Applications of vibrational circular dichroism for determining absolute confi guration in early drug discovery

American Laboratory

Volumn 42, Issue 10, 2010, Pages 33-34

  Qiu, Feng ^a   Zhang, Yingru ^a   Caceres Cortes, Janet ^a   Reily, Michael D ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABSOLUTE CONFIGURATION; ABSOLUTE STEREOCHEMISTRY; BIOTOOLS; DRUG DISCOVERY; GAUSSIAN03; GAUSSIANS; INTRAMOLECULAR HYDROGEN BOND; JUPITERS; PHOTOELASTIC MODULATOR; PITTSBURGH; PYRIDINE NITROGEN; SOLUTE-SOLUTE INTERACTIONS; VIBRATIONAL CIRCULAR DICHROISM; WALLINGFORD;

HYDROGEN; HYDROGEN BONDS; SOFTWARE PACKAGES; STEREOCHEMISTRY;

DICHROISM;

EID: 78549250030     PISSN: 00447749     EISSN: None     Source Type: Trade Journal    
DOI: None     Document Type: Article

References (3)

1. Caner, H.; Groner, E.; Levy, L. Trends in the development of chiral drugs. DDT 2004, 9(3), 105-10.
2. Izumi, H.; Ogata, A.; Nafie, L.A.; Dukor, R.K. A revised conformational code for the exhaustive analysis of conformers with one-to-one correspondence between conformation and code: application to the VCD analysis of (S)-ibuprofen. J. Org. Chem. 2009, 74(3), 1231-6.
3. Debie, E.; Bultinck, P.; Herrebout, W.; van der Veken, B. Solvent effects on IR and VCD spectra of natural products: an experimental and theoretical VCD study of pulegone. Phys. Chem. Chem. Phys. 2008, 10, 3498-3508.