The effects of N-acetylcysteine on spermatogenesis and degree of testicular germ cell apoptosis in an experimental model of varicocele in rats

International Urology and Nephrology

Volumn 42, Issue 3, 2010, Pages 603-608

  Duarte, Fernando ^a   Blaya, Rodrigo ^a   Telöken, Patrick Ely ^a   Becker, Daniel ^a   Fernandes, Marilda ^a   Rhoden, Ernani Luis ^a  

^a UNIVERSIDADE FEDERAL DE CIÊNCIAS DA SAÚDE DE PORTO ALEGRE   (Brazil)

Author keywords

Germ cell apoptosis; Male infertility; N acetylcysteine; Spermatogenesis; Varicocele

Indexed keywords

ACETYLCYSTEINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DRUG EFFICACY; GERM CELL; HISTOPATHOLOGY; MALE; NICK END LABELING; NONHUMAN; PACHYTENE; RAT; SERTOLI CELL; SPERMATID; SPERMATOCYTE; SPERMATOGENESIS; TESTIS WEIGHT; VARICOCELE;

ACETYLCYSTEINE; ANIMALS; ANTIOXIDANTS; APOPTOSIS; CELL COUNT; GERM CELLS; MALE; RATS; SERTOLI CELLS; SPERMATIDS; SPERMATOGENESIS; TESTIS; VARICOCELE;

EID: 78549267157     PISSN: 03011623     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11255-009-9687-x     Document Type: Article

References (13)

1. Nagler HM, Martinis FG (1997) Varicocele. In: Lipshultz LI, Howards S (eds) Infertility in the male. Mosby Year Book, St. Louis, pp 336-359
2. F Killinc, et al. 2004 p53 expression and apoptosis in varicocele in the rat testis J Urol 172 2475 2478 10.1097/01.ju.0000138471.35553.ce (Pubitemid 39507556)
3. A Agarwal, et al. 2008 Clinical relevance of oxidative stress in male factor infertility: an update Am J Reprod Immunol 59 2 11 1:CAS:528: DC%2BD1cXis1Wjsbc%3D 10.1111/j.1600-0897.2007.00559.x 18154591 (Pubitemid 350285578)
4. C Chen, et al. 2008 Attenuation of oxidative stress after varicocelectomy in subfertile patients with varicocele J Urol 179 639 642 1:CAS:528: DC%2BD1cXhvVCmt78%3D 10.1016/j.juro.2007.09.039 18082213
5. H Sakamoto, et al. 2008 Relationship between testicular volume and varicocele in patients with infertility Urology 71 104 109 10.1016/j.urology. 2007.08.019 18242375 (Pubitemid 351173256)
6. A Jung HC SCHUPPE 2007 Influence of genital heat stress on semen quality in humans Andrologia 9 203 215 10.1111/j.1439-0272.2007.00794.x (Pubitemid 351738021)
7. R Demiralay, et al. 2008 The effects of erdosteine, N-acetylcysteine, and vitamin E on nicotine-induced apoptosis of hippocampal neural cells J Cell Biochem 104 1740 1746 1:CAS:528:DC%2BD1cXpvVOjtLg%3D 10.1002/jcb.21739 18348255
8. K Cam, et al. 2004 The role of reactive oxygen species and apoptosis in the pathogenesis of varicocele in a rat model and efficiency of vitamin E treatment Int J Androl 27 228 233 1:CAS:528:DC%2BD2cXns1GmsLY%3D 10.1111/j.1365-2605.2004.00476.x 15271202 (Pubitemid 39062084)
9. DC Saypol, et al. 1981 Influence of surgically induced varicocele on testicular blood flow, temperature, and histology in adult rats and dogs J Clin Invest 68 39 45 1:STN:280:DyaL3M3ktVWisQ%3D%3D 10.1172/JCI110252 7251866
10. CP Leblond Y Clermont 1952 Definition of the stages of the cycle of the seminiferous epithelium in the rat Ann N Y Acad Sci 55 548 573 1:STN:280:DyaG2c%2FlvFSgtg%3D%3D 10.1111/j.1749-6632.1952.tb26576.x 13139144
11. S Benoff, et al. 2004 Bilateral increased apoptosis and bilateral accumulation of cadmium in infertile men with left varicocele Hum Reprod 19 616 627 1:CAS:528:DC%2BD2cXhvFSqt7w%3D 10.1093/humrep/deh139 14998961 (Pubitemid 38344526)
12. Q Xia, et al. 2002 The apoptosis in damaged testicular tissue caused by varicocele Zhonghua Nan Ke Xue 8 414 415 12593014
13. A Barqawi, et al. 2004 Experimental varicocele induces testicular germ cell apoptosis in the rat J Urol 171 501 503 10.1097/01.ju.0000088775.69010.61 14665963 (Pubitemid 37549219)