Safety of ultra-rush titration of sublingual immunotherapy in asthmatic children with tree-pollen allergy

Pediatric Allergy and Immunology

Volumn 21, Issue 8, 2010, Pages 1135-1138

  Mösges, Ralph ^a   Graute, Vera ^a   Christ, Hildegard ^a   Sieber, Hans Jochen ^b   Wahn, Ulrich ^c   Niggemann, Bodo ^d  

^a UNIVERSITY HOSPITAL OF COLOGNE   (Germany)

^b Stallergenes GmbH   (Germany)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^d German Red Cross Hospital   (Germany)

Author keywords

Allergic asthma; Birch pollen; Children; Sublingual immunotherapy; Ultra rush titration

Indexed keywords

POLLEN EXTRACT; STALORAL; UNCLASSIFIED DRUG;

ABSENCE OF SIDE EFFECTS; ADOLESCENT; ALLERGIC RHINITIS; ARTICLE; ASTHMA; CHILD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG SAFETY; FEMALE; GERMANY; HUMAN; IMMUNOTHERAPY; LUNG FUNCTION TEST; MAJOR CLINICAL STUDY; MALE; PEAK EXPIRATORY FLOW; POLLEN ALLERGY; PRESCHOOL CHILD; PRIORITY JOURNAL; PROBABILITY; RANDOMIZED CONTROLLED TRIAL; SCHOOL CHILD; SUBLINGUAL SWALLOW IMMUNOTHERAPY; TITRIMETRY; UNSPECIFIED SIDE EFFECT;

ADMINISTRATION, SUBLINGUAL; ADOLESCENT; ALLERGENS; ASTHMA; CHILD; DESENSITIZATION, IMMUNOLOGIC; DRUG DOSAGE CALCULATIONS; FEASIBILITY STUDIES; FEMALE; HUMANS; MALE; POLLEN; RESPIRATORY FUNCTION TESTS; RHINITIS, ALLERGIC, SEASONAL; TREES;

EID: 78549296764     PISSN: 09056157     EISSN: 13993038     Source Type: Journal    
DOI: 10.1111/j.1399-3038.2010.01078.x     Document Type: Article

References (14)

1. Bousquet J, Van Cauwenberge P, Khaltaev N. Allergic rhinitis and its impact on asthma. J Allergy Clin Immunol 2001: 5 (Suppl): S147-334.
2. Bousquet J, Khaltaev N, Cruz AA, et al. Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 Update (in collaboration with the World Health Organization, GA2LEN and AllerGen). Allergy 2008: 63 (Suppl 86): 8-160.
3. Bousquet J, Lockey RF, Malling HJ. Allergen immunotherapy: therapeutic vaccines for allergic diseases. Geneva: January 27-29 1997. Allergy 1998: 44 (Suppl): 1-42.
4. Wilson DR, Lima MT, Durham SR. Sublingual immunotherapy for allergic rhinitis: systematic review and meta-analysis. Allergy 2005: 60: 4-12.
5. Penagos M, Compalati E, Tarantini F, et al. Efficacy of sublingual immunotherapy in the treatment of allergic rhinitis in pediatric patients 3 to 18 years of age: a meta-analysis of randomized, placebo-controlled, double-blind trials. Ann Allergy Asthma Immunol 2006: 97: 141-8.
6. Bousquet J, Vignola AM, Demoly P. Links between rhinitis and asthma. Allergy 2003: 58: 691-706.
7. Bousquet J, Jacot W, Vignola AM, Bachert C, Van Cauwenberge P. Allergic rhinitis: a disease remodeling the upper airways? J Allergy Clin Immunol 2004: 113: 43-9.
8. Bachert C, Vignola AM, Gevaert P, Leynaert B, Van Cauwenberge P, Bousquet J. Allergic rhinitis, rhinosinusitis, and asthma: one airway disease. Immunol Allergy Clin North Am 2004: 24: 19-43.
9. Feliziani V, Lattuada G, Parmiani S, Dall'Aglio PP. Safety and efficacy of sublingual rush immunotherapy with grass allergen extracts. A double blind study. Allergol Immunopathol (Madr) 1995: 23: 224-30.
10. Gammeri E, Arena A, D'Anneo R, La Grutta S. Safety and tolerability of ultra-rush (20 minutes) sublingual immunotherapy in patients with allergic rhinitis and/or asthma. Allergol Immunopathol (Madr) 2005: 33: 221-3.
11. Tripodi S, Di Rienzo Businco A, Benincori N, Scala G, Pingitore G. Safety and tolerability of ultra-rush induction, less than one hour, of sublingual immunotherapy in children. Int Arch Allergy Immunol 2006: 139: 149-52.
12. Seidenberg J, Pajno GB, Bauer CP, La Grutta S, Sieber J. Safety and tolerability of seasonal ultra-rush, high-dose sublingual-swallow immunotherapy in allergic rhinitis to grass and tree pollens: an observational study in 193 children and adolescents. J Investig Allergol Clin Immunol 2009: 19: 125-31.
13. Expert Panel Report 3 (EPR-3): Guidelines for the Diagnosis and Management of Asthma-Summary Report 2007. J Allergy Clin Immunol 2007;120(5 Suppl):S94-138.
14. Clavel R, Bousquet J, André C. Clinical efficacy of sublingual-swallow immunotherapy: a double-blind, placebo-controlled trial of a standardized five-grass-pollen extract in rhinitis. Allergy 1998: 53: 493-8.