17.
15. Mustoe T, Cooter R, Gold MH, et al. International clinical recommend-ations on scar management. Plast Reconstr Surg. 2002, 110:560-571.
16. Davison SP, Sobanko JE, Clemens MW. Use of a Collagen glyco-saminoglycan copolymer (Integra) in combination with adjuvant treat-ments for reconstruction of severe chest keloids. J Drugs Dermatol. 2010;9(5):542-548.
17. Reish R, Eriksson E. Scars: a review of emerging and currently available therapies. Plast Reconstr Surg. 2008;122:1068.
18. Butler P, Longaker M, Yang G. Current progress in keloid research and treatment. J Am Coll Surg. 2008;206:731
19. Berman B, Perez O, Konda S, et al. A review of the biologic effects, clinical efficacy, and safety of silicone elastomer sheeting for hypertrophic and keloid scar treatment and management. Dermatologic Surgery: Official Publication For American Society For Dermatologic Surgery. 2007;33(11):1291-1230.
20. McGrath M. Topical scar modification: help or hype? Aesthet Surg J. 2005;25:304-306.
21. Brissett A, Sherris D. Scar contractures, hypertrophic scars, and keloids. Facial Plast Surg. 2001;17: 263-272.
22. Borgognoni L. Biological effects of silicone gel sheeting. Wound Repair and Regeneration: Official Publication of The Wound Healing Society [And] The European Tissue Repair Society. 2002;10(2):118-121.
23. Chang CC, Kuo YF, Chiu MS, et al. Hydration, not silicone, modulates the effects of keratinocytes on fibroblasts. J Surg Res. 1995;59:705-711.
24. Suetake T, Sasai S, Zhen Y, Tagami H. Effects of silicone gel sheet on the stratum corneum hydration. Br J Plast Surg. 2000;53(6):503-507.
25. Mustoe T. Evolution of silicone therapy and mechanism of action in scar management. Aesthet Plast Surg. January 2008;32(1):82-92.
26. Kloeters O, Tandara A, Mustoe T. Hypertrophic scar model in the rabbit ear: a reproducible model for studying scar tissue behavior with new observations on silicone gel sheeting for scar reduction. Wound Rep Reg. 2007;15:S40-S45.
27. Ogawa R. The most current algorithms for the treatment and prevention of hypertrophic scars and keloids. Plast Reconstr Surg. 2010;125:557.
28. Perez OA, Viera MH, Patel JK, et al. A comparative study evaluating the tolerability and efficacy of two topical therapies for the treatment of keloids and hypertrophic scars. J Drugs Dermatol. 2010;9(5):514-518.