Effect of simvastatin on collagen i deposition in non-infarcted myocardium: Role of NF-κB and osteopontin

Canadian Journal of Physiology and Pharmacology

Volumn 88, Issue 11, 2010, Pages 1026-1034

  Zhang, Jianhua ^a   Xu, Yan ^a   Pan, Lingxin ^a   Chen, Ting ^a   Chen, Zhiwu ^a   Zhao, Ren ^a  

^a ANHUI MEDICAL UNIVERSITY   (China)

Author keywords

Collagen i; Myocardial fibrosis; NF B; Osteopontin; Simvastatin

Indexed keywords

COLLAGEN TYPE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; OSTEOPONTIN; PYRROLIDINE DITHIOCARBAMATE; SIMVASTATIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CLINICAL EVALUATION; DRUG MECHANISM; HEART FUNCTION; HEART INFARCTION; HEART INFARCTION SIZE; HEART LEFT VENTRICLE ENDDIASTOLIC PRESSURE; HEART LEFT VENTRICLE ENDSYSTOLIC VOLUME; HEART LEFT VENTRICLE FAILURE; HEART MUSCLE FIBROSIS; IMMUNOHISTOCHEMISTRY; LEFT ANTERIOR DESCENDING CORONARY ARTERY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TREATMENT OUTCOME;

ANIMALS; COLLAGEN TYPE I; FIBROSIS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MALE; MYOCARDIAL INFARCTION; MYOCARDIUM; NF-KAPPA B; NF-KAPPA B P50 SUBUNIT; OSTEOPONTIN; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SIMVASTATIN; VENTRICULAR FUNCTION, LEFT;

BIOLOGICAL EFFECTS; CARDIAC FUNCTIONS; CARDIAC PARAMETERS; COLLAGEN I; CORONARY ARTERIES; DITHIOCARBAMATES; END-DIASTOLIC; FUNCTIONAL MYOCARDIAL PARAMETERS; LEFT ANTERIOR DESCENDING; LEFT VENTRICULAR; MAXIMAL RATES; MYOCARDIAL FIBROSIS; MYOCARDIAL INFARCTION; OSTEOPONTIN; OVER-EXPRESSION; PROTEIN EXPRESSIONS; PYRROLIDINES; RAT MODEL; SIMVASTATIN; STATINS; UNDERLYING MECHANISM; UP-REGULATION;

BLOOD PRESSURE;

COLLAGEN;

EID: 78549273404     PISSN: 00084212     EISSN: 12057541     Source Type: Journal    
DOI: 10.1139/Y10-075     Document Type: Article

References (33)

1. Anjos Ferreira, A.L., Russell, R.M., Rocha, N., Placido Ladeira, M.S., Favero Salvadori, D.M., Oliveira Nascimento, M.C., et al. 2007. Effect of lycopene on doxorubicin-induced cardiotoxicity: an echocardiographic, histological and morphometrical assessment. Basic Clin. Pharmacol. Toxicol. 101(1): 16-24. doi:10. 1111/j.1742-7843.2007.00070.x. PMID:17577311.
2. Ashizawa, N., Graf, K., Do, Y.S., Nunohiro, T., Giachelli, C.M., Meehan, W.P., et al. 1996. Osteopontin is produced by rat cardiac fibroblasts and mediates A(II)-induced DNA synthesis and collagen gel contraction. J. Clin. Invest. 98(10): 2218-2227. doi:10.1172/JCI119031. PMID:8941637.
3. Bates, K., Ruggeroli, C.E., Goldman, S., and Gaballa, M.A. 2002. Simvastatin restores endothelial NO-mediated vasorelaxation in large arteries after myocardial infarction. Am. J. Physiol. Heart Circ. Physiol. 283(2): H768-H775. PMID:12124226.
4. Bauersachs, J., Galuppo, P., Fraccarollo, D., Christ, M., and Ertl, G. 2001. Improvement of left ventricular remodeling and function by hydroxymethylglutaryl coenzyme a reductase inhibition with cerivastatin in rats with heart failure after myocardial infarction. Circulation, 104(9): 982-985. doi:10.1161/hc3401.095946. PMID:11524389.
5. Bishop, J.E., Greenbaum, R., Gibson, D.G., Yacoub, M., and Laurent, G.J. 1990. Enhanced deposition of predominantly type I collagen in myocardial disease. J. Mol. Cell. Cardiol. 22(10): 1157-1165. doi:10.1016/0022-2828(90)90079-H. PMID:2095438.
6. Burton, A.C. 1954. Relation of structure to function of the tissues of the wall of blood vessels. Physiol. Rev. 34(4): 619-642. PMID:13215088.
7. Chen, J., and Mehta, J.L. 2006. Angiotensin II-mediated oxidative stress and procollagen-1 expression in cardiac fibroblasts: blockade by pravastatin and pioglitazone. Am. J. Physiol. Heart Circ. Physiol. 291(4): H1738-H1745. doi:10.1152/ajpheart.00341.2006. PMID:16714359.
8. Cleutjens, J.P., Kandala, J.C., Guarda, E., Guntaka, R.V., and Weber, K.T. 1995. Regulation of collagen degradation in the rat myocardium after infarction. J. Mol. Cell. Cardiol. 27(6): 1281-1292. doi:10.1016/S0022-2828(05)82390-9. PMID:8531210.
9. Dechend, R., Fiebeler, A., Park, J.K., Muller, D.N., Theuer, J., Mervaala, E., et al. 2001. Amelioration of angiotensin II-induced cardiac injury by a 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor. Circulation, 104(5): 576-581. doi:10.1161/hc3001.092039. PMID:11479256.
10. Delbosc, S., Cristol, J.P., Descomps, B., Mimran, A., and Jover, B. 2002. Simvastatin prevents angiotensin II-induced cardiac alteration and oxidative stress. Hypertension, 40(2): 142-147. doi:10. 1161/01.HYP.0000024348.87637.6F. PMID:12154104.
11. Fletcher, P.J., Pfeffer, J.M., Pfeffer, M.A., and Braunwald, E. 1981. Left ventricular diastolic pressure-volume relations in rats with healed myocardial infarction. Effects on systolic function. Circ. Res. 49(3): 618-626. PMID:7261261.
12. Frantz, S., Hu, K., Bayer, B., Gerondakis, S., Strotmann, J., Adamek, A., et al. 2006. Absence of NF-κB subunit p50 improves heart failure after myocardial infarction. FASEB J. 20(11): 1918-1920. doi:10.1096/fj.05-5133fje. PMID:16837548.
13. Grundy, S.M., Cleeman, J.I., Merz, C.N., Brewer, H.B., Jr., Clark, L.T., Hunninghake, D.B., et al. 2004. Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines. Circulation, 110(2): 227-239. doi:10.1161/01.CIR.0000133317.49796.0E. PMID:15249516.
14. Hayashidani, S., Tsutsui, H., Shiomi, T., Suematsu, N., Kinugawa, S., Ide, T., et al. 2002. Fluvastatin, a 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor, attenuates left ventricular remodeling and failure after experimental myocardial infarction. Circulation, 105(7): 868-873. doi:10.1161/hc0702.104164. PMID: 11854129.
15. Hirotani, S., Otsu, K., Nishida, K., Higuchi, Y., Morita, T., Nakayama, H., et al. 2002. Involvement of nuclear factor-kB and apoptosis signal-regulating kinase 1 in G-protein-coupled receptor agonist-induced cardiomyocyte hypertrophy. Circulation, 105(4): 509-515. doi:10.1161/hc0402.102863. PMID:11815436.
16. Irita, J., Okura, T., Kurata, M., Miyoshi, K., Fukuoka, T., and Higaki, J. 2008. Osteopontin in rat renal fibroblasts: functional properties and transcriptional regulation by aldosterone. Hypertension, 51(2): 507-513. doi:10.1161/HYPERTENSIONAHA.107.102640. PMID:18158341.
17. Kawano, S., Kubota, T., Monden, Y., Tsutsumi, T., Inoue, T., Kawamura, N., et al. 2006. Blockade of NF-κB improves cardiac function and survival after myocardial infarction. Am. J. Physiol. Heart Circ. Physiol. 291(3): H1337-H1344. doi:10.1152/ajpheart.01175.2005. PMID:16632551.
18. Litwin, S.E., Litwin, C.M., Raya, T.E., Warner, A.L., and Goldman, S. 1991. Contractility and stiffness of noninfarcted myocardium after coronary ligation in rats. Effects of chronic angiotensin converting enzyme inhibition. Circulation, 83(3): 1028-1037. PMID:1999008.
19. Matsui, Y., Jia, N., Okamoto, H., Kon, S., Onozuka, H., Akino, M., et al. 2004. Role of osteopontin in cardiac fibrosis and remodeling in angiotensin II-induced cardiac hypertrophy. Hypertension, 43(6): 1195-1201. doi:10.1161/01.HYP.0000128621.68160.dd. PMID:15123578.
20. Medugorac, I. 1982. Characterization of intramuscular collagen in mammalian left ventricle. Basic Res. Cardiol. 77(6): 589-598. doi:10.1007/BF01908312. PMID:7159357.
21. Milliez, P., Deangelis, N., Rucker-Martin, C., Leenhardt, A., Vicaut, E., Robidel, E., et al. 2005. Spironolactone reduces fibrosis of dilated atria during heart failure in rats with myocardial infarction. Eur. Heart J. 26(20): 2193-2199. doi:10.1093/eurheartj/ehi478. PMID:16141258.
22. Muller, D.N., Dechend, R., Mervaala, E.M., Park, J.K., Schmidt, F., Fiebeler, A., et al. 2000. NF-κB inhibition ameliorates angiotensin II-induced inflammatory damage in rats. Hypertension, 35(1 Pt 2): 193-201. PMID:10642297.
23. Raya, T.E., Gay, R.G., Lancaster, L., Aguirre, M., Moffett, C., and Goldman, S. 1988. Serial changes in left ventricular relaxation and chamber stiffness after large myocardial infarction in rats. Circulation, 77(6): 1424-1431. PMID:3370778.
24. Renault, M.A., Jalvy, S., Potier, M., Belloc, I., Genot, E., Dekker, L.V., et al. 2005. UTP induces osteopontin expression through a coordinate action of NFκB, activator protein-1, and upstream stimulatory factor in arterial smooth muscle cells. J. Biol. Chem. 280(4): 2708-2713. doi:10.1074/jbc.M411786200. PMID:15557322.
25. Scatena, M., Almeida, M., Chaisson, M.L., Fausto, N., Nicosia, R.F., and Giachelli, C.M. 1998. NF-κB mediates avb3 integrininduced endothelial cell survival. J. Cell Biol. 141(4): 1083-1093. doi:10.1083/jcb.141.4.1083. PMID:9585425.
26. Trueblood, N.A., Xie, Z., Communal, C., Sam, F., Ngoy, S., Liaw, L., et al. 2001. Exaggerated left ventricular dilation and reduced collagen deposition after myocardial infarction in mice lacking osteopontin. Circ. Res. 88(10): 1080-1087. doi:10.1161/hh1001. 090842. PMID:11375279.
27. van Krimpen, C., Smits, J.F.M, Cleutjens, J.P.M., Debets, J.J.M., Schoemaker, R.G., Struyker Boudier, H.A.J., et al. 1991. DNA synthesis in the non-infarcted cardiac interstitium after left coronary artery ligation in the rat: effects of captopril. J. Mol. Cell. Cardiol. 23(11): 1245-1253. doi:10.1016/0022-2828(91)90082-W. PMID:1803017.
28. Weber, K.T., Sun, Y., Tyagi, S.C., and Cleutjens, J.P. 1994. Collagen network of the myocardium: function, structural remodeling and regulatory mechanisms. J. Mol. Cell. Cardiol. 26(3): 279-292. doi:10.1006/jmcc.1994.1036. PMID:8028011.
29. Weber, K.T., Sun, Y., and Katwa, L.C. 1996. Wound healing following myocardial infarction. Clin. Cardiol. 19(6): 447-455. doi:10.1002/clc.4960190602. PMID:8790947.
30. Whittaker, P., Boughner, D.R., and Kloner, R.A. 1991. Role of collagen in acute myocardial infarct expansion. Circulation, 84(5): 2123-2134. PMID:1934383.
31. Yang, N., Ying, C., Xu, M., Zuo, X., Ye, X., Liu, L., et al. 2007. High-fat diet up-regulates caveolin-1 expression in aorta of dietinduced obese but not in diet-resistant rats. Cardiovasc. Res. 76(1): 167-174. doi:10.1016/j.cardiores.2007.05.028. PMID: 17599814.
32. Yu, Y., Kang, Y.M., Zhang, Z.H., Wei, S.G., Chu, Y., Weiss, R.M., and Felder, R.B. 2007. Increased cyclooxygenase-2 expression in hypothalamic paraventricular nucleus in rats with heart failure: role of nuclear factor kB. Hypertension, 49(3): 511-518. doi:10.1161/01.HYP.0000257356.20527.c5. PMID: 17242297.
33. Zhang, J.H., Chen, Z.W., and Wu, Z. 2008. Late protective effect of pharmacological preconditioning with total flavones of rhododendra against myocardial ischemia-reperfusion injury. Can. J. Physiol. Pharmacol. 86(3): 131-138. doi:10.1139/Y08-016. PMID:18418440.