Hypofractionated radiotherapy after conservative surgery for breast cancer: Analysis of acute and late toxicity

Radiation Oncology

Volumn 5, Issue 1, 2010, Pages

  Deantonio, Letizia ^a   Gambaro, Giuseppina ^a   Beldì, Debora ^a   Masini, Laura ^a   Tunesi, Sara ^a   Magnani, Corrado ^a   Krengli, Marco ^a  

^a University Hospital Maggiore della Carita   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATASE INHIBITOR; CYCLOPHOSPHAMIDE; DOXORUBICIN; EPIRUBICIN; FLUOROURACIL; METHOTREXATE; TAMOXIFEN;

ADULT; ARTICLE; BREAST CANCER; CANCER RADIOTHERAPY; CLINICAL PRACTICE; CLINICAL TRIAL; CONSERVATIVE TREATMENT; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; OUTCOME ASSESSMENT; RADIATION DOSE; RADIATION DOSE FRACTIONATION; RETROSPECTIVE STUDY; SKIN TOXICITY; TREATMENT OUTCOME; ADJUVANT THERAPY; AGED; BREAST TUMOR; CARCINOMA; FOLLOW UP; METHODOLOGY; MIDDLE AGED; MULTIMODALITY CANCER THERAPY; RADIATION INJURY; RADIATION PNEUMONIA; SEGMENTAL MASTECTOMY;

AGED; BREAST NEOPLASMS; CARCINOMA; COMBINED MODALITY THERAPY; DOSE FRACTIONATION; FEMALE; FOLLOW-UP STUDIES; HUMANS; MASTECTOMY, SEGMENTAL; MIDDLE AGED; RADIATION INJURIES; RADIATION PNEUMONITIS; RADIOTHERAPY, ADJUVANT; RETROSPECTIVE STUDIES;

EID: 78549285312     PISSN: None     EISSN: 1748717X     Source Type: Journal    
DOI: 10.1186/1748-717X-5-112     Document Type: Article

References (15)

1. Clarke M, Collins R, Darby S, . Early Breast Cancer Trialists' Collaborative Group (EBCTCG) Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of randomized trials. Lancet 2005, 366:2087-06. Early Breast Cancer Trialists' Collaborative Group (EBCTCG).
2. Fisher B, Anderson S, Redmond R, Wolmark DL, Cronin W. Re-analysis and results after 12 years of follow-up in a randomized clinical trial comparing total mastectomy with lumpectomy with or without irradiation in the treatment of breast cancer. N Engl J Med 1995, 333:1456-61. 10.1056/NEJM199511303332203, 7477145.
3. Whelan TJ, MacKenzie R, Julian J, Levine M, Shelley W, Grimard L, Lada B, Lukka H, Perera F, Fyles A, Laukkanen E, Gulavita S, Benk V, Szechtman B. Randomized trial of breast irradiation schedules after lumpectomy for women with lymph node-negative breast cancer. J Natl Cancer Inst 2002, 94(15):1143-50.
4. Owen JR, Ashton A, Bliss JM, Homewood J, Harper C, Hanson J, Haviland J, Bentzen SM, Yarnold JR. Effect of radiotherapy fraction size on tumour control in patients with early-stage breast cancer after local tumour excision: long-term results of a randomised trial. Lancet Oncol 2006, 7:467-71. 10.1016/S1470-2045(06)70699-4, 16750496.
5. The START Trialists' Group The UK Standardisation of Breast Radiotherapy (START) Trial A of radiotherapy hypofractionation for treatment of early breast cancer: a randomised trial. Lancet 2008, 9:331-41. The START Trialists' Group.
6. The START Trialists' Group The UK Standardisation of Breast Radiotherapy (START) Trial B of radiotherapy hypofractionation for treatment of early breast cancer: a randomised trial. Lancet 2008, 371:1098-17. 10.1016/S0140-6736(08)60348-7, 2277488, 18355913, The START Trialists' Group.
7. International Commission of Radiation Units and Measurements ICRU Report 50: Prescribing, recording, and reporting photon beam therapy. Bethesda, MD: International Commission of Radiation Units and Measurements; 1993. International Commission of Radiation Units and Measurements, International Commission of Radiation Units and Measurements.
8. ICRU Report 62: Prescribing, recording, and reporting photon beam therapy (supplement to ICRU Report 50). 1999, Bethesda, MD: International Commission of Radiation Units and Measurements.
9. Cox JD, Stetz J, Pajak TF. Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC). Int J Radiat Oncol Biol Phys 1995, 31:1341-46. 10.1016/0360-3016(95)00060-C, 7713792.
10. Formenti SC. External-Beam partial breast irradiation. Semin Radiat Oncol 2005, 15:92. 10.1016/j.semradonc.2004.10.008, 15809934.
11. Fowler JF. The linear-quadratic formula and progress in fractionated radiotherapy. Br J Radiol 1989, 62(740):679-94. 10.1259/0007-1285-62-740-679, 2670032.
12. Plataniotis GA, Dale RG. FIPEM., FRCR. Biologically effective dose-response relationship for breast cancer treated by conservative surgery and postoperative radiotherapy. Int J Radiat Oncol Biol Phys 2009, 75:512-7. 10.1016/j.ijrobp.2009.05.013, 19625139.
13. Taher AN, El-Baradie MM, Essa H, Zaki O, Ezzat S. Hypofractionation versus conventional fractionation radiotherapy after conservative treatment of breast cancer: Early Skin Reactions and Cosmetic Results. J. of the Egyptian Nat. Cancer Inst 2004, 16:178-187.
14. Osako T, Oguchi M, Kumada M, Nemoto K, Iwase T, Yamashita T. Acute radiation dermatitis and pneumonitis in Japanese breast cancer patients with whole breast hypofractionated radiotherapy compared to conventional radiotherapy. Jpn J Clin Oncol 2008, 38:334-338. 10.1093/jjco/hyn030, 18417501.
15. Olivotto IA, Weir LM, Kim-Sing C, Bajdik CD, Trevisan CH, Doll CM. Late cosmetic results of short fractionation for breast conservation. Radiother Oncol 1996, 41:7-13.