One-pot conversion of alkyl aldehydes into substituted propanoic acids via Knoevenagel condensation with Meldrum's acid

Tetrahedron Letters

Volumn 51, Issue 38, 2010, Pages 4972-4974

  Mudhar, Harminder ^a   Witty, Andrew ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACID; ALDEHYDE DERIVATIVE; AMMONIUM FORMATE; CARBOXYLIC ACID DERIVATIVE; DECANOIC ACID; MELDRUM ACID; PROPIONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; KNOEVENAGEL CONDENSATION; MICHAEL ADDITION; ONE POT SYNTHESIS; TEMPERATURE;

EID: 78549247084     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2010.07.054     Document Type: Article

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19. 6): δ 30.7, 31.4, 32.3, 33.8, 66.9, 174.5.
20. 6): d 1.06 (m, 2H), 1.46 (m, 3H), 1.72 (m, 2H), 2.25 (m, 5H), 2.77 (dt, 2H, J = 12.7, 2.4 Hz), 4.32 (m, 2H), 7.66 (s, 1H), 8.08 (s, 1H), 12.06 (br s, 1H). LC/MS [M+H]+ = 250.