Incidence of small lymph node metastases with evidence of extracapsular extension: Clinical implications in patients with head and neck squamous cell carcinoma

International Journal of Radiation Oncology Biology Physics

Volumn 78, Issue 5, 2010, Pages 1366-1372

  Ghadjar, Pirus ^a   Simcock, Mathew ^b   Schreiber Facklam, Heide ^c   Zimmer, Yitzhak ^c   Gräter, Ruth ^a   Evers, Christina ^a   Arnold, Andreas ^a   Wilkens, Ludwig ^c   Aebersold, Daniel M ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b Intl Breast Cancer Stud Grp   (Switzerland)

^c UNIVERSITY OF BERN   (Switzerland)

Author keywords

Extracapsular extension; Head and neck cancer; Lymph node metastases; Prognosis; Radiation therapy

Indexed keywords

EXTRACAPSULAR EXTENSION; HEAD-AND-NECK CANCER; LYMPH NODE METASTASIS; PROGNOSIS; RADIATION THERAPY;

BODY FLUIDS; PATHOLOGY; REGRESSION ANALYSIS; TUMORS;

RADIOTHERAPY;

CARBOPLATIN; CISPLATIN; FLUOROURACIL;

ADULT; AGED; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CANCER PATIENT; CANCER RADIOTHERAPY; CANCER RELAPSE; CANCER SURVIVAL; DISTANT METASTASIS; EXTRACAPSULAR EXTENSION; FEMALE; FOLLOW UP; HEAD AND NECK CARCINOMA; HUMAN; HUMAN TISSUE; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; NECK DISSECTION; ONCOLOGICAL PARAMETERS; PRIORITY JOURNAL; PROGNOSIS; PROPORTIONAL HAZARDS MODEL; RETROSPECTIVE STUDY; SQUAMOUS CELL CARCINOMA;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, SQUAMOUS CELL; CONFIDENCE INTERVALS; DISEASE-FREE SURVIVAL; FEMALE; HEAD AND NECK NEOPLASMS; HUMANS; LYMPH NODE EXCISION; LYMPH NODES; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; NECK; NEOPLASM INVASIVENESS; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; RADIOTHERAPY DOSAGE; RADIOTHERAPY, ADJUVANT; REGRESSION ANALYSIS; RETROSPECTIVE STUDIES; TUMOR BURDEN;

EID: 78549295850     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2009.09.043     Document Type: Article

References (21)

1. C. Leonard, M. Corkill, J. Tompkin, and B. Zhen Are axillary recurrence and overall survival affected by axillary extranodal tumor extension in breast cancer? Implications for radiation therapy J Clin Oncol 13 1995 47 53
2. B.J. Fisher, F.E. Perera, and A.L. Cooke Extracapsular axillary node extension in patients receiving adjuvant systemic therapy: An indication for radiotherapy? Int J Radiat Oncol Biol Phys 38 1997 551 559
3. J. van der Velden, A.C.M. van Lindert, and F.B. Lammes Extracapsular growth of lymph node metastases in squamous cell carcinoma of the vulva: The impact on recurrence and survival Cancer 75 1995 2885 2890
4. J.R. Coster, R.L. Foote, and K.D. Olsen Cervical nodal metastasis of squamous cell carcinoma of unknown origin: Indications for withholding radiation therapy Int J Radiat Oncol Biol Phys 23 1992 743 749
5. J. Heide, A. Krüll, and J. Berger Extracapsular spread of nodal metastasis as a prognostic factor in rectal cancer Int J Radiat Oncol Biol Phys 58 2004 773 778
6. J.T. Johnson, E.N. Myers, and C.D. Bedetti Cervical lymph node metastases. Incidence and implications of extracapsular carcinoma Arch Otolaryngol 111 1985 534 537
7. G.B. Snow, A.A. Annyas, and E.A. van Slooten Prognostic factors of neck node metastasis Clin Otolaryngol Allied Sci 7 1982 185 192
8. N.L. Snyderman, J.T. Johnson, and V.L. Schramm Jr. Extracapsular spread of carcinoma in cervical lymph nodes. Impact upon survival in patients with carcinoma of the supraglottic larynx Cancer 56 1985 1597 1599
9. R.L. Carter, J.M. Bliss, and K.C. Soo Radical neck dissections for squamous carcinomas: Pathological findings and their clinical implications with particular reference to transcapsular spread Int J Radiat Oncol Biol Phys 13 1987 825 832
10. H. Hirabayashi, K. Koshii, and K. Uno Extracapsular spread of squamous cell carcinoma in neck lymph nodes: Prognostic factor of laryngeal cancer Laryngoscope 101 1991 502 506
11. D.T. Huang, C.R. Johnson, and R. Schmidt-Ullrich Postoperative radiotherapy in head and neck carcinoma with extracapsular lymph node extension and/or positive resection margins: A comparative study Int J Radiat Oncol Biol Phys 23 1992 737 742
12. M. Brasilino de Carvalho Quantitative analysis of the extent of extracapsular invasion and its prognostic significance: A prospective study of 170 cases of carcinoma of the larynx and hypopharynx Head Neck 20 1998 16 21
13. J.A. Woolgar, S. Rogers, and C.R. West Survival and patterns of recurrence in 200 oral cancer patients treated by radical surgery and neck dissection Oral Oncol 35 1999 257 265
14. J.N. Myers, J.S. Greenberg, and V. Mo Extracapsular spread. A significant predictor of treatment failure in patients with squamous cell carcinoma of the tongue Cancer 92 2001 3030 3036
15. J.A. Woolgar, S.N. Rogers, and D. Lowe Cervical lymph node metastasis in oral cancer: The importance of even microscopic extracapsular spread Oral Oncol 39 2003 130 137
16. J.S. Greenberg, R. Fowler, and J. Gomez Extent of extracapsular spread. A critical prognosticator in oral tongue cancer Cancer 97 2003 1464 1470
17. S. Oosterkamp, J.M.A. de Jong, and P.L. Van den Ende Predictive value of lymph node metastases and extracapsular extension fort the risk of distant metastases in laryngeal carcinoma Laryngoscope 116 2006 2067 2070
18. P. Ghadjar, H. Schreiber-Facklam, and R. Gräter Quantitative analysis of extracapsular extension of metastatic lymph nodes in head and neck squamous cell carcinoma and its significance for radiotherapy planning Int J Radiother Oncol Biol Phys 2009 (in press)
19. F.L. Greene, D.L. Page, and I.D. Fleming AJCC cancer staging manual 6th ed 2002 Springer Philadelphia
20. E.L. Kaplan, and P. Meier Nonparametric estimation from incomplete observation J Am Stat Assoc 53 1958 457 481
21. D.R. Cox Regression models and life tables J R Stat Soc B 34 1972 187 220