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Volumn 116, Issue 20, 2010, Pages 4175-4184

Th17 immune responses contribute to the pathophysiology of aplastic anemia

Author keywords

[No Author keywords available]

Indexed keywords

ALEMTUZUMAB; DACLIZUMAB; DANAZOL; INTERLEUKIN 17; INTERLEUKIN 17 ANTIBODY; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; RAPAMYCIN; TRANSCRIPTION FACTOR FOXP3;

EID: 78549248224     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2010-01-266098     Document Type: Article
Times cited : (156)

References (50)
  • 1
    • 27544490377 scopus 로고    scopus 로고
    • Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
    • Harrington LE, Hatton RD, Mangan PR, et al. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol. 2005;6(11):1123-1132.
    • (2005) Nat Immunol , vol.6 , Issue.11 , pp. 1123-1132
    • Harrington, L.E.1    Hatton, R.D.2    Mangan, P.R.3
  • 3
    • 33646397611 scopus 로고    scopus 로고
    • IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6
    • Yen D, Cheung J, Scheerens H, et al. IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6. J Clin Invest. 2006;116(5):1310-1316.
    • (2006) J Clin Invest , vol.116 , Issue.5 , pp. 1310-1316
    • Yen, D.1    Cheung, J.2    Scheerens, H.3
  • 4
    • 34248572345 scopus 로고    scopus 로고
    • T(H)-17 cells in the circle of immunity and autoimmunity
    • Bettelli E, Oukka M, Kuchroo VK. T(H)-17 cells in the circle of immunity and autoimmunity. Nat Immunol. 2007;8(4):345-350.
    • (2007) Nat Immunol , vol.8 , Issue.4 , pp. 345-350
    • Bettelli, E.1    Oukka, M.2    Kuchroo, V.K.3
  • 5
    • 5644277476 scopus 로고    scopus 로고
    • Interleukin-17 family members and inflammation
    • Kolls JK, Linden A. Interleukin-17 family members and inflammation. Immunity. 2004;21(4):467-476.
    • (2004) Immunity , vol.21 , Issue.4 , pp. 467-476
    • Kolls, J.K.1    Linden, A.2
  • 7
    • 33646560950 scopus 로고    scopus 로고
    • Transforming growth factor-beta induces development of the T(H)17 lineage
    • Mangan PR, Harrington LE, O'Quinn DB, et al. Transforming growth factor-beta induces development of the T(H)17 lineage. Nature. 2006;441(7090):231-234.
    • (2006) Nature , vol.441 , Issue.7090 , pp. 231-234
    • Mangan, P.R.1    Harrington, L.E.2    O'Quinn, D.B.3
  • 8
    • 33646577466 scopus 로고    scopus 로고
    • Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
    • Bettelli E, Carrier Y, Gao W, et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature. 2006;441(7090):235-238.
    • (2006) Nature , vol.441 , Issue.7090 , pp. 235-238
    • Bettelli, E.1    Carrier, Y.2    Gao, W.3
  • 9
    • 34548125305 scopus 로고    scopus 로고
    • Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells
    • DOI 10.1038/ni1496, PII NI1496
    • Acosta-Rodriguez EV, Napolitani G, Lanzavecchia A, Sallusto F. Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells. Nat Immunol. 2007;8(9):942-949. (Pubitemid 47300008)
    • (2007) Nature Immunology , vol.8 , Issue.9 , pp. 942-949
    • Acosta-Rodriguez, E.V.1    Napolitani, G.2    Lanzavecchia, A.3    Sallusto, F.4
  • 10
    • 34548133583 scopus 로고    scopus 로고
    • Development, cytokine profile and function of human interleukin 17-producing helper T cells
    • Wilson NJ, Boniface K, Chan JR, et al. Development, cytokine profile and function of human interleukin 17-producing helper T cells. Nat Immunol. 2007;8(9):950-957.
    • (2007) Nat Immunol , vol.8 , Issue.9 , pp. 950-957
    • Wilson, N.J.1    Boniface, K.2    Chan, J.R.3
  • 12
    • 78549246971 scopus 로고    scopus 로고
    • Over-expression of Th17 and Th1/17 cells in patients with myelodysplastic syndrome
    • Solomou EE, Tsanaktsi A, Fertakis V, et al. Over-expression of Th17 and Th1/17 cells in patients with myelodysplastic syndrome. Blood. 2008;112(11):2698.
    • (2008) Blood , vol.112 , Issue.11 , pp. 2698
    • Solomou, E.E.1    Tsanaktsi, A.2    Fertakis, V.3
  • 13
    • 61849168098 scopus 로고    scopus 로고
    • IL-17-producing CD4(+) T cells, pro-inflammatory cytokines and apoptosis are increased in low risk myelodysplastic syndrome
    • Kordasti SY, Afzali B, Lim Z, et al. IL-17-producing CD4(+) T cells, pro-inflammatory cytokines and apoptosis are increased in low risk myelodysplastic syndrome. Br J Haematol. 2009;145(1):64-72.
    • (2009) Br J Haematol , vol.145 , Issue.1 , pp. 64-72
    • Kordasti, S.Y.1    Afzali, B.2    Lim, Z.3
  • 14
    • 70349690173 scopus 로고    scopus 로고
    • Increased frequencies of T helper type 17 cells in the peripheral blood of patients with acute myeloid leukaemia
    • Wu C, Wang S, Wang F, et al. Increased frequencies of T helper type 17 cells in the peripheral blood of patients with acute myeloid leukaemia. Clin Exp Immunol. 2009;158(2):199-204.
    • (2009) Clin Exp Immunol , vol.158 , Issue.2 , pp. 199-204
    • Wu, C.1    Wang, S.2    Wang, F.3
  • 16
    • 0030912049 scopus 로고    scopus 로고
    • The pathophysiology of acquired aplastic anemia
    • Young NS, Maciejewski J. The pathophysiology of acquired aplastic anemia. N Engl J Med. 1997;336(19):1365-1372.
    • (1997) N Engl J Med , vol.336 , Issue.19 , pp. 1365-1372
    • Young, N.S.1    Maciejewski, J.2
  • 17
    • 0014953726 scopus 로고
    • Bone marrow graft in man after conditioning by antilymphocytic serum
    • Mathe G, Amiel JL, Schwarzenberg L, et al. Bone marrow graft in man after conditioning by antilymphocytic serum. Br Med J. 1970;2(5702):131-136.
    • (1970) Br Med J , vol.2 , Issue.5702 , pp. 131-136
    • Mathe, G.1    Amiel, J.L.2    Schwarzenberg, L.3
  • 18
    • 0025865140 scopus 로고
    • Treatment of aplastic anemia with antilymphocyte globulin and methylprednisolone with or without cyclosporine: The German Aplastic Anemia Study Group
    • Frickhofen N, Kaltwasser JP, Schrezenmeier H, et al. Treatment of aplastic anemia with antilymphocyte globulin and methylprednisolone with or without cyclosporine: the German Aplastic Anemia Study Group. N Engl J Med. 1991;324(19):1297-1304.
    • (1991) N Engl J Med , vol.324 , Issue.19 , pp. 1297-1304
    • Frickhofen, N.1    Kaltwasser, J.P.2    Schrezenmeier, H.3
  • 19
    • 0023376168 scopus 로고
    • Gamma interferon and aplastic anemia
    • Young NS. Gamma interferon and aplastic anemia. Blood. 1987;70(1):337-339.
    • (1987) Blood , vol.70 , Issue.1 , pp. 337-339
    • Young, N.S.1
  • 20
    • 9144270491 scopus 로고    scopus 로고
    • Clinical relevance of balance between type 1 and type 2 immune responses of lymphocyte subpopulations in aplastic anaemia patients
    • Giannakoulas NC, Karakantza M, Theodorou GL, et al. Clinical relevance of balance between type 1 and type 2 immune responses of lymphocyte subpopulations in aplastic anaemia patients. Br J Haematol. 2004;124(1):97-105.
    • (2004) Br J Haematol , vol.124 , Issue.1 , pp. 97-105
    • Giannakoulas, N.C.1    Karakantza, M.2    Theodorou, G.L.3
  • 21
    • 0037103384 scopus 로고    scopus 로고
    • Intracellular interferon-gamma in circulating and marrow T cells detected by flow cytometry and the response to immunosuppressive therapy in patients with aplastic anemia
    • DOI 10.1182/blood-2002-01-0035
    • Sloand E, Kim S, Maciejewski JP, Tisdale J, Follmann D, Young NS. Intracellular interferon-gamma in circulating and marrow T cells detected by flow cytometry and the response to immunosuppressive therapy in patients with aplastic anemia. Blood. 2002;100(4):1185-1191. (Pubitemid 34864270)
    • (2002) Blood , vol.100 , Issue.4 , pp. 1185-1191
    • Sloand, E.1    Kim, S.2    Maciejewski, J.P.3    Tisdale, J.4    Follmann, D.5    Young, N.S.6
  • 22
    • 33646546357 scopus 로고    scopus 로고
    • T-bet, a Th1 transcription factor, is up-regulated in T cells from patients with aplastic anemia
    • Solomou EE, Keyvanfar K, Young NS. T-bet, a Th1 transcription factor, is up-regulated in T cells from patients with aplastic anemia. Blood. 2006;107(10):3983-3991.
    • (2006) Blood , vol.107 , Issue.10 , pp. 3983-3991
    • Solomou, E.E.1    Keyvanfar, K.2    Young, N.S.3
  • 23
    • 3242782610 scopus 로고    scopus 로고
    • In-vivo dominant immune responses in aplastic anaemia: Molecular tracking of putatively pathogenetic T-cell clones by TCR beta-CDR3 sequencing
    • Risitano AM, Maciejewski JP, Green S, Plasilova M, Zeng W, Young NS. In-vivo dominant immune responses in aplastic anaemia: molecular tracking of putatively pathogenetic T-cell clones by TCR beta-CDR3 sequencing. Lancet. 2004;364(9431):355-364.
    • (2004) Lancet , vol.364 , Issue.9431 , pp. 355-364
    • Risitano, A.M.1    Maciejewski, J.P.2    Green, S.3    Plasilova, M.4    Zeng, W.5    Young, N.S.6
  • 24
    • 34548848237 scopus 로고    scopus 로고
    • Deficient CD4+ CD25+ FOXP3+ T regulatory cells in acquired aplastic anemia
    • Solomou EE, Rezvani K, Mielke S, et al. Deficient CD4+ CD25+ FOXP3+ T regulatory cells in acquired aplastic anemia. Blood. 2007;110(5):1603-1606.
    • (2007) Blood , vol.110 , Issue.5 , pp. 1603-1606
    • Solomou, E.E.1    Rezvani, K.2    Mielke, S.3
  • 26
    • 10044264467 scopus 로고    scopus 로고
    • A mouse model of lymphocyte infusion-induced bone marrow failure
    • DOI 10.1016/j.exphem.2004.08.006, PII S0301472X04002887
    • Bloom ML, Wolk AG, Simon-Stoos KL, Bard JS, Chen J, Young NS. A mouse model of lymphocyte infusion-induced bone marrow failure. Exp Hematol. 2004;32(12):1163-1172. (Pubitemid 39601122)
    • (2004) Experimental Hematology , vol.32 , Issue.12 , pp. 1163-1172
    • Bloom, M.L.1    Wolk, A.G.2    Simon-Stoos, K.L.3    Bard, J.S.4    Chen, J.5    Young, N.S.6
  • 27
    • 77449092131 scopus 로고    scopus 로고
    • The role of the Th1 transcription factor T-bet in a mouse model of immune-mediated bone marrow failure
    • Tang Y, Desierto MJ, Chen J, Young NS. The role of the Th1 transcription factor T-bet in a mouse model of immune-mediated bone marrow failure. Blood. 2009;115(3):541-548.
    • (2009) Blood , vol.115 , Issue.3 , pp. 541-548
    • Tang, Y.1    Desierto, M.J.2    Chen, J.3    Young, N.S.4
  • 28
    • 44649126261 scopus 로고    scopus 로고
    • Interleukin (IL)-17 promotes macrophages to produce IL-8, IL-6 and tumour necrosis factor-alpha in aplastic anaemia
    • Gu Y, Hu X, Liu C, Qv X, Xu C. Interleukin (IL)-17 promotes macrophages to produce IL-8, IL-6 and tumour necrosis factor-alpha in aplastic anaemia. Br J Haematol. 2008;142(1):109-114.
    • (2008) Br J Haematol , vol.142 , Issue.1 , pp. 109-114
    • Gu, Y.1    Hu, X.2    Liu, C.3    Qv, X.4    Xu, C.5
  • 29
    • 78549278297 scopus 로고    scopus 로고
    • Contrasting roles of Th1 and Th17 in aplastic anemia and myelodysplastic syndrome
    • Kordasti SY, Alkhan SM, Lim Z, Abellan PP, Marsh JCW, Mufti GJ. Contrasting roles of Th1 and Th17 in aplastic anemia and myelodysplastic syndrome. Blood. 2009;114(22):1090.
    • (2009) Blood , vol.114 , Issue.22 , pp. 1090
    • Kordasti, S.Y.1    Alkhan, S.M.2    Lim, Z.3    Abellan, P.P.4    Marsh, J.C.W.5    Mufti, G.J.6
  • 30
    • 56649106476 scopus 로고    scopus 로고
    • Interplay between effector Th17 and regulatory T cells
    • Awasthi A, Murugaiyan G, Kuchroo VK. Interplay between effector Th17 and regulatory T cells. J Clin Immunol. 2008;28(6):660-670.
    • (2008) J Clin Immunol , vol.28 , Issue.6 , pp. 660-670
    • Awasthi, A.1    Murugaiyan, G.2    Kuchroo, V.K.3
  • 31
    • 77957971080 scopus 로고    scopus 로고
    • Hematopoiesis in 3 dimensions: Human and murine bone marrow architecture visualized by confocal microscopy
    • Takaku T, Malide D, Chen J, Calado RT, Kajigaya S, Young NS. Hematopoiesis in 3 dimensions: human and murine bone marrow architecture visualized by confocal microscopy. Blood. 2010;116(15):e41-e55.
    • (2010) Blood , vol.116 , Issue.15
    • Takaku, T.1    Malide, D.2    Chen, J.3    Calado, R.T.4    Kajigaya, S.5    Young, N.S.6
  • 32
    • 13144261691 scopus 로고    scopus 로고
    • FOXP3 acts as a rheostat of the immune response
    • Ochs HD, Ziegler SF, Torgerson TR. FOXP3 acts as a rheostat of the immune response. Immunol Rev. 2005;203:156-164.
    • (2005) Immunol Rev , vol.203 , pp. 156-164
    • Ochs, H.D.1    Ziegler, S.F.2    Torgerson, T.R.3
  • 34
    • 4444327634 scopus 로고    scopus 로고
    • Bystander destruction of hematopoietic progenitor and stem cells in a mouse model of infusion-induced bone marrow failure
    • Chen J, Lipovsky K, Ellison FM, Calado RT, Young NS. Bystander destruction of hematopoietic progenitor and stem cells in a mouse model of infusion-induced bone marrow failure. Blood. 2004;104(6):1671-1678.
    • (2004) Blood , vol.104 , Issue.6 , pp. 1671-1678
    • Chen, J.1    Lipovsky, K.2    Ellison, F.M.3    Calado, R.T.4    Young, N.S.5
  • 36
    • 30944452780 scopus 로고    scopus 로고
    • Therapeutic efficacy of IL-17 neutralization in murine experimental autoimmune encephalomyelitis
    • DOI 10.1016/j.cellimm.2005.11.002, PII S000887490500242X
    • Hofstetter HH, Ibrahim SM, Koczan D, et al. Therapeutic efficacy of IL-17 neutralization in murine experimental autoimmune encephalomyelitis. Cell Immunol. 2005;237(2):123-130. (Pubitemid 43117208)
    • (2005) Cellular Immunology , vol.237 , Issue.2 , pp. 123-130
    • Hofstetter, H.H.1    Ibrahim, S.M.2    Koczan, D.3    Kruse, N.4    Weishaupt, A.5    Toyka, K.V.6    Gold, R.7
  • 37
    • 78549288369 scopus 로고    scopus 로고
    • Circulating cytokine signature profiles in patients with acquired aplastic anemia and myelodysplastic syndromes
    • abstract
    • Feng X, Scheinberg P, Wu C, et al. Circulating cytokine signature profiles in patients with acquired aplastic anemia and myelodysplastic syndromes [abstract]. Blood. 2008;112(11):1038.
    • (2008) Blood , vol.112 , Issue.11 , pp. 1038
    • Feng, X.1    Scheinberg, P.2    Wu, C.3
  • 38
    • 34547655804 scopus 로고    scopus 로고
    • Cytokine gene polymorphisms in acquired bone marrow failure
    • Gidvani V, Ramkissoon S, Sloand EM, Young NS. Cytokine gene polymorphisms in acquired bone marrow failure. Am J Hematol. 2007;82(8):721-724.
    • (2007) Am J Hematol , vol.82 , Issue.8 , pp. 721-724
    • Gidvani, V.1    Ramkissoon, S.2    Sloand, E.M.3    Young, N.S.4
  • 39
    • 33745936747 scopus 로고    scopus 로고
    • The IL-17 cytokine family members are inhibitors of human hematopoietic progenitor proliferation
    • Broxmeyer HE, Starnes T, Ramsey H, et al. The IL-17 cytokine family members are inhibitors of human hematopoietic progenitor proliferation. Blood. 2006;108(2):770.
    • (2006) Blood , vol.108 , Issue.2 , pp. 770
    • Broxmeyer, H.E.1    Starnes, T.2    Ramsey, H.3
  • 40
    • 0022521867 scopus 로고
    • Characteristics and clinical relevance of autolymphocytotoxins in patients with aplastic anemia
    • Carpentier N, Fontannaz J, Jeannet M, Nissen C, Speck B. Characteristics and clinical relevance of autolymphocytotoxins in patients with aplastic anemia. Transplantation. 1986;42(2):159-161. (Pubitemid 16040445)
    • (1986) Transplantation , vol.42 , Issue.2 , pp. 159-161
    • Carpentier, N.1    Fontannaz, J.2    Jeannet, M.3
  • 41
    • 42249084849 scopus 로고    scopus 로고
    • Either a Th17 or a Th1 effector response can drive autoimmunity: Conditions of disease induction affect dominant effector category
    • Luger D, Silver PB, Tang J, et al. Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category. J Exp Med. 2008;205(4):799-810.
    • (2008) J Exp Med , vol.205 , Issue.4 , pp. 799-810
    • Luger, D.1    Silver, P.B.2    Tang, J.3
  • 42
    • 61449184521 scopus 로고    scopus 로고
    • Phenotypic characterization and differentiation of human CD8+ T cells producing IL-17
    • Kondo T, Takata H, Matsuki F, Takiguchi M. Phenotypic characterization and differentiation of human CD8+ T cells producing IL-17. J. Immunol. 2009;182:1794-1798.
    • (2009) J. Immunol. , vol.182 , pp. 1794-1798
    • Kondo, T.1    Takata, H.2    Matsuki, F.3    Takiguchi, M.4
  • 43
    • 43549090666 scopus 로고    scopus 로고
    • IL-6-dependent spontaneous proliferation is required for the induction of colitogenic IL-17-producing CD8+T cells
    • Tajima M, Wakita D, Noguchi D, et al. IL-6-dependent spontaneous proliferation is required for the induction of colitogenic IL-17-producing CD8+T cells. J Exp Med. 2008;205(5):1019-1027.
    • (2008) J Exp Med , vol.205 , Issue.5 , pp. 1019-1027
    • Tajima, M.1    Wakita, D.2    Noguchi, D.3
  • 44
    • 73349101421 scopus 로고    scopus 로고
    • Tc17 CD8 T cells: Functional plasticity and subset diversity
    • Yen HR, Harris TJ, Wada S, et al. Tc17 CD8 T cells: functional plasticity and subset diversity. J Immunol. 2009;183(11):7161-7168.
    • (2009) J Immunol , vol.183 , Issue.11 , pp. 7161-7168
    • Yen, H.R.1    Harris, T.J.2    Wada, S.3
  • 45
    • 70149106667 scopus 로고    scopus 로고
    • Type 17 CD8+ T cells display enhanced antitumor immunity
    • Hinrichs CS, Kaiser A, Paulos CM, et al. Type 17 CD8+ T cells display enhanced antitumor immunity. Blood. 2009;114(3):596-599.
    • (2009) Blood , vol.114 , Issue.3 , pp. 596-599
    • Hinrichs, C.S.1    Kaiser, A.2    Paulos, C.M.3
  • 46
    • 59649098784 scopus 로고    scopus 로고
    • IL-17 contributes to CD4-mediated graft-versus-host disease
    • Kappel LW, Goldberg GL, King CG, et al. IL-17 contributes to CD4-mediated graft-versus-host disease. Blood. 2009;113(4):945-952.
    • (2009) Blood , vol.113 , Issue.4 , pp. 945-952
    • Kappel, L.W.1    Goldberg, G.L.2    King, C.G.3
  • 47
    • 34248562792 scopus 로고    scopus 로고
    • IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge
    • Khader SA, Bell GK, Pearl JE, et al. IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge. Nat Immunol. 2007;8(4):369-377.
    • (2007) Nat Immunol , vol.8 , Issue.4 , pp. 369-377
    • Khader, S.A.1    Bell, G.K.2    Pearl, J.E.3
  • 48
    • 43549110961 scopus 로고    scopus 로고
    • Regulation of inflammatory responses by IL-17F
    • Yang XO, Chang SH, Park H, et al. Regulation of inflammatory responses by IL-17F. J Exp Med. 2008;205(5):1063-1075.
    • (2008) J Exp Med , vol.205 , Issue.5 , pp. 1063-1075
    • Yang, X.O.1    Chang, S.H.2    Park, H.3
  • 49
    • 46749138596 scopus 로고    scopus 로고
    • Molecular antagonism and plasticity of regulatory and inflammatory T cell programs
    • Yang XO, Nurieva R, Martinez GJ, et al. Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. Immunity. 2008;29(1):44-56.
    • (2008) Immunity , vol.29 , Issue.1 , pp. 44-56
    • Yang, X.O.1    Nurieva, R.2    Martinez, G.J.3
  • 50
    • 69349093225 scopus 로고    scopus 로고
    • Interleukin-17 and type 17 helper T cells
    • Miossec P, Korn T, Kuchroo VK. Interleukin-17 and type 17 helper T cells. N Engl J Med. 2009;361(9):888-898.
    • (2009) N Engl J Med , vol.361 , Issue.9 , pp. 888-898
    • Miossec, P.1    Korn, T.2    Kuchroo, V.K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.