Efficacy and safety of mycophenolate mofetil vs. methotrexate for the treatment of chronic plaque psoriasis

Journal of the European Academy of Dermatology and Venereology

Volumn 24, Issue 12, 2010, Pages 1447-1451

  Akhyani, M ^a   Chams Davatchi, C ^a   Hemami, M R ^b   Fateh, S ^a  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

methotrexate; mycophenolate mofetil; psoriasis

Indexed keywords

ETRETIN; METHOTREXATE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PSORALEN;

ABDOMINAL CRAMP; ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DRUG DOSE INCREASE; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; FATIGUE; FEMALE; FURUNCULOSIS; HUMAN; MALE; NAUSEA; PRIORITY JOURNAL; PSORIASIS SEVERITY INDEX; PSORIASIS VULGARIS; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; TREATMENT RESPONSE; URTICARIA;

ADOLESCENT; ADULT; CHRONIC DISEASE; DERMATOLOGIC AGENTS; FEMALE; HUMANS; MALE; METHOTREXATE; MIDDLE AGED; MYCOPHENOLIC ACID; PSORIASIS; TREATMENT OUTCOME; YOUNG ADULT;

EID: 78449293438     PISSN: 09269959     EISSN: 14683083     Source Type: Journal    
DOI: 10.1111/j.1468-3083.2010.03667.x     Document Type: Article

References (19)

1. Kalb RE, Strober B, Weinstein G, et al. Methotrexate and psoriasis: 2009 National Psoriasis Foundation Consensus Conference. J Am Acad Dermatol 2009; 60: 824-837.
2. Heydendael VM, Spuls PI, Opmeer BC, et al. Methotrexate versus cyclosporine in moderate-to-severe chronic plaque psoriasis. N Engl J Med 2003; 349: 658-665.
3. Flytstrom I, Stenberg B, Svensson A, et al. Methotrexate vs. ciclosporin in psoriasis: effectiveness, quality of life and safety. A randomized controlled trial. Br J Dermatol 2008; 158: 116-121.
4. Saurat JH, Stingl G, Dubertret L, et al. Efficacy and safety results from the randomizecontrolled comparative study of adalimumab vs. methotrexate vs. placebo in patients with psoriasis (CHAMPION). Br Dermatol 2008; 158: 558-566.
5. Orvis AK, Wesson SK, Breza TS, et al. Mycophenolate mofetil in dermatology. J Am Acad Dermatol 2009; 60: 183-199.
6. Zwerner J, Fiorentino D,. Mycophenolate mufetil. Dermatol Therapy 2007; 20: 229-238.
7. Geilen CC, Arnold M, Orfanos CE,. Mycophenolate mofetil as a systemic antipsoriatic agent: positive experience in 11 patients. Br J Dermatol. 2001; 144: 583-586.
8. Davidson SC, Morris-Jones R, Powles AV, et al. Change of treatment from cyclosporin to mycophenolate mofetil in severe psoriasis. Br J Dermatol 2000; 143: 405-407.
9. Pedraz J, Dauden E, Delgado-Jimenez Y, et al. Sequential study on the treatment of moderate-to-severe chronic plaque psoriasis with mycophenolate mofetil and cyclosporin J Eur Acad Dermatol Venereol. 2006; 20: 702-706.
10. Dauden E, Sanchez-Peinado C, Ruiz-Genao D, et al. Plasma trough levels of mycophenolic acid do not correlate with efficacy and safety of mycophenolate mofetil in psoriasis. Br J Dermatol 2004; 150: 132-135.
11. Zhou Y, Rosenthal D, Dutz F, et al. Mycophenolate mofetil (CellCept) for psoriasis: a two-center prospective open-label clinical trial. J Cutan Med Surg 2003; 7: 193-197.
12. Akhyani M, Toosi S, Robati RM,. Treatment of chronic plaque type psoriasis with systemic mycophenolate mufetil. Acta Medica Iranica 2006; 44: 383-386.
13. Fredriksson T, Pettersson U,. Severe psoriasis - oral therapy with a new retinoid. Dermatologica 1978; 157: 238-244.
14. Weinstein GD, Frost P,. Methotrexate for psoriasis: a new therapeutic schedule. Arch Dermatol 1971; 103: 33-38.
15. Jeffes EW III, McCullough JL, Pittelkow MR, et al. Methotrexate therapy of psoriasis: differential sensitivity of proliferating lymphoid and epithelial cells to the cytotoxic and growth-inhibitory effects of methotrexate. J Invest Dermatol 1995; 104: 183-188.
16. Menter A, Korman NJ, Elmets CA, et al. Guidelines of care for the management of psoriasis and psoriatic arthritis: Section 4. Guidelines of care for the management and treatment of psoriasis with traditional systemic agents. J Am Acad Dermatol 2009; 61: 451-485.
17. Saporito FC, Menter MA,. Methotrexate and psoriasis in the era of new biologic agents. J Am Acad Dermatol 2004; 50: 301-309.
18. Lipsky JJ,. Mycophenolate mofetil. Lancet 1996; 348: 1357-1359.
19. Epinette WW, Parker CM, Jones EL, et al. Mycophenolic acid for psoriasis: a review of pharmacology, long-term efficacy, and safety. J Am Acad Dermatol 1987; 17: 962-971.