Ethical considerations in CYP2D6 genotype testing for codeine-prescribed breastfeeding mothers

Clinical Pharmacology and Therapeutics

Volumn 88, Issue 6, 2010, Pages 760-762

  Kurtz, M ^a   Black Golde, P ^b   Berlinger, N ^b  

^a YALE NEW HAVEN HOSPITAL   (United States)

^b HASTINGS CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CODEINE; CYTOCHROME P450 2D6;

ATTITUDE TO HEALTH; BREAST FEEDING; GENETIC SCREENING; GENOTYPE; HUMAN; INFANT; INFANT DISEASE; MEDICAL ETHICS; MEDICAL RESEARCH; NOTE; PATIENT CARE; POSTPARTUM PAIN; PRIORITY JOURNAL;

BREAST FEEDING; CODEINE; CYTOCHROME P-450 CYP2D6; FEMALE; GENETIC TESTING; GENOTYPE; HUMANS; INFANT;

EID: 78449296987     PISSN: 00099236     EISSN: 15326535     Source Type: Journal    
DOI: 10.1038/clpt.2010.225     Document Type: Note

References (10)

1. Koren, G., Cairns, J. Chitayat, D., Gaedigk, A. & Leeder, S.J. Pharmacogenetics of morphine poisoning in a breastfed neonate of a codeine-prescribed mother. The Lancet 368, 704 (2008).
2. Ferner, R.E. Did the drug cause death? Codeine and breastfeeding. The Lancet 372, 606-608 (2008).
3. Madadi, P. et al. Pharmacogenetics of neonatal opioid toxicity following maternal use of codeine during breastfeeding: a case-control study. Clin. Pharmacol. Ther. 85, 31-35 (2009).
4. Willman, S., Edginton, A.N., Coboeken, K., Ahr, G. & Lippert, J. Risk to the breast-fed neonate from codeine treatment to the mother: a quantitative mechanistic modeling study. Clin. Pharmacol. Ther. 86, 634-643 (2009).
5. Madadi, P. et al. Communicating pharmacogenetic research results to breastfeeding mothers taking codeine: a pilot study of perceptions and benefits. Clin. Pharmacol. Ther. 88, 792-795 (2010).
6. Dressler, L.G. & Juengst, E.T. Thresholds and boundaries in the disclosure of individual genetic research results. Am. J. Bioeth. 6, 18-20 (2006).
7. Ravitsky, V. & Wilfond, B.S. Disclosing individual genetic results to research participants. Am. J. Bioeth. 6, 8-17 (2006).
8. Madadi, P. et al. Guidelines for maternal codeine use during breastfeeding. Can. Fam. Physician 55, 1077-1078 (2009).
9. US Food and Drug Administration. Information for Healthcare Professionals: Use of Codeine Products in Nursing Mothers (17 August 2007).
10. Berlin, C.M. Jr., Paul, I.M. & Vesell, E.S. Safety issues of maternal drug therapy during breastfeeding. Clin. Pharmacol. Ther. 85, 20-22 (2009).